Found 287 hits Enz. Inhib. hit(s) with all data for entry = 1705 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336444
(US9744172, Compound UNC1186A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCC(=O)NCC |r,wD:15.15,(-9.03,-4.37,;-7.69,-3.6,;-6.36,-4.37,;-5.03,-3.6,;-3.69,-4.37,;-2.36,-3.6,;-2.36,-2.06,;-1.02,-1.29,;.31,-2.06,;1.77,-1.58,;2.68,-2.83,;1.77,-4.08,;2.17,-5.56,;3.66,-5.96,;4.06,-7.45,;2.97,-8.54,;3.37,-10.03,;1.48,-8.14,;1.08,-6.65,;.31,-3.6,;-1.02,-4.37,;2.17,-.1,;3.66,.3,;4.06,1.79,;2.97,2.88,;1.48,2.48,;1.08,.99,;3.37,4.37,;1.88,4.77,;2.97,5.85,;4.86,4.77,;5.25,6.25,;6.74,6.65,;7.83,5.56,;7.14,8.14,;8.63,8.54,;9.03,10.03,)| Show InChI InChI=1S/C25H35N7O4S/c1-3-5-14-27-25-28-15-21-23(31-32(24(21)30-25)18-8-10-19(33)11-9-18)17-6-12-20(13-7-17)37(35,36)29-16-22(34)26-4-2/h6-7,12-13,15,18-19,29,33H,3-5,8-11,14,16H2,1-2H3,(H,26,34)(H,27,28,30)/t18?,19- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336445
(US9744172, Compound UNC1187A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)Nc1ccc(C)cc1 |r,wD:15.15,(-8.08,-4.71,;-6.75,-3.94,;-5.42,-4.71,;-4.08,-3.94,;-2.75,-4.71,;-1.42,-3.94,;-1.42,-2.4,;-.08,-1.63,;1.25,-2.4,;2.72,-1.93,;3.62,-3.17,;2.72,-4.42,;3.12,-5.91,;4.6,-6.31,;5,-7.79,;3.91,-8.88,;4.31,-10.37,;2.43,-8.48,;2.03,-7,;1.25,-3.94,;-.08,-4.71,;3.12,-.44,;4.6,-.04,;5,1.45,;3.91,2.53,;2.43,2.14,;2.03,.65,;4.31,4.02,;2.82,4.42,;3.91,5.51,;5.8,4.42,;6.2,5.91,;7.68,6.31,;8.08,7.79,;6.99,8.88,;7.39,10.37,;5.51,8.48,;5.11,7,)| Show InChI InChI=1S/C28H34N6O3S/c1-3-4-17-29-28-30-18-25-26(32-34(27(25)31-28)22-11-13-23(35)14-12-22)20-7-15-24(16-8-20)38(36,37)33-21-9-5-19(2)6-10-21/h5-10,15-16,18,22-23,33,35H,3-4,11-14,17H2,1-2H3,(H,29,30,31)/t22?,23- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336446
(US9744172, Compound UNC1188A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC(=O)N2CCCC2)cc1 |r,wD:15.15,(-7.87,-3.73,;-6.54,-2.96,;-5.21,-3.73,;-3.87,-2.96,;-2.54,-3.73,;-1.2,-2.96,;-1.2,-1.42,;.13,-.65,;1.46,-1.42,;2.93,-.94,;3.83,-2.19,;2.93,-3.43,;3.33,-4.92,;4.81,-5.32,;5.21,-6.81,;4.12,-7.9,;4.52,-9.38,;2.64,-7.5,;2.24,-6.01,;1.46,-2.96,;.13,-3.73,;3.33,.54,;4.81,.94,;5.21,2.43,;4.12,3.52,;4.52,5.01,;6.01,5.41,;7.1,4.32,;6.41,6.89,;7.87,7.37,;7.87,8.91,;6.41,9.38,;5.5,8.14,;2.64,3.12,;2.24,1.63,)| Show InChI InChI=1S/C26H35N7O2/c1-2-3-14-27-25-28-17-22-23(31-33(24(22)30-25)20-10-12-21(34)13-11-20)18-6-8-19(9-7-18)29-26(35)32-15-4-5-16-32/h6-9,17,20-21,34H,2-5,10-16H2,1H3,(H,29,35)(H,27,28,30)/t20?,21- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336448
(US9744172, Compound UNC1190A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC(=O)N2CCOCC2)cc1 |r,wD:15.15,(-8.08,-3.97,;-6.75,-3.2,;-5.42,-3.97,;-4.08,-3.2,;-2.75,-3.97,;-1.42,-3.2,;-1.42,-1.66,;-.08,-.89,;1.25,-1.66,;2.72,-1.18,;3.62,-2.43,;2.72,-3.68,;3.12,-5.16,;4.6,-5.56,;5,-7.05,;3.91,-8.14,;4.31,-9.63,;2.43,-7.74,;2.03,-6.25,;1.25,-3.2,;-.08,-3.97,;3.12,.3,;4.6,.7,;5,2.19,;3.91,3.28,;4.31,4.77,;5.8,5.16,;6.89,4.08,;6.2,6.65,;7.68,7.05,;8.08,8.54,;6.99,9.63,;5.51,9.23,;5.11,7.74,;2.43,2.88,;2.03,1.39,)| Show InChI InChI=1S/C26H35N7O3/c1-2-3-12-27-25-28-17-22-23(31-33(24(22)30-25)20-8-10-21(34)11-9-20)18-4-6-19(7-5-18)29-26(35)32-13-15-36-16-14-32/h4-7,17,20-21,34H,2-3,8-16H2,1H3,(H,29,35)(H,27,28,30)/t20?,21- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336450
(US9744172, Compound UNC1192A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC(=O)NCCC)cc1 |r,wD:15.15,(-8.83,-3.63,;-7.49,-2.86,;-6.16,-3.63,;-4.83,-2.86,;-3.49,-3.63,;-2.16,-2.86,;-2.16,-1.32,;-.83,-.55,;.51,-1.32,;1.97,-.84,;2.88,-2.09,;1.97,-3.33,;2.37,-4.82,;3.86,-5.22,;4.26,-6.7,;3.17,-7.79,;3.57,-9.28,;1.68,-7.4,;1.28,-5.91,;.51,-2.86,;-.83,-3.63,;2.37,.65,;3.86,1.05,;4.26,2.53,;3.17,3.62,;3.57,5.11,;5.05,5.51,;6.14,4.42,;5.45,7,;6.94,7.4,;7.34,8.88,;8.83,9.28,;1.68,3.22,;1.28,1.74,)| Show InChI InChI=1S/C25H35N7O2/c1-3-5-15-26-24-28-16-21-22(17-6-8-18(9-7-17)29-25(34)27-14-4-2)31-32(23(21)30-24)19-10-12-20(33)13-11-19/h6-9,16,19-20,33H,3-5,10-15H2,1-2H3,(H,26,28,30)(H2,27,29,34)/t19?,20- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336452
(US9744172, Compound UNC1222A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC(=O)NC2CCCC2)cc1 |r,wD:15.15,(-9.13,-3.41,;-7.8,-2.64,;-6.46,-3.41,;-5.13,-2.64,;-3.8,-3.41,;-2.46,-2.64,;-2.46,-1.1,;-1.13,-.33,;.21,-1.1,;1.67,-.63,;2.58,-1.87,;1.67,-3.12,;2.07,-4.61,;3.56,-5.01,;3.96,-6.49,;2.87,-7.58,;3.26,-9.07,;1.38,-7.18,;.98,-5.7,;.21,-2.64,;-1.13,-3.41,;2.07,.86,;3.56,1.26,;3.96,2.74,;2.87,3.83,;3.26,5.32,;4.75,5.72,;5.84,4.63,;5.15,7.21,;6.64,7.61,;7.11,9.07,;8.65,9.07,;9.13,7.61,;7.88,6.7,;1.38,3.44,;.98,1.95,)| Show InChI InChI=1S/C27H37N7O2/c1-2-3-16-28-26-29-17-23-24(33-34(25(23)32-26)21-12-14-22(35)15-13-21)18-8-10-20(11-9-18)31-27(36)30-19-6-4-5-7-19/h8-11,17,19,21-22,35H,2-7,12-16H2,1H3,(H,28,29,32)(H2,30,31,36)/t21?,22- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336454
(US9744172, Compound UNC1142A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCN(CC)CC1 |r,wD:15.15,(-7.34,-5.06,;-6.01,-4.29,;-4.67,-5.06,;-3.34,-4.29,;-2,-5.06,;-.67,-4.29,;-.67,-2.75,;.66,-1.98,;2,-2.75,;3.46,-2.27,;4.37,-3.52,;3.46,-4.77,;3.86,-6.25,;5.35,-6.65,;5.75,-8.14,;4.66,-9.23,;5.05,-10.72,;3.17,-8.83,;2.77,-7.34,;2,-4.29,;.66,-5.06,;3.86,-.79,;5.35,-.39,;5.75,1.1,;4.66,2.19,;3.17,1.79,;2.77,.3,;5.05,3.68,;3.57,4.08,;6.54,3.28,;5.45,5.16,;6.94,5.56,;7.34,7.05,;6.25,8.14,;6.65,9.63,;5.56,10.72,;4.76,7.74,;4.36,6.25,)| Show InChI InChI=1S/C27H39N7O3S/c1-3-5-14-28-27-29-19-24-25(31-34(26(24)30-27)21-8-10-22(35)11-9-21)20-6-12-23(13-7-20)38(36,37)33-17-15-32(4-2)16-18-33/h6-7,12-13,19,21-22,35H,3-5,8-11,14-18H2,1-2H3,(H,28,29,30)/t21?,22- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336455
