| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50299065 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_591603 (CHEMBL1042356) |
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| IC50 | >10000±n/a nM |
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| Citation |  Nuti, E; Panelli, L; Casalini, F; Avramova, SI; Orlandini, E; Santamaria, S; Nencetti, S; Tuccinardi, T; Martinelli, A; Cercignani, G; D'Amelio, N; Maiocchi, A; Uggeri, F; Rossello, A Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhibitors. J Med Chem52:6347-61 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50299065 |
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| n/a |
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| Name | BDBM50299065 |
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| Synonyms: | CHEMBL575896 | N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide |
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| Type | Small organic molecule |
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| Emp. Form. | C19H15NO5S |
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| Mol. Mass. | 369.391 |
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| SMILES | ONC(=O)c1ccccc1S(=O)(=O)c1ccc(Oc2ccccc2)cc1 |
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| Structure | 
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