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Found 1 hit Enz. Inhib. hit(s) with Target = 'Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)' and Ligand = 'BDBM484569'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)


(Homo sapiens (Human))		BDBM484569
PNG
(US10934294, Example 90)
Show SMILES C[C@H](c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)[C@H]1CC[C@@H]1c1ncc(cn1)C#N
Show InChI InChI=1S/C23H16F3N9O/c1-11(13-2-5-17(29-10-13)23(24,25)26)35-21-18(16(7-28)34-35)22(36)33-20(32-21)15-4-3-14(15)19-30-8-12(6-27)9-31-19/h2,5,8-11,14-15H,3-4H2,1H3,(H,32,33,36)/t11-,14+,15+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
 0.300n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...

US Patent US10934294 (2021)


BindingDB Entry DOI: 10.7270/Q2C250JS
More data for this
Ligand-Target Pair