(US9744172, Compound UNC1143A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCCN(CC)CC1 |r,wD:15.15,(-7.48,-5.3,;-6.15,-4.53,;-4.81,-5.3,;-3.48,-4.53,;-2.15,-5.3,;-.81,-4.53,;-.81,-2.99,;.52,-2.22,;1.85,-2.99,;3.32,-2.52,;4.22,-3.76,;3.32,-5.01,;3.72,-6.5,;5.21,-6.89,;5.6,-8.38,;4.51,-9.47,;4.91,-10.96,;3.03,-9.07,;2.63,-7.58,;1.85,-4.53,;.52,-5.3,;3.72,-1.03,;5.21,-.63,;5.6,.86,;4.51,1.95,;3.03,1.55,;2.63,.06,;4.91,3.43,;3.43,3.83,;6.4,3.04,;5.31,4.92,;6.81,5.26,;7.48,6.65,;6.81,8.04,;5.31,8.38,;4.91,9.87,;6,10.96,;4.11,7.42,;4.11,5.88,)| Show InChI InChI=1S/C28H41N7O3S/c1-3-5-15-29-28-30-20-25-26(32-35(27(25)31-28)22-9-11-23(36)12-10-22)21-7-13-24(14-8-21)39(37,38)34-17-6-16-33(4-2)18-19-34/h7-8,13-14,20,22-23,36H,3-6,9-12,15-19H2,1-2H3,(H,29,30,31)/t22?,23- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336456
(US9744172, Compound UNC1144A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCC(CC1)N1CCCCC1 |r,wD:15.15,(-7.94,-6,;-6.6,-5.23,;-5.27,-6,;-3.94,-5.23,;-2.6,-6,;-1.27,-5.23,;-1.27,-3.69,;.06,-2.92,;1.4,-3.69,;2.86,-3.22,;3.77,-4.46,;2.86,-5.71,;3.26,-7.2,;4.75,-7.59,;5.15,-9.08,;4.06,-10.17,;4.46,-11.66,;2.57,-9.77,;2.17,-8.29,;1.4,-5.23,;.06,-6,;3.26,-1.73,;4.75,-1.33,;5.15,.16,;4.06,1.25,;2.57,.85,;2.17,-.64,;4.46,2.73,;2.97,3.13,;5.94,2.33,;4.86,4.22,;6.34,4.62,;6.74,6.11,;5.65,7.2,;4.17,6.8,;3.77,5.31,;6.05,8.68,;7.54,9.08,;7.94,10.57,;6.85,11.66,;5.36,11.26,;4.96,9.77,)| Show InChI InChI=1S/C31H45N7O3S/c1-2-3-17-32-31-33-22-28-29(35-38(30(28)34-31)25-9-11-26(39)12-10-25)23-7-13-27(14-8-23)42(40,41)37-20-15-24(16-21-37)36-18-5-4-6-19-36/h7-8,13-14,22,24-26,39H,2-6,9-12,15-21H2,1H3,(H,32,33,34)/t25?,26- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336457
(US9744172, Compound UNC1145A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCC(CC1)N1CCOCC1 |r,wD:15.15,(-7.94,-6,;-6.6,-5.23,;-5.27,-6,;-3.94,-5.23,;-2.6,-6,;-1.27,-5.23,;-1.27,-3.69,;.06,-2.92,;1.4,-3.69,;2.86,-3.22,;3.77,-4.46,;2.86,-5.71,;3.26,-7.2,;4.75,-7.59,;5.15,-9.08,;4.06,-10.17,;4.46,-11.66,;2.57,-9.77,;2.17,-8.29,;1.4,-5.23,;.06,-6,;3.26,-1.73,;4.75,-1.33,;5.15,.16,;4.06,1.25,;2.57,.85,;2.17,-.64,;4.46,2.73,;2.97,3.13,;5.94,2.33,;4.86,4.22,;6.34,4.62,;6.74,6.11,;5.65,7.2,;4.17,6.8,;3.77,5.31,;6.05,8.68,;7.54,9.08,;7.94,10.57,;6.85,11.66,;5.36,11.26,;4.96,9.77,)| Show InChI InChI=1S/C30H43N7O4S/c1-2-3-14-31-30-32-21-27-28(34-37(29(27)33-30)24-6-8-25(38)9-7-24)22-4-10-26(11-5-22)42(39,40)36-15-12-23(13-16-36)35-17-19-41-20-18-35/h4-5,10-11,21,23-25,38H,2-3,6-9,12-20H2,1H3,(H,31,32,33)/t24?,25- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336458
(US9744172, Compound UNC1146A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N(C)C(C)(C)C |r,wD:15.15,(-7.14,-3.57,;-5.81,-2.8,;-4.47,-3.57,;-3.14,-2.8,;-1.81,-3.57,;-.47,-2.8,;-.47,-1.26,;.86,-.49,;2.2,-1.26,;3.66,-.79,;4.57,-2.03,;3.66,-3.28,;4.06,-4.77,;5.55,-5.17,;5.94,-6.65,;4.86,-7.74,;5.25,-9.23,;3.37,-7.34,;2.97,-5.86,;2.2,-2.8,;.86,-3.57,;4.06,.7,;5.55,1.1,;5.94,2.59,;4.86,3.67,;3.37,3.28,;2.97,1.79,;5.25,5.16,;3.77,5.56,;6.74,4.76,;5.65,6.65,;7.14,7.05,;4.56,7.74,;4.95,9.23,;6.05,8.14,;3.08,7.34,)| Show InChI InChI=1S/C26H38N6O3S/c1-6-7-16-27-25-28-17-22-23(30-32(24(22)29-25)19-10-12-20(33)13-11-19)18-8-14-21(15-9-18)36(34,35)31(5)26(2,3)4/h8-9,14-15,17,19-20,33H,6-7,10-13,16H2,1-5H3,(H,27,28,29)/t19?,20- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336459
(US9744172, Compound UNC1147A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N(C)C |r,wD:15.15,(-7.14,-2.83,;-5.81,-2.06,;-4.47,-2.83,;-3.14,-2.06,;-1.81,-2.83,;-.47,-2.06,;-.47,-.52,;.86,.25,;2.2,-.52,;3.66,-.04,;4.57,-1.29,;3.66,-2.53,;4.06,-4.02,;5.55,-4.42,;5.94,-5.91,;4.86,-7,;5.25,-8.48,;3.37,-6.6,;2.97,-5.11,;2.2,-2.06,;.86,-2.83,;4.06,1.45,;5.55,1.84,;5.94,3.33,;4.86,4.42,;3.37,4.02,;2.97,2.53,;5.25,5.91,;3.77,6.31,;6.74,5.51,;5.65,7.4,;7.14,7.79,;4.56,8.48,)| Show InChI InChI=1S/C23H32N6O3S/c1-4-5-14-24-23-25-15-20-21(16-6-12-19(13-7-16)33(31,32)28(2)3)27-29(22(20)26-23)17-8-10-18(30)11-9-17/h6-7,12-13,15,17-18,30H,4-5,8-11,14H2,1-3H3,(H,24,25,26)/t17?,18- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336460
(US9744172, Compound UNC1148A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCC1 |r,wD:15.15,(-7.06,-3.34,;-5.73,-2.57,;-4.4,-3.34,;-3.06,-2.57,;-1.73,-3.34,;-.4,-2.57,;-.4,-1.03,;.94,-.26,;2.27,-1.03,;3.74,-.55,;4.64,-1.8,;3.74,-3.04,;4.14,-4.53,;5.62,-4.93,;6.02,-6.42,;4.93,-7.5,;5.33,-8.99,;3.45,-7.11,;3.05,-5.62,;2.27,-2.57,;.94,-3.34,;4.14,.94,;5.62,1.34,;6.02,2.82,;4.93,3.91,;3.45,3.51,;3.05,2.03,;5.33,5.4,;3.84,5.8,;6.82,5,;5.73,6.89,;7.06,7.66,;6.29,8.99,;4.96,8.22,)| Show InChI InChI=1S/C24H32N6O3S/c1-2-3-13-25-24-26-16-21-22(28-30(23(21)27-24)18-7-9-19(31)10-8-18)17-5-11-20(12-6-17)34(32,33)29-14-4-15-29/h5-6,11-12,16,18-19,31H,2-4,7-10,13-15H2,1H3,(H,25,26,27)/t18?,19- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336461
