Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosinase (Homo sapiens (Human)) | BDBM50441626 (GLABRIDIN | US9783551, Compound 1) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University Curated by ChEMBL | Assay Description Inhibition of tyrosinase (unknown origin) using L-tyrosine as substrate preincubated for 5 mins followed by substrate addition | J Nat Prod 80: 334-346 (2017) Article DOI: 10.1021/acs.jnatprod.6b00783 BindingDB Entry DOI: 10.7270/Q2XD146V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human)) | BDBM50441626 (GLABRIDIN | US9783551, Compound 1) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 4.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Glaceum Inc. US Patent | Assay Description The degree of inhibition activity for PTP1B was investigated by using 2 mM p-nitrophenyl phosphate (p-NPP) as a substrate to measure the dephosphoryl... | US Patent US9783551 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KWV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human)) | BDBM50441626 (GLABRIDIN | US9783551, Compound 1) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 4.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Glaceum Inc. US Patent | Assay Description The degree of inhibition activity for PTP1B was investigated by using 2 mM p-nitrophenyl phosphate (p-NPP) as a substrate to measure the dephosphoryl... | US Patent US9783551 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KWV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human)) | BDBM50441626 (GLABRIDIN | US9783551, Compound 1) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 7.34E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Toho University Curated by ChEMBL | Assay Description Inhibition of PTP1B (unknown origin) using p-nitrophenyl phosphate as substrate | Bioorg Med Chem Lett 23: 5836-9 (2013) Article DOI: 10.1016/j.bmcl.2013.08.102 BindingDB Entry DOI: 10.7270/Q28W3FQ0 | |||||||||||
More data for this Ligand-Target Pair |