Compile Data Set for Download or QSAR

Found 145 hits of ec50 for UniProtKB: P33533   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM50009146 ((S)-4-((S)-2-{(R)-2-[(S)-2-Amino-3-(4-hydroxy-phen...) Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(O)=O Show InChI InChI=1S/C38H53N7O11/c1-20(2)31(37(55)40-19-30(49)50)45-38(56)32(21(3)4)44-35(53)27(15-16-29(47)48)42-36(54)28(18-23-9-7-6-8-10-23)43-33(51)22(5)41-34(52)26(39)17-24-11-13-25(46)14-12-24/h6-14,20-22,26-28,31-32,46H,15-19,39H2,1-5H3,(H,40,55)(H,41,52)(H,42,54)(H,43,51)(H,44,53)(H,45,56)(H,47,48)(H,49,50)/t22-,26+,27+,28+,31+,32+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.100	n/a	n/a	n/a	n/a
Vrije Universiteit Brussel Curated by ChEMBL					Assay Description Agonist activity at rat delta-opioid receptor expressed in HEK293 cells co-expressing Rluc2-EPAC-GFP10 biosenser assessed as inhibition of forskolin-...				Bioorg Med Chem Lett 28: 2320-2323 (2018) Article DOI: 10.1016/j.bmcl.2018.05.015 BindingDB Entry DOI: 10.7270/Q2KW5JJJ
					More data for this Ligand-Target Pair
Delta-type/Kappa-type/Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM60212 ((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...) Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O Show InChI InChI=1S/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,5-10H2/t15-,18+,19+,20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity to rat brain opioid receptor				J Med Chem 21: 101-6 (1978) Article DOI: 10.1021/jm00199a018 BindingDB Entry DOI: 10.7270/Q2J969CM
					More data for this Ligand-Target Pair
Delta-type/Kappa-type/Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50496883 (CHEMBL3228684) Show SMILES OS(O)(=O)=O.[H][C@@]12CCC[C@@]3([H])[C@@]4([H])Cc5ccc(O)c(O1)c5[C@@]23CCN4C |r,TLB:27:26:10:22.15.14| Show InChI InChI=1S/C17H21NO2.H2O4S/c1-18-8-7-17-11-3-2-4-14(17)20-16-13(19)6-5-10(15(16)17)9-12(11)18;1-5(2,3)4/h5-6,11-12,14,19H,2-4,7-9H2,1H3;(H2,1,2,3,4)/t11-,12+,14-,17+;/m0./s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.600	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity to opioid receptor in rat brain homogenates				J Med Chem 22: 256-9 (1979) Article DOI: 10.1021/jm00189a007 BindingDB Entry DOI: 10.7270/Q2M61P72
					More data for this Ligand-Target Pair
Delta-type/Kappa-type/Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM82427 (CAS_5985-38-6 | LEVORPHANOL-tartarate) Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(O)cc31 |r| Show InChI InChI=1S/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.700	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity to opioid receptor in rat brain homogenates				J Med Chem 22: 256-9 (1979) Article DOI: 10.1021/jm00189a007 BindingDB Entry DOI: 10.7270/Q2M61P72
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM50535347 (CHEMBL4476818) Show SMILES OC(=O)C(F)(F)F.Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H]1CCN(C(=O)C2CC2)c2ccc(Cc3cnc4ccccc4c3)cc12 |r| Show InChI InChI=1S/C34H36N4O3.C2HF3O2/c1-20-13-26(39)14-21(2)27(20)18-29(35)33(40)37-31-11-12-38(34(41)24-8-9-24)32-10-7-22(17-28(31)32)15-23-16-25-5-3-4-6-30(25)36-19-23;3-2(4,5)1(6)7/h3-7,10,13-14,16-17,19,24,29,31,39H,8-9,11-12,15,18,35H2,1-2H3,(H,37,40);(H,6,7)/t29-,31+;/m0./s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.710	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at rat delta opioid receptor expressed in rat C6 cell membranes assessed as stimulation of [35S]GTPgammaS binding measured after 1 h...				J Med Chem 62: 4193-4203 (2019) Article DOI: 10.1021/acs.jmedchem.9b00378 BindingDB Entry DOI: 10.7270/Q2542S2Q
					More data for this Ligand-Target Pair
Delta-type/Kappa-type/Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50241341 ((-)-(5R)-4,5-Epoxy-3-hydroxy-9alpha-methylmorphina...) Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3CCC4=O)ccc5O |r| Show InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,16,19H,3,5-8H2,1H3/t10-,11+,16-,17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity to opioid receptor in rat brain homogenates				J Med Chem 22: 256-9 (1979) Article DOI: 10.1021/jm00189a007 BindingDB Entry DOI: 10.7270/Q2M61P72
					More data for this Ligand-Target Pair
Delta-type/Kappa-type/Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50001707 (10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...) Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@]3(O)CCC4=O)ccc5O |TLB:14:12:8.9.10:1.3.2,THB:13:12:8.9.10:1.3.2| Show InChI InChI=1S/C17H19NO4/c1-18-7-6-16-13-9-2-3-10(19)14(13)22-15(16)11(20)4-5-17(16,21)12(18)8-9/h2-3,12,15,19,21H,4-8H2,1H3/t12-,15+,16+,17-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity to rat brain opioid receptor				J Med Chem 21: 101-6 (1978) Article DOI: 10.1021/jm00199a018 BindingDB Entry DOI: 10.7270/Q2J969CM
