Reaction Details | |||
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Target | Tyrosine-protein kinase Mer | ||
Ligand | BDBM336512 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
IC50 | <10±n/a nM | ||
Citation | Wang, X; Liu, J; Yang, C; Zhang, W; Frye, S; Kireev, D Pyrazolopyrimidine compounds for the treatment of cancer US Patent US9744172 Publication Date 8/29/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase Mer | |||
Name: | Tyrosine-protein kinase Mer | ||
Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
Type: | PROTEIN | ||
Mol. Mass.: | 110234.77 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1498723 | ||
Residue: | 999 | ||
Sequence: |
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BDBM336512 | |||
n/a | |||
Name | BDBM336512 | ||
Synonyms: | US9744172, Compound UNC1285A | ||
Type | Small organic molecule | ||
Emp. Form. | C27H38FN7O | ||
Mol. Mass. | 495.6353 | ||
SMILES | CCCCNc1ncc2c(nn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(N2CCN(CC)CC2)c(F)c1 |r,wU:12.11,wD:15.15,(-7.29,-4.32,;-5.95,-3.55,;-4.62,-4.32,;-3.29,-3.55,;-1.95,-4.32,;-.62,-3.55,;-.62,-2.01,;.72,-1.24,;2.05,-2.01,;3.51,-1.53,;4.42,-2.78,;3.51,-4.02,;3.91,-5.51,;5.4,-5.91,;5.8,-7.4,;4.71,-8.48,;5.11,-9.97,;3.22,-8.09,;2.82,-6.6,;2.05,-3.55,;.72,-4.32,;3.91,-.04,;2.82,1.05,;3.22,2.53,;4.71,2.93,;5.11,4.42,;6.6,4.82,;6.99,6.31,;5.91,7.4,;6.3,8.88,;5.22,9.97,;4.42,7,;4.02,5.51,;5.8,1.84,;7.29,2.24,;5.4,.36,)| | ||
Structure |