Found 7 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human)) | BDBM21753
(2-[(1S)-5-(3-phenoxypropoxy)-2,3-dihydro-1H-inden-...)Show SMILES OC(=O)C[C@@H]1CCc2cc(OCCCOc3ccccc3)ccc12 |r| Show InChI InChI=1S/C20H22O4/c21-20(22)14-16-8-7-15-13-18(9-10-19(15)16)24-12-4-11-23-17-5-2-1-3-6-17/h1-3,5-6,9-10,13,16H,4,7-8,11-12,14H2,(H,21,22)/t16-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | 7.4 | 22 |
Bayer HealthCare Pharmaceuticals Corporation
| Assay Description Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid... |
J Med Chem 50: 984-1000 (2007)
Article DOI: 10.1021/jm061299k BindingDB Entry DOI: 10.7270/Q2NK3C93 |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor delta
(Homo sapiens (Human)) | BDBM21753
(2-[(1S)-5-(3-phenoxypropoxy)-2,3-dihydro-1H-inden-...)Show SMILES OC(=O)C[C@@H]1CCc2cc(OCCCOc3ccccc3)ccc12 |r| Show InChI InChI=1S/C20H22O4/c21-20(22)14-16-8-7-15-13-18(9-10-19(15)16)24-12-4-11-23-17-5-2-1-3-6-17/h1-3,5-6,9-10,13,16H,4,7-8,11-12,14H2,(H,21,22)/t16-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 44 | n/a | n/a | n/a | 25 |
Bayer HealthCare Pharmaceuticals Corporation
| Assay Description Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid... |
J Med Chem 50: 984-1000 (2007)
Article DOI: 10.1021/jm061299k BindingDB Entry DOI: 10.7270/Q2NK3C93 |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM21753
(2-[(1S)-5-(3-phenoxypropoxy)-2,3-dihydro-1H-inden-...)Show SMILES OC(=O)C[C@@H]1CCc2cc(OCCCOc3ccccc3)ccc12 |r| Show InChI InChI=1S/C20H22O4/c21-20(22)14-16-8-7-15-13-18(9-10-19(15)16)24-12-4-11-23-17-5-2-1-3-6-17/h1-3,5-6,9-10,13,16H,4,7-8,11-12,14H2,(H,21,22)/t16-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | 25 |
Bayer HealthCare Pharmaceuticals Corporation
| Assay Description PPAR gamma activity was assessed by using the IRBA in mouse 3T3-L1 cells. This assay measures the ability of test compound to cause an increase in th... |
J Med Chem 50: 984-1000 (2007)
Article DOI: 10.1021/jm061299k BindingDB Entry DOI: 10.7270/Q2NK3C93 |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human)) | BDBM21753
(2-[(1S)-5-(3-phenoxypropoxy)-2,3-dihydro-1H-inden-...)Show SMILES OC(=O)C[C@@H]1CCc2cc(OCCCOc3ccccc3)ccc12 |r| Show InChI InChI=1S/C20H22O4/c21-20(22)14-16-8-7-15-13-18(9-10-19(15)16)24-12-4-11-23-17-5-2-1-3-6-17/h1-3,5-6,9-10,13,16H,4,7-8,11-12,14H2,(H,21,22)/t16-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Guangdong Pharmaceutical University
Curated by ChEMBL
| Assay Description Agonist activity at human GAL4 fused PPARalpha-LBD expressed in human HepG2 cells after 18 hrs by luciferase reporter gene assay |
Eur J Med Chem 159: 267-276 (2018)
Article DOI: 10.1016/j.ejmech.2018.09.071 BindingDB Entry DOI: 10.7270/Q27D2XTM |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM21753
(2-[(1S)-5-(3-phenoxypropoxy)-2,3-dihydro-1H-inden-...)Show SMILES OC(=O)C[C@@H]1CCc2cc(OCCCOc3ccccc3)ccc12 |r| Show InChI InChI=1S/C20H22O4/c21-20(22)14-16-8-7-15-13-18(9-10-19(15)16)24-12-4-11-23-17-5-2-1-3-6-17/h1-3,5-6,9-10,13,16H,4,7-8,11-12,14H2,(H,21,22)/t16-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Guangdong Pharmaceutical University
Curated by ChEMBL
| Assay Description Agonist activity at human GAL4 fused PPARgamma-LBD expressed in HEK293 cells after 18 hrs by luciferase reporter gene assay |
Eur J Med Chem 159: 267-276 (2018)
Article DOI: 10.1016/j.ejmech.2018.09.071 BindingDB Entry DOI: 10.7270/Q27D2XTM |
More data for this Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM21753
(2-[(1S)-5-(3-phenoxypropoxy)-2,3-dihydro-1H-inden-...)Show SMILES OC(=O)C[C@@H]1CCc2cc(OCCCOc3ccccc3)ccc12 |r| Show InChI InChI=1S/C20H22O4/c21-20(22)14-16-8-7-15-13-18(9-10-19(15)16)24-12-4-11-23-17-5-2-1-3-6-17/h1-3,5-6,9-10,13,16H,4,7-8,11-12,14H2,(H,21,22)/t16-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Guangdong Pharmaceutical University
Curated by ChEMBL
| Assay Description Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay |
Eur J Med Chem 159: 267-276 (2018)
Article DOI: 10.1016/j.ejmech.2018.09.071 BindingDB Entry DOI: 10.7270/Q27D2XTM |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor delta
(Homo sapiens (Human)) | BDBM21753
(2-[(1S)-5-(3-phenoxypropoxy)-2,3-dihydro-1H-inden-...)Show SMILES OC(=O)C[C@@H]1CCc2cc(OCCCOc3ccccc3)ccc12 |r| Show InChI InChI=1S/C20H22O4/c21-20(22)14-16-8-7-15-13-18(9-10-19(15)16)24-12-4-11-23-17-5-2-1-3-6-17/h1-3,5-6,9-10,13,16H,4,7-8,11-12,14H2,(H,21,22)/t16-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 170 | n/a | n/a | n/a | n/a |
Guangdong Pharmaceutical University
Curated by ChEMBL
| Assay Description Agonist activity at human GAL4 fused PPARdelta-LBD expressed in HEK293 cells after 18 hrs by luciferase reporter gene assay |
Eur J Med Chem 159: 267-276 (2018)
Article DOI: 10.1016/j.ejmech.2018.09.071 BindingDB Entry DOI: 10.7270/Q27D2XTM |
More data for this Ligand-Target Pair | |