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM50274686 (CHEMBL4129679) Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C28H39N7O6/c1-16-11-19(36)12-17(2)20(16)14-21(29)25(39)34-22(9-6-10-32-28(30)31)27(41)35-23(26(40)33-15-24(37)38)13-18-7-4-3-5-8-18/h3-5,7-8,11-12,21-23,36H,6,9-10,13-15,29H2,1-2H3,(H,33,40)(H,34,39)(H,35,41)(H,37,38)(H4,30,31,32)/t21-,22+,23-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.10	n/a	n/a	n/a	n/a
Vrije Universiteit Brussel Curated by ChEMBL					Assay Description Agonist activity at rat delta-opioid receptor expressed in HEK293 cells co-expressing Rluc2-EPAC-GFP10 biosenser assessed as inhibition of forskolin-...				Bioorg Med Chem Lett 28: 2320-2323 (2018) Article DOI: 10.1016/j.bmcl.2018.05.015 BindingDB Entry DOI: 10.7270/Q2KW5JJJ
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM21008 ((4S,7S,13S)-13-[(2S)-2-amino-3-(4-hydroxyphenyl)pr...) Show SMILES CC1(C)SSC(C)(C)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H]1C(O)=O Show InChI InChI=1S/C30H39N5O7S2/c1-29(2)23(34-25(38)20(31)14-18-10-12-19(36)13-11-18)27(40)32-16-22(37)33-21(15-17-8-6-5-7-9-17)26(39)35-24(28(41)42)30(3,4)44-43-29/h5-13,20-21,23-24,36H,14-16,31H2,1-4H3,(H,32,40)(H,33,37)(H,34,38)(H,35,39)(H,41,42)/t20-,21-,23-,24-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.40	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at rat delta opioid receptor expressed in CHO cells incubated for 1 hr by [35S]GTPgammaS binding based liquid scintillation counting...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112070 BindingDB Entry DOI: 10.7270/Q2JW8JHX
					More data for this Ligand-Target Pair
Delta-type/Kappa-type/Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50000788 ((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...) Show SMILES Oc1ccc2C[C@H]3N(CC=C)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O |r| Show InChI InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.5	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity to rat brain opioid receptor				J Med Chem 21: 101-6 (1978) Article DOI: 10.1021/jm00199a018 BindingDB Entry DOI: 10.7270/Q2J969CM
					More data for this Ligand-Target Pair
Delta-type/Kappa-type/Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50367061 (NALORPHINE | NALORPHINE HYDROCHLORIDE) Show SMILES O[C@H]1C=C[C@H]2[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC=C)c45 |r,c:2,TLB:3:4:22.7.6:18.16.17| Show InChI InChI=1S/C19H21NO3/c1-2-8-20-9-7-19-12-4-6-15(22)18(19)23-17-14(21)5-3-11(16(17)19)10-13(12)20/h2-6,12-13,15,18,21-22H,1,7-10H2/t12-,13+,15-,18-,19-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.5	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity to opioid receptor in rat brain homogenates				J Med Chem 22: 256-9 (1979) Article DOI: 10.1021/jm00189a007 BindingDB Entry DOI: 10.7270/Q2M61P72
					More data for this Ligand-Target Pair
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1 (Rattus norvegicus (rat)-RAT)	BDBM50367061 (NALORPHINE | NALORPHINE HYDROCHLORIDE) Show SMILES O[C@H]1C=C[C@H]2[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC=C)c45 |r,c:2,TLB:3:4:22.7.6:18.16.17| Show InChI InChI=1S/C19H21NO3/c1-2-8-20-9-7-19-12-4-6-15(22)18(19)23-17-14(21)5-3-11(16(17)19)10-13(12)20/h2-6,12-13,15,18,21-22H,1,7-10H2/t12-,13+,15-,18-,19-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1.5	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membrane				J Med Chem 29: 2136-41 (1986) BindingDB Entry DOI: 10.7270/Q2GX4DRM
					More data for this Ligand-Target Pair
Delta-type/Kappa-type/Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50367061 (NALORPHINE | NALORPHINE HYDROCHLORIDE) Show SMILES O[C@H]1C=C[C@H]2[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC=C)c45 |r,c:2,TLB:3:4:22.7.6:18.16.17| Show InChI InChI=1S/C19H21NO3/c1-2-8-20-9-7-19-12-4-6-15(22)18(19)23-17-14(21)5-3-11(16(17)19)10-13(12)20/h2-6,12-13,15,18,21-22H,1,7-10H2/t12-,13+,15-,18-,19-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.5	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity to rat brain opioid receptor				J Med Chem 21: 101-6 (1978) Article DOI: 10.1021/jm00199a018 BindingDB Entry DOI: 10.7270/Q2J969CM
