Compile Data Set for Download or QSAR

Found 6 hits Enz. Inhib. hit(s) with Target = 'Eyes absent homolog 2 [253-538]'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Eyes absent homolog 2 [253-538] (Homo sapiens (Human))	BDBM231626 (NCGC00249327) Show SMILES Fc1cccc(c1)C(=O)N\N=C\c1ccc(Sc2ccccn2)s1 Show InChI InChI=1S/C17H12FN3OS2/c18-13-5-3-4-12(10-13)17(22)21-20-11-14-7-8-16(23-14)24-15-6-1-2-9-19-15/h1-11H,(H,21,22)/b20-11+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	6.5	25
University of Colorado School of Medicine					Assay Description Eya activity was measured in 50-μl reactions using black, 96-well, half-volume microtiter plates (Greiner Bio-one) with the substrate OMFP (3-O-...				J Biol Chem 289: 16349-61 (2014) Article DOI: 10.1074/jbc.M114.566729 BindingDB Entry DOI: 10.7270/Q2CC0ZJK
					More data for this Ligand-Target Pair
Eyes absent homolog 2 [253-538] (Homo sapiens (Human))	BDBM231625 (MLS000544460) Show SMILES Fc1cccc(c1)C(=O)N\N=C\c1ccc(Sc2ccccn2)o1 Show InChI InChI=1S/C17H12FN3O2S/c18-13-5-3-4-12(10-13)17(22)21-20-11-14-7-8-16(23-14)24-15-6-1-2-9-19-15/h1-11H,(H,21,22)/b20-11+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	6.5	25
University of Colorado School of Medicine					Assay Description Eya activity was measured in 50-μl reactions using black, 96-well, half-volume microtiter plates (Greiner Bio-one) with the substrate OMFP (3-O-...				J Biol Chem 289: 16349-61 (2014) Article DOI: 10.1074/jbc.M114.566729 BindingDB Entry DOI: 10.7270/Q2CC0ZJK
					More data for this Ligand-Target Pair				3D Structure (crystal)
Eyes absent homolog 2 [253-538] (Homo sapiens (Human))	BDBM231627 (MLS000585814) Show SMILES Cc1ccccc1C(=O)N\N=C\c1ccc(Sc2ccccn2)o1 Show InChI InChI=1S/C18H15N3O2S/c1-13-6-2-3-7-15(13)18(22)21-20-12-14-9-10-17(23-14)24-16-8-4-5-11-19-16/h2-12H,1H3,(H,21,22)/b20-12+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.30E+4	n/a	n/a	n/a	n/a	6.5	25
University of Colorado School of Medicine					Assay Description Eya activity was measured in 50-μl reactions using black, 96-well, half-volume microtiter plates (Greiner Bio-one) with the substrate OMFP (3-O-...				J Biol Chem 289: 16349-61 (2014) Article DOI: 10.1074/jbc.M114.566729 BindingDB Entry DOI: 10.7270/Q2CC0ZJK
					More data for this Ligand-Target Pair
Eyes absent homolog 2 [253-538] (Homo sapiens (Human))	BDBM231625 (MLS000544460) Show SMILES Fc1cccc(c1)C(=O)N\N=C\c1ccc(Sc2ccccn2)o1 Show InChI InChI=1S/C17H12FN3O2S/c18-13-5-3-4-12(10-13)17(22)21-20-11-14-7-8-16(23-14)24-15-6-1-2-9-19-15/h1-11H,(H,21,22)/b20-11+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	6.5	25
University of Colorado School of Medicine					Assay Description Eya proteins were purified via S200 in isothermal titration calorimetry (ITC) buffer (50mM NaPO4 buffer, pH 6.5, 50 mM NaCl). Inhibitor solutions wer...				J Biol Chem 289: 16349-61 (2014) Article DOI: 10.1074/jbc.M114.566729 BindingDB Entry DOI: 10.7270/Q2CC0ZJK
					More data for this Ligand-Target Pair				3D Structure (crystal)
Eyes absent homolog 2 [253-538] (Homo sapiens (Human))	BDBM231625 (MLS000544460) Show SMILES Fc1cccc(c1)C(=O)N\N=C\c1ccc(Sc2ccccn2)o1 Show InChI InChI=1S/C17H12FN3O2S/c18-13-5-3-4-12(10-13)17(22)21-20-11-14-7-8-16(23-14)24-15-6-1-2-9-19-15/h1-11H,(H,21,22)/b20-11+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	6.10E+3	n/a	n/a	n/a	6.5	25
University of Colorado School of Medicine					Assay Description Eya proteins were purified via S200 in isothermal titration calorimetry (ITC) buffer (50mM NaPO4 buffer, pH 6.5, 50 mM NaCl). Inhibitor solutions wer...				J Biol Chem 289: 16349-61 (2014) Article DOI: 10.1074/jbc.M114.566729 BindingDB Entry DOI: 10.7270/Q2CC0ZJK
					More data for this Ligand-Target Pair				3D Structure (crystal)
Eyes absent homolog 2 [253-538] (Homo sapiens (Human))	BDBM231625 (MLS000544460) Show SMILES Fc1cccc(c1)C(=O)N\N=C\c1ccc(Sc2ccccn2)o1 Show InChI InChI=1S/C17H12FN3O2S/c18-13-5-3-4-12(10-13)17(22)21-20-11-14-7-8-16(23-14)24-15-6-1-2-9-19-15/h1-11H,(H,21,22)/b20-11+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	800	n/a	n/a	n/a	6.5	25
University of Colorado School of Medicine					Assay Description Eya proteins were purified via S200 in isothermal titration calorimetry (ITC) buffer (50mM NaPO4 buffer, pH 6.5, 50 mM NaCl). Inhibitor solutions wer...				J Biol Chem 289: 16349-61 (2014) Article DOI: 10.1074/jbc.M114.566729 BindingDB Entry DOI: 10.7270/Q2CC0ZJK
					More data for this Ligand-Target Pair				3D Structure (crystal)