BindingDB PrimarySearch

Found 10 hits Enz. Inhib. hit(s) with Target = 'ALK tyrosine kinase receptor [C1156Y]' AND taxid = 9606
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
ALK tyrosine kinase receptor [C1156Y] (Homo sapiens (Human))	BDBM199945 (US9226923, 3) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	<1.20	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing Allgen Pharma Co. Ltd. US Patent					Assay Description The inhibitory activities of compounds of Formula I were assay at Reaction Biology Corporation, One Great Valley Parkway, Malvern, Pa., USA. Human ...				US Patent US9226923 (2016) BindingDB Entry DOI: 10.7270/Q2JQ0ZT5
Nanjing Allgen Pharma Co. Ltd. US Patent					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor [C1156Y] (Homo sapiens (Human))	BDBM50306682 ((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB US Patent	n/a	n/a	<1.20	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing Allgen Pharma Co. Ltd. US Patent					Assay Description The inhibitory activities of compounds of Formula I were assay at Reaction Biology Corporation, One Great Valley Parkway, Malvern, Pa., USA. Human ...				US Patent US9226923 (2016) BindingDB Entry DOI: 10.7270/Q2JQ0ZT5
Nanjing Allgen Pharma Co. Ltd. US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
ALK tyrosine kinase receptor [C1156Y] (Homo sapiens (Human))	BDBM50306682 ((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	7.67	n/a	n/a	n/a	n/a	7.5	25
Tianjin University of Science and Technology					Assay Description The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...				Bioorg Chem 65: 146-58 (2016) Article DOI: 10.1016/j.bioorg.2016.02.009 BindingDB Entry DOI: 10.7270/Q2VT1QVX
Tianjin University of Science and Technology					More data for this Ligand-Target Pair				3D Structure (crystal)
ALK tyrosine kinase receptor [C1156Y] (Homo sapiens (Human))	BDBM179803 (3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(pi...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	133	n/a	n/a	n/a	n/a	7.5	25
Tianjin University of Science and Technology					Assay Description The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...				Bioorg Chem 65: 146-58 (2016) Article DOI: 10.1016/j.bioorg.2016.02.009 BindingDB Entry DOI: 10.7270/Q2VT1QVX
Tianjin University of Science and Technology					More data for this Ligand-Target Pair				3D Structure (crystal)
ALK tyrosine kinase receptor [C1156Y] (Homo sapiens (Human))	BDBM179801 (3-((2,6-dichloro-3-fluorophenyl)thio)-5-(1-(piperi...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	651	n/a	n/a	n/a	n/a	7.5	25
Tianjin University of Science and Technology					Assay Description The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...				Bioorg Chem 65: 146-58 (2016) Article DOI: 10.1016/j.bioorg.2016.02.009 BindingDB Entry DOI: 10.7270/Q2VT1QVX
Tianjin University of Science and Technology					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor [C1156Y] (Homo sapiens (Human))	BDBM179800 (3-((2,6-dichloro-3-fluorophenyl)sulfide)-5-(1-(pip...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.31E+3	n/a	n/a	n/a	n/a	7.5	25
Tianjin University of Science and Technology					Assay Description The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...				Bioorg Chem 65: 146-58 (2016) Article DOI: 10.1016/j.bioorg.2016.02.009 BindingDB Entry DOI: 10.7270/Q2VT1QVX
Tianjin University of Science and Technology					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor [C1156Y] (Homo sapiens (Human))	BDBM179798 (3-(1-(2,6-dichloro-3-fluorophenyl)ethyl)-2-methyl-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.52E+3	n/a	n/a	n/a	n/a	7.5	25
Tianjin University of Science and Technology					Assay Description The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...				Bioorg Chem 65: 146-58 (2016) Article DOI: 10.1016/j.bioorg.2016.02.009 BindingDB Entry DOI: 10.7270/Q2VT1QVX
Tianjin University of Science and Technology					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor [C1156Y] (Homo sapiens (Human))	BDBM179804 (3-{[1-(2,6-dichloro-3-fluorophenyl)ethyl]sulfanyl}...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	7.5	25
Tianjin University of Science and Technology					Assay Description The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...				Bioorg Chem 65: 146-58 (2016) Article DOI: 10.1016/j.bioorg.2016.02.009 BindingDB Entry DOI: 10.7270/Q2VT1QVX
Tianjin University of Science and Technology					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor [C1156Y] (Homo sapiens (Human))	BDBM179802 (3-(1-(2,6-dichloro-3-fluorophenyl)cyclopropyl)-5-(...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.99E+3	n/a	n/a	n/a	n/a	7.5	25
Tianjin University of Science and Technology					Assay Description The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...				Bioorg Chem 65: 146-58 (2016) Article DOI: 10.1016/j.bioorg.2016.02.009 BindingDB Entry DOI: 10.7270/Q2VT1QVX
Tianjin University of Science and Technology					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor [C1156Y] (Homo sapiens (Human))	BDBM179799 (4-(4-{2-chloro-3-[1-(2,6-dichloro-3-fluorophenyl)e...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.08E+3	n/a	n/a	n/a	n/a	7.5	25
Tianjin University of Science and Technology					Assay Description The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...				Bioorg Chem 65: 146-58 (2016) Article DOI: 10.1016/j.bioorg.2016.02.009 BindingDB Entry DOI: 10.7270/Q2VT1QVX
Tianjin University of Science and Technology					More data for this Ligand-Target Pair