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM50535339 (CHEMBL4453526) Show SMILES OC(=O)C(F)(F)F.CC(=O)N1CC[C@@H](NC(=O)[C@@H](N)Cc2c(C)cc(O)cc2C)c2cc(Cc3cc4ccccc4o3)ccc12 |r| Show InChI InChI=1S/C31H33N3O4.C2HF3O2/c1-18-12-23(36)13-19(2)25(18)17-27(32)31(37)33-28-10-11-34(20(3)35)29-9-8-21(15-26(28)29)14-24-16-22-6-4-5-7-30(22)38-24;3-2(4,5)1(6)7/h4-9,12-13,15-16,27-28,36H,10-11,14,17,32H2,1-3H3,(H,33,37);(H,6,7)/t27-,28+;/m0./s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.60	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at rat delta opioid receptor expressed in rat C6 cell membranes assessed as stimulation of [35S]GTPgammaS binding measured after 1 h...				J Med Chem 62: 4193-4203 (2019) Article DOI: 10.1021/acs.jmedchem.9b00378 BindingDB Entry DOI: 10.7270/Q2542S2Q
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM50535337 (CHEMBL4446945) Show SMILES OC(=O)C(F)(F)F.Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H]1CCN(C(=O)C2CC2)c2ccc(Cc3ccc4ccccc4c3)cc12 |r| Show InChI InChI=1S/C35H37N3O3.C2HF3O2/c1-21-15-28(39)16-22(2)29(21)20-31(36)34(40)37-32-13-14-38(35(41)26-10-11-26)33-12-8-24(19-30(32)33)17-23-7-9-25-5-3-4-6-27(25)18-23;3-2(4,5)1(6)7/h3-9,12,15-16,18-19,26,31-32,39H,10-11,13-14,17,20,36H2,1-2H3,(H,37,40);(H,6,7)/t31-,32+;/m0./s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.90	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at rat delta opioid receptor expressed in rat C6 cell membranes assessed as stimulation of [35S]GTPgammaS binding measured after 1 h...				J Med Chem 62: 4193-4203 (2019) Article DOI: 10.1021/acs.jmedchem.9b00378 BindingDB Entry DOI: 10.7270/Q2542S2Q
					More data for this Ligand-Target Pair
Delta-type/Kappa-type/Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50231237 (CHEBI:6125 | Cetobemidone | Cliradon | Cymidon | K...) Show SMILES CCC(=O)C1(CCN(C)CC1)c1cccc(O)c1 Show InChI InChI=1S/C15H21NO2/c1-3-14(18)15(7-9-16(2)10-8-15)12-5-4-6-13(17)11-12/h4-6,11,17H,3,7-10H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenates				J Med Chem 22: 889-90 (1979) Article DOI: 10.1021/jm00193a028 BindingDB Entry DOI: 10.7270/Q2QZ2DXM
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM50274689 (CHEMBL4126050) Show SMILES C[C@@H](NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C25H32N4O6/c1-14-9-18(30)10-15(2)19(14)12-20(26)24(34)28-16(3)23(33)29-21(25(35)27-13-22(31)32)11-17-7-5-4-6-8-17/h4-10,16,20-21,30H,11-13,26H2,1-3H3,(H,27,35)(H,28,34)(H,29,33)(H,31,32)/t16-,20+,21+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.40	n/a	n/a	n/a	n/a
Vrije Universiteit Brussel Curated by ChEMBL					Assay Description Agonist activity at rat delta-opioid receptor expressed in HEK293 cells co-expressing Rluc2-EPAC-GFP10 biosenser assessed as inhibition of forskolin-...				Bioorg Med Chem Lett 28: 2320-2323 (2018) Article DOI: 10.1016/j.bmcl.2018.05.015 BindingDB Entry DOI: 10.7270/Q2KW5JJJ
					More data for this Ligand-Target Pair
Delta-type/Kappa-type/Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50000092 ((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...) Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5O |r,c:16,TLB:13:12:8.9.10:3.2.1| Show InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity to rat brain opioid receptor				J Med Chem 21: 101-6 (1978) Article DOI: 10.1021/jm00199a018 BindingDB Entry DOI: 10.7270/Q2J969CM
					More data for this Ligand-Target Pair				3D Structure (crystal)
Delta-type/Kappa-type/Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50000092 ((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...) Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5O |r,c:16,TLB:13:12:8.9.10:3.2.1| Show InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity to opioid receptor in rat brain homogenates				J Med Chem 22: 256-9 (1979) Article DOI: 10.1021/jm00189a007 BindingDB Entry DOI: 10.7270/Q2M61P72
					More data for this Ligand-Target Pair				3D Structure (crystal)
Delta-type/Kappa-type/Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50452273 (Dihydromorphine) Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(C)CC[C@@]14[C@@]5([H])CC[C@@H]2O)ccc3O |TLB:10:9:14:4.5.6| Show InChI InChI=1S/C17H21NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,13,16,19-20H,3,5-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity to opioid receptor in rat brain homogenates				J Med Chem 22: 256-9 (1979) Article DOI: 10.1021/jm00189a007 BindingDB Entry DOI: 10.7270/Q2M61P72
					More data for this Ligand-Target Pair
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1 (Rattus norvegicus (rat)-RAT)	BDBM50000092 ((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...) Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5O |r,c:16,TLB:13:12:8.9.10:3.2.1| Show InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membrane				J Med Chem 29: 2136-41 (1986) BindingDB Entry DOI: 10.7270/Q2GX4DRM
