Compile Data Set for Download or QSAR

Found 71 hits of ic50 for UniProtKB: P10145   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-8 (Homo sapiens (Human))	BDBM277687 (5-((2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-me...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCC2CC(CO2)C(O)=O)c1 Show InChI InChI=1S/C43H49N5O11S/c1-43(2,3)27-18-36(40(55-5)37(19-27)48-60(6,52)53)47-42(51)46-35-11-12-38(34-10-8-7-9-33(34)35)59-29-13-14-44-39(23-29)45-28-20-30(54-4)22-31(21-28)57-16-15-56-25-32-17-26(24-58-32)41(49)50/h7-14,18-23,26,32,48H,15-17,24-25H2,1-6H3,(H,44,45)(H,49,50)(H2,46,47,51)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277693 (2-((2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCSCC(O)=O)c1 Show InChI InChI=1S/C41H47N5O10S2/c1-41(2,3)26-19-34(39(53-5)35(20-26)46-58(6,50)51)45-40(49)44-33-11-12-36(32-10-8-7-9-31(32)33)56-28-13-14-42-37(24-28)43-27-21-29(52-4)23-30(22-27)55-16-15-54-17-18-57-25-38(47)48/h7-14,19-24,46H,15-18,25H2,1-6H3,(H,42,43)(H,47,48)(H2,44,45,49)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277686 (5-((2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(m...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCc2cc(co2)C(O)=O)c1 Show InChI InChI=1S/C43H45N5O11S/c1-43(2,3)27-18-36(40(55-5)37(19-27)48-60(6,52)53)47-42(51)46-35-11-12-38(34-10-8-7-9-33(34)35)59-29-13-14-44-39(23-29)45-28-20-30(54-4)22-31(21-28)57-16-15-56-25-32-17-26(24-58-32)41(49)50/h7-14,17-24,48H,15-16,25H2,1-6H3,(H,44,45)(H,49,50)(H2,46,47,51)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277702 (5-((2-(3-((4-((4-(3-(5-tert-Butyl)-2-methoxy-3-(me...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCc2cc(cs2)C(O)=O)c1 Show InChI InChI=1S/C43H45N5O10S2/c1-43(2,3)27-18-36(40(55-5)37(19-27)48-60(6,52)53)47-42(51)46-35-11-12-38(34-10-8-7-9-33(34)35)58-29-13-14-44-39(23-29)45-28-20-30(54-4)22-31(21-28)57-16-15-56-24-32-17-26(25-59-32)41(49)50/h7-14,17-23,25,48H,15-16,24H2,1-6H3,(H,44,45)(H,49,50)(H2,46,47,51)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277688 (2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl-2-methoxy-3-(...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOC(C)C(O)=O)c1 Show InChI InChI=1S/C42H49N5O11S/c1-26(40(48)49)56-18-16-55-17-19-57-31-23-28(22-30(24-31)53-5)44-38-25-29(14-15-43-38)58-37-13-12-34(32-10-8-9-11-33(32)37)45-41(50)46-35-20-27(42(2,3)4)21-36(39(35)54-6)47-59(7,51)52/h8-15,20-26,47H,16-19H2,1-7H3,(H,43,44)(H,48,49)(H2,45,46,50)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM13066 (2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid...) Show SMILES OC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl Show InChI InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Grupo Uriach Curated by ChEMBL					Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay				Bioorg Med Chem Lett 19: 4026-30 (2009) Article DOI: 10.1016/j.bmcl.2009.06.027 BindingDB Entry DOI: 10.7270/Q2V124TW
