Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii) | BDBM25101 (6,7-diphenylpteridine-2,4-diamine | CHEMBL48296 | ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Inhibitory activity against Dihydrohydrofolate reductase(DHFR) of Toxoplasma gondii | J Med Chem 46: 1726-36 (2003) Article DOI: 10.1021/jm020466n BindingDB Entry DOI: 10.7270/Q2CR5SRW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human)) | BDBM25101 (6,7-diphenylpteridine-2,4-diamine | CHEMBL48296 | ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.50E+3 | n/a | n/a | n/a | n/a | 7.4 | 22 |
TargeGen Inc. | Assay Description The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ... | J Med Chem 50: 4279-94 (2007) Article DOI: 10.1021/jm051056c BindingDB Entry DOI: 10.7270/Q2D798QW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM25101 (6,7-diphenylpteridine-2,4-diamine | CHEMBL48296 | ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.36E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University Curated by ChEMBL | Assay Description Inhibition of recombinant human DHFR using dihydrofolate as substrate in presence of NADPH | ACS Med Chem Lett 11: 1421-1428 (2020) Article DOI: 10.1021/acsmedchemlett.0c00105 BindingDB Entry DOI: 10.7270/Q21C21FQ | |||||||||||
More data for this Ligand-Target Pair |