Found 17 hits of ki for UniProtKB: O43924 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50249989
(CHEMBL1387422)Show SMILES CC(CNC(=O)CCCn1nc(C)c2c(C)n(nc2c1=O)-c1ccc(C)cc1)c1ccccc1 Show InChI InChI=1S/C27H31N5O2/c1-18-12-14-23(15-13-18)32-21(4)25-20(3)29-31(27(34)26(25)30-32)16-8-11-24(33)28-17-19(2)22-9-6-5-7-10-22/h5-7,9-10,12-15,19H,8,11,16-17H2,1-4H3,(H,28,33) | PDB
MMDB
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MCE
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PC sid
UniChem
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| Article
PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50583530
(CHEMBL5092661)Show SMILES Cc1n(nc2c1c(C)nn(CCCC(=O)NCCc1ccc(NC(=O)CCCC(=O)NCC34CC5CC(CC(C5)C3)C4)cc1)c2=O)-c1ccc(C)cc1 |TLB:35:36:33.34.39:40,THB:35:34:40:41.36.37,37:36:33:39.38.40,37:38:33:41.35.36| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 8.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50583533
(CHEMBL5084153)Show SMILES Cc1n(nc2c1c(C)nn(CCCC(=O)NCC13CC4CC(CC(C4)C1)C3)c2=O)-c1ccc(C)cc1 |TLB:20:21:18.19.24:25,THB:20:19:25:26.21.22,22:21:18:24.23.25,22:23:18:26.20.21| | PDB
MMDB
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GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 9.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50583534
(CHEMBL5089219)Show SMILES Cc1n(nc2c1c(C)nn(CCCC(=O)NC13CC4CC(CC(C4)C1)C3)c2=O)-c1ccc(C)cc1 |TLB:19:20:17.18.23:24,THB:19:18:24:25.20.21,21:20:17:23.22.24,21:22:17:25.19.20| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50583525
(CHEMBL5094121)Show SMILES Cc1n(nc2c1c(C)nn(CCCC(=O)NCCCCCCNC(=O)CC13CC4CC(CC(C4)C1)C3)c2=O)-c1ccc(C)cc1 |TLB:29:30:27.28.33:34,THB:29:28:35.30.31:34,31:30:27:33.32.34,31:32:27:35.30.29| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
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| PC cid
PC sid
UniChem
| Article
PubMed
| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50583524
(CHEMBL5077941)Show SMILES Cc1n(nc2c1c(C)nn(CCCC(=O)NCCCCCCCCNC(=O)CC13CC4CC(CC(C4)C1)C3)c2=O)-c1ccc(C)cc1 |TLB:31:32:30.29.35:36,35:30:37:34.33.36,35:34:37:31.30.29,THB:31:30:37.32.33:36| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50583527
(CHEMBL5086138)Show SMILES Cc1n(nc2c1c(C)nn(CCCC(=O)NCCNC(=O)CC13CC4CC(CC(C4)C1)C3)c2=O)-c1ccc(C)cc1 |TLB:25:26:23.24.29:30,THB:25:24:31.26.27:30,27:26:23:29.28.30,27:28:23:31.26.25| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 39 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50583532
(CHEMBL5079726)Show SMILES Cc1n(nc2c1c(C)nn(CCCC(=O)NCCCC(=O)NCC13CC4CC(CC(C4)C1)C3)c2=O)-c1ccc(C)cc1 |TLB:26:27:24.25.30:31,THB:26:25:31:32.27.28,28:27:24:30.29.31,28:29:24:32.26.27| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50583531
(CHEMBL5083136)Show SMILES Cc1n(nc2c1c(C)nn(CCCC(=O)NCCCCCC(=O)NCC13CC4CC(CC(C4)C1)C3)c2=O)-c1ccc(C)cc1 |TLB:28:29:26.27.32:33,THB:28:27:33:34.29.30,30:29:26:32.31.33,30:31:26:34.28.29| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 44 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50583529
(CHEMBL5087129)Show SMILES Cc1n(nc2c1c(C)nn(CCCC(=O)NCCc1ccc(NC(=O)CCCCCC(=O)NCC34CC5CC(CC(C5)C3)C4)cc1)c2=O)-c1ccc(C)cc1 |TLB:37:38:35.36.41:42,THB:37:36:42:43.38.39,39:38:35:41.40.42,39:40:35:43.37.38| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50583526
(CHEMBL5072868)Show SMILES Cc1n(nc2c1c(C)nn(CCCC(=O)NCCCCNC(=O)CC13CC4CC(CC(C4)C1)C3)c2=O)-c1ccc(C)cc1 |TLB:27:28:25.26.31:32,THB:27:26:33.28.29:32,29:28:25:31.30.32,29:30:25:33.28.27| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
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| PC cid
PC sid
UniChem
| Article
PubMed
| 49 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
O43924/P16499/P18545/P35913/P51160/Q13956
(Homo sapiens (Human)) | BDBM14390
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) | PDB
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| Article
PubMed
| 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Inhibition of human phosphodiesterase 6 |
J Med Chem 48: 3449-62 (2005)
Article DOI: 10.1021/jm040217u
BindingDB Entry DOI: 10.7270/Q21G0N2H |
More data for this
Ligand-Target Pair | |
O43924/P16499/P18545/P35913/P51160/Q13956
(Homo sapiens (Human)) | BDBM23620
(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)Show SMILES OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO Show InChI InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2 | PDB
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| Article
PubMed
| 125 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Inhibition of human phosphodiesterase 6 |
J Med Chem 48: 3449-62 (2005)
Article DOI: 10.1021/jm040217u
BindingDB Entry DOI: 10.7270/Q21G0N2H |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50583523
(CHEMBL5084808)Show SMILES Cc1n(nc2c1c(C)nn(CCCC(=O)NCCOCCOCCNC(=O)CC13CC4CC(CC(C4)C1)C3)c2=O)-c1ccc(C)cc1 |TLB:31:32:29.30.35:36,THB:31:30:36:37.32.33,33:32:29:35.34.36,33:34:29:37.31.32| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 132 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50583522
(CHEMBL5082602)Show SMILES Cc1n(nc2c1c(C)nn(CCCC(=O)NCCc1ccc(NC(=O)CCCCCCNC(=O)CC34CC5CC(CC(C5)C3)C4)cc1)c2=O)-c1ccc(C)cc1 |TLB:38:39:36.37.42:43,THB:38:37:43:44.39.40,40:39:36:42.41.43,40:41:36:44.38.39| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
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GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 147 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
O43924/P16499/P18545/P35913/P51160/Q13956
(Homo sapiens (Human)) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB
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UniChem
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| Article
PubMed
| 400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Inhibition of human phosphodiesterase 6 |
J Med Chem 48: 3449-62 (2005)
Article DOI: 10.1021/jm040217u
BindingDB Entry DOI: 10.7270/Q21G0N2H |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50583528
(CHEMBL5092958)Show SMILES Cc1n(nc2c1c(C)nn(CCCC(=O)NCCc1ccc(NC(=O)CCCCCCCCCC(=O)NCC34CC5CC(CC(C5)C3)C4)cc1)c2=O)-c1ccc(C)cc1 |TLB:41:42:39.40.45:46,THB:41:40:46:47.42.43,43:42:39:45.44.46,43:44:39:47.41.42| | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
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