Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 500.5 BDBM50264783

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM50264783 (CHEMBL4086411) Show SMILES OC(=O)CCC1(CCN(CC1)c1ccc(cn1)-c1nc2cc(ccc2[nH]1)C(F)(F)F)C1CCCCC1 Show InChI InChI=1S/C27H31F3N4O2/c28-27(29,30)20-7-8-21-22(16-20)33-25(32-21)18-6-9-23(31-17-18)34-14-12-26(13-15-34,11-10-24(35)36)19-4-2-1-3-5-19/h6-9,16-17,19H,1-5,10-15H2,(H,32,33)(H,35,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	207	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co., Inc. Curated by ChEMBL					Assay Description Inhibition of human DGAT1 expressed in yeast membrane fraction assessed as inhibition of triglyceride formation using diolein/oleoyl-CoA as substrate...				J Med Chem 60: 3594-3605 (2017) Article DOI: 10.1021/acs.jmedchem.6b01543 BindingDB Entry DOI: 10.7270/Q290267S
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