Found 6 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM340888
(3-(naphthalen-1-ylmethyl)-1-(tetrahydro-2H- pyran-...)Show InChI InChI=1S/C21H21N5O/c22-20-19-18(12-15-6-3-5-14-4-1-2-7-17(14)15)25-26(21(19)24-13-23-20)16-8-10-27-11-9-16/h1-7,13,16H,8-12H2,(H2,22,23,24) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 149 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center for Commercialization
US Patent
| Assay Description Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a... |
US Patent US9765037 (2017)
BindingDB Entry DOI: 10.7270/Q2B56MVC |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM340888
(3-(naphthalen-1-ylmethyl)-1-(tetrahydro-2H- pyran-...)Show InChI InChI=1S/C21H21N5O/c22-20-19-18(12-15-6-3-5-14-4-1-2-7-17(14)15)25-26(21(19)24-13-23-20)16-8-10-27-11-9-16/h1-7,13,16H,8-12H2,(H2,22,23,24) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 149 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this Ligand-Target Pair | |
cGMP-dependent protein kinase
() | BDBM340888
(3-(naphthalen-1-ylmethyl)-1-(tetrahydro-2H- pyran-...)Show InChI InChI=1S/C21H21N5O/c22-20-19-18(12-15-6-3-5-14-4-1-2-7-17(14)15)25-26(21(19)24-13-23-20)16-8-10-27-11-9-16/h1-7,13,16H,8-12H2,(H2,22,23,24) | UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 149 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K077GQ |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1, putative
(Cryptosporidium parvum (strain Iowa II)) | BDBM340888
(3-(naphthalen-1-ylmethyl)-1-(tetrahydro-2H- pyran-...)Show InChI InChI=1S/C21H21N5O/c22-20-19-18(12-15-6-3-5-14-4-1-2-7-17(14)15)25-26(21(19)24-13-23-20)16-8-10-27-11-9-16/h1-7,13,16H,8-12H2,(H2,22,23,24) | PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 265 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this Ligand-Target Pair | |
Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands
(Cryptosporidium parvum (strain Iowa II)) | BDBM340888
(3-(naphthalen-1-ylmethyl)-1-(tetrahydro-2H- pyran-...)Show InChI InChI=1S/C21H21N5O/c22-20-19-18(12-15-6-3-5-14-4-1-2-7-17(14)15)25-26(21(19)24-13-23-20)16-8-10-27-11-9-16/h1-7,13,16H,8-12H2,(H2,22,23,24) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 265 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K077GQ |
More data for this Ligand-Target Pair | |
Calcium-dependent protein kinase 1
(Cryptosporidium parvum) | BDBM340888
(3-(naphthalen-1-ylmethyl)-1-(tetrahydro-2H- pyran-...)Show InChI InChI=1S/C21H21N5O/c22-20-19-18(12-15-6-3-5-14-4-1-2-7-17(14)15)25-26(21(19)24-13-23-20)16-8-10-27-11-9-16/h1-7,13,16H,8-12H2,(H2,22,23,24) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 265 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center for Commercialization
US Patent
| Assay Description Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha... |
US Patent US9765037 (2017)
BindingDB Entry DOI: 10.7270/Q2B56MVC |
More data for this Ligand-Target Pair | |