Found 8 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Caspase-8
(Homo sapiens (Human)) | BDBM225
((S)-5-5-(1-Carboxymethyl-2-oxo-ethylcarbamoyl)-thi...)Show SMILES OC(=O)C[C@H](NC(=O)c1ccc(CNS(=O)(=O)c2ccc(O)c(c2)C(O)=O)s1)C=O |r| Show InChI InChI=1S/C17H16N2O9S2/c20-8-9(5-15(22)23)19-16(24)14-4-1-10(29-14)7-18-30(27,28)11-2-3-13(21)12(6-11)17(25)26/h1-4,6,8-9,18,21H,5,7H2,(H,19,24)(H,22,23)(H,25,26)/t9-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 50 | -41.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Sunesis Pharmaceuticals
| Assay Description The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ... |
J Med Chem 45: 5005-22 (2002)
Article DOI: 10.1021/jm020230j BindingDB Entry DOI: 10.7270/Q2B56GW5 |
More data for this Ligand-Target Pair | |
Caspase-7
(Homo sapiens (Human)) | BDBM225
((S)-5-5-(1-Carboxymethyl-2-oxo-ethylcarbamoyl)-thi...)Show SMILES OC(=O)C[C@H](NC(=O)c1ccc(CNS(=O)(=O)c2ccc(O)c(c2)C(O)=O)s1)C=O |r| Show InChI InChI=1S/C17H16N2O9S2/c20-8-9(5-15(22)23)19-16(24)14-4-1-10(29-14)7-18-30(27,28)11-2-3-13(21)12(6-11)17(25)26/h1-4,6,8-9,18,21H,5,7H2,(H,19,24)(H,22,23)(H,25,26)/t9-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 120 | -39.5 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Sunesis Pharmaceuticals
| Assay Description The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ... |
J Med Chem 45: 5005-22 (2002)
Article DOI: 10.1021/jm020230j BindingDB Entry DOI: 10.7270/Q2B56GW5 |
More data for this Ligand-Target Pair | |
Caspase-3
(Homo sapiens (Human)) | BDBM225
((S)-5-5-(1-Carboxymethyl-2-oxo-ethylcarbamoyl)-thi...)Show SMILES OC(=O)C[C@H](NC(=O)c1ccc(CNS(=O)(=O)c2ccc(O)c(c2)C(O)=O)s1)C=O |r| Show InChI InChI=1S/C17H16N2O9S2/c20-8-9(5-15(22)23)19-16(24)14-4-1-10(29-14)7-18-30(27,28)11-2-3-13(21)12(6-11)17(25)26/h1-4,6,8-9,18,21H,5,7H2,(H,19,24)(H,22,23)(H,25,26)/t9-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 120 | -39.5 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Sunesis Pharmaceuticals
| Assay Description The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ... |
J Med Chem 45: 5005-22 (2002)
Article DOI: 10.1021/jm020230j BindingDB Entry DOI: 10.7270/Q2B56GW5 |
More data for this Ligand-Target Pair | |
Caspase-6
(Homo sapiens (Human)) | BDBM225
((S)-5-5-(1-Carboxymethyl-2-oxo-ethylcarbamoyl)-thi...)Show SMILES OC(=O)C[C@H](NC(=O)c1ccc(CNS(=O)(=O)c2ccc(O)c(c2)C(O)=O)s1)C=O |r| Show InChI InChI=1S/C17H16N2O9S2/c20-8-9(5-15(22)23)19-16(24)14-4-1-10(29-14)7-18-30(27,28)11-2-3-13(21)12(6-11)17(25)26/h1-4,6,8-9,18,21H,5,7H2,(H,19,24)(H,22,23)(H,25,26)/t9-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 540 | -35.8 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Sunesis Pharmaceuticals
| Assay Description The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ... |
J Med Chem 45: 5005-22 (2002)
Article DOI: 10.1021/jm020230j BindingDB Entry DOI: 10.7270/Q2B56GW5 |
