Compile Data Set for Download or QSAR

Found 7 hits of ec50 for UniProtKB: P09810   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptophan 5-hydroxylase 1 (Rattus norvegicus)	BDBM50243618 ((2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(2...) Show SMILES N[C@@H](Cc1ccc(cc1)-c1cc(OC(c2ccccc2-c2ccco2)C(F)(F)F)nc(N)n1)C(O)=O |r| Show InChI InChI=1S/C25H21F3N4O4/c26-25(27,28)22(17-5-2-1-4-16(17)20-6-3-11-35-20)36-21-13-19(31-24(30)32-21)15-9-7-14(8-10-15)12-18(29)23(33)34/h1-11,13,18,22H,12,29H2,(H,33,34)(H2,30,31,32)/t18-,22?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	48	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesis				J Med Chem 51: 3684-7 (2008) Article DOI: 10.1021/jm800338j BindingDB Entry DOI: 10.7270/Q2PK0FZM
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 1 (Rattus norvegicus)	BDBM50243617 ((S)-2-Amino-3-(4-{2-amino-6-[2,2,2-trifluoro-1-(3'...) Show SMILES Cc1cccc(c1)-c1ccccc1C(Oc1cc(nc(N)n1)-c1ccc(C[C@H](N)C(O)=O)cc1)C(F)(F)F |r| Show InChI InChI=1S/C28H25F3N4O3/c1-16-5-4-6-19(13-16)20-7-2-3-8-21(20)25(28(29,30)31)38-24-15-23(34-27(33)35-24)18-11-9-17(10-12-18)14-22(32)26(36)37/h2-13,15,22,25H,14,32H2,1H3,(H,36,37)(H2,33,34,35)/t22-,25?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	56	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesis				J Med Chem 51: 3684-7 (2008) Article DOI: 10.1021/jm800338j BindingDB Entry DOI: 10.7270/Q2PK0FZM
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 1 (Rattus norvegicus)	BDBM50243655 ((2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(3...) Show SMILES N[C@@H](Cc1ccc(cc1)-c1cc(OC(c2sccc2-c2ccco2)C(F)(F)F)nc(N)n1)C(O)=O |r| Show InChI InChI=1S/C23H19F3N4O4S/c24-23(25,26)20(19-14(7-9-35-19)17-2-1-8-33-17)34-18-11-16(29-22(28)30-18)13-5-3-12(4-6-13)10-15(27)21(31)32/h1-9,11,15,20H,10,27H2,(H,31,32)(H2,28,29,30)/t15-,20?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	63	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesis				J Med Chem 51: 3684-7 (2008) Article DOI: 10.1021/jm800338j BindingDB Entry DOI: 10.7270/Q2PK0FZM
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 1 (Rattus norvegicus)	BDBM50243619 ((S) -2-amino-3-[4-(2-amino-6-[2,2,2-trifluoro-1-(2...) Show SMILES N[C@@H](Cc1ccc(cc1)-c1cc(OC(c2ccccc2-n2ccc(n2)C(F)(F)F)C(F)(F)F)nc(N)n1)C(O)=O |r| Show InChI InChI=1S/C25H20F6N6O3/c26-24(27,28)19-9-10-37(36-19)18-4-2-1-3-15(18)21(25(29,30)31)40-20-12-17(34-23(33)35-20)14-7-5-13(6-8-14)11-16(32)22(38)39/h1-10,12,16,21H,11,32H2,(H,38,39)(H2,33,34,35)/t16-,21?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesis				J Med Chem 51: 3684-7 (2008) Article DOI: 10.1021/jm800338j BindingDB Entry DOI: 10.7270/Q2PK0FZM
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 1 (Rattus norvegicus)	BDBM50243024 ((2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(n...) Show SMILES N[C@@H](Cc1ccc(cc1)-c1cc(OC(c2ccc3ccccc3c2)C(F)(F)F)nc(N)n1)C(O)=O |r| Show InChI InChI=1S/C25H21F3N4O3/c26-25(27,28)22(18-10-9-15-3-1-2-4-17(15)12-18)35-21-13-20(31-24(30)32-21)16-7-5-14(6-8-16)11-19(29)23(33)34/h1-10,12-13,19,22H,11,29H2,(H,33,34)(H2,30,31,32)/t19-,22?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	510	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesis				J Med Chem 51: 3684-7 (2008) Article DOI: 10.1021/jm800338j BindingDB Entry DOI: 10.7270/Q2PK0FZM
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 1 (Rattus norvegicus)	BDBM50243022 ((S)-2-amino-3-(4-(2-amino-6-((R)-1-(naphthalen-2-y...) Show SMILES C[C@@H](Nc1cc(nc(N)n1)-c1ccc(C[C@H](N)C(O)=O)cc1)c1ccc2ccccc2c1 |r| Show InChI InChI=1S/C25H25N5O2/c1-15(19-11-10-17-4-2-3-5-20(17)13-19)28-23-14-22(29-25(27)30-23)18-8-6-16(7-9-18)12-21(26)24(31)32/h2-11,13-15,21H,12,26H2,1H3,(H,31,32)(H3,27,28,29,30)/t15-,21+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesis				J Med Chem 51: 3684-7 (2008) Article DOI: 10.1021/jm800338j BindingDB Entry DOI: 10.7270/Q2PK0FZM
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 1 (Rattus norvegicus)	BDBM50243023 ((S)-2-amino-3-(4-(2-amino-6-((R)-1-(naphthalen-2-y...) Show SMILES C[C@@H](Oc1cc(nc(N)n1)-c1ccc(C[C@H](N)C(O)=O)cc1)c1ccc2ccccc2c1 |r| Show InChI InChI=1S/C25H24N4O3/c1-15(19-11-10-17-4-2-3-5-20(17)13-19)32-23-14-22(28-25(27)29-23)18-8-6-16(7-9-18)12-21(26)24(30)31/h2-11,13-15,21H,12,26H2,1H3,(H,30,31)(H2,27,28,29)/t15-,21+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibition of TPH1 in RBL cells assessed as inhibition of serotonin biosynthesis				J Med Chem 51: 3684-7 (2008) Article DOI: 10.1021/jm800338j BindingDB Entry DOI: 10.7270/Q2PK0FZM
					More data for this Ligand-Target Pair