Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM50512575 (CHEMBL4554985) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | 214 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Meyer Cancer Center Curated by ChEMBL | Assay Description Mixed type inhibition of PHGDH (unknown origin) using 3-PG as substrate incubated for 20 mins in presence of , PSAT1, PSPH and varying NAD+ by diapho... | Bioorg Med Chem Lett 29: 2503-2510 (2019) Article DOI: 10.1016/j.bmcl.2019.07.011 BindingDB Entry DOI: 10.7270/Q27D2ZGJ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM50230352 (CHEMBL4086943) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Catholique de Louvain Curated by ChEMBL | Assay Description Non-competitive inhibition of recombinant human C-terminal His-tagged PHGDH (1 to 533 residues) expressed in Escherichia coli assessed as reduction i... | J Med Chem 60: 1591-1597 (2017) Article DOI: 10.1021/acs.jmedchem.6b01166 BindingDB Entry DOI: 10.7270/Q21N83CP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM50230352 (CHEMBL4086943) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Catholique de Louvain Curated by ChEMBL | Assay Description Non-competitive inhibition of recombinant human C-terminal His-tagged PHGDH (1 to 533 residues) expressed in Escherichia coli assessed as reduction i... | J Med Chem 60: 1591-1597 (2017) Article DOI: 10.1021/acs.jmedchem.6b01166 BindingDB Entry DOI: 10.7270/Q21N83CP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM50519121 (CHEMBL4436264 | US11304929, Example 03-005) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim RCV GmbH & Co. KG Curated by ChEMBL | Assay Description Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate... | J Med Chem 62: 7976-7997 (2019) Article DOI: 10.1021/acs.jmedchem.9b00718 BindingDB Entry DOI: 10.7270/Q25H7KNJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549366 (2-[(R)-4-[(1S)-1-[(4,5-dichloro-1,6-dimethyl-1H-in...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549371 (2-{4-[(1S)-1-[(4,5-dichloro-1,6-dimethyl-1H-indol-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM50519130 (CHEMBL4520837 | US11304929, Example 03-006) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim RCV GmbH & Co. KG Curated by ChEMBL | Assay Description Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate... | J Med Chem 62: 7976-7997 (2019) Article DOI: 10.1021/acs.jmedchem.9b00718 BindingDB Entry DOI: 10.7270/Q25H7KNJ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM50519122 (CHEMBL4467246 | US11304929, Example 03-009) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim RCV GmbH & Co. KG Curated by ChEMBL | Assay Description Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate... | J Med Chem 62: 7976-7997 (2019) Article DOI: 10.1021/acs.jmedchem.9b00718 BindingDB Entry DOI: 10.7270/Q25H7KNJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM50519130 (CHEMBL4520837 | US11304929, Example 03-006) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549366 (2-[(R)-4-[(1S)-1-[(4,5-dichloro-1,6-dimethyl-1H-in...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM50519121 (CHEMBL4436264 | US11304929, Example 03-005) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549087 (2-{4-[(1S)-1-[(4,5-dichloro-1,6-dimethyl-1H-indol-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM50519121 (CHEMBL4436264 | US11304929, Example 03-005) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim RCV GmbH & Co. KG Curated by ChEMBL | Assay Description Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate... | J Med Chem 62: 7976-7997 (2019) Article DOI: 10.1021/acs.jmedchem.9b00718 BindingDB Entry DOI: 10.7270/Q25H7KNJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM50519130 (CHEMBL4520837 | US11304929, Example 03-006) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549351 (2-{4-[(1R)-1-[(4-chloro-5-fluoro-1,6-dimethyl-1H-i...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549372 (2-{4-[(1R)-1-[(4,5-dichloro-1,6-dimethyl-1H-indol-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549371 (2-{4-[(1S)-1-[(4,5-dichloro-1,6-dimethyl-1H-indol-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549355 (2-{4-[(1S)-1-[(4-chloro-5-fluoro-1,6-dimethyl-1H-i...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549424 (1-{4-[(1R)-1-[(4-chloro-1,6-dimethyl-1H-indol-2- y...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549392 (2-{4-[(1R)-1-[(4-chloro-1,6-dimethyl-1H-indol-2- y...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549087 (2-{4-[(1S)-1-[(4,5-dichloro-1,6-dimethyl-1H-indol-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549410 (2-{4-[(1S)-1-[(4-chloro-1,6-dimethyl-1H-indol-2-yl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549357 (2-[(S)-4-[(1S)-1-[(4,5-dichloro-1,6-dimethyl-1H-in...