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Compile Data Set for Download or QSAR

Found 4 hits of ic50 for monomerid = 200360   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))
BDBM200360
PNG
(US9227956, 44 | US9227956, 45)
Show SMILES CCC(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C28H33N9O3/c1-5-24(38)40-19(3)37-33-26(32-34-37)25-23(17-31-35(25)4)20-10-12-21(13-11-20)28(39)36(22-9-7-14-29-16-22)27-18(2)8-6-15-30-27/h6,8,10-13,15,17,19,22,29H,5,7,9,14,16H2,1-4H3/t19?,22-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.39E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))
BDBM200360
PNG
(US9227956, 44 | US9227956, 45)
Show SMILES CCC(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C28H33N9O3/c1-5-24(38)40-19(3)37-33-26(32-34-37)25-23(17-31-35(25)4)20-10-12-21(13-11-20)28(39)36(22-9-7-14-29-16-22)27-18(2)8-6-15-30-27/h6,8,10-13,15,17,19,22,29H,5,7,9,14,16H2,1-4H3/t19?,22-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>2.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...


US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))
BDBM200360
PNG
(US9227956, 44 | US9227956, 45)
Show SMILES CCC(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C28H33N9O3/c1-5-24(38)40-19(3)37-33-26(32-34-37)25-23(17-31-35(25)4)20-10-12-21(13-11-20)28(39)36(22-9-7-14-29-16-22)27-18(2)8-6-15-30-27/h6,8,10-13,15,17,19,22,29H,5,7,9,14,16H2,1-4H3/t19?,22-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>2.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...


US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))
BDBM200360
PNG
(US9227956, 44 | US9227956, 45)
Show SMILES CCC(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C28H33N9O3/c1-5-24(38)40-19(3)37-33-26(32-34-37)25-23(17-31-35(25)4)20-10-12-21(13-11-20)28(39)36(22-9-7-14-29-16-22)27-18(2)8-6-15-30-27/h6,8,10-13,15,17,19,22,29H,5,7,9,14,16H2,1-4H3/t19?,22-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.51E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair