Compile Data Set for Download or QSAR

Found 526 hits of ec50 for UniProtKB: P19099   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM347679 ((E)-2-(4-Chlorophenoxy)-3- (dimethylamino)-1-(2-me...) Show SMILES COc1ccccc1C(=O)C(\Oc1ccc(Cl)cc1)=C/N(C)C Show InChI InChI=1S/C18H18ClNO3/c1-20(2)12-17(23-14-10-8-13(19)9-11-14)18(21)15-6-4-5-7-16(15)22-3/h4-12H,1-3H3/b17-12+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.000100	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...				US Patent US9790217 (2017) BindingDB Entry DOI: 10.7270/Q2K64M6M
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM347718 (4-[(Z)-1-(2-Benzyloxybenzoyl)-2- (dimethylamino)vi...) Show SMILES CN(C)\C=C(/Oc1ccc(cc1)C#N)C(=O)c1ccccc1OCc1ccccc1 Show InChI InChI=1S/C25H22N2O3/c1-27(2)17-24(30-21-14-12-19(16-26)13-15-21)25(28)22-10-6-7-11-23(22)29-18-20-8-4-3-5-9-20/h3-15,17H,18H2,1-2H3/b24-17-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.000100	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...				US Patent US9790217 (2017) BindingDB Entry DOI: 10.7270/Q2K64M6M
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM347757 (CHEM-US-00174 | US9790217, 79) Show SMILES N#Cc1ccc(Oc2cn[nH]c2-c2ccccc2OCc2ccccn2)cc1 Show InChI InChI=1S/C22H16N4O2/c23-13-16-8-10-18(11-9-16)28-21-14-25-26-22(21)19-6-1-2-7-20(19)27-15-17-5-3-4-12-24-17/h1-12,14H,15H2,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.000200	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...				US Patent US9790217 (2017) BindingDB Entry DOI: 10.7270/Q2K64M6M
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM347703 ((E)-1-[(2-Chlorobenzoyl)-2- (dimethylamino)vinylox...) Show SMILES CN(C)C(=C\OC1(CC=CC=C1)C#N)\C(=O)c1ccccc1Cl |c:8,10| Show InChI InChI=1S/C18H17ClN2O2/c1-21(2)16(17(22)14-8-4-5-9-15(14)19)12-23-18(13-20)10-6-3-7-11-18/h3-10,12H,11H2,1-2H3/b16-12+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.000200	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...				US Patent US9790217 (2017) BindingDB Entry DOI: 10.7270/Q2K64M6M
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM347754 (4-[[3-[2-(Pyridin-4-ylmethoxy)phenyl]-1H-pyrazol-4...) Show SMILES N#Cc1ccc(Oc2cn[nH]c2-c2ccccc2OCc2ccncc2)cc1 Show InChI InChI=1S/C22H16N4O2/c23-13-16-5-7-18(8-6-16)28-21-14-25-26-22(21)19-3-1-2-4-20(19)27-15-17-9-11-24-12-10-17/h1-12,14H,15H2,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.000200	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...				US Patent US9790217 (2017) BindingDB Entry DOI: 10.7270/Q2K64M6M
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM347758 (CHEM-US-00175 | US9790217, 80) Show SMILES N#Cc1ccc(Oc2cn[nH]c2-c2ccccc2OCc2cn[nH]c2)cc1 Show InChI InChI=1S/C20H15N5O2/c21-9-14-5-7-16(8-6-14)27-19-12-24-25-20(19)17-3-1-2-4-18(17)26-13-15-10-22-23-11-15/h1-8,10-12H,13H2,(H,22,23)(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.000300	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...				US Patent US9790217 (2017) BindingDB Entry DOI: 10.7270/Q2K64M6M
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM347763 (CHEM-US-00182 | US9790217, 85) Show SMILES Fc1c(OCc2ccncc2)cccc1-c1[nH]ncc1Oc1ccc(cc1)C#N Show InChI InChI=1S/C22H15FN4O2/c23-21-18(2-1-3-19(21)28-14-16-8-10-25-11-9-16)22-20(13-26-27-22)29-17-6-4-15(12-24)5-7-17/h1-11,13H,14H2,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.000300	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...				US Patent US9790217 (2017) BindingDB Entry DOI: 10.7270/Q2K64M6M
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM347756 (CHEM-US-00173 | US9790217, 78) Show SMILES Oc1ccccc1-c1[nH]ncc1Oc1ccc(cc1)C#N Show InChI InChI=1S/C16H11N3O2/c17-9-11-5-7-12(8-6-11)21-15-10-18-19-16(15)13-3-1-2-4-14(13)20/h1-8,10,20H,(H,18,19)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.000300	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...				US Patent US9790217 (2017) BindingDB Entry DOI: 10.7270/Q2K64M6M
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM347755 (CHEM-US-00172 | US9790217, 77) Show SMILES N#Cc1ccc(Oc2cn[nH]c2-c2ccccc2OCc2ccnnc2)cc1 Show InChI InChI=1S/C21H15N5O2/c22-11-15-5-7-17(8-6-15)28-20-13-25-26-21(20)18-3-1-2-4-19(18)27-14-16-9-10-23-24-12-16/h1-10,12-13H,14H2,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.000300	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...				US Patent US9790217 (2017) BindingDB Entry DOI: 10.7270/Q2K64M6M
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM347762 (4-[[3-(2-Fluoro-3-hydroxyphenyl)-1H-pyrazol-4-yl]o...) Show SMILES Oc1cccc(-c2[nH]ncc2Oc2ccc(cc2)C#N)c1F Show InChI InChI=1S/C16H10FN3O2/c17-15-12(2-1-3-13(15)21)16-14(9-19-20-16)22-11-6-4-10(8-18)5-7-11/h1-7,9,21H,(H,19,20)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.000400	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...				US Patent US9790217 (2017) BindingDB Entry DOI: 10.7270/Q2K64M6M
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM279788 (US10035804, Example 59) Show SMILES Cn1cc(cn1)C(=O)N1CC2(C1)CCN(CC2)c1cncc(c1)N1C(=O)c2ccc(Cl)cc2C1(C)C Show InChI InChI=1S/C27H29ClN6O2/c1-26(2)23-10-19(28)4-5-22(23)25(36)34(26)21-11-20(13-29-14-21)32-8-6-27(7-9-32)16-33(17-27)24(35)18-12-30-31(3)15-18/h4-5,10-15H,6-9,16-17H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00100	n/a	n/a	n/a	n/a
Hoffman-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US10035804 (2018) BindingDB Entry DOI: 10.7270/Q2GT5Q6H
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM351259 (5-Fluoro-1-methyl-6-[4-[[1-(1-methylpyrazole-4-car...) Show SMILES CN1C(=O)CCc2c(F)c(ccc12)-c1n[nH]cc1CC1CCN(CC1)C(=O)c1cnn(C)c1 Show InChI InChI=1S/C24H27FN6O2/c1-29-14-17(13-27-29)24(33)31-9-7-15(8-10-31)11-16-12-26-28-23(16)19-3-5-20-18(22(19)25)4-6-21(32)30(20)2/h3,5,12-15H,4,6-11H2,1-2H3,(H,26,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00200	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita...				US Patent US9796702 (2017) BindingDB Entry DOI: 10.7270/Q2DB840G
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM347712 (4-[(Z)-1-(2-Chloro-3-fluoro- benzoyl)- (dimethylam...) Show SMILES CN(C)\C=C(/Oc1ccc(cc1)C#N)C(=O)c1cccc(F)c1Cl Show InChI InChI=1S/C18H14ClFN2O2/c1-22(2)11-16(24-13-8-6-12(10-21)7-9-13)18(23)14-4-3-5-15(20)17(14)19/h3-9,11H,1-2H3/b16-11-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00200	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...				US Patent US9790217 (2017) BindingDB Entry DOI: 10.7270/Q2K64M6M
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM279728 (5-Chloro-3,3-dimethyl-2-[5-[2-(1-methylpyrazole-4-...) Show SMILES Cn1cc(cn1)C(=O)N1CC2(C1)CN(C2)c1cncc(c1)N1C(=O)c2ccc(Cl)cc2C1(C)C Show InChI InChI=1S/C25H25ClN6O2/c1-24(2)21-6-17(26)4-5-20(21)23(34)32(24)19-7-18(9-27-10-19)30-12-25(13-30)14-31(15-25)22(33)16-8-28-29(3)11-16/h4-11H,12-15H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00200	n/a	n/a	n/a	n/a
Hoffman-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US10035804 (2018) BindingDB Entry DOI: 10.7270/Q2GT5Q6H
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM279789 (US10035804, Example 60) Show SMILES CCn1cc(cn1)C(=O)N1CC2(C1)CCN(CC2)c1cncc(c1)N1C(=O)c2ccc(Cl)cc2C1(C)C Show InChI InChI=1S/C28H31ClN6O2/c1-4-34-16-19(13-31-34)25(36)33-17-28(18-33)7-9-32(10-8-28)21-12-22(15-30-14-21)35-26(37)23-6-5-20(29)11-24(23)27(35,2)3/h5-6,11-16H,4,7-10,17-18H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00200	n/a	n/a	n/a	n/a
Hoffman-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US10035804 (2018) BindingDB Entry DOI: 10.7270/Q2GT5Q6H
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM279790 (US10035804, Example 61) Show SMILES Cc1ccncc1C(=O)N1CC2(C1)CCN(CC2)c1cncc(c1)N1C(=O)c2ccc(Cl)cc2C1(C)C Show InChI InChI=1S/C29H30ClN5O2/c1-19-6-9-31-16-24(19)26(36)34-17-29(18-34)7-10-33(11-8-29)21-13-22(15-32-14-21)35-27(37)23-5-4-20(30)12-25(23)28(35,2)3/h4-6,9,12-16H,7-8,10-11,17-18H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00200	n/a	n/a	n/a	n/a
Hoffman-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US10035804 (2018) BindingDB Entry DOI: 10.7270/Q2GT5Q6H
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM351261 (CHEM-US-00072 | US9796702, 22) Show SMILES CCS(=O)(=O)N1CCC(Cc2c[nH]nc2-c2ccc3N(C)C(=O)CCc3c2F)CC1 Show InChI InChI=1S/C21H27FN4O3S/c1-3-30(28,29)26-10-8-14(9-11-26)12-15-13-23-24-21(15)17-4-6-18-16(20(17)22)5-7-19(27)25(18)2/h4,6,13-14H,3,5,7-12H2,1-2H3,(H,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00200	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita...				US Patent US9796702 (2017) BindingDB Entry DOI: 10.7270/Q2DB840G
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM347705 (4-[(E)-1-(2-Chlorobenzoyl)-2- (dimethylamino)vinyl...) Show SMILES CN(C)\C=C(\Oc1ccc(cc1F)C#N)C(=O)c1ccccc1Cl Show InChI InChI=1S/C18H14ClFN2O2/c1-22(2)11-17(18(23)13-5-3-4-6-14(13)19)24-16-8-7-12(10-21)9-15(16)20/h3-9,11H,1-2H3/b17-11+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00200	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...				US Patent US9790217 (2017) BindingDB Entry DOI: 10.7270/Q2K64M6M
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM347681 ((E)-2-(4-Chlorophenoxy)-1-(2- chlorophenyl)-3-(dim...) Show SMILES CN(C)\C=C(\Oc1ccc(Cl)cc1)C(=O)c1ccccc1Cl Show InChI InChI=1S/C17H15Cl2NO2/c1-20(2)11-16(22-13-9-7-12(18)8-10-13)17(21)14-5-3-4-6-15(14)19/h3-11H,1-2H3/b16-11+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00300	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...				US Patent US9790217 (2017) BindingDB Entry DOI: 10.7270/Q2K64M6M
