Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM24238
(Benzthiazole compound, 33p | N-(1-{[4-(1,3-benzoth...)Show SMILES OCC(=O)NC1CCN(Cc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C21H23N3O3S/c25-14-20(26)22-16-9-11-24(12-10-16)13-15-5-7-17(8-6-15)27-21-23-18-3-1-2-4-19(18)28-21/h1-8,16,25H,9-14H2,(H,22,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | 25 |
Johnson & Johnson Pharmaceutical
| Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,... |
J Med Chem 51: 4150-69 (2008)
Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM24238
(Benzthiazole compound, 33p | N-(1-{[4-(1,3-benzoth...)Show SMILES OCC(=O)NC1CCN(Cc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C21H23N3O3S/c25-14-20(26)22-16-9-11-24(12-10-16)13-15-5-7-17(8-6-15)27-21-23-18-3-1-2-4-19(18)28-21/h1-8,16,25H,9-14H2,(H,22,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 9.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development LLC
Curated by ChEMBL
| Assay Description Inhibition of dofetilide binding to human ERG by patch clamp assay |
Bioorg Med Chem Lett 22: 7504-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.036 BindingDB Entry DOI: 10.7270/Q2ZG6TDQ |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM24238
(Benzthiazole compound, 33p | N-(1-{[4-(1,3-benzoth...)Show SMILES OCC(=O)NC1CCN(Cc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C21H23N3O3S/c25-14-20(26)22-16-9-11-24(12-10-16)13-15-5-7-17(8-6-15)27-21-23-18-3-1-2-4-19(18)28-21/h1-8,16,25H,9-14H2,(H,22,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical
| Assay Description Compounds were assessed for their ability to displace [3H]astemizole using membranes from HEK-293 cells expressing the hERG K+ channel. |
J Med Chem 51: 4150-69 (2008)
Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX |
More data for this Ligand-Target Pair | |