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277682 (2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy)-3...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(c4OC)S(C)=O)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(O)=O)c1 Show InChI InChI=1S/C41H46N4O10S/c1-41(2,3)26-19-34(39(51-5)36(20-26)56(6)49)45-40(48)44-33-11-12-35(32-10-8-7-9-31(32)33)55-28-13-14-42-37(24-28)43-27-21-29(50-4)23-30(22-27)54-18-17-52-15-16-53-25-38(46)47/h7-14,19-24H,15-18,25H2,1-6H3,(H,42,43)(H,46,47)(H2,44,45,48)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM50295276 (2-(2-(2-fluorophenylamino)phenyl)acetic acid | CHE...) Show SMILES OC(=O)Cc1ccccc1Nc1ccccc1F Show InChI InChI=1S/C14H12FNO2/c15-11-6-2-4-8-13(11)16-12-7-3-1-5-10(12)9-14(17)18/h1-8,16H,9H2,(H,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Grupo Uriach Curated by ChEMBL					Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay				Bioorg Med Chem Lett 19: 4026-30 (2009) Article DOI: 10.1016/j.bmcl.2009.06.027 BindingDB Entry DOI: 10.7270/Q2V124TW
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM50295266 (2-{2-[(2,6-Dichlorophenyl)amino]phenyl}propanoic a...) Show SMILES CC(C(O)=O)c1ccccc1Nc1c(Cl)cccc1Cl Show InChI InChI=1S/C15H13Cl2NO2/c1-9(15(19)20)10-5-2-3-8-13(10)18-14-11(16)6-4-7-12(14)17/h2-9,18H,1H3,(H,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Grupo Uriach Curated by ChEMBL					Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay				Bioorg Med Chem Lett 19: 4026-30 (2009) Article DOI: 10.1016/j.bmcl.2009.06.027 BindingDB Entry DOI: 10.7270/Q2V124TW
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277694 (US10072034, Example 20(a) | US10072034, Example 20...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOC(C)C(O)=O)c1 |w:53.57| Show InChI InChI=1S/C42H49N5O11S/c1-26(40(48)49)56-18-16-55-17-19-57-31-23-28(22-30(24-31)53-5)44-38-25-29(14-15-43-38)58-37-13-12-34(32-10-8-9-11-33(32)37)45-41(50)46-35-20-27(42(2,3)4)21-36(39(35)54-6)47-59(7,51)52/h8-15,20-26,47H,16-19H2,1-7H3,(H,43,44)(H,48,49)(H2,45,46,50)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.4	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277685 (2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(N(C)S(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(O)=O)c1 Show InChI InChI=1S/C42H49N5O11S/c1-42(2,3)27-20-35(40(54-6)36(21-27)47(4)59(7,51)52)46-41(50)45-34-12-13-37(33-11-9-8-10-32(33)34)58-29-14-15-43-38(25-29)44-28-22-30(53-5)24-31(23-28)57-19-18-55-16-17-56-26-39(48)49/h8-15,20-25H,16-19,26H2,1-7H3,(H,43,44)(H,48,49)(H2,45,46,50)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11.7	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277683 (2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(c4OC)S(C)(=O)=O)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(O)=O)c1 Show InChI InChI=1S/C41H46N4O11S/c1-41(2,3)26-19-34(39(52-5)36(20-26)57(6,49)50)45-40(48)44-33-11-12-35(32-10-8-7-9-31(32)33)56-28-13-14-42-37(24-28)43-27-21-29(51-4)23-30(22-27)55-18-17-53-15-16-54-25-38(46)47/h7-14,19-24H,15-18,25H2,1-6H3,(H,42,43)(H,46,47)(H2,44,45,48)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11.7	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM50295267 (2-{2-[(2,6-Dichlorophenyl)amino]phenyl}propanamide...) Show SMILES CC(C(N)=O)c1ccccc1Nc1c(Cl)cccc1Cl Show InChI InChI=1S/C15H14Cl2N2O/c1-9(15(18)20)10-5-2-3-8-13(10)19-14-11(16)6-4-7-12(14)17/h2-9,19H,1H3,(H2,18,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Grupo Uriach Curated by ChEMBL					Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay				Bioorg Med Chem Lett 19: 4026-30 (2009) Article DOI: 10.1016/j.bmcl.2009.06.027 BindingDB Entry DOI: 10.7270/Q2V124TW
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM50295281 (2-(2-(2-fluorophenoxy)phenyl)acetic acid | CHEMBL2...) Show SMILES OC(=O)Cc1ccccc1Oc1ccccc1F Show InChI InChI=1S/C14H11FO3/c15-11-6-2-4-8-13(11)18-12-7-3-1-5-10(12)9-14(16)17/h1-8H,9H2,(H,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Grupo Uriach Curated by ChEMBL					Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay				Bioorg Med Chem Lett 19: 4026-30 (2009) Article DOI: 10.1016/j.bmcl.2009.06.027 BindingDB Entry DOI: 10.7270/Q2V124TW
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM50295268 (2-{2-[(2,6-Dichlorophenyl)amino]phenyl}-N-(methyls...) Show SMILES CC(C(=O)NS(C)(=O)=O)c1ccccc1Nc1c(Cl)cccc1Cl Show InChI InChI=1S/C16H16Cl2N2O3S/c1-10(16(21)20-24(2,22)23)11-6-3-4-9-14(11)19-15-12(17)7-5-8-13(15)18/h3-10,19H,1-2H3,(H,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Grupo Uriach Curated by ChEMBL					Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay				Bioorg Med Chem Lett 19: 4026-30 (2009) Article DOI: 10.1016/j.bmcl.2009.06.027 BindingDB Entry DOI: 10.7270/Q2V124TW
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277696 (2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOC(C)(C)C(O)=O)c1 Show InChI InChI=1S/C43H51N5O11S/c1-42(2,3)27-21-35(39(55-7)36(22-27)48-60(8,52)53)47-41(51)46-34-13-14-37(33-12-10-9-11-32(33)34)59-29-15-16-44-38(26-29)45-28-23-30(54-6)25-31(24-28)57-19-17-56-18-20-58-43(4,5)40(49)50/h9-16,21-26,48H,17-20H2,1-8H3,(H,44,45)(H,49,50)(H2,46,47,51)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14.4	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277701 (5-((2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(m...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCc2ccc(s2)C(O)=O)c1 Show InChI InChI=1S/C43H45N5O10S2/c1-43(2,3)26-19-35(40(55-5)36(20-26)48-60(6,52)53)47-42(51)46-34-12-13-37(33-10-8-7-9-32(33)34)58-28-15-16-44-39(24-28)45-27-21-29(54-4)23-30(22-27)57-18-17-56-25-31-11-14-38(59-31)41(49)50/h7-16,19-24,48H,17-18,25H2,1-6H3,(H,44,45)(H,49,50)(H2,46,47,51)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15.3	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277690 (2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-3-(ethylsulf...) Show SMILES CCS(=O)(=O)Nc1cc(cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(OC)cc(OCCOCCOCC(O)=O)c4)c3)c3ccccc23)c1OC)C(C)(C)C Show InChI InChI=1S/C42H49N5O11S/c1-7-59(51,52)47-36-21-27(42(2,3)4)20-35(40(36)54-6)46-41(50)45-34-12-13-37(33-11-9-8-10-32(33)34)58-29-14-15-43-38(25-29)44-28-22-30(53-5)24-31(23-28)57-19-18-55-16-17-56-26-39(48)49/h8-15,20-25,47H,7,16-19,26H2,1-6H3,(H,43,44)(H,48,49)(H2,45,46,50)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16.3	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277689 (2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl-3-(ethylsulfo...) Show SMILES CCS(=O)(=O)c1cc(cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(OC)cc(OCCOCCOCC(O)=O)c4)c3)c3ccccc23)c1OC)C(C)(C)C Show InChI InChI=1S/C42H48N4O11S/c1-7-58(50,51)37-21-27(42(2,3)4)20-35(40(37)53-6)46-41(49)45-34-12-13-36(33-11-9-8-10-32(33)34)57-29-14-15-43-38(25-29)44-28-22-30(52-5)24-31(23-28)56-19-18-54-16-17-55-26-39(47)48/h8-15,20-25H,7,16-19,26H2,1-6H3,(H,43,44)(H,47,48)(H2,45,46,49)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16.4	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277691 (2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl) isoxazol-3-y...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(on4)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(O)=O)c1 Show InChI InChI=1S/C36H39N5O9/c1-36(2,3)31-21-33(41-50-31)40-35(44)39-29-9-10-30(28-8-6-5-7-27(28)29)49-24-11-12-37-32(20-24)38-23-17-25(45-4)19-26(18-23)48-16-15-46-13-14-47-22-34(42)43/h5-12,17-21H,13-16,22H2,1-4H3,(H,37,38)(H,42,43)(H2,39,40,41,44)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17.2	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277677 (2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy)-3...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(O)=O)c1 Show InChI InChI=1S/C41H47N5O11S/c1-41(2,3)26-19-34(39(53-5)35(20-26)46-58(6,50)51)45-40(49)44-33-11-12-36(32-10-8-7-9-31(32)33)57-28-13-14-42-37(24-28)43-27-21-29(52-4)23-30(22-27)56-18-17-54-15-16-55-25-38(47)48/h7-14,19-24,46H,15-18,25H2,1-6H3,(H,42,43)(H,47,48)(H2,44,45,49)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17.3	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277697 (1-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCn2cc(cn2)C(O)=O)c1 Show InChI InChI=1S/C43H47N7O10S/c1-43(2,3)28-19-36(40(57-5)37(20-28)49-61(6,54)55)48-42(53)47-35-11-12-38(34-10-8-7-9-33(34)35)60-30-13-14-44-39(24-30)46-29-21-31(56-4)23-32(22-29)59-18-17-58-16-15-50-26-27(25-45-50)41(51)52/h7-14,19-26,49H,15-18H2,1-6H3,(H,44,46)(H,51,52)(H2,47,48,53)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18.1	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277680 (2-(2-(2-(3-((4-((4-(3-(5-tert-Butyl-2-methoxy-3-(m...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(=O)NS(C)(=O)=O)c1 Show InChI InChI=1S/C42H50N6O12S2/c1-42(2,3)27-20-35(40(56-5)36(21-27)47-61(6,51)52)46-41(50)45-34-12-13-37(33-11-9-8-10-32(33)34)60-29-14-15-43-38(25-29)44-28-22-30(55-4)24-31(23-28)59-19-18-57-16-17-58-26-39(49)48-62(7,53)54/h8-15,20-25,47H,16-19,26H2,1-7H3,(H,43,44)(H,48,49)(H2,45,46,50)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18.1	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277694 (US10072034, Example 20(a) | US10072034, Example 20...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOC(C)C(O)=O)c1 |w:53.57| Show InChI InChI=1S/C42H49N5O11S/c1-26(40(48)49)56-18-16-55-17-19-57-31-23-28(22-30(24-31)53-5)44-38-25-29(14-15-43-38)58-37-13-12-34(32-10-8-9-11-33(32)37)45-41(50)46-35-20-27(42(2,3)4)21-36(39(35)54-6)47-59(7,51)52/h8-15,20-26,47H,16-19H2,1-7H3,(H,43,44)(H,48,49)(H2,45,46,50)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19.1	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277679 (2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-(methoxy-d...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(C)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(O)=O)c1 Show InChI InChI=1S/C41H46N4O9/c1-26-19-27(41(2,3)4)20-35(39(26)50-6)45-40(48)44-34-11-12-36(33-10-8-7-9-32(33)34)54-29-13-14-42-37(24-29)43-28-21-30(49-5)23-31(22-28)53-18-17-51-15-16-52-25-38(46)47/h7-14,19-24H,15-18,25H2,1-6H3,(H,42,43)(H,46,47)(H2,44,45,48)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19.5	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM50295270 (2-{2-[(2,6-Dichlorophenyl)amino]phenyl}-N-(2-hydro...) Show SMILES CC(C(=O)NCCO)c1ccccc1Nc1c(Cl)cccc1Cl Show InChI InChI=1S/C17H18Cl2N2O2/c1-11(17(23)20-9-10-22)12-5-2-3-8-15(12)21-16-13(18)6-4-7-14(16)19/h2-8,11,21-22H,9-10H2,1H3,(H,20,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Grupo Uriach Curated by ChEMBL					Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay				Bioorg Med Chem Lett 19: 4026-30 (2009) Article DOI: 10.1016/j.bmcl.2009.06.027 BindingDB Entry DOI: 10.7270/Q2V124TW