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM347679 ((E)-2-(4-Chlorophenoxy)-3- (dimethylamino)-1-(2-me...) Show SMILES COc1ccccc1C(=O)C(\Oc1ccc(Cl)cc1)=C/N(C)C Show InChI InChI=1S/C18H18ClNO3/c1-20(2)12-17(23-14-10-8-13(19)9-11-14)18(21)15-6-4-5-7-16(15)22-3/h4-12H,1-3H3/b17-12+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00300	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...				US Patent US9790217 (2017) BindingDB Entry DOI: 10.7270/Q2K64M6M
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM279785 (US10035804, Example 56) Show SMILES Cn1cc(cn1)C(=O)N1CCC2(CN(C2)c2cncc(c2)N2C(=O)c3ccc(Cl)cc3C2(C)C)CC1 Show InChI InChI=1S/C27H29ClN6O2/c1-26(2)23-10-19(28)4-5-22(23)25(36)34(26)21-11-20(13-29-14-21)33-16-27(17-33)6-8-32(9-7-27)24(35)18-12-30-31(3)15-18/h4-5,10-15H,6-9,16-17H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00300	n/a	n/a	n/a	n/a
Hoffman-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US10035804 (2018) BindingDB Entry DOI: 10.7270/Q2GT5Q6H
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM279748 (US10035804, Example 19) Show SMILES Cn1cc(cn1)C(=O)N1CC2(C1)CN(C2)c1cncc(c1)N1C(=O)c2ccc(Cl)cc2C11CC1 Show InChI InChI=1S/C25H23ClN6O2/c1-29-11-16(8-28-29)22(33)31-14-24(15-31)12-30(13-24)18-7-19(10-27-9-18)32-23(34)20-3-2-17(26)6-21(20)25(32)4-5-25/h2-3,6-11H,4-5,12-15H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00300	n/a	n/a	n/a	n/a
Hoffman-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US10035804 (2018) BindingDB Entry DOI: 10.7270/Q2GT5Q6H
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM279731 (US10035804, Example 2) Show SMILES CCn1cc(cn1)C(=O)N1CC2(C1)CN(C2)c1cncc(c1)N1C(=O)c2ccc(Cl)cc2C1(C)C Show InChI InChI=1S/C26H27ClN6O2/c1-4-32-12-17(9-29-32)23(34)31-15-26(16-31)13-30(14-26)19-8-20(11-28-10-19)33-24(35)21-6-5-18(27)7-22(21)25(33,2)3/h5-12H,4,13-16H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00300	n/a	n/a	n/a	n/a
Hoffman-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US10035804 (2018) BindingDB Entry DOI: 10.7270/Q2GT5Q6H
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM351275 ((rac)-6-[4-[1-(1-Acetylpiperidin-4-yl)ethyl]-1H-py...) Show SMILES CC(C1CCN(CC1)C(C)=O)c1c[nH]nc1-c1ccc2N(C)C(=O)CCc2c1F Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00300	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita...				US Patent US9796702 (2017) BindingDB Entry DOI: 10.7270/Q2DB840G
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM347759 (CHEM-US-00176 | US9790217, 81) Show SMILES Cn1nncc1COc1ccccc1-c1[nH]ncc1Oc1ccc(cc1)C#N Show InChI InChI=1S/C20H16N6O2/c1-26-15(11-23-25-26)13-27-18-5-3-2-4-17(18)20-19(12-22-24-20)28-16-8-6-14(10-21)7-9-16/h2-9,11-12H,13H2,1H3,(H,22,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00300	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...				US Patent US9790217 (2017) BindingDB Entry DOI: 10.7270/Q2K64M6M
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM279787 (US10035804, Example 58) Show SMILES CCn1cc(cn1)C(=O)N1CCC2(CN(C2)c2cncc(c2)N2C(=O)c3ccc(Cl)cc3C2(C)C)CC1 Show InChI InChI=1S/C28H31ClN6O2/c1-4-34-16-19(13-31-34)25(36)32-9-7-28(8-10-32)17-33(18-28)21-12-22(15-30-14-21)35-26(37)23-6-5-20(29)11-24(23)27(35,2)3/h5-6,11-16H,4,7-10,17-18H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00400	n/a	n/a	n/a	n/a
