Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Replicase polyprotein 1ab (HCoV-OC43) | BDBM525229 (N-[(1S)-1-(1-bicyclo[1.1.1]pentanylmethyl)-2-[2-[(...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022043374 | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For the HCoV-OC433CLpro assay, 2 μL of 0.02 μM recombinant HCoV-OC433CL protease were mixed with serial dilutions of each comp... | Citation and Details BindingDB Entry DOI: 10.7270/Q2SF30BV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM525230 (WO2022043374, Example 72) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022043374 | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For the HCoV-OC433CLpro assay, 2 μL of 0.02 μM recombinant HCoV-OC433CL protease were mixed with serial dilutions of each comp... | Citation and Details BindingDB Entry DOI: 10.7270/Q2SF30BV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM525228 (N-[(1S)-2-[2-[(2R)-2-chloro-2-fluoro-acetyl]-2-[[(...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022043374 | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For the HCoV-OC433CLpro assay, 2 μL of 0.02 μM recombinant HCoV-OC433CL protease were mixed with serial dilutions of each comp... | Citation and Details BindingDB Entry DOI: 10.7270/Q2SF30BV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM525176 (N-[(1S)-1-[[(3-amino-3-oxo-propyl)-(2-chloroacetyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022043374 | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For the HCoV-OC433CLpro assay, 2 μL of 0.02 μM recombinant HCoV-OC433CL protease were mixed with serial dilutions of each comp... | Citation and Details BindingDB Entry DOI: 10.7270/Q2SF30BV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM525251 (N-[(1S)-2-[2-[(2R)-2-chloro-2-fluoro-acetyl]-2-[[(...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022043374 | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For the HCoV-OC433CLpro assay, 2 μL of 0.02 μM recombinant HCoV-OC433CL protease were mixed with serial dilutions of each comp... | Citation and Details BindingDB Entry DOI: 10.7270/Q2SF30BV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM525203 (N-[(1S)-1-[[(2-Chloroacetyl)-[(2-oxo-pyrrolidin-3-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022043374 | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For the HCoV-OC433CLpro assay, 2 μL of 0.02 μM recombinant HCoV-OC433CL protease were mixed with serial dilutions of each comp... | Citation and Details BindingDB Entry DOI: 10.7270/Q2SF30BV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM525250 (N-[(1S)-1-(1-bicyclo[1.1.1]pentanylmethyl)-2-[2-[(...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022043374 | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For the HCoV-OC433CLpro assay, 2 μL of 0.02 μM recombinant HCoV-OC433CL protease were mixed with serial dilutions of each comp... | Citation and Details BindingDB Entry DOI: 10.7270/Q2SF30BV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM525252 (N-[(1S)-1-[[[(2R)-2-chloro-2-fluoro-acetyl]-[[(3S)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022043374 | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For the HCoV-OC433CLpro assay, 2 μL of 0.02 μM recombinant HCoV-OC433CL protease were mixed with serial dilutions of each comp... | Citation and Details BindingDB Entry DOI: 10.7270/Q2SF30BV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM448319 (GC-376 | GC376) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona | Assay Description Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre... | ACS Pharmacol Transl Sci 4: 1408-1421 (2021) Article DOI: 10.1021/acsptsci.1c00099 BindingDB Entry DOI: 10.7270/Q20V8GWQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM525253 (WO2022043374, Example 73) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022043374 | n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For the HCoV-OC433CLpro assay, 2 μL of 0.02 μM recombinant HCoV-OC433CL protease were mixed with serial dilutions of each comp... | Citation and Details BindingDB Entry DOI: 10.7270/Q2SF30BV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM484194 (UAWJ9-36-1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona | Assay Description Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre... | ACS Pharmacol Transl Sci 4: 1408-1421 (2021) Article DOI: 10.1021/acsptsci.1c00099 BindingDB Entry DOI: 10.7270/Q20V8GWQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM484195 (UAWJ9-36-3) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona | Assay Description Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre... | ACS Pharmacol Transl Sci 4: 1408-1421 (2021) Article DOI: 10.1021/acsptsci.1c00099 BindingDB Entry DOI: 10.7270/Q20V8GWQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM420980 (US9975885, Compound 37) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
PURDUE RESEARCH FOUNDATION US Patent | Assay Description The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following... | US Patent US9975885 (2018) BindingDB Entry DOI: 10.7270/Q2TQ63XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM420974 (US9975885, Compound 30) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
PURDUE RESEARCH FOUNDATION US Patent | Assay Description The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following... | US Patent US9975885 (2018) BindingDB Entry DOI: 10.7270/Q2TQ63XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM420977 (US9975885, Compound 32) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
PURDUE RESEARCH FOUNDATION US Patent | Assay Description The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following... | US Patent US9975885 (2018) BindingDB Entry DOI: 10.7270/Q2TQ63XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM420960 (US9975885, Compound 19) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
PURDUE RESEARCH FOUNDATION US Patent | Assay Description The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following... | US Patent US9975885 (2018) BindingDB Entry DOI: 10.7270/Q2TQ63XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM420981 (US9975885, Compound 64) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
PURDUE RESEARCH FOUNDATION US Patent | Assay Description The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following... | US Patent US9975885 (2018) BindingDB Entry DOI: 10.7270/Q2TQ63XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM420975 (US9975885, Compound 31) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 5.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