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM50169048 ((R)-2-(3-Benzoyl-phenyl)-propionic acid | (R)-2-(3...) Show SMILES C[C@@H](C(O)=O)c1cccc(c1)C(=O)c1ccccc1 Show InChI InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)/t11-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Grupo Uriach Curated by ChEMBL					Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay				Bioorg Med Chem Lett 19: 4026-30 (2009) Article DOI: 10.1016/j.bmcl.2009.06.027 BindingDB Entry DOI: 10.7270/Q2V124TW
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277703 (2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-...) Show SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(OCCOCCOCC(O)=O)cc(OC(F)F)c4)c3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C Show InChI InChI=1S/C41H45F2N5O11S/c1-41(2,3)25-18-33(38(54-4)34(19-25)48-60(5,52)53)47-40(51)46-32-10-11-35(31-9-7-6-8-30(31)32)58-27-12-13-44-36(23-27)45-26-20-28(22-29(21-26)59-39(42)43)57-17-16-55-14-15-56-24-37(49)50/h6-13,18-23,39,48H,14-17,24H2,1-5H3,(H,44,45)(H,49,50)(H2,46,47,51)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20.6	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277681 (2-(2-(2-(3-(4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(...) Show SMILES CNC(=O)c1cc(cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(OC)cc(OCCOCCOCC(O)=O)c4)c3)c3ccccc23)c1OC)C(C)(C)C Show InChI InChI=1S/C42H47N5O10/c1-42(2,3)26-19-33(40(50)43-4)39(53-6)35(20-26)47-41(51)46-34-11-12-36(32-10-8-7-9-31(32)34)57-28-13-14-44-37(24-28)45-27-21-29(52-5)23-30(22-27)56-18-17-54-15-16-55-25-38(48)49/h7-14,19-24H,15-18,25H2,1-6H3,(H,43,50)(H,44,45)(H,48,49)(H2,46,47,51)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20.8	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277676 (2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-...) Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)n2)cc(OCCOCCOCC(O)=O)c1 Show InChI InChI=1S/C40H46N6O11S/c1-40(2,3)25-19-32(37(53-5)33(20-25)46-58(6,50)51)44-39(49)43-31-11-12-34(30-10-8-7-9-29(30)31)57-35-13-14-41-38(45-35)42-26-21-27(52-4)23-28(22-26)56-18-17-54-15-16-55-24-36(47)48/h7-14,19-23,46H,15-18,24H2,1-6H3,(H,47,48)(H,41,42,45)(H2,43,44,49)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	24.6	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM50090679 (2-(2-(2,5-dichlorophenylamino)phenyl)acetic acid |...) Show SMILES OC(=O)Cc1ccccc1Nc1cc(Cl)ccc1Cl Show InChI InChI=1S/C14H11Cl2NO2/c15-10-5-6-11(16)13(8-10)17-12-4-2-1-3-9(12)7-14(18)19/h1-6,8,17H,7H2,(H,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Grupo Uriach Curated by ChEMBL					Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay				Bioorg Med Chem Lett 19: 4026-30 (2009) Article DOI: 10.1016/j.bmcl.2009.06.027 BindingDB Entry DOI: 10.7270/Q2V124TW