Hoffman-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US10035804 (2018) BindingDB Entry DOI: 10.7270/Q2GT5Q6H
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM347764 (CHEM-US-00183 | US9790217, 86) Show SMILES Fc1c(OCc2ccc(Cl)nc2)cccc1-c1[nH]ncc1Oc1ccc(cc1)C#N Show InChI InChI=1S/C22H14ClFN4O2/c23-20-9-6-15(11-26-20)13-29-18-3-1-2-17(21(18)24)22-19(12-27-28-22)30-16-7-4-14(10-25)5-8-16/h1-9,11-12H,13H2,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00400	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...				US Patent US9790217 (2017) BindingDB Entry DOI: 10.7270/Q2K64M6M
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM347685 ((E)-2-(4-Chlorophenoxy)-1-[2- (difluoromethoxy)phe...) Show SMILES CN(C)\C=C(\Oc1ccc(Cl)cc1)C(=O)c1ccccc1OC(F)F Show InChI InChI=1S/C18H16ClF2NO3/c1-22(2)11-16(24-13-9-7-12(19)8-10-13)17(23)14-5-3-4-6-15(14)25-18(20)21/h3-11,18H,1-2H3/b16-11+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00400	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...				US Patent US9790217 (2017) BindingDB Entry DOI: 10.7270/Q2K64M6M
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM347731 (CHEM-US-00131 | US9790217, 54) Show SMILES N#Cc1ccc(Oc2cn[nH]c2-c2cccc(OCc3ccncc3)c2)cc1 Show InChI InChI=1S/C22H16N4O2/c23-13-16-4-6-19(7-5-16)28-21-14-25-26-22(21)18-2-1-3-20(12-18)27-15-17-8-10-24-11-9-17/h1-12,14H,15H2,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00400	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...				US Patent US9790217 (2017) BindingDB Entry DOI: 10.7270/Q2K64M6M
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM351257 (6-[4-[(1-Ethylsulfonyl-4-piperidyl)methyl]-1H-pyra...) Show SMILES CCS(=O)(=O)N1CCC(Cc2c[nH]nc2-c2ccc3N(C)C(=O)CCc3c2)CC1 Show InChI InChI=1S/C21H28N4O3S/c1-3-29(27,28)25-10-8-15(9-11-25)12-18-14-22-23-21(18)17-4-6-19-16(13-17)5-7-20(26)24(19)2/h4,6,13-15H,3,5,7-12H2,1-2H3,(H,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00500	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita...				US Patent US9796702 (2017) BindingDB Entry DOI: 10.7270/Q2DB840G
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM351274 ((rac)-6-[4-[1-(1-Acetylpiperidin-4-yl)ethyl]-1H-py...) Show SMILES CC(C1CCN(CC1)C(C)=O)c1c[nH]nc1-c1cc2CCC(=O)N(C)c2cc1F Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00500	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita...				US Patent US9796702 (2017) BindingDB Entry DOI: 10.7270/Q2DB840G
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM351259 (5-Fluoro-1-methyl-6-[4-[[1-(1-methylpyrazole-4-car...) Show SMILES CN1C(=O)CCc2c(F)c(ccc12)-c1n[nH]cc1CC1CCN(CC1)C(=O)c1cnn(C)c1 Show InChI InChI=1S/C24H27FN6O2/c1-29-14-17(13-27-29)24(33)31-9-7-15(8-10-31)11-16-12-26-28-23(16)19-3-5-20-18(22(19)25)4-6-21(32)30(20)2/h3,5,12-15H,4,6-11H2,1-2H3,(H,26,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00500	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita...				US Patent US9796702 (2017) BindingDB Entry DOI: 10.7270/Q2DB840G
