Compile Data Set for Download or QSAR

Found 1162 hits Enz. Inhib. hit(s) with all data for entry = 10754   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM97529 (Roche-Dataset for PDE10A, Compound 46 | US8470820,...) Show SMILES Cn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccc2ccccc2n1 Show InChI InChI=1S/C26H22N8O/c1-34-24(12-23(33-34)21-9-8-16-4-2-3-5-19(16)30-21)32-26(35)25-22(29-18-13-27-15-28-14-18)11-10-20(31-25)17-6-7-17/h2-5,8-15,17,29H,6-7H2,1H3,(H,32,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0800	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM564307 (Roche-Dataset for PDE10A, Compound 621) Show SMILES CNC(=O)c1cc2[nH]c(nc2cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.0900	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM97514 (Roche-Dataset for PDE10A, Compound 6 | US8470820, ...) Show SMILES OCCn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccc2ccccc2n1 Show InChI InChI=1S/C27H24N8O2/c36-12-11-35-25(13-24(34-35)22-8-7-17-3-1-2-4-20(17)31-22)33-27(37)26-23(30-19-14-28-16-29-15-19)10-9-21(32-26)18-5-6-18/h1-4,7-10,13-16,18,30,36H,5-6,11-12H2,(H,33,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0900	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM239752 (Roche-Dataset for PDE10A, Compound 308 | US9394311...) Show SMILES Cc1cc(Cl)c(C)n2nc(\C=C\c3nc(N4CCCC4)n(C)n3)nc12 Show InChI InChI=1S/C17H20ClN7/c1-11-10-13(18)12(2)25-16(11)19-14(22-25)6-7-15-20-17(23(3)21-15)24-8-4-5-9-24/h6-7,10H,4-5,8-9H2,1-3H3/b7-6+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.150	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM239837 (Roche-Dataset for PDE10A, Compound 146 | US9394311...) Show SMILES COCCOc1cc(Cl)c(C)n2nc(CCc3nc(nn3C)N3CCCC3)nc12 Show InChI InChI=1S/C19H26ClN7O2/c1-13-14(20)12-15(29-11-10-28-3)18-21-16(23-27(13)18)6-7-17-22-19(24-25(17)2)26-8-4-5-9-26/h12H,4-11H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM97527 (Roche-Dataset for PDE10A, Compound 53 | US8470820,...) Show SMILES COCCn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccn1 Show InChI InChI=1S/C24H24N8O2/c1-34-11-10-32-22(12-21(31-32)19-4-2-3-9-27-19)30-24(33)23-20(28-17-13-25-15-26-14-17)8-7-18(29-23)16-5-6-16/h2-4,7-9,12-16,28H,5-6,10-11H2,1H3,(H,30,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.180	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM563882 (Roche-Dataset for PDE10A, Compound 196) Show SMILES Cc1cn2nc(nc2cc1NC(=O)c1c(cnn1C)C(=O)N1CCC1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.190	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM563870 (Roche-Dataset for PDE10A, Compound 184) Show SMILES CNC(=O)c1cn2cc(nc2cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.220	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM239785 (Roche-Dataset for PDE10A, Compound 522 | US9394311...) Show SMILES Cc1c(Cl)cc(Cl)c2nc(CCc3n[nH]c(n3)N3CCCC3)nn12 Show InChI InChI=1S/C15H17Cl2N7/c1-9-10(16)8-11(17)14-18-13(22-24(9)14)5-4-12-19-15(21-20-12)23-6-2-3-7-23/h8H,2-7H2,1H3,(H,19,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.220	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM239812 (Roche-Dataset for PDE10A, Compound 227 | US9394311...) Show SMILES Cc1c(Cl)cc(OC(F)F)c2nc(CCc3nc(nn3C)N3CCCC3)nn12 Show InChI InChI=1S/C17H20ClF2N7O/c1-10-11(18)9-12(28-16(19)20)15-21-13(23-27(10)15)5-6-14-22-17(24-25(14)2)26-7-3-4-8-26/h9,16H,3-8H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.230	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM564109 (Roche-Dataset for PDE10A, Compound 