Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ubiquitin-like modifier-activating enzyme 6 (Homo sapiens (Human)) | BDBM299259 (US9593121, I-08 | {(1S,2S,4R)-2-hydroxy-4-[4-(1H-i...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc. US Patent | Assay Description The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60... | US Patent US9593121 (2017) BindingDB Entry DOI: 10.7270/Q24F1SSJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ubiquitin-like modifier-activating enzyme 6 (Homo sapiens (Human)) | BDBM299257 (US9593121, I-07 | {(1S,2S,4R)-2-hydroxy-4-[4-(6-me...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc. US Patent | Assay Description The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60... | US Patent US9593121 (2017) BindingDB Entry DOI: 10.7270/Q24F1SSJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ubiquitin-like modifier-activating enzyme 6 (Homo sapiens (Human)) | BDBM299236 (((1S,2S,4R)-4-(4-(1H-indol-2-yl)-7H-pyrrolo[2,3- d...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc. US Patent | Assay Description The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60... | US Patent US9593121 (2017) BindingDB Entry DOI: 10.7270/Q24F1SSJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ubiquitin-like modifier-activating enzyme 6 (Homo sapiens (Human)) | BDBM299243 (US9593121, I-06 | {(1S,2S,4R)-2-hydroxy-4-[4-(6-me...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc. US Patent | Assay Description The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60... | US Patent US9593121 (2017) BindingDB Entry DOI: 10.7270/Q24F1SSJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ubiquitin-like modifier-activating enzyme 6 (Homo sapiens (Human)) | BDBM299240 (US9593121, I-03 | {(1S,2S,4R)-2-hydroxy-4-[4-(5-me...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc. US Patent | Assay Description The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60... | US Patent US9593121 (2017) BindingDB Entry DOI: 10.7270/Q24F1SSJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ubiquitin-like modifier-activating enzyme 6 (Homo sapiens (Human)) | BDBM299241 (US9593121, I-04 | {(1S,2S,4R)-4-[4-(6-chloro-1H-in...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc. US Patent | Assay Description The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60... | US Patent US9593121 (2017) BindingDB Entry DOI: 10.7270/Q24F1SSJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ubiquitin-like modifier-activating enzyme 6 (Homo sapiens (Human)) | BDBM299242 (US9593121, I-05 | {(1S,2S,4R)-4-[4-(6-cyano-1H-ind...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc. US Patent | Assay Description The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60... | US Patent US9593121 (2017) BindingDB Entry DOI: 10.7270/Q24F1SSJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ubiquitin-like modifier-activating enzyme 6 (Homo sapiens (Human)) | BDBM50427035 (CHEMBL2017005) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 920 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto Mississauga Curated by ChEMBL | Assay Description Inhibition of UBA6 (unknown origin) in presence of ATP | J Med Chem 56: 2165-77 (2013) Article DOI: 10.1021/jm301420b BindingDB Entry DOI: 10.7270/Q29P32ZT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ubiquitin-like modifier-activating enzyme 6 (Homo sapiens (Human)) | BDBM50285607 (MLN-4924 | MLN-4924003 | Pevonedistat) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Temple University Curated by ChEMBL | Assay Description Inhibition of UBA6 (unknown origin) assessed as decrease in formation of E2-UBL thioester reaction product | J Med Chem 61: 3239-3252 (2018) Article DOI: 10.1021/acs.jmedchem.6b01817 BindingDB Entry DOI: 10.7270/Q2542R5N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ubiquitin-like modifier-activating enzyme 6 (Homo sapiens (Human)) | BDBM299276 (US9593121, I-11 | {(1S,2S,4R)-4-[4-(5-fluoro-1H-in...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc. US Patent | Assay Description The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60... | US Patent US9593121 (2017) BindingDB Entry DOI: 10.7270/Q24F1SSJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ubiquitin-like modifier-activating enzyme 6 (Homo sapiens (Human)) | BDBM299322 (US9593121, I-14 | [(1S,2S,4R)-2-hydroxy-4-{4-[6-(t...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc. US Patent | Assay Description The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60... | US Patent US9593121 (2017) BindingDB Entry DOI: 10.7270/Q24F1SSJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ubiquitin-like modifier-activating enzyme 6 (Homo sapiens (Human)) | BDBM299263 (US9593121, I-09 | {(1S,2S,4R)-4-[4-(6-chloro-5-flu...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc. US Patent | Assay Description The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60... | US Patent US9593121 (2017) BindingDB Entry DOI: 10.7270/Q24F1SSJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ubiquitin-like modifier-activating enzyme 6 (Homo sapiens (Human)) | BDBM299265 (US9593121, I-10 | tert-butyl 2-(7-{(1R,3S,4S)-3-hy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc. US Patent | Assay Description The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60... | US Patent US9593121 (2017) BindingDB Entry DOI: 10.7270/Q24F1SSJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ubiquitin-like modifier-activating enzyme 6 (Homo sapiens (Human)) | BDBM299237 (US9593121, I-02 | {(1S,2S,4R)-2-hydroxy-4-[4-(1-me...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc. US Patent | Assay Description The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60... | US Patent US9593121 (2017) BindingDB Entry DOI: 10.7270/Q24F1SSJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ubiquitin-like modifier-activating enzyme 6 (Homo sapiens (Human)) | BDBM299282 (US9593121, I-12 | {(1S,2S,4R)-2-hydroxy-4-[4-(7-me...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc. US Patent | Assay Description The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60... | US Patent US9593121 (2017) BindingDB Entry DOI: 10.7270/Q24F1SSJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ubiquitin-like modifier-activating enzyme 6 (Homo sapiens (Human)) | BDBM299284 (US9593121, I-13 | {(1S,2S,4R)-2-hydroxy-4-[4-(3-me...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc. US Patent | Assay Description The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60... | US Patent US9593121 (2017) BindingDB Entry DOI: 10.7270/Q24F1SSJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ubiquitin-like modifier-activating enzyme 6 (Homo sapiens (Human)) | BDBM50285607 (MLN-4924 | MLN-4924003 | Pevonedistat) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1016/j.ejmech.2022.114156 BindingDB Entry DOI: 10.7270/Q21C21WJ | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ubiquitin-like modifier-activating enzyme 6 (Homo sapiens (Human)) | BDBM50427034 (CHEMBL2322194) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto Mississauga Curated by ChEMBL | Assay Description Inhibition of UBA6 (unknown origin) | J Med Chem 56: 2165-77 (2013) Article DOI: 10.1021/jm301420b BindingDB Entry DOI: 10.7270/Q29P32ZT | |||||||||||
More data for this Ligand-Target Pair |