Compile Data Set for Download or QSAR

Found 265 hits Enz. Inhib. hit(s) with Target = 'A disintegrin and metalloproteinase with thrombospondin motifs 6'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429772 ((5R)-5-[3-[4- (4,5-dichloro- 2-methoxy- phenyl)-1-...) Show SMILES COc1cc(Cl)c(Cl)cc1C1CCN(CC1)C(=O)CC[C@@]1(C)NC(=O)NC1=O |r| Show InChI InChI=1S/C19H23Cl2N3O4/c1-19(17(26)22-18(27)23-19)6-3-16(25)24-7-4-11(5-8-24)12-9-13(20)14(21)10-15(12)28-2/h9-11H,3-8H2,1-2H3,(H2,22,23,26,27)/t19-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471743 (5-cyclopropyl-5- [3-[(3S)-4-(3,4- difluoro-5- meth...) Show SMILES COc1cc(cc(F)c1F)N1CCN(C[C@@H]1C)C(=O)CCC1(NC(=O)NC1=O)C1CC1 |r| Show InChI InChI=1S/C21H26F2N4O4/c1-12-11-26(7-8-27(12)14-9-15(22)18(23)16(10-14)31-2)17(28)5-6-21(13-3-4-13)19(29)24-20(30)25-21/h9-10,12-13H,3-8,11H2,1-2H3,(H2,24,25,29,30)/t12-,21?/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471757 (5-[3-[(3S)-4-(3,4- difluoro-5- methoxy-phenyl)- 3-...) Show SMILES COc1cc(cc(F)c1F)N1CCN(C[C@@H]1C)C(=O)CCC1(C)NC(=O)NC1=O |r| Show InChI InChI=1S/C19H24F2N4O4/c1-11-10-24(15(26)4-5-19(2)17(27)22-18(28)23-19)6-7-25(11)12-8-13(20)16(21)14(9-12)29-3/h8-9,11H,4-7,10H2,1-3H3,(H2,22,23,27,28)/t11-,19?/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471761 (5-[3-[(3S)-4-(4- chloro-3-methoxy- phenyl)-3-methy...) Show SMILES COc1cc(ccc1Cl)N1CCN(C[C@@H]1C)C(=O)CCC1(C)NC(=O)NC1=O |r| Show InChI InChI=1S/C19H25ClN4O4/c1-12-11-23(16(25)6-7-19(2)17(26)21-18(27)22-19)8-9-24(12)13-4-5-14(20)15(10-13)28-3/h4-5,10,12H,6-9,11H2,1-3H3,(H2,21,22,26,27)/t12-,19?/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471764 ((5S)-5- cyclopropyl- 5-[(2S)-3-[4-(3- fluoro-5-met...) Show SMILES COc1cc(F)cc(c1)N1CCN(CC1)C(=O)[C@@H](C)C[C@]1(NC(=O)NC1=O)C1CC1 |r| Show InChI InChI=1S/C21H27FN4O4/c1-13(12-21(14-3-4-14)19(28)23-20(29)24-21)18(27)26-7-5-25(6-8-26)16-9-15(22)10-17(11-16)30-2/h9-11,13-14H,3-8,12H2,1-2H3,(H2,23,24,28,29)/t13-,21-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471766 ((5R)-5-[(2S)-3-[4- (3-fluoro-5- methoxy- phenyl) p...) Show SMILES COc1cc(F)cc(c1)N1CCN(CC1)C(=O)[C@@H](C)C[C@@]1(C)NC(=O)NC1=O |r| Show InChI InChI=1S/C19H25FN4O4/c1-12(11-19(2)17(26)21-18(27)22-19)16(25)24-6-4-23(5-7-24)14-8-13(20)9-15(10-14)28-3/h8-10,12H,4-7,11H2,1-3H3,(H2,21,22,26,27)/t12-,19+/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471769 (5-cyclopropyl-5- [(2S)-3-[(3S)-4- (3,4-difluoro-5-...) Show SMILES COc1cc(cc(F)c1F)N1CCN(C[C@@H]1C)C(=O)[C@@H](C)C[C@]1(NC(=O)NC1=O)C1CC1 |r| Show InChI