BindingDB PrimarySearch

Found 17 hits Enz. Inhib. hit(s) with Target = 'Heat shock protein beta-1' AND taxid = 9606
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Heat shock protein beta-1 (Homo sapiens (Human))	BDBM50263167 (3,4,5,6-Tetrahydro-2H-[1,2']bipyridinyl-4'-carboxy...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of HSP27 phosphorylation in IL1alpha-stimulated HLF cells				Bioorg Med Chem Lett 18: 4433-7 (2008) Article DOI: 10.1016/j.bmcl.2008.06.028 BindingDB Entry DOI: 10.7270/Q2JH3M0B
GlaxoSmithKline R&D Curated by ChEMBL					More data for this Ligand-Target Pair
Heat shock protein beta-1 (Homo sapiens (Human))	BDBM50263168 (CHEMBL476351 \| N-[4'-(Cyclopropylmethyl-carbamoyl)...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of HSP27 phosphorylation in IL1alpha-stimulated HLF cells				Bioorg Med Chem Lett 18: 4433-7 (2008) Article DOI: 10.1016/j.bmcl.2008.06.028 BindingDB Entry DOI: 10.7270/Q2JH3M0B
GlaxoSmithKline R&D Curated by ChEMBL					More data for this Ligand-Target Pair
Heat shock protein beta-1 (Homo sapiens (Human))	BDBM50263093 (6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of HSP27 phosphorylation in IL1alpha-stimulated HLF cells				Bioorg Med Chem Lett 18: 4433-7 (2008) Article DOI: 10.1016/j.bmcl.2008.06.028 BindingDB Entry DOI: 10.7270/Q2JH3M0B
GlaxoSmithKline R&D Curated by ChEMBL					More data for this Ligand-Target Pair
Heat shock protein beta-1 (Homo sapiens (Human))	BDBM13533 (1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of HSP27 phosphorylation in IL1alpha-stimulated HLF cells				Bioorg Med Chem Lett 18: 4433-7 (2008) Article DOI: 10.1016/j.bmcl.2008.06.028 BindingDB Entry DOI: 10.7270/Q2JH3M0B
GlaxoSmithKline R&D Curated by ChEMBL					More data for this Ligand-Target Pair
Heat shock protein beta-1 (Homo sapiens (Human))	BDBM50262865 (CHEMBL477583 \| Furan-3-carboxylic acid [4'-(cyclop...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of HSP27 phosphorylation in IL1alpha-stimulated HLF cells				Bioorg Med Chem Lett 18: 4433-7 (2008) Article DOI: 10.1016/j.bmcl.2008.06.028 BindingDB Entry DOI: 10.7270/Q2JH3M0B
GlaxoSmithKline R&D Curated by ChEMBL					More data for this Ligand-Target Pair
Heat shock protein beta-1 (Homo sapiens (Human))	BDBM15458 (4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of HSP27 phosphorylation in IL1alpha-stimulated HLF cells				Bioorg Med Chem Lett 18: 4433-7 (2008) Article DOI: 10.1016/j.bmcl.2008.06.028 BindingDB Entry DOI: 10.7270/Q2JH3M0B
GlaxoSmithKline R&D Curated by ChEMBL					More data for this Ligand-Target Pair
Heat shock protein beta-1 (Homo sapiens (Human))	BDBM50097558 (CHEMBL1935538 \| NSC-751382) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Genova Curated by ChEMBL					Assay Description Inhibition of HSP27 (unknown origin) by insulin aggregation assay				Bioorg Med Chem 23: 3215-20 (2015) Article DOI: 10.1016/j.bmc.2015.04.070 BindingDB Entry DOI: 10.7270/Q24B332K
Universit£ degli Studi di Genova Curated by ChEMBL					More data for this Ligand-Target Pair
Heat shock protein beta-1 (Homo sapiens (Human))	BDBM50559487 (CHEMBL4755850) Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(F)cc2F)nc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	6.30E+4	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to HSP27 (79 to 176 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells by HSQC NMR analysis				Citation and Details Article DOI: 10.1016/j.bmc.2020.115990 BindingDB Entry DOI: 10.7270/Q2PN99B0
TBA					More data for this Ligand-Target Pair
Heat shock protein beta-1 (Homo sapiens (Human))	BDBM50559488 (CHEMBL1562220) Show SMILES [O-][N+](=O)c1cccnc1Oc1ccc(F)cc1F Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	1.77E+5	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to HSP27 (79 to 176 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells by HSQC NMR analysis				Citation and Details Article DOI: 10.1016/j.bmc.2020.115990 BindingDB Entry DOI: 10.7270/Q2PN99B0