(US9744172, Compound UNC1149A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(N2CCOCC2)c(F)c1 |r,wD:15.15,(-7.29,-3.03,;-5.95,-2.26,;-4.62,-3.03,;-3.29,-2.26,;-1.95,-3.03,;-.62,-2.26,;-.62,-.72,;.72,.05,;2.05,-.72,;3.51,-.24,;4.42,-1.49,;3.51,-2.73,;3.91,-4.22,;5.4,-4.62,;5.8,-6.11,;4.71,-7.2,;5.11,-8.68,;3.22,-6.8,;2.82,-5.31,;2.05,-2.26,;.72,-3.03,;3.91,1.25,;2.82,2.33,;3.22,3.82,;4.71,4.22,;5.11,5.71,;6.6,6.11,;6.99,7.59,;5.91,8.68,;4.42,8.29,;4.02,6.8,;5.8,3.13,;7.29,3.53,;5.4,1.64,)| Show InChI InChI=1S/C25H33FN6O2/c1-2-3-10-27-25-28-16-20-23(30-32(24(20)29-25)18-5-7-19(33)8-6-18)17-4-9-22(21(26)15-17)31-11-13-34-14-12-31/h4,9,15-16,18-19,33H,2-3,5-8,10-14H2,1H3,(H,27,28,29)/t18?,19- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336462
(US9744172, Compound UNC1150A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCC(N)CC1 |r,wD:15.15,(-7.34,-4.52,;-6.01,-3.75,;-4.67,-4.52,;-3.34,-3.75,;-2,-4.52,;-.67,-3.75,;-.67,-2.21,;.66,-1.44,;2,-2.21,;3.46,-1.73,;4.37,-2.98,;3.46,-4.22,;3.86,-5.71,;5.35,-6.11,;5.75,-7.59,;4.66,-8.68,;5.05,-10.17,;3.17,-8.29,;2.77,-6.8,;2,-3.75,;.66,-4.52,;3.86,-.24,;5.35,.16,;5.75,1.64,;4.66,2.73,;3.17,2.33,;2.77,.85,;5.05,4.22,;3.57,4.62,;6.54,3.82,;5.45,5.71,;6.94,6.11,;7.34,7.59,;6.25,8.68,;6.65,10.17,;4.76,8.29,;4.36,6.8,)| Show InChI InChI=1S/C26H37N7O3S/c1-2-3-14-28-26-29-17-23-24(31-33(25(23)30-26)20-6-8-21(34)9-7-20)18-4-10-22(11-5-18)37(35,36)32-15-12-19(27)13-16-32/h4-5,10-11,17,19-21,34H,2-3,6-9,12-16,27H2,1H3,(H,28,29,30)/t20?,21- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336463
(US9744172, Compound UNC1224A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCCN1CCCC1 |r,wD:15.15,(-10.07,-4.36,;-8.74,-3.59,;-7.41,-4.36,;-6.07,-3.59,;-4.74,-4.36,;-3.4,-3.59,;-3.4,-2.05,;-2.07,-1.28,;-.74,-2.05,;.73,-1.57,;1.63,-2.82,;.73,-4.06,;1.13,-5.55,;2.61,-5.95,;3.01,-7.44,;1.92,-8.53,;2.32,-10.01,;.44,-8.13,;.04,-6.64,;-.74,-3.59,;-2.07,-4.36,;1.13,-.08,;2.61,.31,;3.01,1.8,;1.92,2.89,;.44,2.49,;.04,1,;2.32,4.38,;.83,4.78,;1.92,5.87,;3.81,4.78,;4.21,6.26,;5.7,6.66,;6.09,8.15,;7.58,8.55,;8.06,10.01,;9.6,10.01,;10.07,8.55,;8.83,7.64,)| Show InChI InChI=1S/C28H41N7O3S/c1-2-3-15-29-28-30-20-25-26(33-35(27(25)32-28)22-9-11-23(36)12-10-22)21-7-13-24(14-8-21)39(37,38)31-16-6-19-34-17-4-5-18-34/h7-8,13-14,20,22-23,31,36H,2-6,9-12,15-19H2,1H3,(H,29,30,32)/t22?,23- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336464
(US9744172, Compound UNC1225A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCC(=O)NCCC1CCOCC1 |r,wD:15.15,(-11.26,-5.51,;-9.92,-4.74,;-8.59,-5.51,;-7.26,-4.74,;-5.92,-5.51,;-4.59,-4.74,;-4.59,-3.2,;-3.26,-2.43,;-1.92,-3.2,;-.46,-2.73,;.45,-3.97,;-.46,-5.22,;-.06,-6.7,;1.43,-7.1,;1.83,-8.59,;.74,-9.68,;1.14,-11.17,;-.75,-9.28,;-1.15,-7.79,;-1.92,-4.74,;-3.26,-5.51,;-.06,-1.24,;1.43,-.84,;1.83,.65,;.74,1.74,;-.75,1.34,;-1.15,-.15,;1.14,3.22,;-.35,3.62,;.74,4.71,;2.62,3.62,;3.02,5.11,;4.51,5.51,;5.6,4.42,;4.91,7,;6.4,7.4,;6.8,8.88,;8.28,9.28,;9.37,8.19,;10.86,8.59,;11.26,10.08,;10.17,11.17,;8.68,10.77,)| Show InChI InChI=1S/C30H43N7O5S/c1-2-3-15-32-30-33-19-26-28(36-37(29(26)35-30)23-6-8-24(38)9-7-23)22-4-10-25(11-5-22)43(40,41)34-20-27(39)31-16-12-21-13-17-42-18-14-21/h4-5,10-11,19,21,23-24,34,38H,2-3,6-9,12-18,20H2,1H3,(H,31,39)(H,32,33,35)/t23?,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336465
(US9744172, Compound UNC1226A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCC(=O)NC1CC1 |r,wD:15.15,(-9.57,-4.17,;-8.24,-3.4,;-6.9,-4.17,;-5.57,-3.4,;-4.24,-4.17,;-2.9,-3.4,;-2.9,-1.86,;-1.57,-1.09,;-.24,-1.86,;1.23,-1.38,;2.13,-2.63,;1.23,-3.88,;1.63,-5.36,;3.12,-5.76,;3.51,-7.25,;2.43,-8.34,;2.82,-9.83,;.94,-7.94,;.54,-6.45,;-.24,-3.4,;-1.57,-4.17,;1.63,.1,;3.12,.5,;3.51,1.99,;2.43,3.08,;.94,2.68,;.54,1.19,;2.82,4.57,;1.34,4.96,;2.43,6.05,;4.31,4.96,;4.71,6.45,;6.2,6.85,;7.29,5.76,;6.6,8.34,;8.08,8.74,;9.57,8.34,;9.17,9.83,)| Show InChI InChI=1S/C26H35N7O4S/c1-2-3-14-27-26-28-15-22-24(32-33(25(22)31-26)19-8-10-20(34)11-9-19)17-4-12-21(13-5-17)38(36,37)29-16-23(35)30-18-6-7-18/h4-5,12-13,15,18-20,29,34H,2-3,6-11,14,16H2,1H3,(H,30,35)(H,27,28,31)/t19?,20- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336466
(US9744172, Compound UNC1265A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCC(=O)NC1CCN(C)CC1 |r,wD:15.15,(-9.97,-6.6,;-8.64,-5.83,;-7.3,-6.6,;-5.97,-5.83,;-4.63,-6.6,;-3.3,-5.83,;-3.3,-4.29,;-1.97,-3.52,;-.63,-4.29,;.83,-3.81,;1.74,-5.06,;.83,-6.31,;1.23,-7.79,;2.72,-8.19,;3.12,-9.68,;2.03,-10.77,;2.43,-12.26,;.54,-10.37,;.14,-8.88,;-.63,-5.83,;-1.97,-6.6,;1.23,-2.33,;2.72,-1.93,;3.12,-.44,;2.03,.65,;.54,.25,;.14,-1.24,;2.43,2.14,;.94,2.53,;2.03,3.62,;3.91,2.53,;4.31,4.02,;5.8,4.42,;6.2,5.91,;5.11,7,;7.68,6.31,;8.08,7.79,;9.57,8.19,;9.97,9.68,;8.88,10.77,;9.28,12.26,;7.39,10.37,;6.99,8.88,)| Show InChI InChI=1S/C30H44N8O4S/c1-3-4-16-31-30-32-20-26-28(36-38(29(26)35-30)23-7-9-24(39)10-8-23)21-5-11-25(12-6-21)43(41,42)33-17-13-27(40)34-22-14-18-37(2)19-15-22/h5-6,11-12,20,22-24,33,39H,3-4,7-10,13-19H2,1-2H3,(H,34,40)(H,31,32,35)/t23?,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336467