423) Show SMILES O=C(Nc1ccc2[nH]c(nc2c1)-c1ccccc1)c1nc(ccc1Nc1cncnc1)C1CC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.240	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM239755 (Roche-Dataset for PDE10A, Compound 359 | US9394311...) Show SMILES Cc1cc(Cl)c(C)n2nc(CCc3nc(nn3C)N3CCCC3)nc12 Show InChI InChI=1S/C17H22ClN7/c1-11-10-13(18)12(2)25-16(11)19-14(21-25)6-7-15-20-17(22-23(15)3)24-8-4-5-9-24/h10H,4-9H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	0.280	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM239826 (Roche-Dataset for PDE10A, Compound 244 | US9394311...) Show SMILES Cc1cnc(C)c2nc(CCc3nc(nn3-c3ccccc3)N3CCCC3)nn12 Show InChI InChI=1S/C21H24N8/c1-15-14-22-16(2)20-23-18(25-28(15)20)10-11-19-24-21(27-12-6-7-13-27)26-29(19)17-8-4-3-5-9-17/h3-5,8-9,14H,6-7,10-13H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.290	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM563697 (Roche-Dataset for PDE10A, Compound 11) Show SMILES Cn1ncc(C(=O)N2CCC2)c1C(=O)Nc1ccn2nc(nc2c1)-c1ccccc1OCCCF Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM120583 (Roche-Dataset for PDE10A, Compound 707 | US8703768...) Show SMILES Cc1ccc(NC(=O)c2nc(cnc2Nc2cncnc2)C2CC2)c(n1)C(=O)NCC(C)(C)O Show InChI InChI=1S/C23H26N8O3/c1-13-4-7-16(18(28-13)21(32)27-11-23(2,3)34)31-22(33)19-20(29-15-8-24-12-25-9-15)26-10-17(30-19)14-5-6-14/h4,7-10,12,14,34H,5-6,11H2,1-3H3,(H,26,29)(H,27,32)(H,31,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM563771 (Roche-Dataset for PDE10A, Compound 85) Show SMILES COc1cccc(c1)-c1nc2cc(NC(=O)c3c(cnn3C)C(=O)N3CCC3)ccn2n1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.310	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM120672 (Roche-Dataset for PDE10A, Compound 803 | US8703768...) Show SMILES CC(C)(CO)NC(=O)c1ncccc1NC(=O)c1nc(cnc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C22H24N8O3/c1-22(2,11-31)30-21(33)17-15(4-3-7-25-17)29-20(32)18-19(27-14-8-23-12-24-9-14)26-10-16(28-18)13-5-6-13/h3-4,7-10,12-13,31H,5-6,11H2,1-2H3,(H,26,27)(H,29,32)(H,30,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.310	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM120698 (Roche-Dataset for PDE10A, Compound 927 | US8703768...) Show SMILES CNC(=O)c1c(F)cc(F)cc1NC(=O)c1nc(cnc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C20H17F2N7O2/c1-23-19(30)16-13(22)4-11(21)5-14(16)29-20(31)17-18(27-12-6-24-9-25-7-12)26-8-15(28-17)10-2-3-10/h4-10H,2-3H2,1H3,(H,23,30)(H,26,27)(H,29,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM563986 (Roche-Dataset for PDE10A, Compound 300) Show SMILES Cc1cc(Cl)c(C)n2nc(\C=C\c3nc(nn3C)N3CCCC3)nc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.330	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM239840 (Roche-Dataset for PDE10A, Compound 47 | US9394311,...) Show SMILES Cc1c(Cl)cc(c2nc(CCc3nc(nn3C3CCOCC3)N3CCCC3)nn12)C(F)(F)F Show InChI InChI=1S/C21H25ClF3N7O/c1-13-16(22)12-15(21(23,24)25)19-26-17(28-31(13)19)4-5-18-27-20(30-8-2-3-9-30)29-32(18)14-6-10-33-11-7-14/h12,14H,2-11H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.350	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM563700 (Roche-Dataset for PDE10A, Compound 14) Show SMILES Cn1ncc(C(=O)N2CCC2)c1C(=O)Nc1ccn2nc(nc2c1)-c1ccccc1OCCF Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.350	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM120670 (Roche-Dataset for PDE10A, Compound 852 | US8703768...) Show SMILES OCCNC(=O)c1ncccc1NC(=O)c1nc(cnc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C20H20N8O3/c29-7-6-24-19(30)16-14(2-1-5-23-16)28-20(31)17-18(26-13-8-21-11-22-9-13)25-10-15(27-17)12-3-4-12/h1-2,5,8-12,29H,3-4,6-7H2,(H,24,30)(H,25,26)(H,28,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.360	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM563881 (Roche-Dataset for PDE10A, Compound 195) Show SMILES CN(C)C(=O)c1cnn(C)c1C(=O)Nc1ccc2[nH]c(nc2c1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	0.360	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM239838 (Roche-Dataset for PDE10A, Compound 208 | US9394311...) Show SMILES Cc1c(Cl)cc(OC2CCOCC2)c2nc(CCc3nc(nn3C)N3CCCC3)nn12 Show InChI InChI=1S/C21H28ClN7O2/c1-14-16(22)13-17(31-15-7-11-30-12-8-15)20-23-18(25-29(14)20)5-6-19-24-21(26-27(19)2)28-9-3-4-10-28/h13,15H,3-12H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.360	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM563851 (Roche-Dataset for PDE10A, Compound 165) Show SMILES Cn1ncc(C(=O)N2CC(F)C2)c1C(=O)Nc1ccn2nc(nc2c1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.360	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM120674 (Roche-Dataset for PDE10A, Compound 770 | US8703768...) Show SMILES CC1(COC1)NC(=O)c1ncccc1NC(=O)c1nc(cnc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C22H22N8O3/c1-22(10-33-11-22)30-21(32)17-15(3-2-6-25-17)29-20(31)18-19(27-14-7-23-12-24-8-14)26-9-16(28-18)13-4-5-13/h2-3,6-9,12-13H,4-5,10-11H2,1H3,(H,26,27)(H,29,31)(H,30,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.380	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM120673 (Roche-Dataset for PDE10A, Compound 599 | US8703768...) Show SMILES CNC(=O)c1cc(NC(C)=O)ccc1NC(=O)c1nc(cnc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C22H22N8O3/c1-12(31)27-14-5-6-17(16(7-14)21(32)23-2)30-22(33)19-20(28-15-8-24-11-25-9-15)26-10-18(29-19)13-3-4-13/h5-11,13H,3-4H2,1-2H3,(H,23,32)(H,26,28)(H,27,31)(H,30,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.380	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM120727 (Roche-Dataset for PDE10A, Compound 481 | US8703768...) Show SMILES CNC(=O)c1cc(CCC(O)=O)ccc1NC(=O)c1nc(cnc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C23H23N7O4/c1-24-22(33)16-8-13(3-7-19(31)32)2-6-17(16)30-23(34)20-21(28-15-9-25-12-26-10-15)27-11-18(29-20)14-4-5-14/h2,6,8-12,14H,3-5,7H2,1H3,(H,24,33)(H,27,28)(H,30,34)(H,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.390	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM120700 (Roche-Dataset for PDE10A, Compound 902 | US8703768...) Show SMILES CC(C)(O)CNC(=O)c1ccc(F)cc1NC(=O)c1nc(cnc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C23H24FN7O3/c1-23(2,34)11-28-21(32)16-6-5-14(24)7-17(16)31-22(33)19-20(29-15-8-25-12-26-9-15)27-10-18(30-19)13-3-4-13/h5-10,12-13,34H,3-4,11H2,1-2H3,(H,27,29)(H,28,32)(H,31,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM120581 (Roche-Dataset for PDE10A, Compound 553 | US8703768...) Show SMILES CCc1ccc(NC(=O)c2nc(cnc2Nc2cncnc2)C2CC2)c(n1)C(=O)NCC(C)(C)O Show InChI InChI=1S/C24H28N8O3/c1-4-15-7-8-17(19(29-15)22(33)28-12-24(2,3)35)32-23(34)20-21(30-16-9-25-13-26-10-16)27-11-18(31-20)14-5-6-14/h7-11,13-14,35H,4-6,12H2,1-3H3,(H,27,30)(H,28,33)(H,32,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.410	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM239799 (Roche-Dataset for PDE10A, Compound 135 | US9394311...) Show SMILES Cc1c(Br)cc(c2nc(CCc3nc(nn3C)N3CCCC3)nn12)C(F)(F)F Show InChI InChI=1S/C17H19BrF3N7/c1-10-12(18)9-11(17(19,20)21)15-22-13(24-28(10)15)5-6-14-23-16(25-26(14)2)27-7-3-4-8-27/h9H,3-8H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.430	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM120490 (Roche-Dataset for PDE10A, Compound 743 | US8703768...) Show SMILES O=C(Nc1sccc1C(=O)N1CCOCC1)c1nc(ccc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C22H22N6O3S/c29-20(27-21-16(5-10-32-21)22(30)28-6-8-31-9-7-28)19-18(25-15-11-23-13-24-12-15)4-3-17(26-19)14-1-2-14/h3-5,10-14,25H,1-2,6-9H2,(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.440	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM239793 (Roche-Dataset for PDE10A, Compound 313 | US9394311...) Show SMILES COc1cc(Cl)c(C)n2nc(CCc3nc(nn3C)N3CCCC3)nc12 Show InChI InChI=1S/C17H22ClN7O/c1-11-12(18)10-13(26-3)16-19-14(21-25(11)16)6-7-15-20-17(22-23(15)2)24-8-4-5-9-24/h10H,4-9H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.440	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM239822 (Roche-Dataset for PDE10A, Compound 158 | US9394311...) Show SMILES Cc1c(Cl)cc(c2nc(CCc3nc(N4CCCC4)n(C)n3)nn12)C(F)(F)F Show InChI InChI=1S/C17H19ClF3N7/c1-10-12(18)9-11(17(19,20)21)15-22-13(25-28(10)15)5-6-14-23-16(26(2)24-14)27-7-3-4-8-27/h9H,3-8H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.440	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM563801 (Roche-Dataset for PDE10A, Compound 115) Show SMILES Cn1c(Cl)nc(C(=O)N2CCC2)c1C(=O)Nc1ccn2nc(nc2c1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.450	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM239753 (Roche-Dataset for PDE10A, Compound 374 | US9394311...) Show SMILES Cc1cc(Cl)c(C)n2nc(CCc3nc(N4CCCC4)n(C)n3)nc12 Show InChI InChI=1S/C17H22ClN7/c1-11-10-13(18)12(2)25-16(11)19-14(22-25)6-7-15-20-17(23(3)21-15)24-8-4-5-9-24/h10H,4-9H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.470	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM200541 (Roche-Dataset for PDE10A, Compound 469 | US9227970...) Show SMILES Cn1ncc(C(=O)N2CCC2)c1C(=O)Nc1ccc2nc(nn2c1)N1CCCC1 Show InChI InChI=1S/C19H22N8O2/c1-24-16(14(11-20-24)18(29)25-9-4-10-25)17(28)21-13-5-6-15-22-19(23-27(15)12-13)26-7-2-3-8-26/h5-6,11-12H,2-4,7-10H2,1H3,(H,21,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.480	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM120489 (Roche-Dataset for PDE10A, Compound 997 | US8703768...) Show SMILES O=C(NC1CC1)c1ccsc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C21H20N6O2S/c28-19(25-13-3-4-13)15-7-8-30-21(15)27-20(29)18-17(24-14-9-22-11-23-10-14)6-5-16(26-18)12-1-2-12/h5-13,24H,1-4H2,(H,25,28)(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.480	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM120609 (Roche-Dataset for PDE10A, Compound 539 | US8703768...) Show SMILES COCc1ccc(NC(=O)c2nc(cnc2Nc2cncnc2)C2CC2)c(n1)C(=O)NCC(C)(C)O Show InChI InChI=1S/C24H28N8O4/c1-24(2,35)12-28-22(33)19-17(7-6-15(29-19)11-36-3)32-23(34)20-21(30-16-8-25-13-26-9-16)27-10-18(31-20)14-4-5-14/h6-10,13-14,35H,4-5,11-12H2,1-3H3,(H,27,30)(H,28,33)(H,32,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.480	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM120624 (Roche-Dataset for PDE10A, Compound 933 | US8703768...) Show SMILES CNC(=O)c1cc(OC)ccc1NC(=O)c1nc(cnc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C21H21N7O3/c1-22-20(29)15-7-14(31-2)5-6-16(15)28-21(30)18-19(26-13-8-23-11-24-9-13)25-10-17(27-18)12-3-4-12/h5-12H,3-4H2,1-2H3,(H,22,29)(H,25,26)(H,28,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.480	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM120614 (Roche-Dataset for PDE10A, Compound 464 | US8703768...) Show SMILES