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM279751 (US10035804, Example 22) Show SMILES C[C@H]1N(C(=O)c2ccc(Cl)cc12)c1cncc(c1)N1CC2(CN(C2)C(=O)c2cnn(C)c2)C1 |r| Show InChI InChI=1S/C24H23ClN6O2/c1-15-21-5-17(25)3-4-20(21)23(33)31(15)19-6-18(8-26-9-19)29-11-24(12-29)13-30(14-24)22(32)16-7-27-28(2)10-16/h3-10,15H,11-14H2,1-2H3/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00600	n/a	n/a	n/a	n/a
Hoffman-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US10035804 (2018) BindingDB Entry DOI: 10.7270/Q2GT5Q6H
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM351278 (5-Chloro-6-[4-[(2-ethylsulfonyl-2-azaspiro[3.3]hep...) Show SMILES CCS(=O)(=O)N1CC2(CC(Cc3c[nH]nc3-c3ccc4N(C)C(=O)CCc4c3Cl)C2)C1 Show InChI InChI=1S/C22H27ClN4O3S/c1-3-31(29,30)27-12-22(13-27)9-14(10-22)8-15-11-24-25-21(15)17-4-6-18-16(20(17)23)5-7-19(28)26(18)2/h4,6,11,14H,3,5,7-10,12-13H2,1-2H3,(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00600	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita...				US Patent US9796702 (2017) BindingDB Entry DOI: 10.7270/Q2DB840G
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM279752 (US10035804, Example 23) Show SMILES C[C@@H]1N(C(=O)c2ccc(Cl)cc12)c1cncc(c1)N1CC2(CN(C2)C(=O)c2cnn(C)c2)C1 |r| Show InChI InChI=1S/C24H23ClN6O2/c1-15-21-5-17(25)3-4-20(21)23(33)31(15)19-6-18(8-26-9-19)29-11-24(12-29)13-30(14-24)22(32)16-7-27-28(2)10-16/h3-10,15H,11-14H2,1-2H3/t15-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00700	n/a	n/a	n/a	n/a
Hoffman-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US10035804 (2018) BindingDB Entry DOI: 10.7270/Q2GT5Q6H
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM279784 (US10035804, Example 55) Show SMILES C[C@@H]1N(C(=O)c2ccc(Cl)cc12)c1cncc(N2CC3(CN(C3)C(=O)c3cnn(C)c3)C2)c1C |r| Show InChI InChI=1S/C25H25ClN6O2/c1-15-21(30-11-25(12-30)13-31(14-25)23(33)17-7-28-29(3)10-17)8-27-9-22(15)32-16(2)20-6-18(26)4-5-19(20)24(32)34/h4-10,16H,11-14H2,1-3H3/t16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00700	n/a	n/a	n/a	n/a
Hoffman-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US10035804 (2018) BindingDB Entry DOI: 10.7270/Q2GT5Q6H
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM347706 ((E)-1-[(2,3-Difluorobenzoyl)-2-(dimethylamino)viny...) Show SMILES CN(C)C(=C\OC1(CC=CC=C1)C#N)\C(=O)c1cccc(F)c1F |c:8,10| Show InChI InChI=1S/C18H16F2N2O2/c1-22(2)15(11-24-18(12-21)9-4-3-5-10-18)17(23)13-7-6-8-14(19)16(13)20/h3-9,11H,10H2,1-2H3/b15-11+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00700	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...				US Patent US9790217 (2017) BindingDB Entry DOI: 10.7270/Q2K64M6M
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM351272 (CHEM-US-00083 | US9796702, 33) Show SMILES CN1C(=O)CCc2cc(ccc12)-c1n[nH]cc1CC1CCN(CC1)C(=O)c1cccnc1 Show InChI InChI=1S/C25H27N5O2/c1-29-22-6-4-19(14-18(22)5-7-23(29)31)24-21(16-27-28-24)13-17-8-11-30(12-9-17)25(32)20-3-2-10-26-15-20/h2-4,6,10,14-17H,5,7-9,11-13H2,1H3,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00700	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita...				US Patent US9796702 (2017) BindingDB Entry DOI: 10.7270/Q2DB840G
