Found 55 hits Enz. Inhib. hit(s) with Target = 'Probable G-protein coupled receptor 142' AND taxid = 10090 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50395775
(CHEMBL2164857)Show SMILES CNc1cc(ccn1)-c1nnc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)s1 |r| Show InChI InChI=1S/C21H21N7OS2/c1-22-18-10-15(7-8-23-18)20-27-28-21(31-20)26-19(29)17(9-14-5-3-2-4-6-14)24-11-16-12-30-13-25-16/h2-8,10,12-13,17,24H,9,11H2,1H3,(H,22,23)(H,26,28,29)/t17-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Partial agonist activity at mouse GPR142 expressed in HEK293 cells |
Bioorg Med Chem Lett 22: 6218-23 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558195
(CHEMBL4800653)Show SMILES Fc1c(Cl)cccc1NC(=O)N1CCOc2ccc(cc2C1)-c1ccncc1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558200
(CHEMBL4785678)Show SMILES O=C(Nc1cccc(c1)-c1ccccc1)N1CCOc2ccc(cc2C1)-c1ccncc1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558199
(CHEMBL4763234)Show SMILES O=C(Nc1cccc(c1)C#N)N1CCOc2ccc(cc2C1)-c1ccncc1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558206
(CHEMBL4760456) | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 92 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558198
(CHEMBL4756319)Show SMILES FC(F)(F)c1cccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccncc2)c1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558173
(CHEMBL4755668)Show SMILES Clc1ccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccncc2)cc1Cl | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 138 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558197
(CHEMBL4756931)Show SMILES O=C(Nc1cccc(Oc2ccccc2)c1)N1CCOc2ccc(cc2C1)-c1ccncc1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 146 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558194
(CHEMBL4754434)Show SMILES Clc1cccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccncc2)c1Cl | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 157 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558191
(CHEMBL4751751)Show SMILES FC(F)(F)c1cccc(CS(=O)(=O)N2CCOc3ccc(cc3C2)-c2ccncc2)c1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 157 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558190
(CHEMBL4782723)Show SMILES Clc1ccc(NC(=O)N2CCNc3ccc(cc3C2)-c2ccncc2)cc1Cl | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558174
(CHEMBL4787638)Show SMILES Clc1cccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccncc2)c1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 164 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558176
(CHEMBL4779679)Show SMILES COc1cccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccnc3ccccc23)c1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 216 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558202
(CHEMBL4750832)Show SMILES COc1cccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccncc2)c1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 305 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558201
(CHEMBL4792959)Show SMILES Fc1cccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccncc2)c1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 413 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558180
(CHEMBL4781458)Show SMILES Nc1cc(ccn1)-c1ccc2OCCN(Cc2c1)C(=O)Nc1cccc(c1)C#N | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 448 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558178
(CHEMBL4750165)Show SMILES COc1cccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccncc2OC)c1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 486 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558187
(CHEMBL4743675)Show SMILES Clc1ccc(NC(=O)N2CCCc3ccc(cc3C2)-c2ccncc2)cc1Cl | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 590 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558205
(CHEMBL4781462) | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 604 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558192
(CHEMBL4781022)Show SMILES FC(F)(F)c1cccc(CC(=O)N2CCOc3ccc(cc3C2)-c2ccncc2)c1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 611 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558193
(CHEMBL4753373)Show SMILES Fc1ccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccncc2)cc1Cl | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 613 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558207