(US9744172, Compound UNC1266A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCC(=O)NC1CCN(C)CC1 |r,wU:15.15,(-9.97,-6.6,;-8.64,-5.83,;-7.3,-6.6,;-5.97,-5.83,;-4.63,-6.6,;-3.3,-5.83,;-3.3,-4.29,;-1.97,-3.52,;-.63,-4.29,;.83,-3.81,;1.74,-5.06,;.83,-6.31,;1.23,-7.79,;.14,-8.88,;.54,-10.37,;2.03,-10.77,;2.43,-12.26,;3.12,-9.68,;2.72,-8.19,;-.63,-5.83,;-1.97,-6.6,;1.23,-2.33,;2.72,-1.93,;3.12,-.44,;2.03,.65,;.54,.25,;.14,-1.24,;2.43,2.14,;.94,2.53,;2.03,3.62,;3.91,2.53,;4.31,4.02,;5.8,4.42,;6.2,5.91,;5.11,7,;7.68,6.31,;8.08,7.79,;9.57,8.19,;9.97,9.68,;8.88,10.77,;9.28,12.26,;7.39,10.37,;6.99,8.88,)| Show InChI InChI=1S/C30H44N8O4S/c1-3-4-16-31-30-32-20-26-28(36-38(29(26)35-30)23-7-9-24(39)10-8-23)21-5-11-25(12-6-21)43(41,42)33-17-13-27(40)34-22-14-18-37(2)19-15-22/h5-6,11-12,20,22-24,33,39H,3-4,7-10,13-19H2,1-2H3,(H,34,40)(H,31,32,35)/t23?,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336468
(US9744172, Compound UNC1267A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCC(=O)NCCCN1CCOCC1 |r,wD:15.15,(-12.2,-6.45,;-10.87,-5.68,;-9.53,-6.45,;-8.2,-5.68,;-6.87,-6.45,;-5.53,-5.68,;-5.53,-4.14,;-4.2,-3.37,;-2.87,-4.14,;-1.4,-3.67,;-.5,-4.91,;-1.4,-6.16,;-1,-7.65,;.49,-8.05,;.88,-9.53,;-.2,-10.62,;.19,-12.11,;-1.69,-10.22,;-2.09,-8.74,;-2.87,-5.68,;-4.2,-6.45,;-1,-2.18,;.49,-1.78,;.88,-.29,;-.2,.79,;-1.69,.4,;-2.09,-1.09,;.19,2.28,;-1.29,2.68,;-.2,3.77,;1.68,2.68,;2.08,4.17,;3.57,4.57,;3.97,6.05,;2.88,7.14,;5.45,6.45,;5.85,7.94,;7.34,8.34,;7.74,9.83,;9.23,10.22,;10.31,9.14,;11.8,9.53,;12.2,11.02,;11.11,12.11,;9.62,11.71,)| Show InChI InChI=1S/C31H46N8O5S/c1-2-3-14-33-31-34-22-27-29(37-39(30(27)36-31)24-7-9-25(40)10-8-24)23-5-11-26(12-6-23)45(42,43)35-16-13-28(41)32-15-4-17-38-18-20-44-21-19-38/h5-6,11-12,22,24-25,35,40H,2-4,7-10,13-21H2,1H3,(H,32,41)(H,33,34,36)/t24?,25- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336469
(US9744172, Compound UNC1268A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCC(=O)NCCCN1CCOCC1 |r,wU:15.15,(-12.2,-6.45,;-10.87,-5.68,;-9.53,-6.45,;-8.2,-5.68,;-6.87,-6.45,;-5.53,-5.68,;-5.53,-4.14,;-4.2,-3.37,;-2.87,-4.14,;-1.4,-3.67,;-.5,-4.91,;-1.4,-6.16,;-1,-7.65,;-2.09,-8.74,;-1.69,-10.22,;-.2,-10.62,;.19,-12.11,;.88,-9.53,;.49,-8.05,;-2.87,-5.68,;-4.2,-6.45,;-1,-2.18,;.49,-1.78,;.88,-.29,;-.2,.79,;-1.69,.4,;-2.09,-1.09,;.19,2.28,;-1.29,2.68,;-.2,3.77,;1.68,2.68,;2.08,4.17,;3.57,4.57,;3.97,6.05,;2.88,7.14,;5.45,6.45,;5.85,7.94,;7.34,8.34,;7.74,9.83,;9.23,10.22,;10.31,9.14,;11.8,9.53,;12.2,11.02,;11.11,12.11,;9.62,11.71,)| Show InChI InChI=1S/C31H46N8O5S/c1-2-3-14-33-31-34-22-27-29(37-39(30(27)36-31)24-7-9-25(40)10-8-24)23-5-11-26(12-6-23)45(42,43)35-16-13-28(41)32-15-4-17-38-18-20-44-21-19-38/h5-6,11-12,22,24-25,35,40H,2-4,7-10,13-21H2,1H3,(H,32,41)(H,33,34,36)/t24?,25- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336470
(US9744172, Compound UNC1269A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCC(=O)NC1CCCCC1 |r,wD:15.15,(-9.97,-5.86,;-8.64,-5.09,;-7.3,-5.86,;-5.97,-5.09,;-4.63,-5.86,;-3.3,-5.09,;-3.3,-3.55,;-1.97,-2.78,;-.63,-3.55,;.83,-3.07,;1.74,-4.32,;.83,-5.56,;1.23,-7.05,;2.72,-7.45,;3.12,-8.94,;2.03,-10.03,;2.43,-11.51,;.54,-9.63,;.14,-8.14,;-.63,-5.09,;-1.97,-5.86,;1.23,-1.58,;2.72,-1.18,;3.12,.3,;2.03,1.39,;.54,.99,;.14,-.49,;2.43,2.88,;.94,3.28,;2.03,4.37,;3.91,3.28,;4.31,4.77,;5.8,5.16,;6.2,6.65,;5.11,7.74,;7.68,7.05,;8.08,8.54,;9.57,8.94,;9.97,10.42,;8.88,11.51,;7.39,11.11,;6.99,9.63,)| Show InChI InChI=1S/C30H43N7O4S/c1-2-3-18-31-30-32-20-26-28(36-37(29(26)35-30)23-11-13-24(38)14-12-23)21-9-15-25(16-10-21)42(40,41)33-19-17-27(39)34-22-7-5-4-6-8-22/h9-10,15-16,20,22-24,33,38H,2-8,11-14,17-19H2,1H3,(H,34,39)(H,31,32,35)/t23?,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336472
(US9744172, Compound UNC1234A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(N)cc1 |r,wD:15.15,(-6.54,-1.54,;-5.21,-.77,;-3.88,-1.54,;-2.54,-.77,;-1.21,-1.54,;.13,-.77,;.13,.77,;1.46,1.54,;2.79,.77,;4.26,1.25,;5.16,,;4.26,-1.25,;4.66,-2.73,;6.14,-3.13,;6.54,-4.62,;5.45,-5.71,;5.85,-7.2,;3.97,-5.31,;3.57,-3.82,;2.79,-.77,;1.46,-1.54,;4.66,2.73,;6.14,3.13,;6.54,4.62,;5.45,5.71,;5.85,7.2,;3.97,5.31,;3.57,3.82,)| Show InChI InChI=1S/C21H28N6O/c1-2-3-12-23-21-24-13-18-19(14-4-6-15(22)7-5-14)26-27(20(18)25-21)16-8-10-17(28)11-9-16/h4-7,13,16-17,28H,2-3,8-12,22H2,1H3,(H,23,24,25)/t16?,17- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336474
(US9744172, Compound UNC1236A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCC(O)=O |r,wD:15.15,(-8.83,-3.97,;-7.49,-3.2,;-6.16,-3.97,;-4.83,-3.2,;-3.49,-3.97,;-2.16,-3.2,;-2.16,-1.66,;-.83,-.89,;.51,-1.66,;1.97,-1.18,;2.88,-2.43,;1.97,-3.68,;2.37,-5.16,;3.86,-5.56,;4.26,-7.05,;3.17,-8.14,;3.57,-9.63,;1.68,-7.74,;1.28,-6.25,;.51,-3.2,;-.83,-3.97,;2.37,.3,;3.86,.7,;4.26,2.19,;3.17,3.28,;1.68,2.88,;1.28,1.39,;3.57,4.77,;2.08,5.16,;3.17,6.25,;5.05,5.16,;5.45,6.65,;6.94,7.05,;7.34,8.54,;8.83,8.94,;6.25,9.63,)| Show InChI InChI=1S/C24H32N6O5S/c1-2-3-13-25-24-26-15-20-22(29-30(23(20)28-24)17-6-8-18(31)9-7-17)16-4-10-19(11-5-16)36(34,35)27-14-12-21(32)33/h4-5,10-11,15,17-18,27,31H,2-3,6-9,12-14H2,1H3,(H,32,33)(H,25,26,28)/t17?,18- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336475
(US9744172, Compound UNC1281A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCC(=O)N1CCOCC1 |r,wD:15.15,(-10.31,-4.57,;-8.98,-3.8,;-7.65,-4.57,;-6.31,-3.8,;-4.98,-4.57,;-3.65,-3.8,;-3.65,-2.26,;-2.31,-1.49,;-.98,-2.26,;.49,-1.78,;1.39,-3.03,;.49,-4.27,;.88,-5.76,;2.37,-6.16,;2.77,-7.65,;1.68,-8.74,;2.08,-10.22,;.19,-8.34,;-.2,-6.85,;-.98,-3.8,;-2.31,-4.57,;.88,-.3,;2.37,.1,;2.77,1.59,;1.68,2.68,;.19,2.28,;-.2,.79,;2.08,4.17,;.59,4.57,;1.68,5.66,;3.57,4.57,;3.97,6.05,;5.45,6.45,;5.85,7.94,;4.76,9.03,;7.34,8.34,;8.43,7.25,;9.92,7.65,;10.31,9.14,;9.23,10.22,;7.74,9.83,)| Show InChI InChI=1S/C28H39N7O5S/c1-2-3-13-29-28-30-19-24-26(33-35(27(24)32-28)21-6-8-22(36)9-7-21)20-4-10-23(11-5-20)41(38,39)31-14-12-25(37)34-15-17-40-18-16-34/h4-5,10-11,19,21-22,31,36H,2-3,6-9,12-18H2,1H3,(H,29,30,32)/t21?,22- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336477
