Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM68208 (Type II inhibitor, 2) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using dephophorylated conformationally inactive Abl kinase was obtained by treating pure recombinant Abl with Yersinia ester... | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM68217 (Type I progenitor, 11) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using phosphorylated recombinant human Abl kinase domains to phosphorylate a peptide substrate. | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM68217 (Type I progenitor, 11) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using dephophorylated conformationally inactive Abl kinase was obtained by treating pure recombinant Abl with Yersinia ester... | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM50242740 (CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using dephophorylated conformationally inactive Abl kinase was obtained by treating pure recombinant Abl with Yersinia ester... | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM68219 (Type II inhibitor, 13) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using dephophorylated conformationally inactive Abl kinase was obtained by treating pure recombinant Abl with Yersinia ester... | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM50242740 (CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using phosphorylated recombinant human Abl kinase domains to phosphorylate a peptide substrate. | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM68218 (Type II inhibitor, 12) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 19.6 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using phosphorylated recombinant human Abl kinase domains to phosphorylate a peptide substrate. | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM6568 (6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfa...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 23 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using dephophorylated conformationally inactive Abl kinase was obtained by treating pure recombinant Abl with Yersinia ester... | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM6568 (6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfa...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 24 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using phosphorylated recombinant human Abl kinase domains to phosphorylate a peptide substrate. | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM13530 (4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | 27 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using dephophorylated conformationally inactive Abl kinase was obtained by treating pure recombinant Abl with Yersinia ester... | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM68218 (Type II inhibitor, 12) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 27.2 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using dephophorylated conformationally inactive Abl kinase was obtained by treating pure recombinant Abl with Yersinia ester... | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM68219 (Type II inhibitor, 13) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using phosphorylated recombinant human Abl kinase domains to phosphorylate a peptide substrate. | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM68208 (Type II inhibitor, 2) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 152 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using phosphorylated recombinant human Abl kinase domains to phosphorylate a peptide substrate. | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM68214 (Type II inhibitor, 8) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 154 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using dephophorylated conformationally inactive Abl kinase was obtained by treating pure recombinant Abl with Yersinia ester... | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM68211 (Type II inhibitor, 5) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 374 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using dephophorylated conformationally inactive Abl kinase was obtained by treating pure recombinant Abl with Yersinia ester... | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM68209 (Type II inhibitor, 3) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.36E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using dephophorylated conformationally inactive Abl kinase was obtained by treating pure recombinant Abl with Yersinia ester... | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM68207 (Type I progenitor, 1) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using phosphorylated recombinant human Abl kinase domains to phosphorylate a peptide substrate. | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM68216 (Type II inhibitor, 10) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using phosphorylated recombinant human Abl kinase domains to phosphorylate a peptide substrate. | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM68216 (Type II inhibitor, 10) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using dephophorylated conformationally inactive Abl kinase was obtained by treating pure recombinant Abl with Yersinia ester... | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM68213 (Type I progenitor, 7) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using dephophorylated conformationally inactive Abl kinase was obtained by treating pure recombinant Abl with Yersinia ester... | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM68212 (Type II inhibitor, 6) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using dephophorylated conformationally inactive Abl kinase was obtained by treating pure recombinant Abl with Yersinia ester... | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM68210 (Type I progenitor, 4) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using dephophorylated conformationally inactive Abl kinase was obtained by treating pure recombinant Abl with Yersinia ester... | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM68207 (Type I progenitor, 1) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using dephophorylated conformationally inactive Abl kinase was obtained by treating pure recombinant Abl with Yersinia ester... | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM13530 (4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using phosphorylated recombinant human Abl kinase domains to phosphorylate a peptide substrate. | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM68220 (Type II inhibitor, 15) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using phosphorylated recombinant human Abl kinase domains to phosphorylate a peptide substrate. | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM68220 (Type II inhibitor, 15) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using dephophorylated conformationally inactive Abl kinase was obtained by treating pure recombinant Abl with Yersinia ester... | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM68214 (Type II inhibitor, 8) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using phosphorylated recombinant human Abl kinase domains to phosphorylate a peptide substrate. | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM68213 (Type I progenitor, 7) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using phosphorylated recombinant human Abl kinase domains to phosphorylate a peptide substrate. | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM68212 (Type II inhibitor, 6) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using phosphorylated recombinant human Abl kinase domains to phosphorylate a peptide substrate. | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM68211 (Type II inhibitor, 5) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using phosphorylated recombinant human Abl kinase domains to phosphorylate a peptide substrate. | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM68210 (Type I progenitor, 4) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using phosphorylated recombinant human Abl kinase domains to phosphorylate a peptide substrate. | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM68209 (Type II inhibitor, 3) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Scripps Research Institute | Assay Description An in vitro kinase assay using phosphorylated recombinant human Abl kinase domains to phosphorylate a peptide substrate. | Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM25118 ((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 2.70E+6 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q20G3HJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM21 (CHEMBL24828 | N-(4-bromo-2-fluorophenyl)-6-methoxy...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Similars | PCBioAssay | n/a | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q20G3HJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM6866 (1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 1.20E+6 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q20G3HJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM16673 (4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 4.80E+5 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q20G3HJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM4779 (CHEMBL31965 | CHEMBL545315 | CI-1033 | Canertinib ...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 2.00E+5 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q20G3HJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM13216 (BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB PCBioAssay | n/a | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q20G3HJZ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM31096 (CHEMBL290084 | Staurosporine | cid_451705) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 9.10E+4 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q20G3HJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM4814 (CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 8.90E+5 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q20G3HJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM13534 (CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PCBioAssay | n/a | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q20G3HJZ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM15244 (5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 2.20E+6 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q20G3HJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM31090 ((E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-eth...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 2.30E+5 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q20G3HJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM31085 (1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluorom...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | n/a | 8.40E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q20G3HJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM5446 (CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 1.90E+5 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q20G3HJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM31093 (4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 6.40E+5 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q20G3HJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM31088 (1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-y...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 5.80E+5 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q20G3HJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM13530 (4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB PCBioAssay | n/a | n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q20G3HJZ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM13533 (1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 6.90E+6 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q20G3HJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human)) | BDBM31095 (5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 2.10E+6 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q20G3HJZ | |||||||||||
More data for this Ligand-Target Pair |