TBA					More data for this Ligand-Target Pair
Heat shock protein beta-1 (Homo sapiens (Human))	BDBM50559486 (CHEMBL4777949) Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(F)cc2)nc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	6.40E+4	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to HSP27 (79 to 176 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells by HSQC NMR analysis				Citation and Details Article DOI: 10.1016/j.bmc.2020.115990 BindingDB Entry DOI: 10.7270/Q2PN99B0
TBA					More data for this Ligand-Target Pair
Heat shock protein beta-1 (Homo sapiens (Human))	BDBM50559485 (CHEMBL4787246) Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(F)cc2F)cc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	6.80E+4	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to HSP27 (79 to 176 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells by HSQC NMR analysis				Citation and Details Article DOI: 10.1016/j.bmc.2020.115990 BindingDB Entry DOI: 10.7270/Q2PN99B0
TBA					More data for this Ligand-Target Pair
Heat shock protein beta-1 (Homo sapiens (Human))	BDBM50559484 (CHEMBL4784519) Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(F)cc2)cc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to HSP27 (79 to 176 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells by HSQC NMR analysis				Citation and Details Article DOI: 10.1016/j.bmc.2020.115990 BindingDB Entry DOI: 10.7270/Q2PN99B0
TBA					More data for this Ligand-Target Pair
Heat shock protein beta-1 (Homo sapiens (Human))	BDBM50559483 (CHEMBL4784495) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	4.70E+4	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to HSP27 (79 to 176 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells by HSQC NMR analysis				Citation and Details Article DOI: 10.1016/j.bmc.2020.115990 BindingDB Entry DOI: 10.7270/Q2PN99B0
TBA					More data for this Ligand-Target Pair
Heat shock protein beta-1 (Homo sapiens (Human))	BDBM50559482 (CHEMBL4761994) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	8.00E+4	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to HSP27 (79 to 176 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells by HSQC NMR analysis				Citation and Details Article DOI: 10.1016/j.bmc.2020.115990 BindingDB Entry DOI: 10.7270/Q2PN99B0
TBA					More data for this Ligand-Target Pair
Heat shock protein beta-1 (Homo sapiens (Human))	BDBM50559489 (CHEMBL1608020) Show SMILES Nc1cccnc1Oc1ccc(F)cc1F Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to HSP27 (79 to 176 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells by HSQC NMR analysis				Citation and Details Article DOI: 10.1016/j.bmc.2020.115990 BindingDB Entry DOI: 10.7270/Q2PN99B0
TBA					More data for this Ligand-Target Pair
Heat shock protein beta-1 (Homo sapiens (Human))	BDBM50559480 (CHEMBL4760956) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	7.00E+4	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to HSP27 (79 to 176 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells by HSQC NMR analysis				Citation and Details Article DOI: 10.1016/j.bmc.2020.115990 BindingDB Entry DOI: 10.7270/Q2PN99B0
TBA					More data for this Ligand-Target Pair
Heat shock protein beta-1 (Homo sapiens (Human))	BDBM50559481 (CHEMBL4799413) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to HSP27 (79 to 176 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells by HSQC NMR analysis				Citation and Details Article DOI: 10.1016/j.bmc.2020.115990 BindingDB Entry DOI: 10.7270/Q2PN99B0
TBA					More data for this Ligand-Target Pair