Compile Data Set for Download or QSAR

Found 414 hits Enz. Inhib. hit(s) with Target = '2-Hydroxyacid oxidase 1'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM50463046 (CHEMBL1229989) Show SMILES CCCCCCCCCCCCSc1[nH]nnc1C(O)=O Show InChI InChI=1S/C15H27N3O2S/c1-2-3-4-5-6-7-8-9-10-11-12-21-14-13(15(19)20)16-18-17-14/h2-12H2,1H3,(H,19,20)(H,16,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidad de Granada Curated by ChEMBL					Assay Description Inhibition of human N-terminal His-tagged glycolate oxidase expressed in C41(D43) Escherichia coli using glycolate as substrate preincubated for 30 m...				J Med Chem 61: 7144-7167 (2018) Article DOI: 10.1021/acs.jmedchem.8b00399 BindingDB Entry DOI: 10.7270/Q23B62SD
					More data for this Ligand-Target Pair				3D Structure (crystal)
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM50463046 (CHEMBL1229989) Show SMILES CCCCCCCCCCCCSc1[nH]nnc1C(O)=O Show InChI InChI=1S/C15H27N3O2S/c1-2-3-4-5-6-7-8-9-10-11-12-21-14-13(15(19)20)16-18-17-14/h2-12H2,1H3,(H,19,20)(H,16,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human glycolate oxidase expressed in Escherichia coli using glycolate as substrate by DCIP dye based spectrophotometry analysis				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00196 BindingDB Entry DOI: 10.7270/Q2V128MV
					More data for this Ligand-Target Pair				3D Structure (crystal)
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM50594014 (CHEMBL5182027) Show SMILES N.OC(=O)c1cc(ccc1O)-c1ccc(CNc2ccc(Br)cc2)o1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114396 BindingDB Entry DOI: 10.7270/Q2W38196
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM50594018 (CHEMBL5180187) Show SMILES N.N.OC(=O)c1cc(ccc1O)-c1ccc(CN(Cc2ccc(o2)-c2ccc(O)c(c2)C(O)=O)Cc2ccccc2)o1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114396 BindingDB Entry DOI: 10.7270/Q2W38196
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Mus musculus)	BDBM50463047 (CHEMBL1794748) Show SMILES OC(=O)c1nnsc1Sc1ccc(Cl)cc1 Show InChI InChI=1S/C9H5ClN2O2S2/c10-5-1-3-6(4-2-5)15-9-7(8(13)14)11-12-16-9/h1-4H,(H,13,14)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Non competitive inhibition of mouse glycolate oxidase in hyperoxaluric-Agxt knockdown mouse primary hepatocyte assessed as reduction in oxalate produ...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00196 BindingDB Entry DOI: 10.7270/Q2V128MV
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Mus musculus)	BDBM50463040 (CHEMBL4247590) Show SMILES OC(=O)c1cc(ccc1O)-c1ccc(C=O)o1 Show InChI InChI=1S/C12H8O5/c13-6-8-2-4-11(17-8)7-1-3-10(14)9(5-7)12(15)16/h1-6,14H,(H,15,16)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	7.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114396 BindingDB Entry DOI: 10.7270/Q2W38196
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Mus musculus)	BDBM50594017 (CHEMBL5190607) Show SMILES N.OC(=O)c1cc(ccc1O)-c1ccc(CNCC#C)o1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.11E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114396 BindingDB Entry DOI: 10.7270/Q2W38196