(CHEMBL4779820) | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 851 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558186
(CHEMBL4764518)Show SMILES Clc1ccc(NC(=O)N2CCc3ccc(cc3C2)-c2ccncc2)cc1Cl | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558179
(CHEMBL4790417)Show SMILES COc1cccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccncc2C)c1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558181
(CHEMBL4741033)Show SMILES COc1cccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccnc(OC)c2)c1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.57E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558189
(CHEMBL4755519)Show SMILES CN1CCN(Cc2cc(ccc12)-c1ccncc1)C(=O)Nc1ccc(Cl)c(Cl)c1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.57E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558204
(CHEMBL4744210)Show SMILES Fc1ccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccncc2)cc1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.61E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558183
(CHEMBL4797579)Show SMILES Clc1ccc(NC(=O)N2CCc3ccc(cc23)-c2ccncc2)cc1Cl | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.95E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558188
(CHEMBL4741265)Show SMILES CCCCN1CCN(Cc2cc(ccc12)-c1ccncc1)C(=O)Nc1ccc(Cl)c(Cl)c1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558184
(CHEMBL4748192)Show SMILES Clc1ccc(NC(=O)N2Cc3ccc(cc3C2)-c2ccncc2)cc1Cl | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558203
(CHEMBL4751866)Show SMILES COc1ccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccncc2)cc1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558185
(CHEMBL4791903)Show SMILES Clc1ccc(NC(=O)N2CCCc3ccc(cc23)-c2ccncc2)cc1Cl | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558196
(CHEMBL4786908)Show SMILES COc1cccc(c1)N(C)C(=O)N1CCOc2ccc(cc2C1)-c1ccncc1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50201577
(CHEMBL3967871)Show SMILES Cc1cn(cn1)-c1ccc(cc1)-c1cn(CC(=O)Nc2cccc(Cl)c2Cl)nn1 Show InChI InChI=1S/C20H16Cl2N6O/c1-13-9-27(12-23-13)15-7-5-14(6-8-15)18-10-28(26-25-18)11-19(29)24-17-4-2-3-16(21)20(17)22/h2-10,12H,11H2,1H3,(H,24,29) | KEGG
UniProtKB/SwissProt
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| CHEMBL
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PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a |
Merck& Co.
Curated by ChEMBL
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ACS Med Chem Lett 7: 1107-1111 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50201607
(CHEMBL3905835)Show SMILES Cc1nccn1-c1ccc(cc1)-c1cn(CC(=O)Nc2cccc(Cl)c2Cl)nn1 Show InChI InChI=1S/C20H16Cl2N6O/c1-13-23-9-10-28(13)15-7-5-14(6-8-15)18-11-27(26-25-18)12-19(29)24-17-4-2-3-16(21)20(17)22/h2-11H,12H2,1H3,(H,24,29) | KEGG
UniProtKB/SwissProt
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
Merck& Co.
Curated by ChEMBL
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ACS Med Chem Lett 7: 1107-1111 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50201606
(CHEMBL3896713)Show SMILES Cc1cn(cn1)-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)c(F)c1 Show InChI InChI=1S/C20H15Cl2FN6O/c1-12-8-28(11-24-12)13-5-6-14(16(23)7-13)18-9-29(27-26-18)10-19(30)25-17-4-2-3-15(21)20(17)22/h2-9,11H,10H2,1H3,(H,25,30) | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 687 | n/a | n/a | n/a | n/a |
Merck& Co.
Curated by ChEMBL
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ACS Med Chem Lett 7: 1107-1111 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50201577
(CHEMBL3967871)Show SMILES Cc1cn(cn1)-c1ccc(cc1)-c1cn(CC(=O)Nc2cccc(Cl)c2Cl)nn1 Show InChI InChI=1S/C20H16Cl2N6O/c1-13-9-27(12-23-13)15-7-5-14(6-8-15)18-10-28(26-25-18)11-19(29)24-17-4-2-3-16(21)20(17)22/h2-10,12H,11H2,1H3,(H,24,29) | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 19 | n/a | n/a | n/a | n/a |
Merck& Co.
Curated by ChEMBL
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ACS Med Chem Lett 7: 1107-1111 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50201572
(CHEMBL3965469)Show SMILES Cc1nccn1-c1ccc(cn1)-c1cn(CC(=O)Nc2cccc(Cl)c2Cl)nn1 Show InChI InChI=1S/C19H15Cl2N7O/c1-12-22-7-8-28(12)17-6-5-13(9-23-17)16-10-27(26-25-16)11-18(29)24-15-4-2-3-14(20)19(15)21/h2-10H,11H2,1H3,(H,24,29) | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 8 | n/a | n/a | n/a | n/a |
Merck& Co.