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM50295269 (2-{2-[(2,6-Dichlorophenyl)amino]phenyl}-N,N'-[3,3-...) Show SMILES CC(C(=O)NCCCN(C)C)c1ccccc1Nc1c(Cl)cccc1Cl Show InChI InChI=1S/C20H25Cl2N3O/c1-14(20(26)23-12-7-13-25(2)3)15-8-4-5-11-18(15)24-19-16(21)9-6-10-17(19)22/h4-6,8-11,14,24H,7,12-13H2,1-3H3,(H,23,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Grupo Uriach Curated by ChEMBL					Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay				Bioorg Med Chem Lett 19: 4026-30 (2009) Article DOI: 10.1016/j.bmcl.2009.06.027 BindingDB Entry DOI: 10.7270/Q2V124TW
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277700 (2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl-2-methoxy-3-(...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(=O)NS(=O)(=O)N(C)C)c1 Show InChI InChI=1S/C43H53N7O12S2/c1-43(2,3)28-21-36(41(58-7)37(22-28)48-63(8,53)54)47-42(52)46-35-13-14-38(34-12-10-9-11-33(34)35)62-30-15-16-44-39(26-30)45-29-23-31(57-6)25-32(24-29)61-20-19-59-17-18-60-27-40(51)49-64(55,56)50(4)5/h9-16,21-26,48H,17-20,27H2,1-8H3,(H,44,45)(H,49,51)(H2,46,47,52)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	26.3	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277684 (2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-3-(dimethylp...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(c4OC)P(C)(C)=O)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(O)=O)c1 Show InChI InChI=1S/C42H49N4O10P/c1-42(2,3)27-20-35(40(52-5)37(21-27)57(6,7)50)46-41(49)45-34-12-13-36(33-11-9-8-10-32(33)34)56-29-14-15-43-38(25-29)44-28-22-30(51-4)24-31(23-28)55-19-18-53-16-17-54-26-39(47)48/h8-15,20-25H,16-19,26H2,1-7H3,(H,43,44)(H,47,48)(H2,45,46,49)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	26.5	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277698 (N-(3-(3-(4-((2-((3-(2-(2-(1H-Tetrazol-5-yl)methoxy...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCc2nnn[nH]2)c1 Show InChI InChI=1S/C41H47N9O9S/c1-41(2,3)26-19-34(39(55-5)35(20-26)48-60(6,52)53)45-40(51)44-33-11-12-36(32-10-8-7-9-31(32)33)59-28-13-14-42-37(24-28)43-27-21-29(54-4)23-30(22-27)58-18-17-56-15-16-57-25-38-46-49-50-47-38/h7-14,19-24,48H,15-18,25H2,1-6H3,(H,42,43)(H2,44,45,51)(H,46,47,49,50)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	29.2	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277692 (N-(5-(tert-Butl-2-methoxy-3-(3-(4-((2-((3-methoxy-...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCc2cc(=O)o[nH]2)c1 Show InChI InChI=1S/C43H48N6O11S/c1-43(2,3)27-19-36(41(55-5)37(20-27)49-61(6,52)53)47-42(51)46-35-11-12-38(34-10-8-7-9-33(34)35)59-30-13-14-44-39(25-30)45-28-21-31(54-4)24-32(22-28)58-18-17-56-15-16-57-26-29-23-40(50)60-48-29/h7-14,19-25,48-49H,15-18,26H2,1-6H3,(H,44,45)(H2,46,47,51)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	29.3	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM50295283 (2-[2-(2-Fluorophenoxy)phenyl]-N-(methylsulfonyl)ac...) Show SMILES CS(=O)(=O)NC(=O)Cc1ccccc1Oc1ccccc1F Show InChI InChI=1S/C15H14FNO4S/c1-22(19,20)17-15(18)10-11-6-2-4-8-13(11)21-14-9-5-3-7-12(14)16/h2-9H,10H2,1H3,(H,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Grupo Uriach Curated by ChEMBL					Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay				Bioorg Med Chem Lett 19: 4026-30 (2009) Article DOI: 10.1016/j.bmcl.2009.06.027 BindingDB Entry DOI: 10.7270/Q2V124TW
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM17638 (2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...) Show SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1 Show InChI InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Grupo Uriach Curated by ChEMBL					Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay				Bioorg Med Chem Lett 19: 4026-30 (2009) Article DOI: 10.1016/j.bmcl.2009.06.027 BindingDB Entry DOI: 10.7270/Q2V124TW
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM50169044 ((-)-ibuprofen | (2R)-2-(4-isobutylphenyl)propanoic...) Show SMILES CC(C)Cc1ccc(cc1)[C@@H](C)C(O)=O Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Grupo Uriach Curated by ChEMBL					Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay				Bioorg Med Chem Lett 19: 4026-30 (2009) Article DOI: 10.1016/j.bmcl.2009.06.027 BindingDB Entry DOI: 10.7270/Q2V124TW
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277699 (2-(2-(3-((4-((4-(3-(5-(tert-Buty-2-methoxy-3-(meth...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCC(O)=O)c1 Show InChI InChI=1S/C39H43N5O10S/c1-39(2,3)24-17-32(37(51-5)33(18-24)44-55(6,48)49)43-38(47)42-31-11-12-34(30-10-8-7-9-29(30)31)54-26-13-14-40-35(22-26)41-25-19-27(50-4)21-28(20-25)53-16-15-52-23-36(45)46/h7-14,17-22,44H,15-16,23H2,1-6H3,(H,40,41)(H,45,46)(H2,42,43,47)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	61.9	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM50295287 (2-(1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl)ace...) Show SMILES Cc1ccc(cc1)C(=O)c1ccc(CC(O)=O)n1C Show InChI InChI=1S/C15H15NO3/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18/h3-8H,9H2,1-2H3,(H,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Grupo Uriach Curated by ChEMBL					Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay				Bioorg Med Chem Lett 19: 4026-30 (2009) Article DOI: 10.1016/j.bmcl.2009.06.027 BindingDB Entry DOI: 10.7270/Q2V124TW
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM277678 (2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-...) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C(=O)NCCOCCOCC(O)=O Show InChI InChI=1S/C42H48N6O11S/c1-42(2,3)27-21-34(39(56-5)35(22-27)48-60(6,53)54)47-41(52)46-33-11-12-36(32-10-8-7-9-31(32)33)59-29-13-14-43-37(24-29)45-28-19-26(20-30(23-28)55-4)40(51)44-15-16-57-17-18-58-25-38(49)50/h7-14,19-24,48H,15-18,25H2,1-6H3,(H,43,45)(H,44,51)(H,49,50)(H2,46,47,52)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	115	n/a	n/a	n/a	n/a	n/a	n/a
Respivert Limited; Topivert Pharma Limited US Patent					Assay Description PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...				US Patent US10072034 (2018) BindingDB Entry DOI: 10.7270/Q2B85B49
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM50295275 (2-(2-(2-chlorophenylamino)phenyl)acetic acid | CHE...) Show SMILES OC(=O)Cc1ccccc1Nc1ccccc1Cl Show InChI InChI=1S/C14H12ClNO2/c15-11-6-2-4-8-13(11)16-12-7-3-1-5-10(12)9-14(17)18/h1-8,16H,9H2,(H,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Grupo Uriach Curated by ChEMBL					Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay				Bioorg Med Chem Lett 19: 4026-30 (2009) Article DOI: 10.1016/j.bmcl.2009.06.027 BindingDB Entry DOI: 10.7270/Q2V124TW
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM50295282 (2-(2-(2-chlorophenoxy)phenyl)acetic acid | CHEMBL3...) Show SMILES OC(=O)Cc1ccccc1Oc1ccccc1Cl Show InChI InChI=1S/C14H11ClO3/c15-11-6-2-4-8-13(11)18-12-7-3-1-5-10(12)9-14(16)17/h1-8H,9H2,(H,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Grupo Uriach Curated by ChEMBL					Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay				Bioorg Med Chem Lett 19: 4026-30 (2009) Article DOI: 10.1016/j.bmcl.2009.06.027 BindingDB Entry DOI: 10.7270/Q2V124TW
