Reaction Details |
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Target | Caspase-5 |
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Ligand | BDBM225 |
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Substrate/Competitor | Caspase-1 Fluorogenic Substrate Ac-Trp-Glu-His-Asp-AFC |
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Meas. Tech. | Fluorometric Assay |
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pH | 7.4±n/a |
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Temperature | 298.15±n/a K |
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Ki | 24000±n/a nM |
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Citation | Choong, IC; Lew, W; Lee, D; Pham, P; Burdett, MT; Lam, JW; Wiesmann, C; Luong, TN; Fahr, B; DeLano, WL; McDowell, RS; Allen, DA; Erlanson, DA; Gordon, EM; O'Brien, T Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design. J Med Chem45:5005-22 (2002) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Caspase-5 |
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Name: | Caspase-5 |
Synonyms: | CASP-5 | CASP5 | CASP5_HUMAN | Caspase 5 | Caspase-5 subunit p10 | Caspase-5 subunit p20 | ICE(rel)-III | ICH-3 protease | ICH3 | Protease ICH-3 | Protease TY | TY protease |
Type: | Enzyme |
Mol. Mass.: | 49760.80 |
Organism: | Homo sapiens (Human) |
Description: | P51878 |
Residue: | 434 |
Sequence: | MAEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQTLVPNTDQKSTSVK
KDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR
KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD
EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD
MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC
LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF
CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE
RATLTRDFYLFPGN
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BDBM225 |
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Caspase-1 Fluorogenic Substrate Ac-Trp-Glu-His-Asp-AFC |
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Name: | Caspase-1 Fluorogenic Substrate Ac-Trp-Glu-His-Asp-AFC |
Synonyms: | Caspase-4 Fluorometric Substrate Ac-Trp-Glu-His-Asp-AFC | Caspase-5 Fluorometric Substrate Ac-Trp-Glu-His-Asp-AFC |
Type: | Peptide |
Mol. Mass.: | 584.05 |
Organism: | n/a |
Description: | Molecular Mass of WEHD |
Residue: | 4 |
Sequence: | |