Curated by ChEMBL
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ACS Med Chem Lett 7: 1107-1111 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50381477
(CHEMBL2017410)Show SMILES COc1cc(ccc1-n1cnc(C)c1)-c1cn(CC(=O)Nc2cccc3ccccc23)nn1 Show InChI InChI=1S/C25H22N6O2/c1-17-13-30(16-26-17)23-11-10-19(12-24(23)33-2)22-14-31(29-28-22)15-25(32)27-21-9-5-7-18-6-3-4-8-20(18)21/h3-14,16H,15H2,1-2H3,(H,27,32) | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 23 | n/a | n/a | n/a | n/a |
Merck& Co.
Curated by ChEMBL
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ACS Med Chem Lett 7: 1107-1111 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50201575
(CHEMBL3903475)Show SMILES Cc1cn(cn1)-c1ccc(cc1F)-c1cn(CC(=O)Nc2cccc(Cl)c2Cl)nn1 Show InChI InChI=1S/C20H15Cl2FN6O/c1-12-8-28(11-24-12)18-6-5-13(7-15(18)23)17-9-29(27-26-17)10-19(30)25-16-4-2-3-14(21)20(16)22/h2-9,11H,10H2,1H3,(H,25,30) | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 9 | n/a | n/a | n/a | n/a |
Merck& Co.
Curated by ChEMBL
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ACS Med Chem Lett 7: 1107-1111 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50201606
(CHEMBL3896713)Show SMILES Cc1cn(cn1)-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)c(F)c1 Show InChI InChI=1S/C20H15Cl2FN6O/c1-12-8-28(11-24-12)13-5-6-14(16(23)7-13)18-9-29(27-26-18)10-19(30)25-17-4-2-3-15(21)20(17)22/h2-9,11H,10H2,1H3,(H,25,30) | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 19 | n/a | n/a | n/a | n/a |
Merck& Co.
Curated by ChEMBL
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ACS Med Chem Lett 7: 1107-1111 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50201604
(CHEMBL3976574)Show SMILES Clc1cccc(NC(=O)Cn2cc(nn2)-c2ccc(cc2)-n2ccnc2)c1Cl Show InChI InChI=1S/C19H14Cl2N6O/c20-15-2-1-3-16(19(15)21)23-18(28)11-27-10-17(24-25-27)13-4-6-14(7-5-13)26-9-8-22-12-26/h1-10,12H,11H2,(H,23,28) | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 18 | n/a | n/a | n/a | n/a |
Merck& Co.
Curated by ChEMBL
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ACS Med Chem Lett 7: 1107-1111 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50201575
(CHEMBL3903475)Show SMILES Cc1cn(cn1)-c1ccc(cc1F)-c1cn(CC(=O)Nc2cccc(Cl)c2Cl)nn1 Show InChI InChI=1S/C20H15Cl2FN6O/c1-12-8-28(11-24-12)18-6-5-13(7-15(18)23)17-9-29(27-26-17)10-19(30)25-16-4-2-3-14(21)20(16)22/h2-9,11H,10H2,1H3,(H,25,30) | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 78 | n/a | n/a | n/a | n/a |
Merck& Co.
Curated by ChEMBL
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ACS Med Chem Lett 7: 1107-1111 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50201574
(CHEMBL3895853)Show SMILES CN(C(=O)Cn1cc(nn1)-c1ccc(cc1)-n1ccnc1C)c1cccc(Cl)c1Cl Show InChI InChI=1S/C21H18Cl2N6O/c1-14-24-10-11-29(14)16-8-6-15(7-9-16)18-12-28(26-25-18)13-20(30)27(2)19-5-3-4-17(22)21(19)23/h3-12H,13H2,1-2H3 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a |
Merck& Co.