InChI=1S/C22H28F2N4O4/c1-12(10-22(14-4-5-14)20(30)25-21(31)26-22)19(29)27-6-7-28(13(2)11-27)15-8-16(23)18(24)17(9-15)32-3/h8-9,12-14H,4-7,10-11H2,1-3H3,(H2,25,26,30,31)/t12-,13-,22-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471771 (5-[3-[(3S)-4-(4- chloro-3,5- dimethoxy- phenyl)- 3...) Show SMILES COc1cc(cc(OC)c1Cl)N1CCN(C[C@@H]1C)C(=O)CCC1(C)NC(=O)NC1=O |r| Show InChI InChI=1S/C20H27ClN4O5/c1-12-11-24(16(26)5-6-20(2)18(27)22-19(28)23-20)7-8-25(12)13-9-14(29-3)17(21)15(10-13)30-4/h9-10,12H,5-8,11H2,1-4H3,(H2,22,23,27,28)/t12-,20?/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471775 (5-[3-[4-(4-chloro- 3,5-dimethoxy- phenyl) piperazi...) Show SMILES COc1cc(cc(OC)c1Cl)N1CCN(CC1)C(=O)CCC1(C)NC(=O)NC1=O Show InChI InChI=1S/C19H25ClN4O5/c1-19(17(26)21-18(27)22-19)5-4-15(25)24-8-6-23(7-9-24)12-10-13(28-2)16(20)14(11-12)29-3/h10-11H,4-9H2,1-3H3,(H2,21,22,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471788 ((5S)-5- cyclopropyl- 5-[3-[(3S)-4-(3,4- difluoro-5...) Show SMILES COc1cc(cc(F)c1F)N1CCN(C[C@@H]1C)C(=O)CC[C@]1(NC(=O)NC1=O)C1CC1 |r| Show InChI InChI=1S/C21H26F2N4O4/c1-12-11-26(7-8-27(12)14-9-15(22)18(23)16(10-14)31-2)17(28)5-6-21(13-3-4-13)19(29)24-20(30)25-21/h9-10,12-13H,3-8,11H2,1-2H3,(H2,24,25,29,30)/t12-,21-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471789 (5-[3-[4-(4-chloro- 3-fluoro-5- methoxy- phenyl) pi...) Show SMILES COc1cc(cc(F)c1Cl)N1CCN(CC1)C(=O)CCC1(C)NC(=O)NC1=O Show InChI InChI=1S/C18H22ClFN4O4/c1-18(16(26)21-17(27)22-18)4-3-14(25)24-7-5-23(6-8-24)11-9-12(20)15(19)13(10-11)28-2/h9-10H,3-8H2,1-2H3,(H2,21,22,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471790 (5-[3-[(3S)-4-(4- chloro-3-fluoro-5- methoxy-phenyl...) Show SMILES COc1cc(cc(F)c1Cl)N1CCN(C[C@@H]1C)C(=O)CCC1(C)NC(=O)NC1=O |r| Show InChI InChI=1S/C19H24ClFN4O4/c1-11-10-24(15(26)4-5-19(2)17(27)22-18(28)23-19)6-7-25(11)12-8-13(21)16(20)14(9-12)29-3/h8-9,11H,4-7,10H2,1-3H3,(H2,22,23,27,28)/t11-,19?/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471791 (5-[3-[4-(4-chloro- 3,5-dimethoxy- phenyl) piperazi...) Show SMILES COc1cc(cc(OC)c1Cl)N1CCN(CC1)C(=O)[C@@H](C)C[C@@]1(C)NC(=O)NC1=O |r| Show InChI InChI=1S/C20H27ClN4O5/c1-12(11-20(2)18(27)22-19(28)23-20)17(26)25-7-5-24(6-8-25)13-9-14(29-3)16(21)15(10-13)30-4/h9-10,12H,5-8,11H2,1-4H3,(H2,22,23,27,28)/t12-,20+/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471792 (5-[3-[4-(4-chloro- 3-methoxy- phenyl)-3-methyl- pi...) Show SMILES COc1cc(ccc1Cl)N1CCN(C[C@@H]1C)C(=O)[C@@H](C)C[C@@]1(C)NC(=O)NC1=O |r| Show InChI InChI=1S/C20H27ClN4O4/c1-12(10-20(3)18(27)22-19(28)23-20)17(26)24-7-8-25(13(2)11-24)14-5-6-15(21)16(9-14)29-4/h5-6,9,12-13H,7-8,10-11H2,1-4H3,(H2,22,23,27,28)/t12-,13-,20+/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471793 (5-[3-[(3S)-4-(3,4- difluoro-5- methoxy-phenyl)- 3-...) Show SMILES COc1cc(cc(F)c1F)N1CCN(C[C@@H]1C)C(=O)[C@@H](C)C[C@@]1(C)NC(=O)NC1=O |r| Show InChI InChI=1S/C20H26F2N4O4/c1-11(9-20(3)18(28)23-19(29)24-20)17(27)25-5-6-26(12(2)10-25)13-7-14(21)16(22)15(8-13)30-4/h7-8,11-12H,5-6,9-10H2,1-4H3,(H2,23,24,28,29)/t11-,12-,20+/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471794 (5-[3-[4-(3,4- difluoro-5- methoxy- phenyl) piperaz...) Show SMILES COc1cc(cc(F)c1F)N1CCN(CC1)C(=O)[C@@H](C)C[C@@]1(C)NC(=O)NC1=O |r| Show InChI InChI=1S/C19H24F2N4O4/c1-11(10-19(2)17(27)22-18(28)23-19)16(26)25-6-4-24(5-7-25)12-8-13(20)15(21)14(9-12)29-3/h8-9,11H,4-7,10H2,1-3H3,(H2,22,23,27,28)/t11-,19+/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471933 (5-[3-[(3S)-4-(4- chloro-3,5- dimethoxy- phenyl)- 3...) Show SMILES COc1cc(cc(OC)c1Cl)N1CCN(C[C@@H]1C)C(=O)[C@@H](C)C[C@@]1(C)NC(=O)NC1=O |r| Show InChI InChI=1S/C21H29ClN4O5/c1-12(10-21(3)19(28)23-20(29)24-21)18(27)25-6-7-26(13(2)11-25)14-8-15(30-4)17(22)16(9-14)31-5/h8-9,12-13H,6-7,10-11H2,1-5H3,(H2,23,24,28,29)/t12-,13-,21+/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471795 (5-[3-[(3S)-4-(3,4- difluoro-5- methoxy-phenyl)- 3-...) Show SMILES COC[C@]1(C[C@H](C)C(=O)N2CCN([C@@H](C)C2)c2cc(F)c(F)c(OC)c2)NC(=O)NC1=O |r| Show InChI InChI=1S/C21H28F2N4O5/c1-12(9-21(11-31-3)19(29)24-20(30)25-21)18(28)26-5-6-27(13(2)10-26)14-7-15(22)17(23)16(8-14)32-4/h7-8,12-13H,5-6,9-11H2,1-4H3,(H2,24,25,29,30)/t12-,13-,21-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471796 (5-[3-[(3S)-4-(4- chloro-3-methoxy- phenyl)-3-methy...) Show SMILES COC[C@]1(C[C@H](C)C(=O)N2CCN([C@@H](C)C2)c2ccc(Cl)c(OC)c2)NC(=O)NC1=O |r| Show InChI InChI=1S/C21H29ClN4O5/c1-13(10-21(12-30-3)19(28)23-20(29)24-21)18(27)25-7-8-26(14(2)11-25)15-5-6-16(22)17(9-15)31-4/h5-6,9,13-14H,7-8,10-12H2,1-4H3,(H2,23,24,28,29)/t13-,14-,21-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471797 (5-[3-[4-(3,4- dichloro-5- methoxy- phenyl) piperaz...) Show SMILES COc1cc(cc(Cl)c1Cl)N1CCN(CC1)C(=O)CCC1(C)NC(=O)NC1=O Show InChI InChI=1S/C18H22Cl2N4O4/c1-18(16(26)21-17(27)22-18)4-3-14(25)24-7-5-23(6-8-24)11-9-12(19)15(20)13(10-11)28-2/h9-10H,3-8H2,1-2H3,(H2,21,22,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471798 (5-[3-[(3S)-4-(3,4- difluoro-5- methoxy-phenyl)- 3-...) Show SMILES COc1cc(cc(F)c1F)N1CCN(C[C@@H]1C)C(=O)[C@@H](C)C[C@]1(NC(=O)NC1=O)c1ccccn1 |r| Show InChI InChI=1S/C24H27F2N5O4/c1-14(12-24(19-6-4-5-7-27-19)22(33)28-23(34)29-24)21(32)30-8-9-31(15(2)13-30)16-10-17(25)20(26)18(11-16)35-3/h4-7,10-11,14-15H,8-9,12-13H2,1-3H3,(H2,28,29,33,34)/t14-,15-,24-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471799 (5-[3-[4-(3-chloro- 4-fluoro-5- methoxy- phenyl) pi...) Show SMILES COc1cc(cc(Cl)c1F)N1CCN(CC1)C(=O)CCC1(C)NC(=O)NC1=O Show InChI InChI=1S/C18H22ClFN4O4/c1-18(16(26)21-17(27)22-18)4-3-14(25)24-7-5-23(6-8-24)11-9-12(19)15(20)13(10-11)28-2/h9-10H,3-8H2,1-2H3,(H2,21,22,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471800 (5-[3-[4-(3,4- difluoro-5- methoxy- phenyl) piperaz...) Show SMILES COc1cc(cc(F)c1F)N1CCN(CC1)C(=O)[C@@H](C)C[C@H]1NC(=O)NC1=O |r| Show InChI InChI=1S/C18H22F2N4O4/c1-10(7-13-16(25)22-18(27)21-13)17(26)24-5-3-23(4-6-24)11-8-12(19)15(20)14(9-11)28-2/h8-10,13H,3-7H2,1-2H3,(H2,21,22,25,27)/t10-,13+/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471801 (5-[3-[4-(3,4- difluoro-5- methoxy- phenyl) piperaz...) Show SMILES COc1cc(cc(F)c1F)N1CCN(CC1)C(=O)[C@@H](C)C[C@@]1(CN2CCC(F)(F)C2)NC(=O)NC1=O |r| Show InChI InChI=1S/C23H29F4N5O4/c1-14(11-22(20(34)28-21(35)29-22)12-30-4-3-23(26,27)13-30)19(33)32-7-5-31(6-8-32)15-9-16(24)18(25)17(10-15)36-2/h9-10,14H,3-8,11-13H2,1-2H3,(H2,28,29,34,35)/t14-,22-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471827 (5-[3-[(3S)-4-(3- chloro-4-fluoro-5- methoxy-phenyl...) Show SMILES COc1cc(cc(Cl)c1F)N1CCN(C[C@@H]1C)C(=O)CCC1(C)NC(=O)NC1=O |r| Show InChI InChI=1S/C19H24ClFN4O4/c1-11-10-24(15(26)4-5-19(2)17(27)22-18(28)23-19)6-7-25(11)12-8-13(20)16(21)14(9-12)29-3/h8-9,11H,4-7,10H2,1-3H3,(H2,22,23,27,28)/t11-,19?/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471828 ((5S)-5-[(2S)-3-[4- (3,4-difluoro-5- methoxy- pheny...) Show SMILES COc1cc(cc(F)c1F)N1CCN(CC1)C(=O)[C@@H](C)C[C@]1(NC(=O)NC1=O)c1ccccn1 |r| Show InChI InChI=1S/C23H25F2N5O4/c1-14(13-23(18-5-3-4-6-26-18)21(32)27-22(33)28-23)20(31)30-9-7-29(8-10-30)15-11-16(24)19(25)17(12-15)34-2/h3-6,11-12,14H,7-10,13H2,1-2H3,(H2,27,28,32,33)/t14-,23-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471829 ((5R)-5-[3-[(3S)-4- (4-chloro-3- methoxy-phenyl)- 3...) Show SMILES COc1cc(ccc1Cl)N1CCN(C[C@@H]1C)C(=O)CC[C@@]1(C)NC(=O)NC1=O |r| Show InChI InChI=1S/C19H25ClN4O4/c1-12-11-23(16(25)6-7-19(2)17(26)21-18(27)22-19)8-9-24(12)13-4-5-14(20)15(10-13)28-3/h4-5,10,12H,6-9,11H2,1-3H3,(H2,21,22,26,27)/t12-,19+/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471830 ((5R)-5-[(2R)-3-[4- (3,4-difluoro-5- methoxy- pheny...) Show SMILES COc1cc(cc(F)c1F)N1CCN(CC1)C(=O)[C@@H](CO)C[C@@]1(C)NC(=O)NC1=O |r| Show InChI InChI=1S/C19H24F2N4O5/c1-19(17(28)22-18(29)23-19)9-11(10-26)16(27)25-5-3-24(4-6-25)12-7-13(20)15(21)14(8-12)30-2/h7-8,11,26H,3-6,9-10H2,1-2H3,(H2,22,23,28,29)/t11-,19-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471831 ((5R)-5-[(2S)-3- [4-(3,4-difluoro- 5-methoxy- pheny...) Show SMILES CC[C@]1(C[C@H](C)C(=O)N2CCN(CC2)c2cc(F)c(F)c(OC)c2)NC(=O)NC1=O |r| Show InChI InChI=1S/C20H26F2N4O4/c1-4-20(18(28)23-19(29)24-20)11-12(2)17(27)26-7-5-25(6-8-26)13-9-14(21)16(22)15(10-13)30-3/h9-10,12H,4-8,11H2,1-3H3,(H2,23,24,28,29)/t12-,20+/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471834 ((5S)-5-[(2S)-3-[4- (3,4-difluoro-5- methoxy- pheny...) Show SMILES COC[C@]1(C[C@H](C)C(=O)N2CCN(CC2)c2cc(F)c(F)c(OC)c2)NC(=O)NC1=O |r| Show InChI InChI=1S/C20H26F2N4O5/c1-12(10-20(11-30-2)18(28)23-19(29)24-20)17(27)26-6-4-25(5-7-26)13-8-14(21)16(22)15(9-13)31-3/h8-9,12H,4-7,10-11H2,1-3H3,(H2,23,24,28,29)/t12-,20-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471837 (5-[3-[(3S)-4-(3,4- difluoro-5- methoxy-phenyl)- 3-...) Show SMILES COc1cc(cc(F)c1F)N1CCN(C[C@@H]1C)C(=O)CCC1(NC(=O)NC1=O)c1cccc(C)n1 |r| Show InChI InChI=1S/C24H27F2N5O4/c1-14-5-4-6-19(27-14)24(22(33)28-23(34)29-24)8-7-20(32)30-9-10-31(15(2)13-30)16-11-17(25)21(26)18(12-16)35-3/h4-6,11-12,15H,7-10,13H2,1-3H3,(H2,28,29,33,34)/t15-,24?/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471838 ((5S)-5-[3-[(3S)-4- (3-chloro- 4-fluoro- 5-methoxy-...) Show SMILES COc1cc(cc(Cl)c1F)N1CCN(C[C@@H]1C)C(=O)CC[C@]1(NC(=O)NC1=O)C1CC1 |r| Show InChI InChI=1S/C21H26ClFN4O4/c1-12-11-26(7-8-27(12)14-9-15(22)18(23)16(10-14)31-2)17(28)5-6-21(13-3-4-13)19(29)24-20(30)25-21/h9-10,12-13H,3-8,11H2,1-2H3,(H2,24,25,29,30)/t12-,21-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471839 ((5R)-5-[3-[(3S)-4- (3-chloro- 4-fluoro- 5-methoxy-...) Show SMILES COc1cc(cc(Cl)c1F)N1CCN(C[C@@H]1C)C(=O)CC[C@@]1(C)NC(=O)NC1=O |r| Show InChI InChI=1S/C19H24ClFN4O4/c1-11-10-24(15(26)4-5-19(2)17(27)22-18(28)23-19)6-7-25(11)12-8-13(20)16(21)14(9-12)29-3/h8-9,11H,4-7,10H2,1-3H3,(H2,22,23,27,28)/t11-,19+/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471841 ((5S)-5-[3-[(3S)- 4-(4-chloro- 3-fluoro- 5-methoxy-...) Show SMILES COc1cc(cc(F)c1Cl)N1CCN(C[C@@H]1C)C(=O)CC[C@]1(NC(=O)NC1=O)C1CC1 |r| Show InChI InChI=1S/C21H26ClFN4O4/c1-12-11-26(7-8-27(12)14-9-15(23)18(22)16(10-14)31-2)17(28)5-6-21(13-3-4-13)19(29)24-20(30)25-21/h9-10,12-13H,3-8,11H2,1-2H3,(H2,24,25,29,30)/t12-,21-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429688 ((R)-5-(3-(4-(4- chloro-3,5- dimethoxy- phenyl)pipe...) Show SMILES COc1cc(cc(OC)c1Cl)C1CCN(CC1)C(=O)CC[C@H]1NC(=O)NC1=O |r| Show InChI InChI=1S/C19H24ClN3O5/c1-27-14-9-12(10-15(28-2)17(14)20)11-5-7-23(8-6-11)16(24)4-3-13-18(25)22-19(26)21-13/h9-11,13H,3-8H2,1-2H3,(H2,21,22,25,26)/t13-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429689 (5-(3-(4-(4- chloro-3,5- dimethoxy- phenyl)piperidi...) Show SMILES COc1cc(cc(OC)c1Cl)C1CCN(CC1)C(=O)CCC1(C)NC(=O)NC1=O Show InChI InChI=1S/C20H26ClN3O5/c1-20(18(26)22-19(27)23-20)7-4-16(25)24-8-5-12(6-9-24)13-10-14(28-2)17(21)15(11-13)29-3/h10-12H,4-9H2,1-3H3,(H2,22,23,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429691 (5-(3-(4-(4- chlorophenyl) piperidin-1- yl)-2-methy...) Show SMILES C[C@@H](C[C@@]1(C)NC(=O)NC1=O)C(=O)N1CCC(CC1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C19H24ClN3O3/c1-12(11-19(2)17(25)21-18(26)22-19)16(24)23-9-7-14(8-10-23)13-3-5-15(20)6-4-13/h3-6,12,14H,7-11H2,1-2H3,(H2,21,22,25,26)/t12-,19+/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429692 (5-(3-(4-(3,5- dichlorophenyl) piperidin-1- yl)-2-m...) Show SMILES C[C@@H](C[C@@]1(C)NC(=O)NC1=O)C(=O)N1CCC(CC1)c1cc(Cl)cc(Cl)c1 |r| Show InChI InChI=1S/C19H23Cl2N3O3/c1-11(10-19(2)17(26)22-18(27)23-19)16(25)24-5-3-12(4-6-24)13-7-14(20)9-15(21)8-13/h7-9,11-12H,3-6,10H2,1-2H3,(H2,22,23,26,27)/t11-,19+/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429715 (5-(3-(4-(4- chloro-3- methoxyl- phenyl)piperidin-1...) Show SMILES COc1cc(ccc1Cl)C1CCN(CC1)C(=O)CCC1(C)NC(=O)NC1=O Show InChI InChI=1S/C19H24ClN3O4/c1-19(17(25)21-18(26)22-19)8-5-16(24)23-9-6-12(7-10-23)13-3-4-14(20)15(11-13)27-2/h3-4,11-12H,5-10H2,1-2H3,(H2,21,22,25,26)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429716 (5-(3-(4-(4- chloro-5- methoxy-2- methylphenyl) pip...) Show SMILES COc1cc(C2CCN(CC2)C(=O)CCC2(C)NC(=O)NC2=O)c(C)cc1Cl Show InChI InChI=1S/C20H26ClN3O4/c1-12-10-15(21)16(28-3)11-14(12)13-5-8-24(9-6-13)17(25)4-7-20(2)18(26)22-19(27)23-20/h10-11,13H,4-9H2,1-3H3,(H2,22,23,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429723 (5-(3-(4-(4- chloro-2- methoxyphenyl) piperidin-1- ...) Show SMILES COc1cc(Cl)ccc1C1CCN(CC1)C(=O)CCC1(C)NC(=O)NC1=O Show InChI InChI=1S/C19H24ClN3O4/c1-19(17(25)21-18(26)22-19)8-5-16(24)23-9-6-12(7-10-23)14-4-3-13(20)11-15(14)27-2/h3-4,11-12H,5-10H2,1-2H3,(H2,21,22,25,26)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429724 (5-(3-(4-(3,4- difluoro-5- methoxyphenyl) piperidin...) Show SMILES COc1cc(cc(F)c1F)C1CCN(CC1)C(=O)CCC1(C)NC(=O)NC1=O Show InChI InChI=1S/C19H23F2N3O4/c1-19(17(26)22-18(27)23-19)6-3-15(25)24-7-4-11(5-8-24)12-9-13(20)16(21)14(10-12)28-2/h9-11H,3-8H2,1-2H3,(H2,22,23,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429725 ((R)-5-(3-(4-(4- chloro-3- fluoro-5- methoxyphenyl)...) Show SMILES COc1cc(cc(F)c1Cl)C1CCN(CC1)C(=O)CC[C@H]1NC(=O)NC1=O |r| Show InChI