Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
KiSS-1 receptor
(Homo sapiens (Human)) | BDBM50322299
(CHEMBL1173643 | N-[3-Cyano-6-(4-fluoro-2-hydroxyph...)Show SMILES Oc1cc(F)ccc1-c1cc(-c2cccc(c2)N2CCNCC2)c(C#N)c(NC(=O)c2ccco2)n1 Show InChI InChI=1S/C27H22FN5O3/c28-18-6-7-20(24(34)14-18)23-15-21(17-3-1-4-19(13-17)33-10-8-30-9-11-33)22(16-29)26(31-23)32-27(35)25-5-2-12-36-25/h1-7,12-15,30,34H,8-11H2,(H,31,32,35) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description Displacement of [125I]metastin from human GPR54 receptor expressed in CHO cells |
Bioorg Med Chem 18: 5157-71 (2010)
Article DOI: 10.1016/j.bmc.2010.05.061 BindingDB Entry DOI: 10.7270/Q21R6RHM |
More data for this Ligand-Target Pair | |
KiSS-1 receptor
(Rattus norvegicus) | BDBM50322299
(CHEMBL1173643 | N-[3-Cyano-6-(4-fluoro-2-hydroxyph...)Show SMILES Oc1cc(F)ccc1-c1cc(-c2cccc(c2)N2CCNCC2)c(C#N)c(NC(=O)c2ccco2)n1 Show InChI InChI=1S/C27H22FN5O3/c28-18-6-7-20(24(34)14-18)23-15-21(17-3-1-4-19(13-17)33-10-8-30-9-11-33)22(16-29)26(31-23)32-27(35)25-5-2-12-36-25/h1-7,12-15,30,34H,8-11H2,(H,31,32,35) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description Displacement of [125I]metastin from rat GPR54 receptor expressed in CHO cells |
Bioorg Med Chem 18: 5157-71 (2010)
Article DOI: 10.1016/j.bmc.2010.05.061 BindingDB Entry DOI: 10.7270/Q21R6RHM |
More data for this Ligand-Target Pair | |
KiSS-1 receptor
(Homo sapiens (Human)) | BDBM50322299
(CHEMBL1173643 | N-[3-Cyano-6-(4-fluoro-2-hydroxyph...)Show SMILES Oc1cc(F)ccc1-c1cc(-c2cccc(c2)N2CCNCC2)c(C#N)c(NC(=O)c2ccco2)n1 Show InChI InChI=1S/C27H22FN5O3/c28-18-6-7-20(24(34)14-18)23-15-21(17-3-1-4-19(13-17)33-10-8-30-9-11-33)22(16-29)26(31-23)32-27(35)25-5-2-12-36-25/h1-7,12-15,30,34H,8-11H2,(H,31,32,35) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 930 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description Antagonist activity at human GPR54 receptor assessed as inhibition of metastin-induced calcium mobilization |
Bioorg Med Chem 18: 5157-71 (2010)
Article DOI: 10.1016/j.bmc.2010.05.061 BindingDB Entry DOI: 10.7270/Q21R6RHM |
More data for this Ligand-Target Pair | |