Found 2 hits of ic50 for monomerid = 50162888 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50162888
(CHEMBL426604 | [2-(4-Fluoro-phenyl)-ethyl]-(1H-imi...)Show SMILES Fc1ccc(CCN(Cc2cnc[nH]2)Cc2ccc(Oc3ccccc3)cc2)cc1 Show InChI InChI=1S/C25H24FN3O/c26-22-10-6-20(7-11-22)14-15-29(18-23-16-27-19-28-23)17-21-8-12-25(13-9-21)30-24-4-2-1-3-5-24/h1-13,16,19H,14-15,17-18H2,(H,27,28) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research Foundation
Curated by ChEMBL
| Assay Description Inhibition of Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 15: 1713-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.01.042 BindingDB Entry DOI: 10.7270/Q24F1Q7J |
More data for this Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50162888
(CHEMBL426604 | [2-(4-Fluoro-phenyl)-ethyl]-(1H-imi...)Show SMILES Fc1ccc(CCN(Cc2cnc[nH]2)Cc2ccc(Oc3ccccc3)cc2)cc1 Show InChI InChI=1S/C25H24FN3O/c26-22-10-6-20(7-11-22)14-15-29(18-23-16-27-19-28-23)17-21-8-12-25(13-9-21)30-24-4-2-1-3-5-24/h1-13,16,19H,14-15,17-18H2,(H,27,28) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research Foundation
Curated by ChEMBL
| Assay Description Inhibition of Farnesyltransferase |
Bioorg Med Chem Lett 15: 1713-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.01.042 BindingDB Entry DOI: 10.7270/Q24F1Q7J |
More data for this Ligand-Target Pair | |