InChI=1S/C18H21ClFN3O4/c1-27-14-9-11(8-12(20)16(14)19)10-4-6-23(7-5-10)15(24)3-2-13-17(25)22-18(26)21-13/h8-10,13H,2-7H2,1H3,(H2,21,22,25,26)/t13-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429726 (5-(3-(4-(4- chloro-3- fluoro-5- methoxyphenyl) pip...) Show SMILES COc1cc(cc(F)c1Cl)C1CCN(CC1)C(=O)CCC1(C)NC(=O)NC1=O Show InChI InChI=1S/C19H23ClFN3O4/c1-19(17(26)22-18(27)23-19)6-3-15(25)24-7-4-11(5-8-24)12-9-13(21)16(20)14(10-12)28-2/h9-11H,3-8H2,1-2H3,(H2,22,23,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429740 ((R)-5-(3-(4- (4,5-dichloro- 2- methoxyphenyl) pipe...) Show SMILES COc1cc(Cl)c(Cl)cc1C1CCN(CC1)C(=O)CC[C@H]1NC(=O)NC1=O |r| Show InChI InChI=1S/C18H21Cl2N3O4/c1-27-15-9-13(20)12(19)8-11(15)10-4-6-23(7-5-10)16(24)3-2-14-17(25)22-18(26)21-14/h8-10,14H,2-7H2,1H3,(H2,21,22,25,26)/t14-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429741 (5-(3-(4-(4,5- dichloro-2- methoxyphenyl) piperidin...) Show SMILES COc1cc(Cl)c(Cl)cc1C1CCN(CC1)C(=O)CCC1(C)NC(=O)NC1=O Show InChI InChI=1S/C19H23Cl2N3O4/c1-19(17(26)22-18(27)23-19)6-3-16(25)24-7-4-11(5-8-24)12-9-13(20)14(21)10-15(12)28-2/h9-11H,3-8H2,1-2H3,(H2,22,23,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429745 ((R)-5-(3-(4-(3- chloro-5- methoxyphenyl) piperidin...) Show SMILES COc1cc(Cl)cc(c1)C1CCN(CC1)C(=O)CC[C@@]1(C)NC(=O)NC1=O |r| Show InChI InChI=1S/C19H24ClN3O4/c1-19(17(25)21-18(26)22-19)6-3-16(24)23-7-4-12(5-8-23)13-9-14(20)11-15(10-13)27-2/h9-12H,3-8H2,1-2H3,(H2,21,22,25,26)/t19-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429747 ((R)-5-(3-(4- (3,4-dichloro-5- methoxyphenyl) piper...) Show SMILES COc1cc(cc(Cl)c1Cl)C1CCN(CC1)C(=O)CC[C@@]1(C)NC(=O)NC1=O |r| Show InChI InChI=1S/C19H23Cl2N3O4/c1-19(17(26)22-18(27)23-19)6-3-15(25)24-7-4-11(5-8-24)12-9-13(20)16(21)14(10-12)28-2/h9-11H,3-8H2,1-2H3,(H2,22,23,26,27)/t19-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429748 ((R)-5-(3-(4- (3,4-dichloro-5- methoxyphenyl) piper...) Show SMILES COc1cc(cc(Cl)c1Cl)C1CCN(CC1)C(=O)CC[C@H]1NC(=O)NC1=O |r| Show InChI InChI=1S/C18H21Cl2N3O4/c1-27-14-9-11(8-12(19)16(14)20)10-4-6-23(7-5-10)15(24)3-2-13-17(25)22-18(26)21-13/h8-10,13H,2-7H2,1H3,(H2,21,22,25,26)/t13-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429750 (5-(3-(4-(4,5- dichloro-2- methylphenyl) piperidin-...) Show SMILES Cc1cc(Cl)c(Cl)cc1C1CCN(CC1)C(=O)CCC1(C)NC(=O)NC1=O Show InChI InChI=1S/C19H23Cl2N3O3/c1-11-9-14(20)15(21)10-13(11)12-4-7-24(8-5-12)16(25)3-6-19(2)17(26)22-18(27)23-19/h9-10,12H,3-8H2,1-2H3,(H2,22,23,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair

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