					More data for this Ligand-Target Pair				3D Structure (crystal)
Delta-type/Kappa-type/Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50000092 ((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...) Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5O |r,c:16,TLB:13:12:8.9.10:3.2.1| Show InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenates				J Med Chem 22: 889-90 (1979) Article DOI: 10.1021/jm00193a028 BindingDB Entry DOI: 10.7270/Q2QZ2DXM
					More data for this Ligand-Target Pair				3D Structure (crystal)
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM50535349 (CHEMBL4451910) Show SMILES OC(=O)C(F)(F)F.Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H]1CCN(C(=O)C2CC2)c2ccc(Cc3cc4ccccc4o3)cc12 |r| Show InChI InChI=1S/C33H35N3O4.C2HF3O2/c1-19-13-24(37)14-20(2)26(19)18-28(34)32(38)35-29-11-12-36(33(39)22-8-9-22)30-10-7-21(16-27(29)30)15-25-17-23-5-3-4-6-31(23)40-25;3-2(4,5)1(6)7/h3-7,10,13-14,16-17,22,28-29,37H,8-9,11-12,15,18,34H2,1-2H3,(H,35,38);(H,6,7)/t28-,29+;/m0./s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.70	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at rat delta opioid receptor expressed in rat C6 cell membranes assessed as stimulation of [35S]GTPgammaS binding measured after 1 h...				J Med Chem 62: 4193-4203 (2019) Article DOI: 10.1021/acs.jmedchem.9b00378 BindingDB Entry DOI: 10.7270/Q2542S2Q
					More data for this Ligand-Target Pair
Delta-type/Kappa-type/Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50496876 (CHEMBL3228291) Show SMILES CC[C@H]1C2Cc3ccc(O)cc3[C@@]1(C)CCN2CCC#N |r,TLB:17:16:2:5.11.4,10:11:2:14.15.16| Show InChI InChI=1S/C18H24N2O/c1-3-15-17-11-13-5-6-14(21)12-16(13)18(15,2)7-10-20(17)9-4-8-19/h5-6,12,15,17,21H,3-4,7,9-11H2,1-2H3/t15-,17?,18-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenates				J Med Chem 22: 889-90 (1979) Article DOI: 10.1021/jm00193a028 BindingDB Entry DOI: 10.7270/Q2QZ2DXM
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM50274679 (CHEMBL4128530) Show SMILES C[C@@H](NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N(C)[C@@H](Cc1ccccc1C=C)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C28H37N5O5/c1-6-19-9-7-8-10-20(19)13-24(27(37)31-15-25(30)35)33(5)28(38)18(4)32-26(36)23(29)14-22-16(2)11-21(34)12-17(22)3/h6-12,18,23-24,34H,1,13-15,29H2,2-5H3,(H2,30,35)(H,31,37)(H,32,36)/t18-,23+,24+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4.40	n/a	n/a	n/a	n/a
Vrije Universiteit Brussel Curated by ChEMBL					Assay Description Agonist activity at rat delta-opioid receptor expressed in HEK293 cells co-expressing Rluc2-EPAC-GFP10 biosenser assessed as inhibition of forskolin-...				Bioorg Med Chem Lett 28: 2320-2323 (2018) Article DOI: 10.1016/j.bmcl.2018.05.015 BindingDB Entry DOI: 10.7270/Q2KW5JJJ
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM50274741 (CHEMBL4126470) Show SMILES C[C@@H](NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](Cc1ccccc1-c1ccccc1)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C31H37N5O5/c1-18-13-23(37)14-19(2)25(18)16-26(32)30(40)35-20(3)29(39)36-27(31(41)34-17-28(33)38)15-22-11-7-8-12-24(22)21-9-5-4-6-10-21/h4-14,20,26-27,37H,15-17,32H2,1-3H3,(H2,33,38)(H,34,41)(H,35,40)(H,36,39)/t20-,26+,27+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.90	n/a	n/a	n/a	n/a
Vrije Universiteit Brussel Curated by ChEMBL					Assay Description Tested for thromboxane antagonist potency (pA2) against U 44619 induced platelet aggregation using human platelet rich plasma				Bioorg Med Chem Lett 28: 2320-2323 (2018) Article DOI: 10.1016/j.bmcl.2018.05.015 BindingDB Entry DOI: 10.7270/Q2KW5JJJ
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM50185312 (CHEMBL3823787) Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H]1CCN(C(=O)C2CCC2)c2ccc(Cc3ccccc3)cc12 |r| Show InChI InChI=1S/C32H37N3O3/c1-20-15-25(36)16-21(2)26(20)19-28(33)31(37)34-29-13-14-35(32(38)24-9-6-10-24)30-12-11-23(18-27(29)30)17-22-7-4-3-5-8-22/h3-5,7-8,11-12,15-16,18,24,28-29,36H,6,9-10,13-14,17,19,33H2,1-2H3,(H,34,37)/t28-,29+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	5.10	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Agonist activity at rat DOR transfected in rat C6 cell membranes after 1 hr by [35S]GTPgammaS assay				J Med Chem 59: 4985-98 (2016) Article DOI: 10.1021/acs.jmedchem.6b00308 BindingDB Entry DOI: 10.7270/Q28917SS
