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Found 170 hits Enz. Inhib. hit(s) with Target = 'Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484541
PNG
(US10934294, Example 62 | US11028092, Example 63)
Show SMILES CCc1cnc(nc1)C1CCC1c1nc2n(nc(C#N)c2c(=O)[nH]1)[C@@H](C)c1ccc(nc1)C(F)(F)F |r|
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
0.0100n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484529
PNG
(US10934294, Example 50 | US10934294, Example 51 | ...)
Show SMILES CC(c1ccc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
0.0100n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484497
PNG
(US10934294, Example 19 | US10934294, Example 20 | ...)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
0.0100n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484570
PNG
(US10934294, Example 91 | US10934294, Example 92 | ...)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(cn1)C1CC1 |r|
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
0.0100n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484551
PNG
(US10934294, Example 72 | US10934294, Example 73 | ...)
Show SMILES CC(c1ccc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(F)cn1
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
0.0200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484572
PNG
(US10934294, Example 93)
Show SMILES C[C@@H](c1cnc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@H]1c1ncccn1 |r|
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
0.0300n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484509
PNG
(US10934294, Example 31 | US10934294, Example 32 | ...)
Show SMILES CC(c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(C)cn1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
0.0400n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484596
PNG
(US10934294, Example 114 | US11028092, Example 114)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@@H]1c1nccc(n1)C1CC1 |r|
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
0.0400n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484593
PNG
(US10934294, Example 111)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@H]1c1nccc(C)n1
Show InChI InChI=1S/C23H19F3N8O/c1-11-7-8-28-19(30-11)14-4-5-15(14)20-31-21-18(22(35)32-20)16(9-27)33-34(21)12(2)13-3-6-17(29-10-13)23(24,25)26/h3,6-8,10,12,14-15H,4-5H2,1-2H3,(H,31,32,35)/t12-,14+,15-/m0/s1
PDB

UniProtKB/SwissProt

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UniChem
US Patent
0.0400n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484591
PNG
(US10934294, Example 110 | US11028092, Example 110)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@@H]1c1nccc(C)n1
Show InChI InChI=1S/C23H19F3N8O/c1-11-7-8-28-19(30-11)14-4-5-15(14)20-31-21-18(22(35)32-20)16(9-27)33-34(21)12(2)13-3-6-17(29-10-13)23(24,25)26/h3,6-8,10,12,14-15H,4-5H2,1-2H3,(H,31,32,35)/t12-,14-,15-/m0/s1
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
0.0500n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484539
PNG
(US10934294, Example 60 | US10934294, Example 61 | ...)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(OC(F)F)cn1 |r|
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
0.0800n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484559
PNG
(US10934294, Example 80 | US10934294, Example 81 | ...)
Show SMILES CC(c1cnc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@@H]1c1ncc(F)cn1 |r|
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
0.0900n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484489
PNG
(US10934294, Example 11 | US10934294, Example 12 | ...)
Show SMILES CC(c1ccc(cc1)C#N)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
0.100n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484501
PNG
(US10934294, Example 23 | US10934294, Example 24 | ...)
Show SMILES CC(c1cccc(c1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/SwissProt

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UniChem
US Patent
0.100n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484484
PNG
(US10934294, Example 6 | US11028092, Example 6)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@@H]1c1ncccn1 |r|
PDB

UniProtKB/SwissProt

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UniChem
US Patent
0.100n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484537
PNG
(US10934294, Example 58 | US10934294, Example 59 | ...)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(Br)cn1 |r|
PDB

UniProtKB/SwissProt

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UniChem
US Patent
0.120n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484594
PNG
(BDBM502802 | US10934294, Example 112)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@@H]1c1nccc(n1)C(F)F |r|
PDB

UniProtKB/SwissProt

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UniChem
US Patent
0.130n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484517
PNG
(US10934294, Example 38 | US10934294, Example 39 | ...)
Show SMILES CC(c1ccc(nc1)C(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
0.130n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484542
PNG
(US10934294, Example 63 | US10934294, Example 97 | ...)
Show SMILES COc1cnc(nc1)C1CCC1c1nc2n(nc(C#N)c2c(=O)[nH]1)[C@@H](C)c1ccc(nc1)C(F)(F)F |r|
PDB

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US Patent
0.150n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484583
PNG
(US10934294, Example 102 | US10934294, Example 103 ...)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(cn1)C(F)F |r|
PDB

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0.180n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484480
PNG
(US10934294, Example 2 | US11028092, Example 2)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@@H]1c1ncccn1 |r|
PDB

UniProtKB/SwissProt

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US Patent
0.200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484587
PNG
(US10934294, Example 106 | US10934294, Example 107 ...)
Show SMILES CC(c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(Cl)cn1
PDB

UniProtKB/SwissProt

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UniChem
US Patent
0.200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484525
PNG
(US10934294, Example 46 | US10934294, Example 47 | ...)
Show SMILES CC(C1CCOCC1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/SwissProt

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UniChem
US Patent
0.220n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484561
PNG
(US10934294, Example 82 | US11028092, Example 82)
Show SMILES CC(c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(cn1)C#C
PDB

UniProtKB/SwissProt

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UniChem
US Patent
0.230n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484563
PNG
(US10934294, Example 84 | US11028092, Example 84)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@@H]1c1ncc(F)cn1 |r|
PDB

UniProtKB/SwissProt

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UniChem
US Patent
0.25n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484595
PNG
(US10934294, Example 113 | US11028092, Example 113)
Show SMILES C[C@@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@@H]1c1nc(cc(n1)C(C)(C)C)C(C)(C)C |r|
PDB