PURDUE RESEARCH FOUNDATION US Patent | Assay Description The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following... | US Patent US9975885 (2018) BindingDB Entry DOI: 10.7270/Q2TQ63XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM420337 (US9975885, Compound 1P) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
PURDUE RESEARCH FOUNDATION US Patent | Assay Description The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following... | US Patent US9975885 (2018) BindingDB Entry DOI: 10.7270/Q2TQ63XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM420996 (US9975885, Compound 77) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PDB UniChem | US Patent | n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
PURDUE RESEARCH FOUNDATION US Patent | Assay Description The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following... | US Patent US9975885 (2018) BindingDB Entry DOI: 10.7270/Q2TQ63XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM420978 (US9975885, Compound 33) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
PURDUE RESEARCH FOUNDATION US Patent | Assay Description The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following... | US Patent US9975885 (2018) BindingDB Entry DOI: 10.7270/Q2TQ63XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM420993 (US9975885, Compound 47) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PDB UniChem | US Patent | n/a | n/a | 7.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
PURDUE RESEARCH FOUNDATION US Patent | Assay Description The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following... | US Patent US9975885 (2018) BindingDB Entry DOI: 10.7270/Q2TQ63XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM420979 (US9975885, Compound 34) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
PURDUE RESEARCH FOUNDATION US Patent | Assay Description The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following... | US Patent US9975885 (2018) BindingDB Entry DOI: 10.7270/Q2TQ63XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM420349 (US9975885, Compound 6) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
PURDUE RESEARCH FOUNDATION US Patent | Assay Description The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following... | US Patent US9975885 (2018) BindingDB Entry DOI: 10.7270/Q2TQ63XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM420973 (US9975885, Compound 29) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 1.11E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
PURDUE RESEARCH FOUNDATION US Patent | Assay Description The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following... | US Patent US9975885 (2018) BindingDB Entry DOI: 10.7270/Q2TQ63XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM420990 (US9975885, Compound 43) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 1.24E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
PURDUE RESEARCH FOUNDATION US Patent | Assay Description The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following... | US Patent US9975885 (2018) BindingDB Entry DOI: 10.7270/Q2TQ63XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM420987 (US9975885, Compound 40) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 1.37E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
PURDUE RESEARCH FOUNDATION US Patent | Assay Description The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following... | US Patent US9975885 (2018) BindingDB Entry DOI: 10.7270/Q2TQ63XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM420983 (US9975885, Compound 3P | med.21724, Compound 125) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 1.37E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
PURDUE RESEARCH FOUNDATION US Patent | Assay Description The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following... | US Patent US9975885 (2018) BindingDB Entry DOI: 10.7270/Q2TQ63XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM420991 (US9975885, Compound 44) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 1.56E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
PURDUE RESEARCH FOUNDATION US Patent | Assay Description The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following... | US Patent US9975885 (2018) BindingDB Entry DOI: 10.7270/Q2TQ63XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM420972 (US9975885, Compound 27) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 1.63E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
PURDUE RESEARCH FOUNDATION US Patent | Assay Description The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following... | US Patent US9975885 (2018) BindingDB Entry DOI: 10.7270/Q2TQ63XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM420985 (US9975885, Compound 38) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 2.44E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
PURDUE RESEARCH FOUNDATION US Patent | Assay Description The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following... | US Patent US9975885 (2018) BindingDB Entry DOI: 10.7270/Q2TQ63XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM420961 (US9975885, Compound 2P | acs.jmedchem.1c00409_ST.4...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 2.44E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
PURDUE RESEARCH FOUNDATION US Patent | Assay Description The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following... | US Patent US9975885 (2018) BindingDB Entry DOI: 10.7270/Q2TQ63XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM420992 (US9975885, Compound 46) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 2.45E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
PURDUE RESEARCH FOUNDATION US Patent | Assay Description The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following... | US Patent US9975885 (2018) BindingDB Entry DOI: 10.7270/Q2TQ63XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM420994 (US9975885, Compound 48) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 4.65E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
PURDUE RESEARCH FOUNDATION US Patent | Assay Description The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following... | US Patent US9975885 (2018) BindingDB Entry DOI: 10.7270/Q2TQ63XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM420989 (US9975885, Compound 42) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 6.31E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
PURDUE RESEARCH FOUNDATION US Patent | Assay Description The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following... | US Patent US9975885 (2018) BindingDB Entry DOI: 10.7270/Q2TQ63XX | |||||||||||
More data for this Ligand-Target Pair |