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM50535343 (CHEMBL4550332) Show SMILES OC(=O)C(F)(F)F.CC(=O)N1CC[C@@H](NC(=O)[C@@H](N)Cc2c(C)cc(O)cc2C)c2cc(Cc3cnc4ccccc4c3)ccc12 |r| Show InChI InChI=1S/C32H34N4O3.C2HF3O2/c1-19-12-25(38)13-20(2)26(19)17-28(33)32(39)35-30-10-11-36(21(3)37)31-9-8-22(16-27(30)31)14-23-15-24-6-4-5-7-29(24)34-18-23;3-2(4,5)1(6)7/h4-9,12-13,15-16,18,28,30,38H,10-11,14,17,33H2,1-3H3,(H,35,39);(H,6,7)/t28-,30+;/m0./s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5.80	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at rat delta opioid receptor expressed in rat C6 cell membranes assessed as stimulation of [35S]GTPgammaS binding measured after 1 h...				J Med Chem 62: 4193-4203 (2019) Article DOI: 10.1021/acs.jmedchem.9b00378 BindingDB Entry DOI: 10.7270/Q2542S2Q
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM50274694 (CHEMBL4129901) Show SMILES C[C@@H](NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](Cc1ccccc1C=C)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C27H35N5O5/c1-5-18-8-6-7-9-19(18)12-23(27(37)30-14-24(29)34)32-25(35)17(4)31-26(36)22(28)13-21-15(2)10-20(33)11-16(21)3/h5-11,17,22-23,33H,1,12-14,28H2,2-4H3,(H2,29,34)(H,30,37)(H,31,36)(H,32,35)/t17-,22+,23+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5.80	n/a	n/a	n/a	n/a
Vrije Universiteit Brussel Curated by ChEMBL					Assay Description Agonist activity at rat delta-opioid receptor expressed in HEK293 cells co-expressing Rluc2-EPAC-GFP10 biosenser assessed as inhibition of forskolin-...				Bioorg Med Chem Lett 28: 2320-2323 (2018) Article DOI: 10.1016/j.bmcl.2018.05.015 BindingDB Entry DOI: 10.7270/Q2KW5JJJ
					More data for this Ligand-Target Pair
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1 (Rattus norvegicus (rat)-RAT)	BDBM50225933 (CHEMBL2310921) Show SMILES OC(=O)C(O)=O.[H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@]51C[C@H](NC(=O)\C=C\C(=O)OC)C2(OC)C=C1)ccc3O |r,wU:23.26,22.21,7.5,wD:25.28,13.12,c:42,THB:26:25:22.7:39.38,16:15:23:10.11.12,(1.76,5.46,;2.53,4.13,;4.07,4.13,;1.76,2.8,;.22,2.8,;2.53,1.46,;-9.74,-.57,;-7.91,-.19,;-8.68,1.56,;-7.91,2.89,;-6.58,2.12,;-5.25,2.89,;-3.91,2.12,;-3.91,.58,;-2.3,1.51,;-2.58,-.19,;-2.18,-1.68,;-.69,-2.08,;.4,-3.16,;.79,-1.68,;-2.58,1.35,;-5.49,1.67,;-6.58,.58,;-5.25,-.19,;-5.25,-1.73,;-6.58,-2.5,;-6.58,-4.04,;-5.25,-4.81,;-3.91,-4.04,;-5.25,-6.35,;-3.91,-7.12,;-3.91,-8.66,;-5.25,-9.43,;-2.58,-9.43,;-2.58,-10.97,;-7.91,-1.73,;-9.25,-2.5,;-9.25,-4.04,;-6.34,-2.08,;-6.73,-.59,;-5.25,4.43,;-6.58,5.2,;-7.91,4.43,;-9.25,5.2,)| Show InChI InChI=1S/C28H32N2O6.C2H2O4/c1-34-22(33)8-7-21(32)29-19-14-26-9-10-28(19,35-2)25-27(26)11-12-30(15-16-3-4-16)20(26)13-17-5-6-18(31)24(36-25)23(17)27;3-1(4)2(5)6/h5-10,16,19-20,25,31H,3-4,11-15H2,1-2H3,(H,29,32);(H,3,4)(H,5,6)/b8-7+;/t19-,20+,25+,26+,27-,28?;/m0./s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membrane				J Med Chem 29: 2136-41 (1986) BindingDB Entry DOI: 10.7270/Q2GX4DRM
					More data for this Ligand-Target Pair
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1 (Rattus norvegicus (rat)-RAT)	BDBM50225937 (CHEMBL3038189) Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@]51C[C@H](N)[C@]2(OC)C=C1)ccc3O |wU:16.16,1.0,wD:17.30,21.26,19.23,7.7,c:29,THB:10:9:17:4.5.6,(6.14,-10.09,;6.66,-8.29,;4.41,-8.23,;4.01,-6.75,;5.33,-5.99,;5.33,-4.44,;6.67,-3.66,;8.01,-4.44,;9.49,-4.84,;9.33,-3.67,;10.29,-2.46,;11.8,-2.71,;12.98,-3.66,;13.22,-2.15,;8.83,-5.24,;6.66,-5.22,;6.67,-6.75,;8.01,-5.99,;9.35,-6.76,;9.33,-8.32,;10.86,-8.32,;7.98,-9.08,;7.81,-10.59,;6.38,-11.19,;8.35,-7.56,;7.61,-7.47,;4.01,-3.67,;2.69,-4.46,;2.69,-5.99,;1.37,-6.73,)| Show InChI InChI=1S/C23H28N2O3/c1-27-23-7-6-21(11-16(23)24)17-10-14-4-5-15(26)19-18(14)22(21,20(23)28-19)8-9-25(17)12-13-2-3-13/h4-7,13,16-17,20,26H,2-3,8-12,24H2,1H3/t16-,17+,20+,21+,22-,23+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membrane				J Med Chem 29: 2136-41 (1986) BindingDB Entry DOI: 10.7270/Q2GX4DRM
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM50274696 (CHEMBL4126102) Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1C=C)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C30H42N8O5/c1-4-19-8-5-6-9-20(19)14-25(28(42)36-16-26(32)40)38-29(43)24(10-7-11-35-30(33)34)37-27(41)23(31)15-22-17(2)12-21(39)13-18(22)3/h4-6,8-9,12-13,23-25,39H,1,7,10-11,14-16,31H2,2-3H3,(H2,32,40)(H,36,42)(H,37,41)(H,38,43)(H4,33,34,35)/t23-,24+,25-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
Vrije Universiteit Brussel Curated by ChEMBL					Assay Description Agonist activity at rat delta-opioid receptor expressed in HEK293 cells co-expressing Rluc2-EPAC-GFP10 biosenser assessed as inhibition of forskolin-...				Bioorg Med Chem Lett 28: 2320-2323 (2018) Article DOI: 10.1016/j.bmcl.2018.05.015 BindingDB Entry DOI: 10.7270/Q2KW5JJJ