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM351270 (CHEM-US-00081 | US9796702, 31) Show SMILES CN1C(=O)CCc2cc(ccc12)-c1n[nH]cc1CC1CCN(CC1)C(=O)c1cncn1C Show InChI InChI=1S/C24H28N6O2/c1-28-15-25-14-21(28)24(32)30-9-7-16(8-10-30)11-19-13-26-27-23(19)18-3-5-20-17(12-18)4-6-22(31)29(20)2/h3,5,12-16H,4,6-11H2,1-2H3,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00700	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita...				US Patent US9796702 (2017) BindingDB Entry DOI: 10.7270/Q2DB840G
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM351201 (1-Methyl-6-[4-[[1-(1-methylpyrazole-4-carbonyl)-4-...) Show SMILES CN1C(=O)CCc2cc(ccc12)-c1n[nH]cc1CC1CCN(CC1)C(=O)c1cnn(C)c1 Show InChI InChI=1S/C24H28N6O2/c1-28-15-20(14-26-28)24(32)30-9-7-16(8-10-30)11-19-13-25-27-23(19)18-3-5-21-17(12-18)4-6-22(31)29(21)2/h3,5,12-16H,4,6-11H2,1-2H3,(H,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00700	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita...				US Patent US9796702 (2017) BindingDB Entry DOI: 10.7270/Q2DB840G
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM347686 ((E)-2-(4-Chlorophenoxy)-3- (dimethylamino)-1-(2-fl...) Show SMILES CN(C)\C=C(\Oc1ccc(Cl)cc1)C(=O)c1ccccc1F Show InChI InChI=1S/C17H15ClFNO2/c1-20(2)11-16(22-13-9-7-12(18)8-10-13)17(21)14-5-3-4-6-15(14)19/h3-11H,1-2H3/b16-11+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00800	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...				US Patent US9790217 (2017) BindingDB Entry DOI: 10.7270/Q2K64M6M
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM351260 (6-[4-[(1-Acetyl-4-piperidyl)methyl]-1H-pyrazol-3-y...) Show SMILES CN1C(=O)CCc2c(F)c(ccc12)-c1n[nH]cc1CC1CCN(CC1)C(C)=O Show InChI InChI=1S/C21H25FN4O2/c1-13(27)26-9-7-14(8-10-26)11-15-12-23-24-21(15)17-3-5-18-16(20(17)22)4-6-19(28)25(18)2/h3,5,12,14H,4,6-11H2,1-2H3,(H,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00800	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita...				US Patent US9796702 (2017) BindingDB Entry DOI: 10.7270/Q2DB840G
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM279747 (US10035804, Example 18) Show SMILES CC1N(C(=O)c2ccc(Cl)cc12)c1cncc(c1)N1CC2(CN(C2)C(=O)c2cnn(C)c2)C1 Show InChI InChI=1S/C24H23ClN6O2/c1-15-21-5-17(25)3-4-20(21)23(33)31(15)19-6-18(8-26-9-19)29-11-24(12-29)13-30(14-24)22(32)16-7-27-28(2)10-16/h3-10,15H,11-14H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00800	n/a	n/a	n/a	n/a
Hoffman-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US10035804 (2018) BindingDB Entry DOI: 10.7270/Q2GT5Q6H
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM279783 (US10035804, Example 54) Show SMILES C[C@H]1N(C(=O)c2ccc(Cl)cc12)c1cncc(N2CC3(CN(C3)C(=O)c3cnn(C)c3)C2)c1C |r| Show InChI InChI=1S/C25H25ClN6O2/c1-15-21(30-11-25(12-30)13-31(14-25)23(33)17-7-28-29(3)10-17)8-27-9-22(15)32-16(2)20-6-18(26)4-5-19(20)24(32)34/h4-10,16H,11-14H2,1-3H3/t16-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00800	n/a	n/a	n/a	n/a
Hoffman-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US10035804 (2018) BindingDB Entry DOI: 10.7270/Q2GT5Q6H
