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Compile Data Set for Download or QSAR

Found 33 hits of ic50 for UniProtKB: Q7TQN9   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50395775
PNG
(CHEMBL2164857)
Show SMILES CNc1cc(ccn1)-c1nnc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)s1 |r|
Show InChI InChI=1S/C21H21N7OS2/c1-22-18-10-15(7-8-23-18)20-27-28-21(31-20)26-19(29)17(9-14-5-3-2-4-6-14)24-11-16-12-30-13-25-16/h2-8,10,12-13,17,24H,9,11H2,1H3,(H,22,23)(H,26,28,29)/t17-/m0/s1
KEGG

UniProtKB/SwissProt

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Article
PubMed
n/an/a 15n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Partial agonist activity at mouse GPR142 expressed in HEK293 cells


Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558195
PNG
(CHEMBL4800653)
Show SMILES Fc1c(Cl)cccc1NC(=O)N1CCOc2ccc(cc2C1)-c1ccncc1
KEGG

UniProtKB/SwissProt

GoogleScholar
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n/an/a 59n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558200
PNG
(CHEMBL4785678)
Show SMILES O=C(Nc1cccc(c1)-c1ccccc1)N1CCOc2ccc(cc2C1)-c1ccncc1
KEGG

UniProtKB/SwissProt

GoogleScholar
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PubMed
n/an/a 62n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558199
PNG
(CHEMBL4763234)
Show SMILES O=C(Nc1cccc(c1)C#N)N1CCOc2ccc(cc2C1)-c1ccncc1
KEGG

UniProtKB/SwissProt

GoogleScholar
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n/an/a 79n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558206
PNG
(CHEMBL4760456)
Show SMILES COc1ccccc1NC(=O)N1CCOc2ccc(cc2C1)-c1ccncc1
KEGG

UniProtKB/SwissProt

GoogleScholar
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PubMed
n/an/a 92n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558198
PNG
(CHEMBL4756319)
Show SMILES FC(F)(F)c1cccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccncc2)c1
KEGG

UniProtKB/SwissProt

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n/an/a 110n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558173
PNG
(CHEMBL4755668)
Show SMILES Clc1ccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccncc2)cc1Cl
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UniProtKB/SwissProt

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n/an/a 138n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558197
PNG
(CHEMBL4756931)
Show SMILES O=C(Nc1cccc(Oc2ccccc2)c1)N1CCOc2ccc(cc2C1)-c1ccncc1
KEGG

UniProtKB/SwissProt

GoogleScholar
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n/an/a 146n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558194
PNG
(CHEMBL4754434)
Show SMILES Clc1cccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccncc2)c1Cl
KEGG

UniProtKB/SwissProt

GoogleScholar
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PubMed
n/an/a 157n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558191
PNG
(CHEMBL4751751)
Show SMILES FC(F)(F)c1cccc(CS(=O)(=O)N2CCOc3ccc(cc3C2)-c2ccncc2)c1
KEGG

UniProtKB/SwissProt

GoogleScholar
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PC sid
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PubMed
n/an/a 157n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558190
PNG
(CHEMBL4782723)
Show SMILES Clc1ccc(NC(=O)N2CCNc3ccc(cc3C2)-c2ccncc2)cc1Cl
KEGG

UniProtKB/SwissProt

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n/an/a 158n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558174
PNG
(CHEMBL4787638)
Show SMILES Clc1cccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccncc2)c1
KEGG

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
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Article
PubMed
n/an/a 164n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558176
PNG
(CHEMBL4779679)
Show SMILES COc1cccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccnc3ccccc23)c1
KEGG

UniProtKB/SwissProt

GoogleScholar
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n/an/a 216n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558202
PNG
(CHEMBL4750832)
Show SMILES COc1cccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccncc2)c1
KEGG

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 305n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558201
PNG
(CHEMBL4792959)
Show SMILES Fc1cccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccncc2)c1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 413n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558180
PNG
(CHEMBL4781458)
Show SMILES Nc1cc(ccn1)-c1ccc2OCCN(Cc2c1)C(=O)Nc1cccc(c1)C#N
KEGG

