Found 27 hits Enz. Inhib. hit(s) with all data for entry = 10714 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM561447
(US11390625, Compound 20 | US11390625, Example 20)Show SMILES COc1cc(N2CCC3(CN(CCN(C)C)C3)CC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccc3ccccc3c2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <0.0510 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM561449
(US11390625, Compound 23 | US11390625, Example 23)Show SMILES COc1cc(N2CCC3(CN(C)C3)CC2)c(C)cc1Nc1ncc(Br)c(Nc2ccc3ccccc3c2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0520 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [L858R,T790M,C797S]
(Homo sapiens (Human)) | BDBM561454
(US11390625, Compound 34 | US11390625, Example 34)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(C)cc1Nc1ncc(Br)c(Nc2ccc3nccnc3c2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [L858R,T790M,C797S]
(Homo sapiens (Human)) | BDBM561456
(US11390625, Compound 44 | US11390625, Example 44)Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(C)cc1Nc1ncc(Br)c(Nc2ccc3nccnc3c2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM561455
(US11390625, Compound 41 | US11390625, Example 41)Show SMILES CCc1cc(Nc2ncc(Br)c(Nc3ccc4nccnc4c3P(C)(C)=O)n2)c(OC)cc1N1CCC(CC1)N1CCN(C)CC1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.212 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM561454
(US11390625, Compound 34 | US11390625, Example 34)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(C)cc1Nc1ncc(Br)c(Nc2ccc3nccnc3c2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.218 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [L858R,T790M,C797S]
(Homo sapiens (Human)) | BDBM561455
(US11390625, Compound 41 | US11390625, Example 41)Show SMILES CCc1cc(Nc2ncc(Br)c(Nc3ccc4nccnc4c3P(C)(C)=O)n2)c(OC)cc1N1CCC(CC1)N1CCN(C)CC1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM561456
(US11390625, Compound 44 | US11390625, Example 44)Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(C)cc1Nc1ncc(Br)c(Nc2ccc3nccnc3c2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.281 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM561441
(US11390625, Compound 9 | US11390625, Example 9)Show SMILES COc1cc(N2CCC3(CN(C)C3)CC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccc3ccccc3c2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.485 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM561443
(US11390625, Compound 16 | US11390625, Example 16)Show SMILES COc1cc(N2CCC3(CN(C)C3)CC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccc3CCCc3c2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.491 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM561437
(US11390625, Example 2)Show SMILES COc1cc(N2CCC3(CN(C)C3)CC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccc3sccc3c2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.613 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM561451
(US11390625, Compound 26 | US11390625, Example 26)Show SMILES COc1cc(N2CCC3(CN(C)C3)CC2)c(C)cc1Nc1ncc(C#N)c(Nc2ccc3ccccc3c2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.679 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM561440
(US11390625, Compound 8 | US11390625, Example 8)Show SMILES COc1cc(N2CCC3(CN(C)C3)CC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccc3nccnc3c2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.792 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM561438
(US11390625, Compound 5 | US11390625, Example 5)Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccc3ccccc3c2P(C)(C)=O)n1)N1CCC2(CN(C)C2)CC1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.63 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM561450
(US11390625, Compound 25 | US11390625, Example 25)Show SMILES COc1cc(N2CCC3(CN(C)C3)CC2)c(C)cc1Nc1ncc(C2CC2)c(Nc2ccc3ccccc3c2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.79 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM561439
(US11390625, Compound 6 | US11390625, Example 6)Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccc3ccccc3c2P(C)(C)=O)n1)N1CCC(CC1)N1CCN(C)CC1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.54 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM561436
(US11390625, Compound 1 | US11390625, Example 1)Show SMILES COc1cc(N2CCC3(CCN(C)CC3)CC2)c(Cl)cc1Nc1ncc(Cl)c(Nc2ccc3sccc3c2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.64 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM561455
(US11390625, Compound 41 | US11390625, Example 41)Show SMILES CCc1cc(Nc2ncc(Br)c(Nc3ccc4nccnc4c3P(C)(C)=O)n2)c(OC)cc1N1CCC(CC1)N1CCN(C)CC1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5.12 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM561442
(US11390625, Compound 13 | US11390625, Example 13)Show SMILES COc1cc(N2CCC3(CN(C)C3)CC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccc3cnn(C)c3c2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5.79 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM561454
(US11390625, Compound 34 | US11390625, Example 34)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(C)cc1Nc1ncc(Br)c(Nc2ccc3nccnc3c2P(C)(C)=O)n1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7.92 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM561456
(US11390625, Compound 44 | US11390625, Example 44)Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(C)cc1Nc1ncc(Br)c(Nc2ccc3nccnc3c2P(C)(C)=O)n1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM561446
(US11390625, Compound 19 | US11390625, Example 19)Show SMILES COc1ccc(OCCNCc2cccnc2)cc1Nc1ncc(Cl)c(Nc2ccc3ccccc3c2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 12.9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM561445
(US11390625, Compound 18 | US11390625, Example 18)Show SMILES COc1ccc(OCCNCc2cnccn2)cc1Nc1ncc(Cl)c(Nc2ccc3ccccc3c2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 25.3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM561448
(US11390625, Compound 21 | US11390625, Example 21)Show SMILES COc1cc(N2CCC3(CN(CC(F)(F)F)C3)CC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccc3ccccc3c2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 30.6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM561453
(US11390625, Compound 29 | US11390625, Example 29)Show SMILES COc1ccc(OCCNS(C)(=O)=O)cc1Nc1ncc(Cl)c(Nc2ccc3ccccc3c2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 67.6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM561452
(US11390625, Compound 28 | US11390625, Example 28)Show SMILES COc1ccc(OCCN2CCNC(=O)C2)cc1Nc1ncc(Cl)c(Nc2ccc3ccccc3c2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 185 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM561444
(US11390625, Compound 17 | US11390625, Example 17)Show SMILES COc1cc(N2CCC3(CN(C)C3)CC2)c(C)cc1Nc1ncc(OC(=O)N(C)C)c(Nc2ccc3ccccc3c2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 856 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
TBD |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RF2 |
More data for this
Ligand-Target Pair | |
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