Compile Data Set for Download or QSAR

Found 885 hits Enz. Inhib. hit(s) with Target = 'Serine protease HTRA1'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521765 (US11149067, Compound Ahp26) Show SMILES CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccc(Cl)cc2)N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC1=O)C1CC1)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	65	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521770 (US11149067, Compound Ahp33) Show SMILES CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccc(Cl)cc2)N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc3cccc(F)c3)NC(=O)[C@H](C)NC(=O)OCc3ccccc3)[C@@H](C)OC1=O)C1CC1)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	610	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521764 (US11149067, Compound Ahp25) Show SMILES CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CCCNC(N)=O)N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC1=O)C1CC1)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521766 (US11149067, Compound Ahp27) Show SMILES CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)OCc3ccccc3)[C@@H](C)OC1=O)C1CC1)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	950	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521759 (US11149067, Compound Ahp19) Show SMILES CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C1CC1)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.24E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521773 (US11149067, Compound Ahp36) Show SMILES CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc3cccc(F)c3)NC(=O)[C@H](C)NC(=O)OCc3ccccc3)[C@@H](C)OC1=O)C1CC1)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521774 (US11149067, Compound Ahp37) Show SMILES CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc3cccc(c3)C#N)NC(=O)[C@H](C)NC(=O)OCc3ccccc3)[C@@H](C)OC1=O)C1CC1)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521763 (US11149067, Compound Ahp24) Show SMILES CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CC(N)=O)N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC1=O)C1CC1)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.66E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521768 (US11149067, Compound Ahp29) Show SMILES CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2cccc(c2)C#N)N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)OCc3ccccc3)[C@@H](C)OC1=O)C1CC1)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521751 (US11149067, Compound Ahp10) Show SMILES CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@H](OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C(C)C)C(C)C)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521767 (US11149067, Compound Ahp28) Show SMILES CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccc(Br)cc2)N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)OCc3ccccc3)[C@@H](C)OC1=O)C1CC1)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521754 (US11149067, Compound Ahp14) Show SMILES CC[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc2ccccc2)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CC(C)C)N2[C@H](O)CC[C@H](NC1=O)C2=O)C(C)C |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.97E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521769 (US11149067, Compound Ahp30) Show SMILES CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2cccc(F)c2)N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)OCc3ccccc3)[C@@H](C)OC1=O)C1CC1)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521753 (US11149067, Compound Ahp13) Show SMILES CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	4.26E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521762 (US11149067, Compound Ahp22) Show SMILES CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CCC(O)=O)N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC1=O)C1CC1)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521772 (US11149067, Compound Ahp35) Show SMILES CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc3cccc(Cl)c3)NC(=O)[C@H](C)NC(=O)OCc3ccccc3)[C@@H](C)OC1=O)C1CC1)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	6.