(US9744172, Compound UNC1283A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCC(=O)N1CCCCC1 |r,wD:15.15,(-10.31,-4.57,;-8.98,-3.8,;-7.65,-4.57,;-6.31,-3.8,;-4.98,-4.57,;-3.65,-3.8,;-3.65,-2.26,;-2.31,-1.49,;-.98,-2.26,;.49,-1.78,;1.39,-3.03,;.49,-4.27,;.88,-5.76,;2.37,-6.16,;2.77,-7.65,;1.68,-8.74,;2.08,-10.22,;.19,-8.34,;-.2,-6.85,;-.98,-3.8,;-2.31,-4.57,;.88,-.3,;2.37,.1,;2.77,1.59,;1.68,2.68,;.19,2.28,;-.2,.79,;2.08,4.17,;.59,4.57,;1.68,5.66,;3.57,4.57,;3.97,6.05,;5.45,6.45,;5.85,7.94,;4.76,9.03,;7.34,8.34,;8.43,7.25,;9.92,7.65,;10.31,9.14,;9.23,10.22,;7.74,9.83,)| Show InChI InChI=1S/C29H41N7O4S/c1-2-3-16-30-29-31-20-25-27(34-36(28(25)33-29)22-9-11-23(37)12-10-22)21-7-13-24(14-8-21)41(39,40)32-17-15-26(38)35-18-5-4-6-19-35/h7-8,13-14,20,22-23,32,37H,2-6,9-12,15-19H2,1H3,(H,30,31,33)/t22?,23- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336478
(US9744172, Compound UNC1284A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCC(=O)N1CCCCC1 |r,wU:15.15,(-10.31,-4.57,;-8.98,-3.8,;-7.65,-4.57,;-6.31,-3.8,;-4.98,-4.57,;-3.65,-3.8,;-3.65,-2.26,;-2.31,-1.49,;-.98,-2.26,;.49,-1.78,;1.39,-3.03,;.49,-4.27,;.88,-5.76,;-.2,-6.85,;.19,-8.34,;1.68,-8.74,;2.08,-10.22,;2.77,-7.65,;2.37,-6.16,;-.98,-3.8,;-2.31,-4.57,;.88,-.3,;2.37,.1,;2.77,1.59,;1.68,2.68,;.19,2.28,;-.2,.79,;2.08,4.17,;.59,4.57,;1.68,5.66,;3.57,4.57,;3.97,6.05,;5.45,6.45,;5.85,7.94,;4.76,9.03,;7.34,8.34,;8.43,7.25,;9.92,7.65,;10.31,9.14,;9.23,10.22,;7.74,9.83,)| Show InChI InChI=1S/C29H41N7O4S/c1-2-3-16-30-29-31-20-25-27(34-36(28(25)33-29)22-9-11-23(37)12-10-22)21-7-13-24(14-8-21)41(39,40)32-17-15-26(38)35-18-5-4-6-19-35/h7-8,13-14,20,22-23,32,37H,2-6,9-12,15-19H2,1H3,(H,30,31,33)/t22?,23- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336483
(US9744172, Compound UNC1311A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC(=O)C2CC2)cc1 |r,wD:15.15,(-7.68,-3.23,;-6.35,-2.46,;-5.02,-3.23,;-3.68,-2.46,;-2.35,-3.23,;-1.02,-2.46,;-1.02,-.92,;.32,-.15,;1.65,-.92,;3.12,-.44,;4.02,-1.69,;3.12,-2.93,;3.51,-4.42,;5,-4.82,;5.4,-6.31,;4.31,-7.4,;4.71,-8.88,;2.82,-7,;2.43,-5.51,;1.65,-2.46,;.32,-3.23,;3.51,1.05,;5,1.45,;5.4,2.93,;4.31,4.02,;4.71,5.51,;6.2,5.91,;7.29,4.82,;6.6,7.4,;7.68,8.48,;6.2,8.88,;2.82,3.62,;2.43,2.14,)| Show InChI InChI=1S/C25H32N6O2/c1-2-3-14-26-25-27-15-21-22(16-6-8-18(9-7-16)28-24(33)17-4-5-17)30-31(23(21)29-25)19-10-12-20(32)13-11-19/h6-9,15,17,19-20,32H,2-5,10-14H2,1H3,(H,28,33)(H,26,27,29)/t19?,20- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336485
(US9744172, Compound UNC1313A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N(C)c1ccc(cc1)C(=O)NCCOCC |r,wD:15.15,(-10.57,-7.54,;-9.23,-6.77,;-7.9,-7.54,;-6.57,-6.77,;-5.23,-7.54,;-3.9,-6.77,;-3.9,-5.23,;-2.57,-4.46,;-1.23,-5.23,;.23,-4.76,;1.14,-6,;.23,-7.25,;.63,-8.74,;2.12,-9.14,;2.52,-10.62,;1.43,-11.71,;1.83,-13.2,;-.06,-11.31,;-.46,-9.83,;-1.23,-6.77,;-2.57,-7.54,;.63,-3.27,;2.12,-2.87,;2.52,-1.38,;1.43,-.29,;-.06,-.69,;-.46,-2.18,;1.83,1.19,;.29,1.19,;1.06,2.53,;3.31,1.59,;4.4,.5,;3.71,3.08,;5.2,3.48,;5.6,4.96,;4.51,6.05,;3.02,5.66,;2.62,4.17,;4.91,7.54,;3.82,8.63,;6.4,7.94,;6.8,9.43,;8.28,9.83,;8.68,11.31,;10.17,11.71,;10.57,13.2,)| Show InChI InChI=1S/C33H43N7O5S/c1-4-6-19-35-33-36-22-29-30(38-40(31(29)37-33)26-13-15-27(41)16-14-26)23-9-17-28(18-10-23)46(43,44)39(3)25-11-7-24(8-12-25)32(42)34-20-21-45-5-2/h7-12,17-18,22,26-27,41H,4-6,13-16,19-21H2,1-3H3,(H,34,42)(H,35,36,37)/t26?,27- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336486
(US9744172, Compound UNC1314A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N(C)c1ccc(cc1)C(=O)NCCOCC |r,wU:15.15,(-10.57,-7.54,;-9.23,-6.77,;-7.9,-7.54,;-6.57,-6.77,;-5.23,-7.54,;-3.9,-6.77,;-3.9,-5.23,;-2.57,-4.46,;-1.23,-5.23,;.23,-4.76,;1.14,-6,;.23,-7.25,;.63,-8.74,;-.46,-9.83,;-.06,-11.31,;1.43,-11.71,;1.83,-13.2,;2.52,-10.62,;2.12,-9.14,;-1.23,-6.77,;-2.57,-7.54,;.63,-3.27,;2.12,-2.87,;2.52,-1.38,;1.43,-.29,;-.06,-.69,;-.46,-2.18,;1.83,1.19,;.29,1.19,;1.06,2.53,;3.31,1.59,;4.4,.5,;3.71,3.08,;5.2,3.48,;5.6,4.96,;4.51,6.05,;3.02,5.66,;2.62,4.17,;4.91,7.54,;3.82,8.63,;6.4,7.94,;6.8,9.43,;8.28,9.83,;8.68,11.31,;10.17,11.71,;10.57,13.2,)| Show InChI InChI=1S/C33H43N7O5S/c1-4-6-19-35-33-36-22-29-30(38-40(31(29)37-33)26-13-15-27(41)16-14-26)23-9-17-28(18-10-23)46(43,44)39(3)25-11-7-24(8-12-25)32(42)34-20-21-45-5-2/h7-12,17-18,22,26-27,41H,4-6,13-16,19-21H2,1-3H3,(H,34,42)(H,35,36,37)/t26?,27- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336487
(US9744172, Compound UNC1315A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N(C)c1ccc(cc1)C(=O)NCCCOC |r,wD:15.15,(-10.57,-7.54,;-9.23,-6.77,;-7.9,-7.54,;-6.57,-6.77,;-5.23,-7.54,;-3.9,-6.77,;-3.9,-5.23,;-2.57,-4.46,;-1.23,-5.23,;.23,-4.76,;1.14,-6,;.23,-7.25,;.63,-8.74,;2.12,-9.14,;2.52,-10.62,;1.43,-11.71,;1.83,-13.2,;-.06,-11.31,;-.46,-9.83,;-1.23,-6.77,;-2.57,-7.54,;.63,-3.27,;2.12,-2.87,;2.52,-1.38,;1.43,-.29,;-.06,-.69,;-.46,-2.18,;1.83,1.19,;.29,1.19,;1.06,2.53,;3.31,1.59,;4.4,.5,;3.71,3.08,;5.2,3.48,;5.6,4.96,;4.51,6.05,;3.02,5.66,;2.62,4.17,;4.91,7.54,;3.82,8.63,;6.4,7.94,;6.8,9.43,;8.28,9.83,;8.68,11.31,;10.17,11.71,;10.57,13.2,)| Show InChI InChI=1S/C33H43N7O5S/c1-4-5-19-35-33-36-22-29-30(38-40(31(29)37-33)26-13-15-27(41)16-14-26)23-9-17-28(18-10-23)46(43,44)39(2)25-11-7-24(8-12-25)32(42)34-20-6-21-45-3/h7-12,17-18,22,26-27,41H,4-6,13-16,19-21H2,1-3H3,(H,34,42)(H,35,36,37)/t26?,27- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336488
