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BDBM50264783 CHEMBL4086411

SMILES: OC(=O)CCC1(CCN(CC1)c1ccc(cn1)-c1nc2cc(ccc2[nH]1)C(F)(F)F)C1CCCCC1

InChI Key: InChIKey=VDPQOBPPLDNPCC-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50264783   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))		BDBM50264783
PNG
(CHEMBL4086411)
Show SMILES OC(=O)CCC1(CCN(CC1)c1ccc(cn1)-c1nc2cc(ccc2[nH]1)C(F)(F)F)C1CCCCC1
Show InChI InChI=1S/C27H31F3N4O2/c28-27(29,30)20-7-8-21-22(16-20)33-25(32-21)18-6-9-23(31-17-18)34-14-12-26(13-15-34,11-10-24(35)36)19-4-2-1-3-5-19/h6-9,16-17,19H,1-5,10-15H2,(H,32,33)(H,35,36)
PDB

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PC sid
UniChem

Similars
Article
PubMed
n/an/a 207n/an/an/an/an/an/a



Merck& Co., Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in yeast membrane fraction assessed as inhibition of triglyceride formation using diolein/oleoyl-CoA as substrate...

J Med Chem 60: 3594-3605 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01543
BindingDB Entry DOI: 10.7270/Q290267S
More data for this
Ligand-Target Pair