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM50463040 (CHEMBL4247590) Show SMILES OC(=O)c1cc(ccc1O)-c1ccc(C=O)o1 Show InChI InChI=1S/C12H8O5/c13-6-8-2-4-11(17-8)7-1-3-10(14)9(5-7)12(15)16/h1-6,14H,(H,15,16)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	1.82E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114396 BindingDB Entry DOI: 10.7270/Q2W38196
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Mus musculus)	BDBM50463047 (CHEMBL1794748) Show SMILES OC(=O)c1nnsc1Sc1ccc(Cl)cc1 Show InChI InChI=1S/C9H5ClN2O2S2/c10-5-1-3-6(4-2-5)15-9-7(8(13)14)11-12-16-9/h1-4H,(H,13,14)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	2.03E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidad de Granada Curated by ChEMBL					Assay Description Inhibition of mouse N-terminal His-tagged glycolate oxidase expressed in BL21(DE3) Escherichia coli using glycolate as substrate by Cornish-Bowden pl...				J Med Chem 61: 7144-7167 (2018) Article DOI: 10.1021/acs.jmedchem.8b00399 BindingDB Entry DOI: 10.7270/Q23B62SD
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM50594017 (CHEMBL5190607) Show SMILES N.OC(=O)c1cc(ccc1O)-c1ccc(CNCC#C)o1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.47E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114396 BindingDB Entry DOI: 10.7270/Q2W38196
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Mus musculus)	BDBM50463040 (CHEMBL4247590) Show SMILES OC(=O)c1cc(ccc1O)-c1ccc(C=O)o1 Show InChI InChI=1S/C12H8O5/c13-6-8-2-4-11(17-8)7-1-3-10(14)9(5-7)12(15)16/h1-6,14H,(H,15,16)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	4.72E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidad de Granada Curated by ChEMBL					Assay Description Inhibition of mouse recombinant glycolate oxidase expressed in Escherichia coli using glycolate as substrate by Dixon plot and Cornish-Bowden plot an...				J Med Chem 61: 7144-7167 (2018) Article DOI: 10.1021/acs.jmedchem.8b00399 BindingDB Entry DOI: 10.7270/Q23B62SD
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581194 (5-(4-(2-(3-chlorophenyl) ethynyl)phenoxy)-1H-1,2,...) Show SMILES OC(=O)c1nn[nH]c1Oc1ccc(cc1)C#Cc1cccc(Cl)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581193 (5-(4-(2-(4-chlorophenyl) ethynyl)phenoxy)-1H-1,2,...) Show SMILES OC(=O)c1nn[nH]c1Oc1ccc(cc1)C#Cc1ccc(Cl)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM50572931 (CHEMBL4855986) Show SMILES NS(=O)(=O)c1ccc(Cc2c(CC3CC3)n(nc2-c2ccc(F)c(c2)-c2cccc(Oc3[nH]nnc3C(O)=O)c2)-c2nc(cs2)C(O)=O)cc1F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human GOX expressed in Escherichia coli C41 (DE3) using glycolate as substrate preincubated for 10 mins followed by substra...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00196 BindingDB Entry DOI: 10.7270/Q2V128MV
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581192 (5-(3-(2-(4-fluorophenyl) ethynyl)phenoxy)-1H-1,2,...) Show SMILES OC(=O)c1nn[nH]c1Oc1cccc(c1)C#Cc1ccc(F)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581191 (5-(4-(2-(4-fluorophenyl) ethynyl)phenoxy)-1H-1,2,...) Show SMILES OC(=O)c1nn[nH]c1Oc1ccc(cc1)C#Cc1ccc(F)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581180 (5-(4-(2-(3-fluorophenyl) ethynyl)phenoxy)-1H-1,2,...) Show SMILES OC(=O)c1nn[nH]c1Oc1ccc(cc1)C#Cc1cccc(F)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581172 (5-(4-((3- cyanophenyl)ethynyl)-3- fluorophenoxy)...) Show SMILES OC(=O)c1nn[nH]c1Oc1ccc(C#Cc2cccc(c2)C#N)c(F)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581171 (5-(4-((4- cyanophenyl)ethynyl)-3- fluorophenoxy)...) Show SMILES OC(=O)c1nn[nH]c1Oc1ccc(C#Cc2ccc(cc2)C#N)c(F)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581170 (5-(3-((4- cyanophenyl)ethynyl)-4- fluorophenoxy)...) Show SMILES OC(=O)c1nn[nH]c1Oc1ccc(F)c(c1)C#Cc1ccc(cc1)C#N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581164 (5-(4-methyl-3-(2- phenylethynyl)phenoxy)-1H- 1,2...) Show SMILES Cc1ccc(Oc2[nH]nnc2C(O)=O)cc1C#Cc1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581161 (5-(4-fluoro-3-(2- phenylethynyl)phenoxy)-1H- 1,2...) Show SMILES OC(=O)c1nn[nH]c1Oc1ccc(F)c(c1)C#Cc1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581159 (5-(3-((1-methyl-2-oxo-1,2- dihydropyridin-4- yl)...) Show SMILES Cn1ccc(cc1=O)C#Cc1cccc(Oc2[nH]nnc2C(O)=O)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581155 (5-(3-(2-(1-methyl-1H-pyrazol- 4-yl)ethynyl)phenox...) Show SMILES Cn1cc(cn1)C#Cc1cccc(Oc2[nH]nnc2C(O)=O)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581148 (5-(3-((3- chlorophenyl)ethynyl)phenoxy)- 1H-1,2,...) Show SMILES OC(=O)c1nn[nH]c1Oc1cccc(c1)C#Cc1cccc(Cl)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581143 (5-(3-fluoro-4- (phenylethynyl)phenoxy)-1H- 1,2,3...) Show SMILES OC(=O)c1nn[nH]c1Oc1ccc(C#Cc2ccccc2)c(F)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581140 (5-(4-(()ethynyl)phenoxy)-1H- 1,2,3-triazole-4-car...) Show SMILES OC(=O)c1nn[nH]c1Oc1ccc(cc1)C#Cc1ccc2[nH]ncc2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581234 (5-(3-(2-(1H-indazol-6- yl)ethynyl)phenoxy)-1H-1,2...) Show SMILES OC(=O)c1nn[nH]c1Oc1cccc(c1)C#Cc1ccc2cn[nH]c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581232 (5-(3-(2-(1H-indazol-4- yl)ethynyl)phenoxy)-1H-1,2...) Show SMILES OC(=O)c1nn[nH]c1Oc1cccc(c1)C#Cc1cccc2[nH]ncc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581211 (5-(3-(2-(1H-indazol-5- yl)ethynyl)phenoxy)-1H-1,2...) Show SMILES OC(=O)c1nn[nH]c1Oc1cccc(c1)C#Cc1ccc2[nH]ncc2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581199 (5-(3-(2-(2-methylpyridin-4- yl)ethynyl)phenoxy)-1...) Show SMILES Cc1cc(ccn1)C#Cc1cccc(Oc2[nH]nnc2C(O)=O)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581198 (5-(3-(2-(6-methylpyridin-3- yl)ethynyl)phenoxy)-1...) Show SMILES Cc1ccc(cn1)C#Cc1cccc(Oc2[nH]nnc2C(O)=O)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM50572933 (CHEMBL4861379) Show SMILES NS(=O)(=O)c1ccc(Cc2c(CC3CC3)n(nc2-c2ccc(F)c(c2)-c2ccc(Sc3nn[nH]c3C(O)=O)cc2)-c2nc(cs2)C(O)=O)cc1F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human GOX expressed in Escherichia coli C41 (DE3) using glycolate as substrate preincubated for 10 mins followed by substra...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00196 BindingDB Entry DOI: 10.7270/Q2V128MV
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM50572932 (CHEMBL4850573) Show SMILES NS(=O)(=O)c1ccc(Cc2c(CC3CC3)n(nc2-c2ccc(F)c(c2)-c2ccc(Oc3nn[nH]c3C(O)=O)cc2)-c2nc(cs2)C(O)=O)cc1F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human GOX expressed in Escherichia coli C41 (DE3) using glycolate as substrate preincubated for 10 mins followed by substra...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00196 BindingDB Entry DOI: 10.7270/Q2V128MV
