Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50053771
(5-[1-Pyrazin-2-yl-1-(3-trifluoromethyl-phenyl)-met...)Show SMILES OC(=O)CCCCO\N=C(/c1cccc(c1)C(F)(F)F)c1cnccn1 Show InChI InChI=1S/C17H16F3N3O3/c18-17(19,20)13-5-3-4-12(10-13)16(14-11-21-7-8-22-14)23-26-9-2-1-6-15(24)25/h3-5,7-8,10-11H,1-2,6,9H2,(H,24,25)/b23-16+ | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Innsbruck
Curated by ChEMBL
| Assay Description TXA2 synthetase inhibition measured by the inhibition of TXB2 formation by human gel-filtered platelets incubated with [14C]-arachidonic acid |
J Med Chem 39: 4058-64 (1996)
Article DOI: 10.1021/jm960341g BindingDB Entry DOI: 10.7270/Q2ZP456G |
More data for this Ligand-Target Pair | |
Thromboxane A2 receptor
(Homo sapiens (Human)) | BDBM50053771
(5-[1-Pyrazin-2-yl-1-(3-trifluoromethyl-phenyl)-met...)Show SMILES OC(=O)CCCCO\N=C(/c1cccc(c1)C(F)(F)F)c1cnccn1 Show InChI InChI=1S/C17H16F3N3O3/c18-17(19,20)13-5-3-4-12(10-13)16(14-11-21-7-8-22-14)23-26-9-2-1-6-15(24)25/h3-5,7-8,10-11H,1-2,6,9H2,(H,24,25)/b23-16+ | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Innsbruck
Curated by ChEMBL
| Assay Description TXA2 receptor antagonism, measured by the displacement of [3H]SQ29,548 from the PGH-2/TXA-2 receptor on human platelets |
J Med Chem 39: 4058-64 (1996)
Article DOI: 10.1021/jm960341g BindingDB Entry DOI: 10.7270/Q2ZP456G |
More data for this Ligand-Target Pair | |