					More data for this Ligand-Target Pair
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1 (Rattus norvegicus (rat)-RAT)	BDBM50225935 (CHEMBL2310915) Show SMILES OC(=O)C(O)=O.[H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@]51C[C@H](N=S)C2(OC)C=C1)ccc3O |r,wU:23.26,22.21,7.5,wD:25.28,13.12,c:35,THB:26:25:22.7:32.31,16:15:23:10.11.12,(1.76,5.46,;2.53,4.13,;4.07,4.13,;1.76,2.8,;.22,2.8,;2.53,1.46,;-9.74,-.57,;-7.91,-.19,;-8.68,1.56,;-7.91,2.89,;-6.58,2.12,;-5.25,2.89,;-3.91,2.12,;-3.91,.58,;-2.3,1.51,;-2.58,-.19,;-2.18,-1.68,;-.69,-2.08,;.4,-3.16,;.79,-1.68,;-2.58,1.35,;-5.49,1.67,;-6.58,.58,;-5.25,-.19,;-5.25,-1.73,;-6.58,-2.5,;-6.58,-4.04,;-5.25,-4.81,;-7.91,-1.73,;-9.25,-2.5,;-9.25,-4.04,;-6.34,-2.08,;-6.73,-.59,;-5.25,4.43,;-6.58,5.2,;-7.91,4.43,;-9.25,5.2,)| Show InChI InChI=1S/C23H26N2O3S.C2H2O4/c1-27-23-7-6-21(11-16(23)24-29)17-10-14-4-5-15(26)19-18(14)22(21,20(23)28-19)8-9-25(17)12-13-2-3-13;3-1(4)2(5)6/h4-7,13,16-17,20,26H,2-3,8-12H2,1H3;(H,3,4)(H,5,6)/t16-,17+,20+,21+,22-,23?;/m0./s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membrane				J Med Chem 29: 2136-41 (1986) BindingDB Entry DOI: 10.7270/Q2GX4DRM
					More data for this Ligand-Target Pair
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1 (Rattus norvegicus (rat)-RAT)	BDBM50225936 (CHEMBL3038190) Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@]51C[C@H](NC(=O)CBr)[C@]2(OC)C=C1)ccc3O |wU:16.16,1.0,wD:17.34,19.23,25.30,7.7,c:33,THB:10:9:17:4.5.6,(6.14,-10.1,;6.67,-8.3,;4.41,-8.24,;4.02,-6.76,;5.34,-6,;5.34,-4.44,;6.68,-3.67,;8.02,-4.44,;9.5,-4.84,;9.35,-3.68,;10.3,-2.47,;11.81,-2.71,;12.99,-3.67,;13.24,-2.15,;8.84,-5.24,;6.67,-5.23,;6.68,-6.76,;8.02,-6,;9.36,-6.77,;9.35,-8.33,;10.88,-8.33,;11.88,-9.45,;11.4,-10.92,;13.38,-9.15,;14.4,-10.28,;7.99,-9.09,;7.81,-10.6,;6.39,-11.21,;8.36,-7.57,;7.62,-7.47,;4.02,-3.68,;2.69,-4.47,;2.69,-6,;1.37,-6.74,)| Show InChI InChI=1S/C25H29BrN2O4/c1-31-25-7-6-23(11-17(25)27-19(30)12-26)18-10-15-4-5-16(29)21-20(15)24(23,22(25)32-21)8-9-28(18)13-14-2-3-14/h4-7,14,17-18,22,29H,2-3,8-13H2,1H3,(H,27,30)/t17-,18+,22+,23+,24-,25+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membrane				J Med Chem 29: 2136-41 (1986) BindingDB Entry DOI: 10.7270/Q2GX4DRM
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM50240354 (CHEMBL274844 | N-{1-[2-(4-Isothiocyanato-phenyl)-e...) Show SMILES CCC(=O)N(C1CCN(CCc2ccc(cc2)N=C=S)CC1)c1ccccc1 Show InChI InChI=1S/C23H27N3OS/c1-2-23(27)26(21-6-4-3-5-7-21)22-13-16-25(17-14-22)15-12-19-8-10-20(11-9-19)24-18-28/h3-11,22H,2,12-17H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description The binding affinity was evaluated against [3H]dalamid binding to neuroblastoma X glioma hybrid cell NG108-15 (Opioid receptor delta 1)membranes				J Med Chem 27: 1570-4 (1985) BindingDB Entry DOI: 10.7270/Q2S18328
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM50185309 (CHEMBL3824052) Show SMILES CCCC(=O)N1CC[C@@H](NC(=O)[C@@H](N)Cc2c(C)cc(O)cc2C)c2cc(Cc3ccccc3)ccc12 |r| Show InChI InChI=1S/C31H37N3O3/c1-4-8-30(36)34-14-13-28(26-18-23(11-12-29(26)34)17-22-9-6-5-7-10-22)33-31(37)27(32)19-25-20(2)15-24(35)16-21(25)3/h5-7,9-12,15-16,18,27-28,35H,4,8,13-14,17,19,32H2,1-3H3,(H,33,37)/t27-,28+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	8.10	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Agonist activity at rat DOR transfected in rat C6 cell membranes after 1 hr by [35S]GTPgammaS assay				J Med Chem 59: 4985-98 (2016) Article DOI: 10.1021/acs.jmedchem.6b00308 BindingDB Entry DOI: 10.7270/Q28917SS
					More data for this Ligand-Target Pair
Delta-type/Kappa-type/Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50496877 (CHEMBL33376) Show SMILES CC1C2Cc3ccc(O)cc3C1(C)CCN2C |TLB:9:10:1:15.13.14| Show InChI InChI=1S/C15H21NO/c1-10-14-8-11-4-5-12(17)9-13(11)15(10,2)6-7-16(14)3/h4-5,9-10,14,17H,6-8H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenates				J Med Chem 22: 889-90 (1979) Article DOI: 10.1021/jm00193a028 BindingDB Entry DOI: 10.7270/Q2QZ2DXM
					More data for this Ligand-Target Pair
Delta-type/Kappa-type/Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50496873 (CHEMBL3228292) Show SMILES CC[C@H]1C2Cc3ccc(O)cc3[C@@]1(C)CCN2CCC(N)=O |r,TLB:17:16:2:5.11.4,10:11:2:14.15.16| Show InChI InChI=1S/C18H26N2O2/c1-3-14-16-10-12-4-5-13(21)11-15(12)18(14,2)7-9-20(16)8-6-17(19)22/h4-5,11,14,16,21H,3,6-10H2,1-2H3,(H2,19,22)/t14-,16?,18-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenates				J Med Chem 22: 889-90 (1979) Article DOI: 10.1021/jm00193a028 BindingDB Entry DOI: 10.7270/Q2QZ2DXM
