Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Mitogen-activated protein kinase kinase kinase kinase 4
(Homo sapiens (Human)) | BDBM299395
(N-[3-(4-amino- quinazolin-6- yl)-5-fluoro- phenyl]...)Show SMILES Nc1ncnc2ccc(cc12)-c1cc(F)cc(NC(=O)CC2CCCO2)c1 Show InChI InChI=1S/C20H19FN4O2/c21-14-6-13(12-3-4-18-17(8-12)20(22)24-11-23-18)7-15(9-14)25-19(26)10-16-2-1-5-27-16/h3-4,6-9,11,16H,1-2,5,10H2,(H,25,26)(H2,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 844 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
| Assay Description
The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ... |
J Med Chem 46: 3709-27 (2003)
BindingDB Entry DOI: 10.7270/Q2VH5R4B |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 4
(Homo sapiens (Human)) | BDBM299395
(N-[3-(4-amino- quinazolin-6- yl)-5-fluoro- phenyl]...)Show SMILES Nc1ncnc2ccc(cc12)-c1cc(F)cc(NC(=O)CC2CCCO2)c1 Show InChI InChI=1S/C20H19FN4O2/c21-14-6-13(12-3-4-18-17(8-12)20(22)24-11-23-18)7-15(9-14)25-19(26)10-16-2-1-5-27-16/h3-4,6-9,11,16H,1-2,5,10H2,(H,25,26)(H2,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 844 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech, Inc.
US Patent
| Assay Description
The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ... |
US Patent US9592235 (2017)
BindingDB Entry DOI: 10.7270/Q2VX0JKX |
More data for this
Ligand-Target Pair | |