Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 369.3 BDBM50299065

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 9 hits in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neutrophil collagenase (Homo sapiens (Human))	BDBM50299065 (CHEMBL575896 | N-Hydroxy-2-(4-phenoxy-benzenesulfo...) Show SMILES ONC(=O)c1ccccc1S(=O)(=O)c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C19H15NO5S/c21-19(20-22)17-8-4-5-9-18(17)26(23,24)16-12-10-15(11-13-16)25-14-6-2-1-3-7-14/h1-13,22H,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Inhibition of para-aminophenylmercuric acetate-activated human pro-MMP8 after 4 hrs by fluorimetry				J Med Chem 52: 6347-61 (2009) Article DOI: 10.1021/jm900335a BindingDB Entry DOI: 10.7270/Q2HQ3ZZS
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50299065 (CHEMBL575896 | N-Hydroxy-2-(4-phenoxy-benzenesulfo...) Show SMILES ONC(=O)c1ccccc1S(=O)(=O)c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C19H15NO5S/c21-19(20-22)17-8-4-5-9-18(17)26(23,24)16-12-10-15(11-13-16)25-14-6-2-1-3-7-14/h1-13,22H,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	690	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Inhibition of para-aminophenylmercuric acetate-activated human recombinant pro-MMP9 catalytic domain after 4 hrs by fluorimetry				J Med Chem 52: 6347-61 (2009) Article DOI: 10.1021/jm900335a BindingDB Entry DOI: 10.7270/Q2HQ3ZZS
					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM50299065 (CHEMBL575896 | N-Hydroxy-2-(4-phenoxy-benzenesulfo...) Show SMILES ONC(=O)c1ccccc1S(=O)(=O)c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C19H15NO5S/c21-19(20-22)17-8-4-5-9-18(17)26(23,24)16-12-10-15(11-13-16)25-14-6-2-1-3-7-14/h1-13,22H,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Inhibition of autoactivated human pro-MMP12 after 4 hrs by fluorimetry				J Med Chem 52: 6347-61 (2009) Article DOI: 10.1021/jm900335a BindingDB Entry DOI: 10.7270/Q2HQ3ZZS
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50299065 (CHEMBL575896 | N-Hydroxy-2-(4-phenoxy-benzenesulfo...) Show SMILES ONC(=O)c1ccccc1S(=O)(=O)c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C19H15NO5S/c21-19(20-22)17-8-4-5-9-18(17)26(23,24)16-12-10-15(11-13-16)25-14-6-2-1-3-7-14/h1-13,22H,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Inhibition of para-aminophenylmercuric acetate-activated human recombinant pro-MMP2 catalytic domain after 4 hrs by fluorimetry				J Med Chem 52: 6347-61 (2009) Article DOI: 10.1021/jm900335a BindingDB Entry DOI: 10.7270/Q2HQ3ZZS
					More data for this Ligand-Target Pair
Matrix metalloproteinase-16 (Homo sapiens (Human))	BDBM50299065 (CHEMBL575896 | N-Hydroxy-2-(4-phenoxy-benzenesulfo...) Show SMILES ONC(=O)c1ccccc1S(=O)(=O)c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C19H15NO5S/c21-19(20-22)17-8-4-5-9-18(17)26(23,24)16-12-10-15(11-13-16)25-14-6-2-1-3-7-14/h1-13,22H,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Inhibition of human recombinant pro-MMP16 catalytic domain after 4 hrs by fluorimetry				J Med Chem 52: 6347-61 (2009) Article DOI: 10.1021/jm900335a BindingDB Entry DOI: 10.7270/Q2HQ3ZZS
					More data for this Ligand-Target Pair
Matrix metalloproteinase-14 (Homo sapiens (Human))	BDBM50299065 (CHEMBL575896 | N-Hydroxy-2-(4-phenoxy-benzenesulfo...) Show SMILES ONC(=O)c1ccccc1S(=O)(=O)c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C19H15NO5S/c21-19(20-22)17-8-4-5-9-18(17)26(23,24)16-12-10-15(11-13-16)25-14-6-2-1-3-7-14/h1-13,22H,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Inhibition of human recombinant pro-MMP14 catalytic domain after 4 hrs by fluorimetry				J Med Chem 52: 6347-61 (2009) Article DOI: 10.1021/jm900335a BindingDB Entry DOI: 10.7270/Q2HQ3ZZS
					More data for this Ligand-Target Pair
Collagenase 3 (Homo sapiens (Human))	BDBM50299065 (CHEMBL575896 | N-Hydroxy-2-(4-phenoxy-benzenesulfo...) Show SMILES ONC(=O)c1ccccc1S(=O)(=O)c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C19H15NO5S/c21-19(20-22)17-8-4-5-9-18(17)26(23,24)16-12-10-15(11-13-16)25-14-6-2-1-3-7-14/h1-13,22H,(H,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Inhibition of para-aminophenylmercuric acetate-activated human pro-MMP13 after 4 hrs by fluorimetry				J Med Chem 52: 6347-61 (2009) Article DOI: 10.1021/jm900335a BindingDB Entry DOI: 10.7270/Q2HQ3ZZS
					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50299065 (CHEMBL575896 | N-Hydroxy-2-(4-phenoxy-benzenesulfo...) Show SMILES ONC(=O)c1ccccc1S(=O)(=O)c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C19H15NO5S/c21-19(20-22)17-8-4-5-9-18(17)26(23,24)16-12-10-15(11-13-16)25-14-6-2-1-3-7-14/h1-13,22H,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Inhibition of para-aminophenylmercuric acetate-activated human pro-MMP1 after 4 hrs by fluorimetry				J Med Chem 52: 6347-61 (2009) Article DOI: 10.1021/jm900335a BindingDB Entry DOI: 10.7270/Q2HQ3ZZS
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50299065 (CHEMBL575896 | N-Hydroxy-2-(4-phenoxy-benzenesulfo...) Show SMILES ONC(=O)c1ccccc1S(=O)(=O)c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C19H15NO5S/c21-19(20-22)17-8-4-5-9-18(17)26(23,24)16-12-10-15(11-13-16)25-14-6-2-1-3-7-14/h1-13,22H,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Inhibition of trypsin activated human pro-MMP3 after 4 hrs by fluorimetry				J Med Chem 52: 6347-61 (2009) Article DOI: 10.1021/jm900335a BindingDB Entry DOI: 10.7270/Q2HQ3ZZS
					More data for this Ligand-Target Pair