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM50185311 (CHEMBL3823231) Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H]1CCN(C(=O)C2CC2)c2ccc(Cc3ccccc3)cc12 |r| Show InChI InChI=1S/C31H35N3O3/c1-19-14-24(35)15-20(2)25(19)18-27(32)30(36)33-28-12-13-34(31(37)23-9-10-23)29-11-8-22(17-26(28)29)16-21-6-4-3-5-7-21/h3-8,11,14-15,17,23,27-28,35H,9-10,12-13,16,18,32H2,1-2H3,(H,33,36)/t27-,28+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Agonist activity at rat DOR transfected in rat C6 cell membranes after 1 hr by [35S]GTPgammaS assay				J Med Chem 59: 4985-98 (2016) Article DOI: 10.1021/acs.jmedchem.6b00308 BindingDB Entry DOI: 10.7270/Q28917SS
					More data for this Ligand-Target Pair
Delta-type/Kappa-type/Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50496881 (CHEMBL3228683) Show SMILES Cl.[H][C@@]12CCC[C@@]3([H])[C@@]4([H])Cc5cccc(O1)c5[C@@]23CCN4 |r| Show InChI InChI=1S/C16H19NO.ClH/c1-3-10-9-12-11-4-2-6-14-16(11,7-8-17-12)15(10)13(5-1)18-14;/h1,3,5,11-12,14,17H,2,4,6-9H2;1H/t11-,12+,14-,16+;/m0./s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity to opioid receptor in rat brain homogenates				J Med Chem 22: 256-9 (1979) Article DOI: 10.1021/jm00189a007 BindingDB Entry DOI: 10.7270/Q2M61P72
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM50535340 (CHEMBL4521319) Show SMILES OC(=O)C(F)(F)F.Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H]1CCN(c2ccc(Cc3ccccc3)cc12)S(C)(=O)=O |r| Show InChI InChI=1S/C28H33N3O4S.C2HF3O2/c1-18-13-22(32)14-19(2)23(18)17-25(29)28(33)30-26-11-12-31(36(3,34)35)27-10-9-21(16-24(26)27)15-20-7-5-4-6-8-20;3-2(4,5)1(6)7/h4-10,13-14,16,25-26,32H,11-12,15,17,29H2,1-3H3,(H,30,33);(H,6,7)/t25-,26+;/m0./s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	12	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at rat delta opioid receptor expressed in rat C6 cell membranes assessed as stimulation of [35S]GTPgammaS binding measured after 1 h...				J Med Chem 62: 4193-4203 (2019) Article DOI: 10.1021/acs.jmedchem.9b00378 BindingDB Entry DOI: 10.7270/Q2542S2Q
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM50185313 (CHEMBL3823830) Show SMILES COC(=O)N1CC[C@@H](NC(=O)[C@@H](N)Cc2c(C)cc(O)cc2C)c2cc(Cc3ccccc3)ccc12 |r| Show InChI InChI=1S/C29H33N3O4/c1-18-13-22(33)14-19(2)23(18)17-25(30)28(34)31-26-11-12-32(29(35)36-3)27-10-9-21(16-24(26)27)15-20-7-5-4-6-8-20/h4-10,13-14,16,25-26,33H,11-12,15,17,30H2,1-3H3,(H,31,34)/t25-,26+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Agonist activity at rat DOR transfected in rat C6 cell membranes after 1 hr by [35S]GTPgammaS assay				J Med Chem 59: 4985-98 (2016) Article DOI: 10.1021/acs.jmedchem.6b00308 BindingDB Entry DOI: 10.7270/Q28917SS
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM50133885 (CHEMBL3634250) Show SMILES CC(=O)N1CC[C@@H](NC(=O)[C@@H](N)Cc2c(C)cc(O)cc2C)c2cc(CC3CCCCC3)ccc12 |r| Show InChI InChI=1S/C29H39N3O3/c1-18-13-23(34)14-19(2)24(18)17-26(30)29(35)31-27-11-12-32(20(3)33)28-10-9-22(16-25(27)28)15-21-7-5-4-6-8-21/h9-10,13-14,16,21,26-27,34H,4-8,11-12,15,17,30H2,1-3H3,(H,31,35)/t26-,27+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Agonist activity at rat delta-opioid receptor expressed in C6 cell membrane assessed as [35S]GTPgammaS binding for 1 hr by liquid scintillation count...				J Med Chem 58: 8952-69 (2015) Article DOI: 10.1021/acs.jmedchem.5b01270 BindingDB Entry DOI: 10.7270/Q2RR213J
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM50185317 (CHEMBL3823815) Show SMILES CCOC(=O)CN1CC[C@@H](NC(=O)[C@@H](N)Cc2c(C)cc(O)cc2C)c2cc(Cc3ccccc3)ccc12 |r| Show InChI InChI=1S/C31H37N3O4/c1-4-38-30(36)19-34-13-12-28(26-17-23(10-11-29(26)34)16-22-8-6-5-7-9-22)33-31(37)27(32)18-25-20(2)14-24(35)15-21(25)3/h5-11,14-15,17,27-28,35H,4,12-13,16,18-19,32H2,1-3H3,(H,33,37)/t27-,28+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Agonist activity at rat DOR transfected in rat C6 cell membranes after 1 hr by [35S]GTPgammaS assay				J Med Chem 59: 4985-98 (2016) Article DOI: 10.1021/acs.jmedchem.6b00308 BindingDB Entry DOI: 10.7270/Q28917SS
					More data for this Ligand-Target Pair
Delta-type/Kappa-type/Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50496874 (CHEMBL3228290) Show SMILES CC[C@H]1C2Cc3ccc(O)cc3[C@@]1(C)CCN2C |r,TLB:17:16:2:5.11.4,10:11:2:14.15.16| Show InChI InChI=1S/C16H23NO/c1-4-13-15-9-11-5-6-12(18)10-14(11)16(13,2)7-8-17(15)3/h5-6,10,13,15,18H,4,7-9H2,1-3H3/t13-,15?,16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenates				J Med Chem 22: 889-90 (1979) Article DOI: 10.1021/jm00193a028 BindingDB Entry DOI: 10.7270/Q2QZ2DXM