(US9744172, Compound UNC1316A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N(C)c1ccc(cc1)C(=O)NCCCOC |r,wU:15.15,(-10.57,-7.54,;-9.23,-6.77,;-7.9,-7.54,;-6.57,-6.77,;-5.23,-7.54,;-3.9,-6.77,;-3.9,-5.23,;-2.57,-4.46,;-1.23,-5.23,;.23,-4.76,;1.14,-6,;.23,-7.25,;.63,-8.74,;-.46,-9.83,;-.06,-11.31,;1.43,-11.71,;1.83,-13.2,;2.52,-10.62,;2.12,-9.14,;-1.23,-6.77,;-2.57,-7.54,;.63,-3.27,;2.12,-2.87,;2.52,-1.38,;1.43,-.29,;-.06,-.69,;-.46,-2.18,;1.83,1.19,;.29,1.19,;1.06,2.53,;3.31,1.59,;4.4,.5,;3.71,3.08,;5.2,3.48,;5.6,4.96,;4.51,6.05,;3.02,5.66,;2.62,4.17,;4.91,7.54,;3.82,8.63,;6.4,7.94,;6.8,9.43,;8.28,9.83,;8.68,11.31,;10.17,11.71,;10.57,13.2,)| Show InChI InChI=1S/C33H43N7O5S/c1-4-5-19-35-33-36-22-29-30(38-40(31(29)37-33)26-13-15-27(41)16-14-26)23-9-17-28(18-10-23)46(43,44)39(2)25-11-7-24(8-12-25)32(42)34-20-6-21-45-3/h7-12,17-18,22,26-27,41H,4-6,13-16,19-21H2,1-3H3,(H,34,42)(H,35,36,37)/t26?,27- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336489
(US9744172, Compound UNC1317A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N(C)c1ccc(cc1)C(=O)NCCC(F)(F)F |r,wD:15.15,(-10.44,-7.42,;-9.11,-6.65,;-7.78,-7.42,;-6.44,-6.65,;-5.11,-7.42,;-3.78,-6.65,;-3.78,-5.11,;-2.44,-4.34,;-1.11,-5.11,;.36,-4.64,;1.26,-5.88,;.36,-7.13,;.75,-8.61,;2.24,-9.01,;2.64,-10.5,;1.55,-11.59,;1.95,-13.08,;.06,-11.19,;-.34,-9.7,;-1.11,-6.65,;-2.44,-7.42,;.75,-3.15,;2.24,-2.75,;2.64,-1.26,;1.55,-.17,;.06,-.57,;-.34,-2.06,;1.95,1.31,;.41,1.31,;1.18,2.65,;3.44,1.71,;4.53,.62,;3.84,3.2,;5.32,3.6,;5.72,5.09,;4.63,6.18,;3.15,5.78,;2.75,4.29,;5.03,7.66,;3.94,8.75,;6.52,8.06,;6.92,9.55,;8.4,9.95,;9.49,8.86,;10.58,7.77,;8.4,7.77,;10.58,9.95,)| Show InChI InChI=1S/C32H38F3N7O4S/c1-3-4-18-37-31-38-20-27-28(40-42(29(27)39-31)24-11-13-25(43)14-12-24)21-7-15-26(16-8-21)47(45,46)41(2)23-9-5-22(6-10-23)30(44)36-19-17-32(33,34)35/h5-10,15-16,20,24-25,43H,3-4,11-14,17-19H2,1-2H3,(H,36,44)(H,37,38,39)/t24?,25- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336498
(US9744172, Compound UNC1326A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1NC(=O)NC(C)=C1C(C)=O |r,wU:15.15,c:37,(-7.88,-3.37,;-6.55,-2.6,;-5.22,-3.37,;-3.88,-2.6,;-2.55,-3.37,;-1.22,-2.6,;-1.22,-1.06,;.12,-.29,;1.45,-1.06,;2.92,-.59,;3.82,-1.83,;2.92,-3.08,;3.31,-4.57,;2.23,-5.66,;2.62,-7.14,;4.11,-7.54,;4.51,-9.03,;5.2,-6.45,;4.8,-4.96,;1.45,-2.6,;.12,-3.37,;3.31,.9,;4.8,1.3,;5.2,2.79,;4.11,3.88,;2.62,3.48,;2.23,1.99,;4.51,5.36,;6,5.76,;6.4,7.25,;7.88,7.65,;5.31,8.34,;3.82,7.94,;2.73,9.03,;3.42,6.45,;1.93,6.05,;.85,7.14,;1.54,4.57,)| Show InChI InChI=1S/C28H35N7O3/c1-4-5-14-29-27-30-15-22-24(34-35(26(22)33-27)20-10-12-21(37)13-11-20)18-6-8-19(9-7-18)25-23(17(3)36)16(2)31-28(38)32-25/h6-9,15,20-21,25,37H,4-5,10-14H2,1-3H3,(H,29,30,33)(H2,31,32,38)/t20?,21-,25? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336499
(US9744172, Compound UNC1343A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1NC(=O)N(C)C(C)=C1C(C)=O |r,wD:15.15,c:38,(-7.88,-3.77,;-6.55,-3,;-5.22,-3.77,;-3.88,-3,;-2.55,-3.77,;-1.22,-3,;-1.22,-1.46,;.12,-.69,;1.45,-1.46,;2.92,-.99,;3.82,-2.23,;2.92,-3.48,;3.31,-4.96,;4.8,-5.36,;5.2,-6.85,;4.11,-7.94,;4.51,-9.43,;2.62,-7.54,;2.23,-6.05,;1.45,-3,;.12,-3.77,;3.31,.5,;4.8,.9,;5.2,2.39,;4.11,3.48,;2.62,3.08,;2.23,1.59,;4.51,4.96,;6,5.36,;6.4,6.85,;7.88,7.25,;5.31,7.94,;5.71,9.43,;3.82,7.54,;2.73,8.63,;3.42,6.05,;1.93,5.66,;.85,6.74,;1.54,4.17,)| Show InChI InChI=1S/C29H37N7O3/c1-5-6-15-30-28-31-16-23-25(34-36(27(23)33-28)21-11-13-22(38)14-12-21)19-7-9-20(10-8-19)26-24(18(3)37)17(2)35(4)29(39)32-26/h7-10,16,21-22,26,38H,5-6,11-15H2,1-4H3,(H,32,39)(H,30,31,33)/t21?,22-,26? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336500
(US9744172, Compound UNC1344A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1NC(=O)NC(CC)=C1C(=O)OC |r,wD:15.15,c:38,(-7.88,-4.12,;-6.55,-3.35,;-5.22,-4.12,;-3.88,-3.35,;-2.55,-4.12,;-1.22,-3.35,;-1.22,-1.81,;.12,-1.04,;1.45,-1.81,;2.92,-1.33,;3.82,-2.58,;2.92,-3.82,;3.31,-5.31,;4.8,-5.71,;5.2,-7.2,;4.11,-8.29,;4.51,-9.77,;2.62,-7.89,;2.23,-6.4,;1.45,-3.35,;.12,-4.12,;3.31,.16,;4.8,.56,;5.2,2.04,;4.11,3.13,;2.62,2.73,;2.23,1.25,;4.51,4.62,;6,5.02,;6.4,6.51,;7.88,6.9,;5.31,7.59,;3.82,7.2,;2.73,8.29,;3.13,9.77,;3.42,5.71,;1.93,5.31,;1.54,3.82,;.85,6.4,;-.64,6,)| Show InChI InChI=1S/C29H37N7O4/c1-4-6-15-30-28-31-16-21-24(35-36(26(21)34-28)19-11-13-20(37)14-12-19)17-7-9-18(10-8-17)25-23(27(38)40-3)22(5-2)32-29(39)33-25/h7-10,16,19-20,25,37H,4-6,11-15H2,1-3H3,(H,30,31,34)(H2,32,33,39)/t19?,20-,25? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336501
(US9744172, Compound UNC1345A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1NC(=O)NC(CC)=C1C(=O)OC |r,wU:15.15,c:38,(-7.88,-4.12,;-6.55,-3.35,;-5.22,-4.12,;-3.88,-3.35,;-2.55,-4.12,;-1.22,-3.35,;-1.22,-1.81,;.12,-1.04,;1.45,-1.81,;2.92,-1.33,;3.82,-2.58,;2.92,-3.82,;3.31,-5.31,;2.23,-6.4,;2.62,-7.89,;4.11,-8.29,;4.51,-9.77,;5.2,-7.2,;4.8,-5.71,;1.45,-3.35,;.12,-4.12,;3.31,.16,;4.8,.56,;5.2,2.04,;4.11,3.13,;2.62,2.73,;2.23,1.25,;4.51,4.62,;6,5.02,;6.4,6.51,;7.88,6.9,;5.31,7.59,;3.82,7.2,;2.73,8.29,;3.13,9.77,;3.42,5.71,;1.93,5.31,;1.54,3.82,;.85,6.4,;-.64,6,)| Show InChI InChI=1S/C29H37N7O4/c1-4-6-15-30-28-31-16-21-24(35-36(26(21)34-28)19-11-13-20(37)14-12-19)17-7-9-18(10-8-17)25-23(27(38)40-3)22(5-2)32-29(39)33-25/h7-10,16,19-20,25,37H,4-6,11-15H2,1-3H3,(H,30,31,34)(H2,32,33,39)/t19?,20-,25? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336502