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549414 (4-{4-[(1R)-1-[(4-chloro-1,6-dimethyl-1H-indol-2- y...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549355 (2-{4-[(1S)-1-[(4-chloro-5-fluoro-1,6-dimethyl-1H-i...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549351 (2-{4-[(1R)-1-[(4-chloro-5-fluoro-1,6-dimethyl-1H-i...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549422 (2-{4-[(1R)-1-[(4-chloro-1,6-dimethyl-1H-indol-2- y...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM50519122 (CHEMBL4467246 | US11304929, Example 03-009) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM50519122 (CHEMBL4467246 | US11304929, Example 03-009) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim RCV GmbH & Co. KG Curated by ChEMBL | Assay Description Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate... | J Med Chem 62: 7976-7997 (2019) Article DOI: 10.1021/acs.jmedchem.9b00718 BindingDB Entry DOI: 10.7270/Q25H7KNJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549405 (2-{4-[(1R)-1-[(4,5-dichloro-1,6-dimethyl-1H-indol-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549374 (2-{4-[(1S)-1-[(4,5-difluoro-1,6-dimethyl-1H-indol-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549123 (2-{4-[(1S)-1-[(4-chloro-1,6-dimethyl-1H-indol-2-yl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM50519121 (CHEMBL4436264 | US11304929, Example 03-005) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549483 (2-{4-[(1S)-1-({4,5-dichloro-1,6-dimethyl-1H-pyrrol...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549372 (2-{4-[(1R)-1-[(4,5-dichloro-1,6-dimethyl-1H-indol-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549357 (2-[(S)-4-[(1S)-1-[(4,5-dichloro-1,6-dimethyl-1H-in...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549401 (1-{4-[(1R)-1-[(4-chloro-1,6-dimethyl-1H-indol-2- y...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549393 (2-[(S)-4-[(1S)-1-[(4,5-difluoro-1,6-dimethyl-1H-in...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549377 (2-{4-[(1R)-1-[(4-chloro-1,6-dimethyl-1H-indol-2- y...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM50519137 (CHEMBL4539932) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim RCV GmbH & Co. KG Curated by ChEMBL | Assay Description Inhibition of His6-tagged PHGDH (unknown origin) expressed in Escherichia coli BL21 assessed as effect on NADH fluorescence incubated for 60 mins usi... | J Med Chem 62: 7976-7997 (2019) Article DOI: 10.1021/acs.jmedchem.9b00718 BindingDB Entry DOI: 10.7270/Q25H7KNJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549123 (2-{4-[(1S)-1-[(4-chloro-1,6-dimethyl-1H-indol-2-yl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM543851 (2-{4-[(1R)-1-[(4-chloro-1,6-dimethyl-1H-indol-2- y...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549463 (2-{4-[(1R)-1-[(4-chloro-1,6-dimethyl-1H-indol-2- y...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549433 (2-{4-[(1R)-1-[(4-chloro-1,6-dimethyl-1H-indol-2- y...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549388 (2-{4-[(1R)-1-[(4-chloro-1,6,7-trimethyl-1H-indol-2...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM50519120 (CHEMBL4438014) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim RCV GmbH & Co. KG Curated by ChEMBL | Assay Description Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate... | J Med Chem 62: 7976-7997 (2019) Article DOI: 10.1021/acs.jmedchem.9b00718 BindingDB Entry DOI: 10.7270/Q25H7KNJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549377 (2-{4-[(1R)-1-[(4-chloro-1,6-dimethyl-1H-indol-2- y...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM50512584 (CHEMBL4443265) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Meyer Cancer Center Curated by ChEMBL | Assay Description Inhibition of PHGDH (unknown origin) using 11 nM of PHGDH and 3-PG as substrate incubated for 20 mins in presence of NAD+, PSAT1, PSPH by diaphorase ... | Bioorg Med Chem Lett 29: 2503-2510 (2019) Article DOI: 10.1016/j.bmcl.2019.07.011 BindingDB Entry DOI: 10.7270/Q27D2ZGJ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549401 (1-{4-[(1R)-1-[(4-chloro-1,6-dimethyl-1H-indol-2- y...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM549392 (2-{4-[(1R)-1-[(4-chloro-1,6-dimethyl-1H-indol-2- y...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are dispensed onto assay plates (black, low volume, flat bottom 384 well, Corning) using an Access Labcyte Workstation with the Labcyte Ech... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DR2ZP7 | |||||||||||
More data for this Ligand-Target Pair |
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