UniProtKB/SwissProt

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US Patent
0.270n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484569
PNG
(US10934294, Example 90)
Show SMILES C[C@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@@H]1c1ncc(cn1)C#N
Show InChI InChI=1S/C23H16F3N9O/c1-11(13-2-5-17(29-10-13)23(24,25)26)35-21-18(16(7-28)34-35)22(36)33-20(32-21)15-4-3-14(15)19-30-8-12(6-27)9-31-19/h2,5,8-11,14-15H,3-4H2,1H3,(H,32,33,36)/t11-,14+,15+/m1/s1
PDB

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US Patent
0.300n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484493
PNG
(US10934294, Example 15 | US10934294, Example 16 | ...)
Show SMILES CC(c1ccc(F)c(F)c1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/SwissProt

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US Patent
0.400n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484505
PNG
(US10934294, Example 27 | US10934294, Example 28 | ...)
Show SMILES CC(c1cnc(cn1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/SwissProt

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US Patent
0.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484567
PNG
(US10934294, Example 88)
Show SMILES C[C@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1(C)CCC1c1ncccn1 |r|
PDB

UniProtKB/SwissProt

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US Patent
0.700n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484529
PNG
(US10934294, Example 50 | US10934294, Example 51 | ...)
Show SMILES CC(c1ccc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/SwissProt

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US Patent
0.800n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484525
PNG
(US10934294, Example 46 | US10934294, Example 47 | ...)
Show SMILES CC(C1CCOCC1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/SwissProt

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US Patent
0.900n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484555
PNG
(US10934294, Example 76 | US10934294, Example 77 | ...)
Show SMILES CC(c1cnc(s1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/SwissProt

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US Patent
1.10n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484513
PNG
(US10934294, Example 34 | US10934294, Example 35 | ...)
Show SMILES CC(c1cnc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/SwissProt

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US Patent
1.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484573
PNG
(US10934294, Example 94 | US11028092, Example 93)
Show SMILES C[C@@H](c1cnc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)[C@@H]1CC[C@H]1c1ncccn1 |r|
PDB

UniProtKB/SwissProt

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US Patent
1.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484574
PNG
(US10934294, Example 95 | US11028092, Example 94)
Show SMILES C[C@@H](c1cnc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@@H]1c1ncccn1 |r|
PDB

UniProtKB/SwissProt

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US Patent
1.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484489
PNG
(US10934294, Example 11 | US10934294, Example 12 | ...)
Show SMILES CC(c1ccc(cc1)C#N)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/SwissProt

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UniChem
US Patent
1.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484559
PNG
(US10934294, Example 80 | US10934294, Example 81 | ...)
Show SMILES CC(c1cnc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@@H]1c1ncc(F)cn1 |r|
PDB

UniProtKB/SwissProt

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US Patent
1.60n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484579
PNG
(US10934294, Example 100 | US10934294, Example 101 ...)
Show SMILES C[C@@H](c1ccc(F)cn1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1 |r|
PDB

UniProtKB/SwissProt

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US Patent
1.70n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484501
PNG
(US10934294, Example 23 | US10934294, Example 24 | ...)
Show SMILES CC(c1cccc(c1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/SwissProt

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US Patent
1.80n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484497
PNG
(US10934294, Example 19 | US10934294, Example 20 | ...)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/SwissProt

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US Patent
1.80n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484551
PNG
(US10934294, Example 72 | US10934294, Example 73 | ...)
Show SMILES CC(c1ccc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(F)cn1
PDB

UniProtKB/SwissProt

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US Patent
2n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484517
PNG
(US10934294, Example 38 | US10934294, Example 39 | ...)
Show SMILES CC(c1ccc(nc1)C(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/SwissProt

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US Patent
2n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484509
PNG
(US10934294, Example 31 | US10934294, Example 32 | ...)
Show SMILES CC(c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(C)cn1
PDB

UniProtKB/SwissProt

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UniChem
US Patent
2.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484505
PNG
(US10934294, Example 27 | US10934294, Example 28 | ...)
Show SMILES CC(c1cnc(cn1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/SwissProt

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US Patent
2.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484485
PNG
(US10934294, Example 7 | US11028092, Example 7)
Show SMILES C[C@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)[C@@H]1CC[C@H]1c1ncccn1 |r|
PDB

UniProtKB/SwissProt

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US Patent
2.80n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484493
PNG
(US10934294, Example 15 | US10934294, Example 16 | ...)
Show SMILES CC(c1ccc(F)c(F)c1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

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3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM409778
PNG
(2-oxo-4-[3- (pyridin-3-yl) pyrrolidin-1- yl]-1,2- ...)
Show SMILES CCc1ccc(cc1)-c1c(C#N)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C18H14N2O/c1-2-12-7-9-13(10-8-12)17-14-5-3-4-6-16(14)20-18(21)15(17)11-19/h3-10H,2H2,1H3,(H,20,21)
PDB

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3.40n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US10370336 (2019)


BindingDB Entry DOI: 10.7270/Q20C4Z49
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484599
PNG
(US10934294, Example 117 | US11028092, Example 117)
Show SMILES C[C@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CC[C@H]1c1nccc(C)n1 |r|
PDB

UniProtKB/SwissProt

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US Patent
3.90n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))
BDBM484497
PNG
(US10934294, Example 19 | US10934294, Example 20 | ...)
Show SMILES CC(c1ccc(cc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
PDB

UniProtKB/SwissProt

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US Patent
4.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...


US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair
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