Found 5 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50326557
((E)-5-((2-hydroxynaphthalen-1-yl)diazenyl)naphthal...)Show SMILES Oc1ccc2ccccc2c1N=Nc1cccc2cc(ccc12)S(O)(=O)=O |w:12.14| Show InChI InChI=1S/C20H14N2O4S/c23-19-11-8-13-4-1-2-6-17(13)20(19)22-21-18-7-3-5-14-12-15(27(24,25)26)9-10-16(14)18/h1-12,23H,(H,24,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from EPAC2 (unknown origin) by fluorescence plate reader analysis |
J Med Chem 57: 3651-65 (2014)
Article DOI: 10.1021/jm401425e BindingDB Entry DOI: 10.7270/Q2WH2RJW |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM50326557
((E)-5-((2-hydroxynaphthalen-1-yl)diazenyl)naphthal...)Show SMILES Oc1ccc2ccccc2c1N=Nc1cccc2cc(ccc12)S(O)(=O)=O |w:12.14| Show InChI InChI=1S/C20H14N2O4S/c23-19-11-8-13-4-1-2-6-17(13)20(19)22-21-18-7-3-5-14-12-15(27(24,25)26)9-10-16(14)18/h1-12,23H,(H,24,25,26) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | 5.0 | n/a |
Purdue University
Curated by ChEMBL
| Assay Description Inhibition of human cytoplasmic protein tyrosine phosphatase B assessed as change in enzyme activity at pH 5 |
Bioorg Med Chem 18: 5449-56 (2010)
Article DOI: 10.1016/j.bmc.2010.04.050 BindingDB Entry DOI: 10.7270/Q2Q52QMC |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase alpha
(Homo sapiens (Human)) | BDBM50326557
((E)-5-((2-hydroxynaphthalen-1-yl)diazenyl)naphthal...)Show SMILES Oc1ccc2ccccc2c1N=Nc1cccc2cc(ccc12)S(O)(=O)=O |w:12.14| Show InChI InChI=1S/C20H14N2O4S/c23-19-11-8-13-4-1-2-6-17(13)20(19)22-21-18-7-3-5-14-12-15(27(24,25)26)9-10-16(14)18/h1-12,23H,(H,24,25,26) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | 5.0 | n/a |
Purdue University
Curated by ChEMBL
| Assay Description Inhibition of human cytoplasmic protein tyrosine phosphatase A assessed as change in enzyme activity at pH 5 |
Bioorg Med Chem 18: 5449-56 (2010)
Article DOI: 10.1016/j.bmc.2010.04.050 BindingDB Entry DOI: 10.7270/Q2Q52QMC |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase alpha
(Homo sapiens (Human)) | BDBM50326557
((E)-5-((2-hydroxynaphthalen-1-yl)diazenyl)naphthal...)Show SMILES Oc1ccc2ccccc2c1N=Nc1cccc2cc(ccc12)S(O)(=O)=O |w:12.14| Show InChI InChI=1S/C20H14N2O4S/c23-19-11-8-13-4-1-2-6-17(13)20(19)22-21-18-7-3-5-14-12-15(27(24,25)26)9-10-16(14)18/h1-12,23H,(H,24,25,26) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.10E+3 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Purdue University
Curated by ChEMBL
| Assay Description Inhibition of human cytoplasmic protein tyrosine phosphatase A assessed as change in enzyme activity at pH 7 |
Bioorg Med Chem 18: 5449-56 (2010)
Article DOI: 10.1016/j.bmc.2010.04.050 BindingDB Entry DOI: 10.7270/Q2Q52QMC |
More data for this Ligand-Target Pair | |
PhoP
(Salmonella enterica) | BDBM50326557
((E)-5-((2-hydroxynaphthalen-1-yl)diazenyl)naphthal...)Show SMILES Oc1ccc2ccccc2c1N=Nc1cccc2cc(ccc12)S(O)(=O)=O |w:12.14| Show InChI InChI=1S/C20H14N2O4S/c23-19-11-8-13-4-1-2-6-17(13)20(19)22-21-18-7-3-5-14-12-15(27(24,25)26)9-10-16(14)18/h1-12,23H,(H,24,25,26) | PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine
| Assay Description Inhibition of a protein-protein activity by EMSA assay. |
Chem Biol Drug Des 79: 1007-17 (2012)
Article DOI: 10.1111/j.1747-0285.2012.01362.x BindingDB Entry DOI: 10.7270/Q2FJ2FC7 |
More data for this Ligand-Target Pair | |