CC(C)(O)CNC(=O)c1cc(OCCO)ccc1NC(=O)c1nc(cnc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C25H29N7O5/c1-25(2,36)13-29-23(34)18-9-17(37-8-7-33)5-6-19(18)32-24(35)21-22(30-16-10-26-14-27-11-16)28-12-20(31-21)15-3-4-15/h5-6,9-12,14-15,33,36H,3-4,7-8,13H2,1-2H3,(H,28,30)(H,29,34)(H,32,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.490	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM239815 (Roche-Dataset for PDE10A, Compound 119 | US9394311...) Show SMILES Cc1c(Cl)cc(OCC(F)(F)F)c2nc(CCc3nc(nn3C)N3CCCC3)nn12 Show InChI InChI=1S/C18H21ClF3N7O/c1-11-12(19)9-13(30-10-18(20,21)22)16-23-14(25-29(11)16)5-6-15-24-17(26-27(15)2)28-7-3-4-8-28/h9H,3-8,10H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM125040 (Roche-Dataset for PDE10A, Compound 21 | US8772510,...) Show SMILES Cn1ncc(C(=O)N2CCC2)c1C(=O)NCCc1nc(nn1-c1cccnc1)-c1ccccc1 Show InChI InChI=1S/C24H24N8O2/c1-30-21(19(16-27-30)24(34)31-13-6-14-31)23(33)26-12-10-20-28-22(17-7-3-2-4-8-17)29-32(20)18-9-5-11-25-15-18/h2-5,7-9,11,15-16H,6,10,12-14H2,1H3,(H,26,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.510	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM239823 (Roche-Dataset for PDE10A, Compound 206 | US9394311...) Show SMILES Cc1c(Cl)cc(OC(F)F)c2nc(CCc3nc(N4CCCC4)n(C)n3)nn12 Show InChI InChI=1S/C17H20ClF2N7O/c1-10-11(18)9-12(28-16(19)20)15-21-13(24-27(10)15)5-6-14-22-17(25(2)23-14)26-7-3-4-8-26/h9,16H,3-8H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.540	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM239769 (Roche-Dataset for PDE10A, Compound 357 | US9394311...) Show SMILES Cc1c(Cl)cc(Cl)c2nc(CCc3nc(nn3C)N3CCCC3)nn12 Show InChI InChI=1S/C16H19Cl2N7/c1-10-11(17)9-12(18)15-19-13(21-25(10)15)5-6-14-20-16(22-23(14)2)24-7-3-4-8-24/h9H,3-8H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM120720 (Roche-Dataset for PDE10A, Compound 329 | US8703768...) Show SMILES CCOC(=O)CCc1ccc(NC(=O)c2nc(cnc2Nc2cncnc2)C2CC2)c(c1)C(=O)NC Show InChI InChI=1S/C25H27N7O4/c1-3-36-21(33)9-5-15-4-8-19(18(10-15)24(34)26-2)32-25(35)22-23(30-17-11-27-14-28-12-17)29-13-20(31-22)16-6-7-16/h4,8,10-14,16H,3,5-7,9H2,1-2H3,(H,26,34)(H,29,30)(H,32,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.590	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM563952 (Roche-Dataset for PDE10A, Compound 266) Show SMILES CCOc1cc(Cl)c(C)n2nc(CCc3nc(nn3C)N3CCCC3)nc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM563806 (Roche-Dataset for PDE10A, Compound 120) Show SMILES COc1ccccc1-c1nc2cc(NC(=O)c3c(cnn3C)C(=O)N3CCC3)ccn2n1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM317196 (3,8-Dimethyl-6-((1-methyl-3-(pyrrolidin-1-yl)-1H-1...) Show SMILES Cc1c(nc2c(C)cc(nn12)C#Cc1nc(nn1C)N1CCCC1)C(F)(F)F Show InChI InChI=1S/C18H18F3N7/c1-11-10-13(24-28-12(2)15(18(19,20)21)23-16(11)28)6-7-14-22-17(25-26(14)3)27-8-4-5-9-27/h10H,4-5,8-9H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.640	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM239778 (Roche-Dataset for PDE10A, Compound 97 | US9394311,...) Show SMILES COc1ccc(Cn2nc(nc2CCc2nc3c(Cl)cc(Cl)c(C)n3n2)N2CCCC2)cc1 Show InChI InChI=1S/C23H25Cl2N7O/c1-15-18(24)13-19(25)22-26-20(28-32(15)22)9-10-21-27-23(30-11-3-4-12-30)29-31(21)14-16-5-7-17(33-2)8-6-16/h5-8,13H,3-4,9-12,14H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.640	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...				Citation and Details Article DOI: 10.1007/s10822-022-00478-x BindingDB Entry DOI: 10.7270/Q29W0JQD
					More data for this Ligand-Target Pair

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