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521755 (US11149067, Compound Ahp15) Show SMILES CCC[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc2ccccc2)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CC(C)C)N2[C@H](O)CC[C@H](NC1=O)C2=O)C(C)C |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521742 (US11149067, Compound Ahp1) Show SMILES CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C(C)C)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	8.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521747 (US11149067, Compound Ahp6) Show SMILES CC(C)[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc2ccccc2)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)N2[C@H](O)CC[C@H](NC1=O)C2=O)C(C)C |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.03E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521771 (US11149067, Compound Ahp34) Show SMILES CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccc(Cl)cc2)N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCc3ccccc3)NC(=O)[C@H](C)NC(=O)OCc3ccccc3)[C@@H](C)OC1=O)C1CC1)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	4.34E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521758 (US11149067, Compound Ahp18) Show SMILES CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@H](CC#C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521757 (US11149067, Compound Ahp17) Show SMILES CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@H](CC=C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521756 (US11149067, Compound Ahp16) Show SMILES CCC(C)[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc2ccccc2)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CC(C)C)N2[C@H](O)CC[C@H](NC1=O)C2=O)C(C)C |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521752 (US11149067, Compound Ahp11) Show SMILES CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)CCc3ccccc3)[C@H](OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C(C)C)C(C)C)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521750 (US11149067, Compound Ahp9) Show SMILES CC(C)C[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc2ccccc2)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CC(C)C)N2[C@H](O)CC[C@H](NC1=O)C2=O)C(C)C |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521761 (US11149067, Compound Ahp21) Show SMILES CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C1CCCCC1)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521760 (US11149067, Compound Ahp20) Show SMILES CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C(C)(C)C)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521748 (US11149067, Compound Ahp7) Show SMILES CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](C)N(C)C1=O)C(C)C)C(C)C)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521745 (US11149067, Compound Ahp4) Show SMILES CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C(C)C)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521746 (US11149067, Compound Ahp5) Show SMILES CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc3ccccc3)NC(=O)OCc3ccccc3)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C(C)C)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521743 (US11149067, Compound Ahp2) Show SMILES CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521744 (US11149067, Compound Ahp3) Show SMILES CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@H](OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)c1ccccc1)C(C)C)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 [158-480] (Homo sapiens (Human))	BDBM521749 (US11149067, Compound Ahp8) Show SMILES CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C2=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22D0
					More data for this Ligand-Target Pair
Serine protease HTRA1 (Homo sapiens (Human))	BDBM496984 (US11001555, Example 7) Show SMILES COC[C@H](NC(=O)C(F)(F)c1cccc(Cl)c1)C(=O)N1C[C@@H](C[C@H]1C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F)S(=O)(=O)Cc1ccc(OC)cc1 Show InChI InChI=1S/C34H38ClF7N4O9S/c1-18(2)26(27(47)34(41,42)30(50)43-17-32(36,37)38)45-28(48)25-13-23(56(52,53)16-19-8-10-22(55-4)11-9-19)14-46(25)29(49)24(15-54-3)44-31(51)33(39,40)20-6-5-7-21(35)12-20/h5-12,18,23-26H,13-17H2,1-4H3,(H,43,50)(H,44,51)(H,45,48)/t23-,24+,25+,26+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.262	n/a	n/a	n/a	n/a	n/a	n/a