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM50274731 (CHEMBL4126322) Show SMILES [#6]\[#6](-[#6])=[#6]\c1ccccc1-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#6]-[#6]-[#7]-[#6](-[#7])=[#7])-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1c(-[#6])cc(-[#8])cc1-[#6])-[#6](=O)-[#7]-[#6]-[#6](-[#7])=O |r| Show InChI InChI=1S/C32H46N8O5/c1-18(2)12-21-8-5-6-9-22(21)15-27(30(44)38-17-28(34)42)40-31(45)26(10-7-11-37-32(35)36)39-29(43)25(33)16-24-19(3)13-23(41)14-20(24)4/h5-6,8-9,12-14,25-27,41H,7,10-11,15-17,33H2,1-4H3,(H2,34,42)(H,38,44)(H,39,43)(H,40,45)(H4,35,36,37)/t25-,26+,27-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	19	n/a	n/a	n/a	n/a
Vrije Universiteit Brussel Curated by ChEMBL					Assay Description Agonist activity at rat delta-opioid receptor expressed in HEK293 cells co-expressing Rluc2-EPAC-GFP10 biosenser assessed as inhibition of forskolin-...				Bioorg Med Chem Lett 28: 2320-2323 (2018) Article DOI: 10.1016/j.bmcl.2018.05.015 BindingDB Entry DOI: 10.7270/Q2KW5JJJ
					More data for this Ligand-Target Pair
Delta-type/Kappa-type/Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50496882 (CHEMBL3228681) Show SMILES Cl.[H][C@@]12Oc3cccc4C[C@@]5([H])N(C)CC[C@@]1(c34)[C@@]5([H])CCC2=O |r,THB:13:12:18:17.8.9| Show InChI InChI=1S/C17H19NO2.ClH/c1-18-8-7-17-11-5-6-13(19)16(17)20-14-4-2-3-10(15(14)17)9-12(11)18;/h2-4,11-12,16H,5-9H2,1H3;1H/t11-,12+,16-,17-;/m0./s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity to opioid receptor in rat brain homogenates				J Med Chem 22: 256-9 (1979) Article DOI: 10.1021/jm00189a007 BindingDB Entry DOI: 10.7270/Q2M61P72
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM50027091 (19-isothiocyanato-15-methoxy-3-methyl-13-oxa-3-aza...) Show SMILES CO[C@]12C=C[C@@]3(C[C@@H]1N=C=S)C1Cc4ccc(O)c5O[C@@H]2C3(CCN1C)c45 |wD:20.20,5.4,7.8,2.1,c:3,TLB:18:26:5:24.22.23,25:24:5:26.13.12,THB:4:5:26.13.12:24.22.23,(20.42,-20.53,;18.87,-20.55,;18.09,-19.26,;16.74,-18.48,;17.9,-17.38,;16.55,-16.6,;18.09,-16.63,;18.85,-17.91,;20.4,-17.91,;21.95,-17.9,;23.51,-17.87,;15.82,-15.24,;14.3,-15.21,;13.51,-16.54,;11.97,-16.5,;11.18,-17.77,;11.92,-19.13,;11.11,-20.43,;13.47,-19.16,;14.9,-20.1,;16.52,-19.22,;15.77,-17.87,;15.58,-16.5,;14.86,-15.77,;15.8,-13.69,;17.15,-12.89,;14.25,-17.84,)| Show InChI InChI=1S/C21H22N2O3S/c1-23-8-7-20-16-12-3-4-13(24)17(16)26-18(20)21(25-2)6-5-19(20,15(23)9-12)10-14(21)22-11-27/h3-6,14-15,18,24H,7-10H2,1-2H3/t14-,15?,18+,19+,20?,21+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description The binding affinity was evaluated against [3H]dalamid binding to neuroblastoma X glioma hybrid cell NG108-15 (Opioid receptor delta 1)membranes				J Med Chem 27: 1570-4 (1985) BindingDB Entry DOI: 10.7270/Q2S18328
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM50506099 (CHEMBL4451186) Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]51CC[C@@]2(OC)[C@H](C1)c1ccc(N)cc1)ccc3OC |r,THB:10:9:17:4.5.6| Show InChI InChI=1S/C30H36N2O3/c1-33-23-10-7-20-15-24-28-11-12-30(34-2,22(16-28)19-5-8-21(31)9-6-19)27-29(28,25(20)26(23)35-27)13-14-32(24)17-18-3-4-18/h5-10,18,22,24,27H,3-4,11-17,31H2,1-2H3/t22-,24-,27-,28-,29+,30-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	21	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Agonist activity at rat DOR expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillat...				J Med Chem 62: 11054-11070 (2019) Article DOI: 10.1021/acs.jmedchem.9b00857 BindingDB Entry DOI: 10.7270/Q2VD72RV
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Rattus norvegicus (rat))	BDBM50142699 (CHEMBL3759831) Show SMILES CCCC[C@@H]1NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@H](CSSC[C@@H](NC1=O)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 |r| Show InChI InChI=1S/C34H41N5O7S2/c1-2-3-11-26-31(42)39-29(34(45)46)19-48-47-18-28(38-30(41)25(35)16-20-12-14-23(40)15-13-20)33(44)37-27(32(43)36-26)17-22-9-6-8-21-7-4-5-10-24(21)22/h4-10,12-15,25-29,40H,2-3,11,16-19,35H2,1H3,(H,36,43)(H,37,44)(H,38,41)(H,39,42)(H,45,46)/t25-,26-,27-,28-,29+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	22	n/a	n/a	n/a	n/a
University of Catania Curated by ChEMBL					Assay Description Agonist activity at rat delta opioid receptor transfected in C6 cells by [35S]GTPgammaS binding assay				Eur J Med Chem 108: 211-28 (2016) Article DOI: 10.1016/j.ejmech.2015.11.028 BindingDB Entry DOI: 10.7270/Q2R2137W
					More data for this Ligand-Target Pair

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