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581165 (5-(4-(trifluoromethyl)-3-(2- phenylethynyl)phenox...) Show SMILES OC(=O)c1nn[nH]c1Oc1ccc(c(c1)C#Cc1ccccc1)C(F)(F)F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581168 (5-(4-fluoro-3-(2-(4- (methylsulfonyl)phenyl)ethyn...) Show SMILES CS(=O)(=O)c1ccc(cc1)C#Cc1cc(Oc2[nH]nnc2C(O)=O)ccc1F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581169 (5-(4-fluoro-3-(2-(3- (methylsulfonyl)phenyl)ethyn...) Show SMILES CS(=O)(=O)c1cccc(c1)C#Cc1cc(Oc2[nH]nnc2C(O)=O)ccc1F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581151 (5-(4-((1-methyl-6-oxo-1,6- dihydropyridin-3- yl)...) Show SMILES Cn1cc(ccc1=O)C#Cc1ccc(Oc2[nH]nnc2C(O)=O)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581174 (5-(3-fluoro-4-(2-(4- (methylsulfonyl)phenyl)ethyn...) Show SMILES CS(=O)(=O)c1ccc(cc1)C#Cc1ccc(Oc2[nH]nnc2C(O)=O)cc1F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581246 (5-(3-(2-(thiazol-2- yl)ethynyl)phenoxy)-1H-1,2,3-...) Show SMILES OC(=O)c1nn[nH]c1Oc1cccc(c1)C#Cc1nccs1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581173 (5-(4-((3- cyanophenyl)ethynyl)-3- fluorophenoxy)...) Show SMILES OC(=O)c1nn[nH]c1Oc1ccc(F)c(c1)C#Cc1cccc(c1)C#N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581233 (5-(4-(2-(1H-indazol-6- yl)ethynyl)phenoxy)-1H-1,2...) Show SMILES OC(=O)c1nn[nH]c1Oc1ccc(cc1)C#Cc1ccc2cn[nH]c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581181 (5-(3-(2-(3-fluorophenyl) ethynyl)phenoxy)-1H-1,2,...) Show SMILES OC(=O)c1nn[nH]c1Oc1cccc(c1)C#Cc1cccc(F)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581231 (5-(4-(2-(1H-indazol-4- yl)ethynyl)phenoxy)-1H-1,2...) Show SMILES OC(=O)c1nn[nH]c1Oc1ccc(cc1)C#Cc1cccc2[nH]ncc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581230 (5-(3-(2-(1-methyl-1H-indazol- 7-yl)ethynyl)phenox...) Show SMILES Cn1ncc2cccc(C#Cc3cccc(Oc4[nH]nnc4C(O)=O)c3)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581229 (5-(4-(2-(1-methyl-1H-indazol- 7-yl)ethynyl)phenox...) Show SMILES Cn1ncc2cccc(C#Cc3ccc(Oc4[nH]nnc4C(O)=O)cc3)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581223 (5-(3-(2-(1-methyl-1H-indazol- 6-yl)ethynyl)phenox...) Show SMILES Cn1ncc2ccc(cc12)C#Cc1cccc(Oc2[nH]nnc2C(O)=O)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581222 (5-(4-(2-(1-methyl-1H-indazol- 6-yl)ethynyl)phenox...) Show SMILES Cn1ncc2ccc(cc12)C#Cc1ccc(Oc2[nH]nnc2C(O)=O)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581221 (5-(3-(2-(1-methyl-1H-indazol- 5-yl)ethynyl)phenox...) Show SMILES Cn1ncc2cc(ccc12)C#Cc1cccc(Oc2[nH]nnc2C(O)=O)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair
2-Hydroxyacid oxidase 1 (Homo sapiens (Human))	BDBM581220 (5-(4-(2-(1-methyl-1H-indazol- 5-yl)ethynyl)phenox...) Show SMILES Cn1ncc2cc(ccc12)C#Cc1ccc(Oc2[nH]nnc2C(O)=O)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...				Citation and Details BindingDB Entry DOI: 10.7270/Q2T157GG
					More data for this Ligand-Target Pair

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