Hoffman-La Roche Inc. US Patent					Assay Description Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...				US Patent US11001555 (2021) BindingDB Entry DOI: 10.7270/Q2G44TD5
					More data for this Ligand-Target Pair
Serine protease HTRA1 (Homo sapiens (Human))	BDBM475923 ((4S)-4-[[(2S)-2-[[(2R)-2- (3-chloro-5- cyanophenox...) Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](Cc1cccc(Cl)c1)Oc1cc(Cl)cc(c1)C#N)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F |r| Show InChI InChI=1S/C33H29Cl2F5N4O5/c1-18(2)26(28(45)33(39,40)31(48)42-17-32(36,37)38)43-30(47)27(21-8-4-3-5-9-21)44-29(46)25(14-19-7-6-10-22(34)11-19)49-24-13-20(16-41)12-23(35)15-24/h3-13,15,18,25-27H,14,17H2,1-2H3,(H,42,48)(H,43,47)(H,44,46)/t25-,26+,27+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.293	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...				US Patent US10865182 (2020) BindingDB Entry DOI: 10.7270/Q2MC9330
					More data for this Ligand-Target Pair
Serine protease HTRA1 (Homo sapiens (Human))	BDBM514085 (US11059858, Example 42) Show SMILES COc1ccc(cc1)[C@H](NC(=O)[C@H](Cc1cccc(F)c1)NC(=O)c1cccc(Cl)c1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...				Citation and Details BindingDB Entry DOI: 10.7270/Q25H7KDD
					More data for this Ligand-Target Pair
Serine protease HTRA1 (Homo sapiens (Human))	BDBM514076 (US11059858, Example 33) Show SMILES COc1ccc(cc1)[C@H](NC(=O)[C@H](Cc1cccc(Cl)c1)NC(=O)c1ccc(Cl)s1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...				Citation and Details BindingDB Entry DOI: 10.7270/Q25H7KDD
					More data for this Ligand-Target Pair
Serine protease HTRA1 (Homo sapiens (Human))	BDBM514094 (US11059858, Example 48) Show SMILES COc1ccc(cc1)[C@H](NC(=O)[C@H](Cc1ccc(Cl)c(c1)C#N)NC(=O)c1cccc(Cl)c1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...				Citation and Details BindingDB Entry DOI: 10.7270/Q25H7KDD
					More data for this Ligand-Target Pair
Serine protease HTRA1 (Homo sapiens (Human))	BDBM496983 (US11001555, Example 6) Show SMILES COC[C@H](NC(=O)c1cccc(Cl)c1)C(=O)N1C[C@@H](C[C@H]1C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F)S(=O)(=O)Cc1ccc(OC)cc1 Show InChI InChI=1S/C33H38ClF5N4O9S/c1-18(2)26(27(44)33(38,39)31(48)40-17-32(35,36)37)42-29(46)25-13-23(53(49,50)16-19-8-10-22(52-4)11-9-19)14-43(25)30(47)24(15-51-3)41-28(45)20-6-5-7-21(34)12-20/h5-12,18,23-26H,13-17H2,1-4H3,(H,40,48)(H,41,45)(H,42,46)/t23-,24+,25+,26+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.351	n/a	n/a	n/a	n/a	n/a	n/a
Hoffman-La Roche Inc. US Patent					Assay Description Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...				US Patent US11001555 (2021) BindingDB Entry DOI: 10.7270/Q2G44TD5
					More data for this Ligand-Target Pair
Serine protease HTRA1 (Homo sapiens (Human))	BDBM514091 (US11059858, Example 45) Show SMILES COc1ccc(cc1)[C@H](NC(=O)[C@H](Cc1cccc(Cl)c1)NC(=O)Cc1cccc(Cl)c1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...				Citation and Details BindingDB Entry DOI: 10.7270/Q25H7KDD
					More data for this Ligand-Target Pair
Serine protease HTRA1 (Homo sapiens (Human))	BDBM514098 (N-[(2S)-3-(3-Chlorophenyl)-1-[[(1S)-2-[[(3S)-5,5-d...) Show SMILES COc1ccc(cc1)[C@H](NC(=O)[C@H](Cc1cccc(Cl)c1)NC(=O)c1cccc(F)c1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...				Citation and Details BindingDB Entry DOI: 10.7270/Q25H7KDD
					More data for this Ligand-Target Pair
Serine protease HTRA1 (Homo sapiens (Human))	BDBM514104 (US11059858, Example 58) Show SMILES COc1ccc(cc1)[C@H](NC(=O)[C@H](Cc1cccc(F)c1)NC(=O)c1cccc(c1)C#N)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...				Citation and Details BindingDB Entry DOI: 10.7270/Q25H7KDD
					More data for this Ligand-Target Pair
Serine protease HTRA1 (Homo sapiens (Human))	BDBM499311 (US11014963, Example 216) Show SMILES COc1ccc(cc1)[C@H](NC(=O)[C@H](Cc1ccc(CNC(=O)c2ccccn2)cc1)NC(=O)C(F)(F)c1cccc(Cl)c1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F |r| Show InChI InChI=1S/C39H37ClF5N5O6/c1-22(2)31(33(51)39(43,44)45)49-36(54)32(25-14-16-28(56-3)17-15-25)50-35(53)30(48-37(55)38(41,42)26-7-6-8-27(40)20-26)19-23-10-12-24(13-11-23)21-47-34(52)29-9-4-5-18-46-29/h4-18,20,22,30-32H,19,21H2,1-3H3,(H,47,52)(H,48,55)(H,49,54)(H,50,53)/t30-,31-,32-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...				US Patent US11014963 (2021) BindingDB Entry DOI: 10.7270/Q22R3VSM
