Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Beta-1 adrenergic receptor
(Homo sapiens (Human)) | BDBM50218172
((R)-2-(2-(4-(2-cyclopentylthiazol-4-yl)phenoxy)eth...)Show SMILES O[C@@H](CNCCOc1ccc(cc1)-c1csc(n1)C1CCCC1)c1cccnc1 Show InChI InChI=1S/C23H27N3O2S/c27-22(19-6-3-11-24-14-19)15-25-12-13-28-20-9-7-17(8-10-20)21-16-29-23(26-21)18-4-1-2-5-18/h3,6-11,14,16,18,22,25,27H,1-2,4-5,12-13,15H2/t22-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cells |
Bioorg Med Chem Lett 17: 5245-50 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.072 BindingDB Entry DOI: 10.7270/Q2MK6CMZ |
More data for this Ligand-Target Pair | |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM50218172
((R)-2-(2-(4-(2-cyclopentylthiazol-4-yl)phenoxy)eth...)Show SMILES O[C@@H](CNCCOc1ccc(cc1)-c1csc(n1)C1CCCC1)c1cccnc1 Show InChI InChI=1S/C23H27N3O2S/c27-22(19-6-3-11-24-14-19)15-25-12-13-28-20-9-7-17(8-10-20)21-16-29-23(26-21)18-4-1-2-5-18/h3,6-11,14,16,18,22,25,27H,1-2,4-5,12-13,15H2/t22-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 290 | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Agonist activity at human adrenergic beta-3 receptor expressed in CHO cells assessed as cAMP production |
Bioorg Med Chem Lett 17: 5245-50 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.072 BindingDB Entry DOI: 10.7270/Q2MK6CMZ |
More data for this Ligand-Target Pair | |