(US9744172, Compound UNC1346A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1NC(=O)N(C)C(CC)=C1C(=O)OC |r,wD:15.15,c:39,(-7.88,-4.12,;-6.55,-3.35,;-5.22,-4.12,;-3.88,-3.35,;-2.55,-4.12,;-1.22,-3.35,;-1.22,-1.81,;.12,-1.04,;1.45,-1.81,;2.92,-1.33,;3.82,-2.58,;2.92,-3.82,;3.31,-5.31,;4.8,-5.71,;5.2,-7.2,;4.11,-8.29,;4.51,-9.77,;2.62,-7.89,;2.23,-6.4,;1.45,-3.35,;.12,-4.12,;3.31,.16,;4.8,.56,;5.2,2.04,;4.11,3.13,;2.62,2.73,;2.23,1.25,;4.51,4.62,;6,5.02,;6.4,6.51,;7.88,6.9,;5.31,7.59,;5.71,9.08,;3.82,7.2,;2.73,8.29,;3.13,9.77,;3.42,5.71,;1.93,5.31,;1.54,3.82,;.85,6.4,;-.64,6,)| Show InChI InChI=1S/C30H39N7O4/c1-5-7-16-31-29-32-17-22-25(35-37(27(22)34-29)20-12-14-21(38)15-13-20)18-8-10-19(11-9-18)26-24(28(39)41-4)23(6-2)36(3)30(40)33-26/h8-11,17,20-21,26,38H,5-7,12-16H2,1-4H3,(H,33,40)(H,31,32,34)/t20?,21-,26? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336503
(US9744172, Compound UNC1347A)Show SMILES CCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1NC(=O)N(C)C(CC)=C1C(=O)OC |r,wU:14.14,c:38,(-7.22,-3.35,;-5.88,-4.12,;-4.55,-3.35,;-3.22,-4.12,;-1.88,-3.35,;-1.88,-1.81,;-.55,-1.04,;.78,-1.81,;2.25,-1.33,;3.15,-2.58,;2.25,-3.82,;2.65,-5.31,;1.56,-6.4,;1.96,-7.89,;3.45,-8.29,;3.84,-9.77,;4.53,-7.2,;4.14,-5.71,;.78,-3.35,;-.55,-4.12,;2.65,.16,;4.14,.56,;4.53,2.04,;3.45,3.13,;1.96,2.73,;1.56,1.25,;3.84,4.62,;5.33,5.02,;5.73,6.51,;7.22,6.9,;4.64,7.59,;5.04,9.08,;3.15,7.2,;2.06,8.29,;2.46,9.77,;2.75,5.71,;1.27,5.31,;.87,3.82,;.18,6.4,;-1.31,6,)| Show InChI InChI=1S/C29H37N7O4/c1-5-15-30-28-31-16-21-24(34-36(26(21)33-28)19-11-13-20(37)14-12-19)17-7-9-18(10-8-17)25-23(27(38)40-4)22(6-2)35(3)29(39)32-25/h7-10,16,19-20,25,37H,5-6,11-15H2,1-4H3,(H,32,39)(H,30,31,33)/t19?,20-,25? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336504
(US9744172, Compound UNC1348A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1NC(=O)NC(C)=C1C(=O)OC |r,wD:15.15,c:37,(-7.88,-3.37,;-6.55,-2.6,;-5.22,-3.37,;-3.88,-2.6,;-2.55,-3.37,;-1.22,-2.6,;-1.22,-1.06,;.12,-.29,;1.45,-1.06,;2.92,-.59,;3.82,-1.83,;2.92,-3.08,;3.31,-4.57,;4.8,-4.96,;5.2,-6.45,;4.11,-7.54,;4.51,-9.03,;2.62,-7.14,;2.23,-5.66,;1.45,-2.6,;.12,-3.37,;3.31,.9,;4.8,1.3,;5.2,2.79,;4.11,3.88,;2.62,3.48,;2.23,1.99,;4.51,5.36,;6,5.76,;6.4,7.25,;7.88,7.65,;5.31,8.34,;3.82,7.94,;2.73,9.03,;3.42,6.45,;1.93,6.05,;1.54,4.57,;.85,7.14,;-.64,6.74,)| Show InChI InChI=1S/C28H35N7O4/c1-4-5-14-29-27-30-15-21-23(34-35(25(21)33-27)19-10-12-20(36)13-11-19)17-6-8-18(9-7-17)24-22(26(37)39-3)16(2)31-28(38)32-24/h6-9,15,19-20,24,36H,4-5,10-14H2,1-3H3,(H,29,30,33)(H2,31,32,38)/t19?,20-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336505
(US9744172, Compound UNC1349A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1NC(=O)NC(C)=C1C(=O)OC |r,wU:15.15,c:37,(-7.88,-3.37,;-6.55,-2.6,;-5.22,-3.37,;-3.88,-2.6,;-2.55,-3.37,;-1.22,-2.6,;-1.22,-1.06,;.12,-.29,;1.45,-1.06,;2.92,-.59,;3.82,-1.83,;2.92,-3.08,;3.31,-4.57,;2.23,-5.66,;2.62,-7.14,;4.11,-7.54,;4.51,-9.03,;5.2,-6.45,;4.8,-4.96,;1.45,-2.6,;.12,-3.37,;3.31,.9,;4.8,1.3,;5.2,2.79,;4.11,3.88,;2.62,3.48,;2.23,1.99,;4.51,5.36,;6,5.76,;6.4,7.25,;7.88,7.65,;5.31,8.34,;3.82,7.94,;2.73,9.03,;3.42,6.45,;1.93,6.05,;1.54,4.57,;.85,7.14,;-.64,6.74,)| Show InChI InChI=1S/C28H35N7O4/c1-4-5-14-29-27-30-15-21-23(34-35(25(21)33-27)19-10-12-20(36)13-11-19)17-6-8-18(9-7-17)24-22(26(37)39-3)16(2)31-28(38)32-24/h6-9,15,19-20,24,36H,4-5,10-14H2,1-3H3,(H,29,30,33)(H2,31,32,38)/t19?,20-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336506
(US9744172, Compound UNC1350A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C(=O)N[C@@H](C(C)C)C(=O)Nc1ccc(F)cc1 |r,wU:30.33,wD:15.15,(-11.06,-4.57,;-9.72,-3.8,;-8.39,-4.57,;-7.06,-3.8,;-5.72,-4.57,;-4.39,-3.8,;-4.39,-2.26,;-3.06,-1.49,;-1.72,-2.26,;-.26,-1.78,;.65,-3.03,;-.26,-4.27,;.14,-5.76,;1.63,-6.16,;2.03,-7.65,;.94,-8.74,;1.34,-10.22,;-.55,-8.34,;-.95,-6.85,;-1.72,-3.8,;-3.06,-4.57,;.14,-.3,;1.63,.1,;2.03,1.59,;.94,2.68,;-.55,2.28,;-.95,.79,;1.34,4.17,;.25,5.26,;2.82,4.57,;3.22,6.05,;2.13,7.14,;.65,6.74,;2.53,8.63,;4.71,6.45,;5.8,5.36,;5.11,7.94,;6.6,8.34,;7.68,7.25,;9.17,7.65,;9.57,9.14,;11.06,9.53,;8.48,10.22,;6.99,9.83,)| Show InChI InChI=1S/C33H40FN7O3/c1-4-5-18-35-33-36-19-27-29(40-41(30(27)39-33)25-14-16-26(42)17-15-25)21-6-8-22(9-7-21)31(43)38-28(20(2)3)32(44)37-24-12-10-23(34)11-13-24/h6-13,19-20,25-26,28,42H,4-5,14-18H2,1-3H3,(H,37,44)(H,38,43)(H,35,36,39)/t25?,26-,28-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336507
(US9744172, Compound UNC1351A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C(=O)N[C@@H](C(C)C)C(=O)Nc1ccc(F)cc1 |r,wU:15.15,30.33,(-11.06,-4.57,;-9.72,-3.8,;-8.39,-4.57,;-7.06,-3.8,;-5.72,-4.57,;-4.39,-3.8,;-4.39,-2.26,;-3.06,-1.49,;-1.72,-2.26,;-.26,-1.78,;.65,-3.03,;-.26,-4.27,;.14,-5.76,;-.95,-6.85,;-.55,-8.34,;.94,-8.74,;1.34,-10.22,;2.03,-7.65,;1.63,-6.16,;-1.72,-3.8,;-3.06,-4.57,;.14,-.3,;1.63,.1,;2.03,1.59,;.94,2.68,;-.55,2.28,;-.95,.79,;1.34,4.17,;.25,5.26,;2.82,4.57,;3.22,6.05,;2.13,7.14,;.65,6.74,;2.53,8.63,;4.71,6.45,;5.8,5.36,;5.11,7.94,;6.6,8.34,;7.68,7.25,;9.17,7.65,;9.57,9.14,;11.06,9.53,;8.48,10.22,;6.99,9.83,)| Show InChI InChI=1S/C33H40FN7O3/c1-4-5-18-35-33-36-19-27-29(40-41(30(27)39-33)25-14-16-26(42)17-15-25)21-6-8-22(9-7-21)31(43)38-28(20(2)3)32(44)37-24-12-10-23(34)11-13-24/h6-13,19-20,25-26,28,42H,4-5,14-18H2,1-3H3,(H,37,44)(H,38,43)(H,35,36,39)/t25?,26-,28-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336508