More data for this Ligand-Target Pair | |
Caspase-1
(Homo sapiens (Human)) | BDBM225
((S)-5-5-(1-Carboxymethyl-2-oxo-ethylcarbamoyl)-thi...)Show SMILES OC(=O)C[C@H](NC(=O)c1ccc(CNS(=O)(=O)c2ccc(O)c(c2)C(O)=O)s1)C=O |r| Show InChI InChI=1S/C17H16N2O9S2/c20-8-9(5-15(22)23)19-16(24)14-4-1-10(29-14)7-18-30(27,28)11-2-3-13(21)12(6-11)17(25)26/h1-4,6,8-9,18,21H,5,7H2,(H,19,24)(H,22,23)(H,25,26)/t9-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.90E+3 | -32.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Sunesis Pharmaceuticals
| Assay Description The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ... |
J Med Chem 45: 5005-22 (2002)
Article DOI: 10.1021/jm020230j BindingDB Entry DOI: 10.7270/Q2B56GW5 |
More data for this Ligand-Target Pair | |
Caspase-2
(Homo sapiens (Human)) | BDBM225
((S)-5-5-(1-Carboxymethyl-2-oxo-ethylcarbamoyl)-thi...)Show SMILES OC(=O)C[C@H](NC(=O)c1ccc(CNS(=O)(=O)c2ccc(O)c(c2)C(O)=O)s1)C=O |r| Show InChI InChI=1S/C17H16N2O9S2/c20-8-9(5-15(22)23)19-16(24)14-4-1-10(29-14)7-18-30(27,28)11-2-3-13(21)12(6-11)17(25)26/h1-4,6,8-9,18,21H,5,7H2,(H,19,24)(H,22,23)(H,25,26)/t9-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 2.10E+4 | -26.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Sunesis Pharmaceuticals
| Assay Description The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ... |
J Med Chem 45: 5005-22 (2002)
Article DOI: 10.1021/jm020230j BindingDB Entry DOI: 10.7270/Q2B56GW5 |
More data for this Ligand-Target Pair | |
Caspase-5
(Homo sapiens (Human)) | BDBM225
((S)-5-5-(1-Carboxymethyl-2-oxo-ethylcarbamoyl)-thi...)Show SMILES OC(=O)C[C@H](NC(=O)c1ccc(CNS(=O)(=O)c2ccc(O)c(c2)C(O)=O)s1)C=O |r| Show InChI InChI=1S/C17H16N2O9S2/c20-8-9(5-15(22)23)19-16(24)14-4-1-10(29-14)7-18-30(27,28)11-2-3-13(21)12(6-11)17(25)26/h1-4,6,8-9,18,21H,5,7H2,(H,19,24)(H,22,23)(H,25,26)/t9-/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 2.40E+4 | -26.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Sunesis Pharmaceuticals
| Assay Description The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ... |
J Med Chem 45: 5005-22 (2002)
Article DOI: 10.1021/jm020230j BindingDB Entry DOI: 10.7270/Q2B56GW5 |
More data for this Ligand-Target Pair | |
Caspase-4
(Homo sapiens (Human)) | BDBM225
((S)-5-5-(1-Carboxymethyl-2-oxo-ethylcarbamoyl)-thi...)Show SMILES OC(=O)C[C@H](NC(=O)c1ccc(CNS(=O)(=O)c2ccc(O)c(c2)C(O)=O)s1)C=O |r| Show InChI InChI=1S/C17H16N2O9S2/c20-8-9(5-15(22)23)19-16(24)14-4-1-10(29-14)7-18-30(27,28)11-2-3-13(21)12(6-11)17(25)26/h1-4,6,8-9,18,21H,5,7H2,(H,19,24)(H,22,23)(H,25,26)/t9-/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 3.80E+4 | -25.2 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Sunesis Pharmaceuticals
| Assay Description The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ... |
J Med Chem 45: 5005-22 (2002)
Article DOI: 10.1021/jm020230j BindingDB Entry DOI: 10.7270/Q2B56GW5 |
More data for this Ligand-Target Pair | |