Curated by ChEMBL
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ACS Med Chem Lett 7: 1107-1111 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50395776
(CHEMBL2164850)Show SMILES O=C(Nc1cc(c[nH]c1=O)-c1ccncc1)[C@H](Cc1ccccc1)NC1(CC1)c1ccccn1 |r| Show InChI InChI=1S/C27H25N5O2/c33-25-22(17-21(18-30-25)20-9-14-28-15-10-20)31-26(34)23(16-19-6-2-1-3-7-19)32-27(11-12-27)24-8-4-5-13-29-24/h1-10,13-15,17-18,23,32H,11-12,16H2,(H,30,33)(H,31,34)/t23-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Agonist activity at mouse GPR142 expressed in HEK293 cells by inositol phosphate accumulation assay |
Bioorg Med Chem Lett 22: 6218-23 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50390577
(CHEMBL2069482)Show SMILES N[C@@H](Cc1ccccc1)C(=O)Nc1cc(c[nH]c1=O)-c1ccncc1 |r| Show InChI InChI=1S/C19H18N4O2/c20-16(10-13-4-2-1-3-5-13)18(24)23-17-11-15(12-22-19(17)25)14-6-8-21-9-7-14/h1-9,11-12,16H,10,20H2,(H,22,25)(H,23,24)/t16-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at mouse GPR142 assessed as inositol phosphate accumulation |
Bioorg Med Chem Lett 22: 5942-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.063
BindingDB Entry DOI: 10.7270/Q2VH5PXT |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50201604
(CHEMBL3976574)Show SMILES Clc1cccc(NC(=O)Cn2cc(nn2)-c2ccc(cc2)-n2ccnc2)c1Cl Show InChI InChI=1S/C19H14Cl2N6O/c20-15-2-1-3-16(19(15)21)23-18(28)11-27-10-17(24-25-27)13-4-6-14(7-5-13)26-9-8-22-12-26/h1-10,12H,11H2,(H,23,28) | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
Merck& Co.
Curated by ChEMBL
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ACS Med Chem Lett 7: 1107-1111 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50381477
(CHEMBL2017410)Show SMILES COc1cc(ccc1-n1cnc(C)c1)-c1cn(CC(=O)Nc2cccc3ccccc23)nn1 Show InChI InChI=1S/C25H22N6O2/c1-17-13-30(16-26-17)23-11-10-19(12-24(23)33-2)22-14-31(29-28-22)15-25(32)27-21-9-5-7-18-6-3-4-8-20(18)21/h3-14,16H,15H2,1-2H3,(H,27,32) | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 37 | n/a | n/a | n/a | n/a |
Merck& Co.
Curated by ChEMBL
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay |
ACS Med Chem Lett 7: 1107-1111 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50201605
(CHEMBL3912504)Show SMILES COc1cc(ccc1-n1cnc(C)c1)-c1cn(CC(=O)Nc2cccc(C)c2C)nn1 Show InChI InChI=1S/C23H24N6O2/c1-15-6-5-7-19(17(15)3)25-23(30)13-29-12-20(26-27-29)18-8-9-21(22(10-18)31-4)28-11-16(2)24-14-28/h5-12,14H,13H2,1-4H3,(H,25,30) | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 80 | n/a | n/a | n/a | n/a |
Merck& Co.
Curated by ChEMBL
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay |
ACS Med Chem Lett 7: 1107-1111 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00314
BindingDB Entry DOI: 10.7270/Q2ZC84V0 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50440693
(CHEMBL2430983)Show SMILES Cn1nc(cc1NC(=O)[C@H](Cc1ccccc1)NCC(O)=O)-c1ccncc1 |r| Show InChI InChI=1S/C20H21N5O3/c1-25-18(12-16(24-25)15-7-9-21-10-8-15)23-20(28)17(22-13-19(26)27)11-14-5-3-2-4-6-14/h2-10,12,17,22H,11,13H2,1H3,(H,23,28)(H,26,27)/t17-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 31 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at mouse GPR142 |
ACS Med Chem Lett 4: 829-34 (2013)
Article DOI: 10.1021/ml4000854
BindingDB Entry DOI: 10.7270/Q2JM2C20 |
More data for this
Ligand-Target Pair | |
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