Compile Data Set for Download or QSAR

Found 91 hits Enz. Inhib. hit(s) with all data for entry = 2135   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287008 (8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...) Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCOC3CN(C3)C(=O)C=C)c2n1 |(-6.94,-1.38,;-6.94,.16,;-5.61,.93,;-5.61,2.47,;-4.28,3.24,;-2.94,2.47,;-1.61,3.24,;-.28,2.47,;1.06,3.24,;1.06,4.78,;-.28,5.55,;2.39,5.55,;2.39,7.09,;1.06,7.86,;3.72,4.78,;3.72,3.24,;5.06,2.47,;6.39,3.24,;2.39,2.47,;2.39,.93,;-.28,.93,;1.06,.16,;-1.61,.16,;-1.61,-1.38,;-.28,-2.15,;-.28,-3.69,;1.06,-4.46,;1.46,-5.95,;2.94,-5.55,;2.55,-4.06,;4.28,-6.32,;4.28,-7.86,;5.61,-5.55,;6.94,-6.32,;-2.94,.93,;-4.28,.16,)| Show InChI InChI=1S/C24H25Cl2N5O5/c1-5-18(32)30-11-14(12-30)36-7-6-31-22-13(10-28-24(27-2)29-22)8-15(23(31)33)19-20(25)16(34-3)9-17(35-4)21(19)26/h5,8-10,14H,1,6-7,11-12H2,2-4H3,(H,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287520 (8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)ethyl...) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N)nc2n(CCN(C)C2CN(C2)C(=O)C=C)c1=O |(3.72,7.86,;2.39,7.09,;2.39,5.55,;3.72,4.78,;3.72,3.24,;5.06,2.47,;6.39,3.24,;2.39,2.47,;2.39,.93,;1.06,3.24,;1.06,4.78,;-.28,5.55,;-.28,2.47,;-1.61,3.24,;-2.94,2.47,;-4.28,3.24,;-5.61,2.47,;-5.61,.93,;-6.94,.16,;-4.28,.16,;-2.94,.93,;-1.61,.16,;-1.61,-1.38,;-.28,-2.15,;-.28,-3.69,;-1.61,-4.46,;1.06,-4.46,;1.46,-5.95,;2.94,-5.55,;2.55,-4.06,;4.28,-6.32,;4.28,-7.86,;5.61,-5.55,;6.94,-6.32,;-.28,.93,;1.06,.16,)| Show InChI InChI=1S/C24H26Cl2N6O4/c1-5-18(33)31-11-14(12-31)30(2)6-7-32-22-13(10-28-24(27)29-22)8-15(23(32)34)19-20(25)16(35-3)9-17(36-4)21(19)26/h5,8-10,14H,1,6-7,11-12H2,2-4H3,(H2,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287526 ((R)-8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)e...) Show SMILES COC[C@@H](C)Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN(C)C3CN(C3)C(=O)C=C)c2n1 |r,wD:3.3,(-8.28,-4.46,;-6.94,-3.69,;-6.94,-2.15,;-5.61,-1.38,;-4.28,-2.15,;-5.61,.16,;-4.28,.93,;-4.28,2.47,;-2.94,3.24,;-1.61,2.47,;-.28,3.24,;1.06,2.47,;2.39,3.24,;2.39,4.78,;1.06,5.55,;3.72,5.55,;3.72,7.09,;5.06,7.86,;5.06,4.78,;5.06,3.24,;6.39,2.47,;7.73,3.24,;3.72,2.47,;3.72,.93,;1.06,.93,;2.39,.16,;-.28,.16,;-.28,-1.38,;1.06,-2.15,;1.06,-3.69,;-.28,-4.46,;2.39,-4.46,;2.79,-5.95,;4.28,-5.55,;3.88,-4.06,;5.61,-6.32,;5.61,-7.86,;6.94,-5.55,;8.28,-6.32,;-1.61,.93,;-2.94,.16,)| Show InChI InChI=1S/C28H34Cl2N6O5/c1-7-22(37)35-13-18(14-35)34(3)8-9-36-26-17(12-31-28(33-26)32-16(2)15-39-4)10-19(27(36)38)23-24(29)20(40-5)11-21(41-6)25(23)30/h7,10-12,16,18H,1,8-9,13-15H2,2-6H3,(H,31,32,33)/t16-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287005 (8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCCO)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(2,8.47,;3.33,7.7,;3.33,6.16,;4.67,5.39,;4.67,3.85,;6,3.08,;7.34,3.85,;3.33,3.08,;3.33,1.54,;2,3.85,;2,5.39,;.67,6.16,;.67,3.08,;-.67,3.85,;-2,3.08,;-3.33,3.85,;-4.67,3.08,;-4.67,1.54,;-6,.77,;-6,-.77,;-7.34,-1.54,;-7.34,-3.08,;-3.33,.77,;-2,1.54,;-.67,.77,;-.67,-.77,;.67,-1.54,;.67,-3.08,;2,-3.85,;2,-5.39,;3.33,-6.16,;4.67,-5.39,;4.67,-3.85,;3.33,-3.08,;6,-6.16,;7.34,-5.39,;6,-7.7,;7.34,-8.47,;.67,1.54,;2,.77,)| Show InChI InChI=1S/C27H32Cl2N6O5/c1-4-21(37)34-11-9-33(10-12-34)7-5-8-35-25-17(16-31-27(32-25)30-6-13-36)14-18(26(35)38)22-23(28)19(39-2)15-20(40-3)24(22)29/h4,14-16,36H,1,5-13H2,2-3H3,(H,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM286977 (8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...) Show SMILES CNc1ncc2cc(-c3cc(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1 Show InChI InChI=1S/C26H31ClN6O4/c1-5-22(34)32-11-9-31(10-12-32)7-6-8-33-24-17(16-29-26(28-2)30-24)13-20(25(33)35)19-14-18(36-3)15-21(37-4)23(19)27/h5,13-16H,1,6-12H2,2-4H3,(H,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM286388 (8-(2-(4-acryloylpiperazin-1-yl)ethyl)-6-(2,6-dichl...) Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN3CCN(CC3)C(=O)C=C)c2n1 |(-6.67,1.54,;-5.33,.77,;-4,1.54,;-4,3.08,;-2.67,3.85,;-1.33,3.08,;,3.85,;1.33,3.08,;2.67,3.85,;2.67,5.39,;1.33,6.16,;4,6.16,;4,7.7,;2.67,8.47,;5.33,5.39,;5.33,3.85,;6.67,3.08,;6.67,1.54,;4,3.08,;4,1.54,;1.33,1.54,;2.67,.77,;,.77,;,-.77,;1.33,-1.54,;1.33,-3.08,;,-3.85,;,-5.39,;1.33,-6.16,;2.67,-5.39,;2.67,-3.85,;1.33,-7.7,;,-8.47,;2.67,-8.47,;4,-7.7,;-1.33,1.54,;-2.67,.77,)| Show InChI InChI=1S/C25H28Cl2N6O4/c1-5-19(34)32-9-6-31(7-10-32)8-11-33-23-15(14-29-25(28-2)30-23)12-16(24(33)35)20-21(26)17(36-3)13-18(37-4)22(20)27/h5,12-14H,1,6-11H2,2-4H3,(H,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287538 (8-(2-((1-acryloylazetidin-3-yl)(2-methoxyethyl)ami...) Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN(CCOC)C3CN(C3)C(=O)C=C)c2n1 |(-6.94,-1.38,;-6.94,.16,;-5.61,.93,;-5.61,2.47,;-4.28,3.24,;-2.94,2.47,;-1.61,3.24,;-.28,2.47,;1.06,3.24,;1.06,4.78,;-.28,5.55,;2.39,5.55,;2.39,7.09,;3.72,7.86,;3.72,4.78,;3.72,3.24,;5.06,2.47,;6.39,3.24,;2.39,2.47,;2.39,.93,;-.28,.93,;1.06,.16,;-1.61,.16,;-1.61,-1.38,;-.28,-2.15,;-.28,-3.69,;-1.61,-4.46,;-2.94,-3.69,;-4.28,-4.46,;-5.61,-3.69,;1.06,-4.46,;1.46,-5.95,;2.94,-5.55,;2.55,-4.06,;4.28,-6.32,;4.28,-7.86,;5.61,-5.55,;6.94,-6.32,;-2.94,.93,;-4.28,.16,)| Show InChI InChI=1S/C27H32Cl2N6O5/c1-6-21(36)34-14-17(15-34)33(9-10-38-3)7-8-35-25-16(13-31-27(30-2)32-25)11-18(26(35)37)22-23(28)19(39-4)12-20(40-5)24(22)29/h6,11-13,17H,1,7-10,14-15H2,2-5H3,(H,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287508 (8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)ethyl...) Show SMILES CCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN(C)C3CN(C3)C(=O)C=C)c2n1 |(-7.61,-2.15,;-6.28,-1.38,;-6.28,.16,;-4.94,.93,;-4.94,2.47,;-3.61,3.24,;-2.28,2.47,;-.94,3.24,;.39,2.47,;1.72,3.24,;1.72,4.78,;.39,5.55,;3.06,5.55,;3.06,7.09,;4.39,7.86,;4.39,4.78,;4.39,3.24,;5.73,2.47,;7.06,3.24,;3.06,2.47,;3.06,.93,;.39,.93,;1.72,.16,;-.94,.16,;-.94,-1.38,;.39,-2.15,;.39,-3.69,;-.94,-4.46,;1.72,-4.46,;2.12,-5.95,;3.61,-5.55,;3.21,-4.06,;4.94,-6.32,;4.94,-7.86,;6.28,-5.55,;7.61,-6.32,;-2.28,.93,;-3.61,.16,)| Show InChI InChI=1S/C26H30Cl2N6O4/c1-6-20(35)33-13-16(14-33)32(3)8-9-34-24-15(12-30-26(31-24)29-7-2)10-17(25(34)36)21-22(27)18(37-4)11-19(38-5)23(21)28/h6,10-12,16H,1,7-9,13-14H2,2-5H3,(H,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM286978 (8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...) Show SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(NCC(C)(C)O)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O Show InChI InChI=1S/C29H37ClN6O5/c1-6-24(37)35-12-10-34(11-13-35)8-7-9-36-26-19(17-31-28(33-26)32-18-29(2,3)39)14-22(27(36)38)21-15-20(40-4)16-23(41-5)25(21)30/h6,14-17,39H,1,7-13,18H2,2-5H3,(H,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287541 (8-(2-((1-acryloylazetidin-3-yl)(2-methoxyethyl)ami...) Show SMILES CCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN(CCOC)C3CN(C3)C(=O)C=C)c2n1 |(-7.61,-2.15,;-6.28,-1.38,;-6.28,.16,;-4.94,.93,;-4.94,2.47,;-3.61,3.24,;-2.28,2.47,;-.94,3.24,;.39,2.47,;1.72,3.24,;1.72,4.78,;.39,5.55,;3.06,5.55,;3.06,7.09,;4.39,7.86,;4.39,4.78,;4.39,3.24,;5.73,2.47,;7.06,3.24,;3.06,2.47,;3.06,.93,;.39,.93,;1.72,.16,;-.94,.16,;-.94,-1.38,;.39,-2.15,;.39,-3.69,;-.94,-4.46,;-2.28,-3.69,;-3.61,-4.46,;-4.94,-3.69,;1.72,-4.46,;2.12,-5.95,;3.61,-5.55,;3.21,-4.06,;4.94,-6.32,;4.94,-7.86,;6.28,-5.55,;7.61,-6.32,;-2.28,.93,;-3.61,.16,)| Show InChI InChI=1S/C28H34Cl2N6O5/c1-6-22(37)35-15-18(16-35)34(10-11-39-3)8-9-36-26-17(14-32-28(33-26)31-7-2)12-19(27(36)38)23-24(29)20(40-4)13-21(41-5)25(23)30/h6,12-14,18H,1,7-11,15-16H2,2-5H3,(H,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM286998 (8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...) Show SMILES CCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1 |(-7.34,-1.54,;-6,-.77,;-6,.77,;-4.67,1.54,;-4.67,3.08,;-3.33,3.85,;-2,3.08,;-.67,3.85,;.67,3.08,;2,3.85,;2,5.39,;.67,6.16,;3.33,6.16,;3.33,7.7,;2,8.47,;4.67,5.39,;4.67,3.85,;6,3.08,;7.34,3.85,;3.33,3.08,;3.33,1.54,;.67,1.54,;2,.77,;-.67,.77,;-.67,-.77,;.67,-1.54,;.67,-3.08,;2,-3.85,;2,-5.39,;3.33,-6.16,;4.67,-5.39,;4.67,-3.85,;3.33,-3.08,;6,-6.16,;7.34,-5.39,;6,-7.7,;7.34,-8.47,;-2,1.54,;-3.33,.77,)| Show InChI InChI=1S/C27H32Cl2N6O4/c1-5-21(36)34-12-10-33(11-13-34)8-7-9-35-25-17(16-31-27(32-25)30-6-2)14-18(26(35)37)22-23(28)19(38-3)15-20(39-4)24(22)29/h5,14-16H,1,6-13H2,2-4H3,(H,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM286999 (8-((1-((4-acryloylpiperazin-1-yl)methyl)cyclopropy...) Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CC3(CN4CCN(CC4)C(=O)C=C)CC3)c2n1 |(-6.67,-.77,;-6.67,.77,;-5.33,1.54,;-5.33,3.08,;-4,3.85,;-2.67,3.08,;-1.33,3.85,;,3.08,;1.33,3.85,;1.33,5.39,;,6.16,;2.67,6.16,;2.67,7.7,;1.33,8.47,;4,5.39,;4,3.85,;5.33,3.08,;6.67,3.85,;2.67,3.08,;2.67,1.54,;,1.54,;1.33,.77,;-1.33,.77,;-1.33,-.77,;,-1.54,;,-3.08,;1.33,-3.85,;1.33,-5.39,;2.67,-6.16,;4,-5.39,;4,-3.85,;2.67,-3.08,;5.33,-6.16,;6.67,-5.39,;5.33,-7.7,;6.67,-8.47,;1.54,-1.54,;.77,-.21,;-2.67,1.54,;-4,.77,)| Show InChI InChI=1S/C28H32Cl2N6O4/c1-5-21(37)35-10-8-34(9-11-35)15-28(6-7-28)16-36-25-17(14-32-27(31-2)33-25)12-18(26(36)38)22-23(29)19(39-3)13-20(40-4)24(22)30/h5,12-14H,1,6-11,15-16H2,2-4H3,(H,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287012 (8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NC3CCOCC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(2,8.47,;3.33,7.7,;3.33,6.16,;4.67,5.39,;4.67,3.85,;6,3.08,;7.34,3.85,;3.33,3.08,;3.33,1.54,;2,3.85,;2,5.39,;.67,6.16,;.67,3.08,;-.67,3.85,;-2,3.08,;-3.33,3.85,;-4.67,3.08,;-4.67,1.54,;-6,.77,;-6,-.77,;-7.34,-1.54,;-7.34,-3.08,;-6,-3.85,;-4.67,-3.08,;-4.67,-1.54,;-3.33,.77,;-2,1.54,;-.67,.77,;-.67,-.77,;.67,-1.54,;.67,-3.08,;2,-3.85,;2,-5.39,;3.33,-6.16,;4.67,-5.39,;4.67,-3.85,;3.33,-3.08,;6,-6.16,;7.34,-5.39,;6,-7.7,;7.34,-8.47,;.67,1.54,;2,.77,)| Show InChI InChI=1S/C30H36Cl2N6O5/c1-4-24(39)37-12-10-36(11-13-37)8-5-9-38-28-19(18-33-30(35-28)34-20-6-14-43-15-7-20)16-21(29(38)40)25-26(31)22(41-2)17-23(42-3)27(25)32/h4,16-18,20H,1,5-15H2,2-3H3,(H,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287018 ((S)-8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-...) Show SMILES COC[C@H](C)Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1 |r,wU:3.3,(-8,-3.85,;-6.67,-3.08,;-6.67,-1.54,;-5.33,-.77,;-4,-1.54,;-5.33,.77,;-4,1.54,;-4,3.08,;-2.67,3.85,;-1.33,3.08,;,3.85,;1.33,3.08,;2.67,3.85,;2.67,5.39,;1.33,6.16,;4,6.16,;4,7.7,;2.67,8.47,;5.33,5.39,;5.33,3.85,;6.67,3.08,;8,3.85,;4,3.08,;4,1.54,;1.33,1.54,;2.67,.77,;,.77,;,-.77,;1.33,-1.54,;1.33,-3.08,;2.67,-3.85,;2.67,-5.39,;4,-6.16,;5.33,-5.39,;5.33,-3.85,;4,-3.08,;6.67,-6.16,;8,-5.39,;6.67,-7.7,;8,-8.47,;-1.33,1.54,;-2.67,.77,)| Show InChI