					More data for this Ligand-Target Pair
Serine protease HTRA1 (Homo sapiens (Human))	BDBM514056 (US11059858, Example 15) Show SMILES COc1ccc(cc1)[C@H](NC(=O)C(Cc1cccc(Cl)c1)NC(=O)c1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...				Citation and Details BindingDB Entry DOI: 10.7270/Q25H7KDD
					More data for this Ligand-Target Pair
Serine protease HTRA1 (Homo sapiens (Human))	BDBM514090 (US11059858, Example 44) Show SMILES COc1ccc(cc1)[C@H](NC(=O)[C@H](Cc1cccc(F)c1)NC(=O)c1cc(Cl)ccc1Cl)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...				Citation and Details BindingDB Entry DOI: 10.7270/Q25H7KDD
					More data for this Ligand-Target Pair
Serine protease HTRA1 (Homo sapiens (Human))	BDBM475927 ((4S)-4-[[(2S)-2-[[(2R)-2- (3-chlorophenoxy)-3-(3- ...) Show SMILES COc1ccc(cc1)[C@H](NC(=O)[C@@H](Cc1cccc(F)c1)Oc1cccc(Cl)c1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F |r| Show InChI InChI=1S/C33H32ClF6N3O6/c1-18(2)26(28(44)33(39,40)31(47)41-17-32(36,37)38)42-30(46)27(20-10-12-23(48-3)13-11-20)43-29(45)25(15-19-6-4-8-22(35)14-19)49-24-9-5-7-21(34)16-24/h4-14,16,18,25-27H,15,17H2,1-3H3,(H,41,47)(H,42,46)(H,43,45)/t25-,26+,27+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.461	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...				US Patent US10865182 (2020) BindingDB Entry DOI: 10.7270/Q2MC9330
					More data for this Ligand-Target Pair
Serine protease HTRA1 (Homo sapiens (Human))	BDBM496981 (US11001555, Example 4) Show SMILES COc1ccc(CS(=O)(=O)[C@@H]2C[C@H](N(C2)C(=O)[C@H](C)NC(=O)C(F)(F)c2cccc(F)c2)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F)cc1 Show InChI InChI=1S/C33H36F8N4O8S/c1-17(2)25(26(46)33(40,41)29(49)42-16-31(35,36)37)44-27(47)24-13-23(54(51,52)15-19-8-10-22(53-4)11-9-19)14-45(24)28(48)18(3)43-30(50)32(38,39)20-6-5-7-21(34)12-20/h5-12,17-18,23-25H,13-16H2,1-4H3,(H,42,49)(H,43,50)(H,44,47)/t18-,23+,24-,25-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.471	n/a	n/a	n/a	n/a	n/a	n/a
Hoffman-La Roche Inc. US Patent					Assay Description Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...				US Patent US11001555 (2021) BindingDB Entry DOI: 10.7270/Q2G44TD5
					More data for this Ligand-Target Pair
Serine protease HTRA1 (Homo sapiens (Human))	BDBM499107 (US11014963, Example 17) Show SMILES COc1ccc(cc1)[C@H](NC(=O)[C@H](Cc1ccc(OCC(=O)OC(C)(C)C)cc1)NC(=O)C(F)(F)c1ccccc1Cl)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F Show InChI InChI=1S/C38H41ClF5N3O8/c1-21(2)30(32(49)38(42,43)44)46-34(51)31(23-13-17-24(53-6)18-14-23)47-33(50)28(45-35(52)37(40,41)26-9-7-8-10-27(26)39)19-22-11-15-25(16-12-22)54-20-29(48)55-36(3,4)5/h7-18,21,28,30-31H,19-20H2,1-6H3,(H,45,52)(H,46,51)(H,47,50)/t28-,30-,31-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.490	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...				US Patent US11014963 (2021) BindingDB Entry DOI: 10.7270/Q22R3VSM
					More data for this Ligand-Target Pair
Serine protease HTRA1 (Homo sapiens (Human))	BDBM499266 (US11014963, Example 166) Show SMILES COc1ccc(cc1)[C@H](NC(=O)[C@H](Cc1ccc(CNC(=O)OC(C)(C)C)cc1)NC(=O)C(F)(F)c1cccc(Cl)c1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F Show InChI InChI=1S/C38H42ClF5N4O7/c1-21(2)29(31(49)38(42,43)44)47-33(51)30(24-14-16-27(54-6)17-15-24)48-32(50)28(46-34(52)37(40,41)25-8-7-9-26(39)19-25)18-22-10-12-23(13-11-22)20-45-35(53)55-36(3,4)5/h7-17,19,21,28-30H,18,20H2,1-6H3,(H,45,53)(H,46,52)(H,47,51)(H,48,50)/t28-,29-,30-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...				US Patent US11014963 (2021) BindingDB Entry DOI: 10.7270/Q22R3VSM
					More data for this Ligand-Target Pair
Serine protease HTRA1 (Homo sapiens (Human))	BDBM514102 (US11059858, Example 56) Show SMILES COc1ccc(cc1)[C@H](NC(=O)[C@H](Cc1cccc(c1)C#N)NC(=O)c1cccc(c1)C#N)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...				Citation and Details BindingDB Entry DOI: 10.7270/Q25H7KDD
					More data for this Ligand-Target Pair

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