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM50295274 (2-(2-(2,6-dichloro-3-methylphenylamino)phenyl)acet...) Show SMILES Cc1ccc(Cl)c(Nc2ccccc2CC(O)=O)c1Cl Show InChI InChI=1S/C15H13Cl2NO2/c1-9-6-7-11(16)15(14(9)17)18-12-5-3-2-4-10(12)8-13(19)20/h2-7,18H,8H2,1H3,(H,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Grupo Uriach Curated by ChEMBL					Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay				Bioorg Med Chem Lett 19: 4026-30 (2009) Article DOI: 10.1016/j.bmcl.2009.06.027 BindingDB Entry DOI: 10.7270/Q2V124TW
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM59542 ((1-tosylbenzimidazol-2-yl)amine | 1-(4-methylpheny...) Show SMILES Cc1ccc(cc1)S(=O)(=O)n1c(N)nc2ccccc12 Show InChI InChI=1S/C14H13N3O2S/c1-10-6-8-11(9-7-10)20(18,19)17-13-5-3-2-4-12(13)16-14(17)15/h2-9H,1H3,(H2,15,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	551	n/a	n/a	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q20Z71QR
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM59542 ((1-tosylbenzimidazol-2-yl)amine | 1-(4-methylpheny...) Show SMILES Cc1ccc(cc1)S(=O)(=O)n1c(N)nc2ccccc12 Show InChI InChI=1S/C14H13N3O2S/c1-10-6-8-11(9-7-10)20(18,19)17-13-5-3-2-4-12(13)16-14(17)15/h2-9H,1H3,(H2,15,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	596	n/a	n/a	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q20Z71QR
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM50295271 (2-{2-[(2,6-Dichlorophenyl)amino]phenyl}-N-(2,6-dim...) Show SMILES CC(C(=O)Nc1c(C)cccc1C)c1ccccc1Nc1c(Cl)cccc1Cl Show InChI InChI=1S/C23H22Cl2N2O/c1-14-8-6-9-15(2)21(14)27-23(28)16(3)17-10-4-5-13-20(17)26-22-18(24)11-7-12-19(22)25/h4-13,16,26H,1-3H3,(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Grupo Uriach Curated by ChEMBL					Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay				Bioorg Med Chem Lett 19: 4026-30 (2009) Article DOI: 10.1016/j.bmcl.2009.06.027 BindingDB Entry DOI: 10.7270/Q2V124TW
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM50295272 (CHEMBL549975 | N-(tert-Butyl)-2-{2-[(2,6-dichlorop...) Show SMILES CC(C(=O)NC(C)(C)C)c1ccccc1Nc1c(Cl)cccc1Cl Show InChI InChI=1S/C19H22Cl2N2O/c1-12(18(24)23-19(2,3)4)13-8-5-6-11-16(13)22-17-14(20)9-7-10-15(17)21/h5-12,22H,1-4H3,(H,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	650	n/a	n/a	n/a	n/a	n/a	n/a
Grupo Uriach Curated by ChEMBL					Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay				Bioorg Med Chem Lett 19: 4026-30 (2009) Article DOI: 10.1016/j.bmcl.2009.06.027 BindingDB Entry DOI: 10.7270/Q2V124TW
					More data for this Ligand-Target Pair
Interleukin-8 (Homo sapiens (Human))	BDBM50295273 (3-(2-(2-(2,6-dichlorophenylamino)phenyl)propanamid...) Show SMILES CC(C(=O)NCCC[N+](C)(C)C)c1ccccc1Nc1c(Cl)cccc1Cl Show InChI InChI=1S/C21H27Cl2N3O/c1-15(21(27)24-13-8-14-26(2,3)4)16-9-5-6-12-19(16)25-20-17(22)10-7-11-18(20)23/h5-7,9-12,15,25H,8,13-14H2,1-4H3/p+1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Grupo Uriach Curated by ChEMBL					Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay				Bioorg Med Chem Lett 19: 4026-30 (2009) Article DOI: 10.1016/j.bmcl.2009.06.027 BindingDB Entry DOI: 10.7270/Q2V124TW
					More data for this Ligand-Target Pair

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