UniProtKB/SwissProt

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n/an/a 448n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558178
PNG
(CHEMBL4750165)
Show SMILES COc1cccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccncc2OC)c1
KEGG

UniProtKB/SwissProt

GoogleScholar
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PC sid
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Article
PubMed
n/an/a 486n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558187
PNG
(CHEMBL4743675)
Show SMILES Clc1ccc(NC(=O)N2CCCc3ccc(cc3C2)-c2ccncc2)cc1Cl
KEGG

UniProtKB/SwissProt

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n/an/a 590n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558205
PNG
(CHEMBL4781462)
Show SMILES Fc1ccccc1NC(=O)N1CCOc2ccc(cc2C1)-c1ccncc1
KEGG

UniProtKB/SwissProt

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n/an/a 604n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558192
PNG
(CHEMBL4781022)
Show SMILES FC(F)(F)c1cccc(CC(=O)N2CCOc3ccc(cc3C2)-c2ccncc2)c1
KEGG

UniProtKB/SwissProt

GoogleScholar
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PC sid
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n/an/a 611n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558193
PNG
(CHEMBL4753373)
Show SMILES Fc1ccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccncc2)cc1Cl
KEGG

UniProtKB/SwissProt

GoogleScholar
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n/an/a 613n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558207
PNG
(CHEMBL4779820)
Show SMILES O=C(Nc1ccccc1)N1CCOc2ccc(cc2C1)-c1ccncc1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 851n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558186
PNG
(CHEMBL4764518)
Show SMILES Clc1ccc(NC(=O)N2CCc3ccc(cc3C2)-c2ccncc2)cc1Cl
KEGG

UniProtKB/SwissProt

GoogleScholar
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n/an/a 1.05E+3n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558179
PNG
(CHEMBL4790417)
Show SMILES COc1cccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccncc2C)c1
KEGG

UniProtKB/SwissProt

GoogleScholar
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Article
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n/an/a 1.18E+3n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558189
PNG
(CHEMBL4755519)
Show SMILES CN1CCN(Cc2cc(ccc12)-c1ccncc1)C(=O)Nc1ccc(Cl)c(Cl)c1
KEGG

UniProtKB/SwissProt

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n/an/a 2.57E+3n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558181
PNG
(CHEMBL4741033)
Show SMILES COc1cccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccnc(OC)c2)c1
KEGG

UniProtKB/SwissProt

GoogleScholar
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n/an/a 2.57E+3n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558204
PNG
(CHEMBL4744210)
Show SMILES Fc1ccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccncc2)cc1
KEGG

UniProtKB/SwissProt

GoogleScholar
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Article
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n/an/a 2.61E+3n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558183
PNG
(CHEMBL4797579)
Show SMILES Clc1ccc(NC(=O)N2CCc3ccc(cc23)-c2ccncc2)cc1Cl
KEGG

UniProtKB/SwissProt

GoogleScholar
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Article
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n/an/a 2.95E+3n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558188
PNG
(CHEMBL4741265)
Show SMILES CCCCN1CCN(Cc2cc(ccc12)-c1ccncc1)C(=O)Nc1ccc(Cl)c(Cl)c1
KEGG

UniProtKB/SwissProt

GoogleScholar
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PC sid
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Article
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n/an/a 4.50E+3n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558184
PNG
(CHEMBL4748192)
Show SMILES Clc1ccc(NC(=O)N2Cc3ccc(cc3C2)-c2ccncc2)cc1Cl
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558203
PNG
(CHEMBL4751866)
Show SMILES COc1ccc(NC(=O)N2CCOc3ccc(cc3C2)-c2ccncc2)cc1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558196
PNG
(CHEMBL4786908)
Show SMILES COc1cccc(c1)N(C)C(=O)N1CCOc2ccc(cc2C1)-c1ccncc1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)
BDBM50558185
PNG
(CHEMBL4791903)
Show SMILES Clc1ccc(NC(=O)N2CCCc3ccc(cc23)-c2ccncc2)cc1Cl
KEGG

UniProtKB/SwissProt

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Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44
More data for this
Ligand-Target Pair