(US9744172, Compound UNC1288A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCN(CCO)CC1 |r,wD:15.15,(-8.28,-4.71,;-6.95,-3.94,;-5.62,-4.71,;-4.28,-3.94,;-2.95,-4.71,;-1.61,-3.94,;-1.61,-2.4,;-.28,-1.63,;1.05,-2.4,;2.52,-1.93,;3.42,-3.17,;2.52,-4.42,;2.92,-5.91,;4.4,-6.31,;4.8,-7.79,;3.71,-8.88,;4.11,-10.37,;2.23,-8.48,;1.83,-7,;1.05,-3.94,;-.28,-4.71,;2.92,-.44,;4.4,-.04,;4.8,1.45,;3.71,2.53,;2.23,2.14,;1.83,.65,;4.11,4.02,;2.62,4.42,;5.6,3.62,;4.51,5.51,;6,5.91,;6.4,7.4,;5.31,8.48,;5.71,9.97,;7.19,10.37,;8.28,9.28,;3.82,8.09,;3.42,6.6,)| Show InChI InChI=1S/C27H39N7O4S/c1-2-3-12-28-27-29-19-24-25(31-34(26(24)30-27)21-6-8-22(36)9-7-21)20-4-10-23(11-5-20)39(37,38)33-15-13-32(14-16-33)17-18-35/h4-5,10-11,19,21-22,35-36H,2-3,6-9,12-18H2,1H3,(H,28,29,30)/t21?,22- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336509
(US9744172, Compound UNC1227A)Show SMILES CCCCNc1ncc2c(nn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCO |r,wU:12.11,wD:15.15,(-6.94,-4.12,;-5.61,-3.35,;-4.27,-4.12,;-2.94,-3.35,;-1.61,-4.12,;-.27,-3.35,;-.27,-1.81,;1.06,-1.04,;2.39,-1.81,;3.86,-1.33,;4.76,-2.58,;3.86,-3.82,;4.26,-5.31,;5.75,-5.71,;6.14,-7.2,;5.05,-8.29,;5.45,-9.77,;3.57,-7.89,;3.17,-6.4,;2.39,-3.35,;1.06,-4.12,;4.26,.16,;5.75,.56,;6.14,2.04,;5.05,3.13,;3.57,2.73,;3.17,1.25,;5.45,4.62,;3.97,5.02,;6.94,4.22,;5.85,6.11,;4.76,7.2,;5.16,8.68,;4.07,9.77,)| Show InChI InChI=1S/C23H32N6O4S/c1-2-3-12-24-23-25-15-20-21(16-4-10-19(11-5-16)34(32,33)26-13-14-30)28-29(22(20)27-23)17-6-8-18(31)9-7-17/h4-5,10-11,15,17-18,26,30-31H,2-3,6-9,12-14H2,1H3,(H,24,25,27)/t17-,18- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336510
(US9744172, Compound UNC1228A)Show SMILES CCCCNc1ncc2c(nn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC[C@H](O)CO |r,wU:12.11,32.36,wD:15.15,(-6.94,-4.86,;-5.61,-4.09,;-4.27,-4.86,;-2.94,-4.09,;-1.61,-4.86,;-.27,-4.09,;-.27,-2.55,;1.06,-1.78,;2.39,-2.55,;3.86,-2.07,;4.76,-3.32,;3.86,-4.57,;4.26,-6.05,;5.75,-6.45,;6.14,-7.94,;5.05,-9.03,;5.45,-10.52,;3.57,-8.63,;3.17,-7.14,;2.39,-4.09,;1.06,-4.86,;4.26,-.59,;5.75,-.19,;6.14,1.3,;5.05,2.39,;3.57,1.99,;3.17,.5,;5.45,3.88,;3.97,4.27,;6.94,3.48,;5.85,5.36,;4.76,6.45,;5.16,7.94,;6.65,8.34,;4.07,9.03,;4.47,10.52,)| Show InChI InChI=1S/C24H34N6O5S/c1-2-3-12-25-24-26-14-21-22(29-30(23(21)28-24)17-6-8-18(32)9-7-17)16-4-10-20(11-5-16)36(34,35)27-13-19(33)15-31/h4-5,10-11,14,17-19,27,31-33H,2-3,6-9,12-13,15H2,1H3,(H,25,26,28)/t17-,18-,19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336511
(US9744172, Compound UNC1229A)Show SMILES CCCCNc1ncc2c(nn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC[C@@H](O)CO |r,wU:12.11,wD:15.15,32.36,(-6.94,-4.86,;-5.61,-4.09,;-4.27,-4.86,;-2.94,-4.09,;-1.61,-4.86,;-.27,-4.09,;-.27,-2.55,;1.06,-1.78,;2.39,-2.55,;3.86,-2.07,;4.76,-3.32,;3.86,-4.57,;4.26,-6.05,;5.75,-6.45,;6.14,-7.94,;5.05,-9.03,;5.45,-10.52,;3.57,-8.63,;3.17,-7.14,;2.39,-4.09,;1.06,-4.86,;4.26,-.59,;5.75,-.19,;6.14,1.3,;5.05,2.39,;3.57,1.99,;3.17,.5,;5.45,3.88,;3.97,4.27,;6.94,3.48,;5.85,5.36,;4.76,6.45,;5.16,7.94,;6.65,8.34,;4.07,9.03,;4.47,10.52,)| Show InChI InChI=1S/C24H34N6O5S/c1-2-3-12-25-24-26-14-21-22(29-30(23(21)28-24)17-6-8-18(32)9-7-17)16-4-10-20(11-5-16)36(34,35)27-13-19(33)15-31/h4-5,10-11,14,17-19,27,31-33H,2-3,6-9,12-13,15H2,1H3,(H,25,26,28)/t17-,18-,19-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336512
(US9744172, Compound UNC1285A)Show SMILES CCCCNc1ncc2c(nn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(N2CCN(CC)CC2)c(F)c1 |r,wU:12.11,wD:15.15,(-7.29,-4.32,;-5.95,-3.55,;-4.62,-4.32,;-3.29,-3.55,;-1.95,-4.32,;-.62,-3.55,;-.62,-2.01,;.72,-1.24,;2.05,-2.01,;3.51,-1.53,;4.42,-2.78,;3.51,-4.02,;3.91,-5.51,;5.4,-5.91,;5.8,-7.4,;4.71,-8.48,;5.11,-9.97,;3.22,-8.09,;2.82,-6.6,;2.05,-3.55,;.72,-4.32,;3.91,-.04,;2.82,1.05,;3.22,2.53,;4.71,2.93,;5.11,4.42,;6.6,4.82,;6.99,6.31,;5.91,7.4,;6.3,8.88,;5.22,9.97,;4.42,7,;4.02,5.51,;5.8,1.84,;7.29,2.24,;5.4,.36,)| Show InChI InChI=1S/C27H38FN7O/c1-3-5-12-29-27-30-18-22-25(32-35(26(22)31-27)20-7-9-21(36)10-8-20)19-6-11-24(23(28)17-19)34-15-13-33(4-2)14-16-34/h6,11,17-18,20-21,36H,3-5,7-10,12-16H2,1-2H3,(H,29,30,31)/t20-,21- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336514
(US9744172, Compound UNC1287A)Show SMILES CCCCNc1ncc2c(nn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(N2CCNCC2)c(F)c1 |r,wU:12.11,wD:15.15,(-7.29,-3.03,;-5.95,-2.26,;-4.62,-3.03,;-3.29,-2.26,;-1.95,-3.03,;-.62,-2.26,;-.62,-.72,;.72,.05,;2.05,-.72,;3.51,-.24,;4.42,-1.49,;3.51,-2.73,;3.91,-4.22,;5.4,-4.62,;5.8,-6.11,;4.71,-7.2,;5.11,-8.68,;3.22,-6.8,;2.82,-5.31,;2.05,-2.26,;.72,-3.03,;3.91,1.25,;2.82,2.33,;3.22,3.82,;4.71,4.22,;5.11,5.71,;6.6,6.11,;6.99,7.59,;5.91,8.68,;4.42,8.29,;4.02,6.8,;5.8,3.13,;7.29,3.53,;5.4,1.64,)| Show InChI InChI=1S/C25H34FN7O/c1-2-3-10-28-25-29-16-20-23(31-33(24(20)30-25)18-5-7-19(34)8-6-18)17-4-9-22(21(26)15-17)32-13-11-27-12-14-32/h4,9,15-16,18-19,27,34H,2-3,5-8,10-14H2,1H3,(H,28,29,30)/t18-,19- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
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