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM347707 (4-[(E)-1-(3-Chloro-2-fluoro- benzoyl)-2- (dimethyl...) Show SMILES CN(C)\C=C(\Oc1ccc(cc1)C#N)C(=O)c1cccc(Cl)c1F Show InChI InChI=1S/C18H14ClFN2O2/c1-22(2)11-16(24-13-8-6-12(10-21)7-9-13)18(23)14-4-3-5-15(19)17(14)20/h3-9,11H,1-2H3/b16-11+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00800	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...				US Patent US9790217 (2017) BindingDB Entry DOI: 10.7270/Q2K64M6M
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM279732 (US10035804, Example 3) Show SMILES CC(C)n1cc(cn1)C(=O)N1CC2(C1)CN(C2)c1cncc(c1)N1C(=O)c2ccc(Cl)cc2C1(C)C Show InChI InChI=1S/C27H29ClN6O2/c1-17(2)33-12-18(9-30-33)24(35)32-15-27(16-32)13-31(14-27)20-8-21(11-29-10-20)34-25(36)22-6-5-19(28)7-23(22)26(34,3)4/h5-12,17H,13-16H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00800	n/a	n/a	n/a	n/a
Hoffman-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US10035804 (2018) BindingDB Entry DOI: 10.7270/Q2GT5Q6H
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM351263 (CHEM-US-00074 | US9796702, 24 | US9796702, 26) Show SMILES CN1C(=O)CCc2c(F)c(ccc12)-c1n[nH]cc1CC1CCN(CC1)C(=O)c1ccnn1C Show InChI InChI=1S/C24H27FN6O2/c1-29-19-5-3-18(22(25)17(19)4-6-21(29)32)23-16(14-26-28-23)13-15-8-11-31(12-9-15)24(33)20-7-10-27-30(20)2/h3,5,7,10,14-15H,4,6,8-9,11-13H2,1-2H3,(H,26,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00800	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description The expression plasmids contains the ORF for either human/cyno CYP11B1 or CYP11B2 under the control of a suitable promoter (CMV-promoter) and a suita...				US Patent US9796702 (2017) BindingDB Entry DOI: 10.7270/Q2DB840G
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM279781 (US10035804, Example 52) Show SMILES CCn1cc(cn1)C(=O)N1CC2(C1)CN(C2)c1cncc(c1)N1[C@H](C)c2cc(Cl)ccc2C1=O |r| Show InChI InChI=1S/C25H25ClN6O2/c1-3-31-11-17(8-28-31)23(33)30-14-25(15-30)12-29(13-25)19-7-20(10-27-9-19)32-16(2)22-6-18(26)4-5-21(22)24(32)34/h4-11,16H,3,12-15H2,1-2H3/t16-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00800	n/a	n/a	n/a	n/a
Hoffman-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US10035804 (2018) BindingDB Entry DOI: 10.7270/Q2GT5Q6H
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM347728 (US9790217, 51) Show SMILES N#Cc1ccc(Oc2cn[nH]c2-c2cccc(OCc3cccnc3)c2)cc1 Show InChI InChI=1S/C22H16N4O2/c23-12-16-6-8-19(9-7-16)28-21-14-25-26-22(21)18-4-1-5-20(11-18)27-15-17-3-2-10-24-13-17/h1-11,13-14H,15H2,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00900	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...				US Patent US9790217 (2017) BindingDB Entry DOI: 10.7270/Q2K64M6M
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM279738 (US10035804, Example 9) Show SMILES CCn1cc(cn1)C(=O)N1CC2(C1)CN(C2)c1cncc(c1)N1C(=O)c2ccc(cc2C1(C)C)C#N Show InChI InChI=1S/C27H27N7O2/c1-4-33-13-19(10-30-33)24(35)32-16-27(17-32)14-31(15-27)20-8-21(12-29-11-20)34-25(36)22-6-5-18(9-28)7-23(22)26(34,2)3/h5-8,10-13H,4,14-17H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.00900	n/a	n/a	n/a	n/a
Hoffman-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US10035804 (2018) BindingDB Entry DOI: 10.7270/Q2GT5Q6H
					More data for this Ligand-Target Pair

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