InChI=1S/C29H36Cl2N6O5/c1-6-23(38)36-12-10-35(11-13-36)8-7-9-37-27-19(16-32-29(34-27)33-18(2)17-40-3)14-20(28(37)39)24-25(30)21(41-4)15-22(42-5)26(24)31/h6,14-16,18H,1,7-13,17H2,2-5H3,(H,32,33,34)/t18-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM286995 (8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(Nc3ccccc3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(2,8.47,;3.33,7.7,;3.33,6.16,;4.67,5.39,;4.67,3.85,;6,3.08,;7.34,3.85,;3.33,3.08,;3.33,1.54,;2,3.85,;2,5.39,;.67,6.16,;.67,3.08,;-.67,3.85,;-2,3.08,;-3.33,3.85,;-4.67,3.08,;-4.67,1.54,;-6,.77,;-6,-.77,;-7.34,-1.54,;-7.34,-3.08,;-6,-3.85,;-4.67,-3.08,;-4.67,-1.54,;-3.33,.77,;-2,1.54,;-.67,.77,;-.67,-.77,;.67,-1.54,;.67,-3.08,;2,-3.85,;2,-5.39,;3.33,-6.16,;4.67,-5.39,;4.67,-3.85,;3.33,-3.08,;6,-6.16,;7.34,-5.39,;6,-7.7,;7.34,-8.47,;.67,1.54,;2,.77,)| Show InChI InChI=1S/C31H32Cl2N6O4/c1-4-25(40)38-15-13-37(14-16-38)11-8-12-39-29-20(19-34-31(36-29)35-21-9-6-5-7-10-21)17-22(30(39)41)26-27(32)23(42-2)18-24(43-3)28(26)33/h4-7,9-10,17-19H,1,8,11-16H2,2-3H3,(H,34,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287511 (8-(2-((1-acryloylazetidin-3-yl)(ethyl)amino)ethyl)...) Show SMILES CCN(CCn1c2nc(NC)ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)C1CN(C1)C(=O)C=C |(-1.61,-6,;-1.61,-4.46,;-.28,-3.69,;-.28,-2.15,;-1.61,-1.38,;-1.61,.16,;-2.94,.93,;-4.28,.16,;-5.61,.93,;-6.94,.16,;-6.94,-1.38,;-5.61,2.47,;-4.28,3.24,;-2.94,2.47,;-1.61,3.24,;-.28,2.47,;1.06,3.24,;1.06,4.78,;-.28,5.55,;2.39,5.55,;2.39,7.09,;3.72,7.86,;3.72,4.78,;3.72,3.24,;5.06,2.47,;6.39,3.24,;2.39,2.47,;2.39,.93,;-.28,.93,;1.06,.16,;1.06,-4.46,;1.46,-5.95,;2.94,-5.55,;2.55,-4.06,;4.28,-6.32,;4.28,-7.86,;5.61,-5.55,;6.94,-6.32,)| Show InChI InChI=1S/C26H30Cl2N6O4/c1-6-20(35)33-13-16(14-33)32(7-2)8-9-34-24-15(12-30-26(29-3)31-24)10-17(25(34)36)21-22(27)18(37-4)11-19(38-5)23(21)28/h6,10-12,16H,1,7-9,13-14H2,2-5H3,(H,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287542 (1-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-3-(2,6-d...) Show SMILES CNc1cc2n(CCOC3CN(C3)C(=O)C=C)c(=O)c(cc2cn1)-c1c(Cl)c(OC)cc(OC)c1Cl |(-6.94,-1.38,;-6.94,.16,;-5.61,.93,;-4.28,.16,;-2.94,.93,;-1.61,.16,;-1.61,-1.38,;-.28,-2.15,;-.28,-3.69,;1.06,-4.46,;1.46,-5.95,;2.94,-5.55,;2.55,-4.06,;4.28,-6.32,;4.28,-7.86,;5.61,-5.55,;6.94,-6.32,;-.28,.93,;1.06,.16,;-.28,2.47,;-1.61,3.24,;-2.94,2.47,;-4.28,3.24,;-5.61,2.47,;1.06,3.24,;1.06,4.78,;-.28,5.55,;2.39,5.55,;2.39,7.09,;3.72,7.86,;3.72,4.78,;3.72,3.24,;5.06,2.47,;6.39,3.24,;2.39,2.47,;2.39,.93,)| Show InChI InChI=1S/C25H26Cl2N4O5/c1-5-21(32)30-12-15(13-30)36-7-6-31-17-9-20(28-2)29-11-14(17)8-16(25(31)33)22-23(26)18(34-3)10-19(35-4)24(22)27/h5,8-11,15H,1,6-7,12-13H2,2-4H3,(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM286523 (8-(2-((1-acryloylpyrrolidin-3-yl)oxy)ethyl)-6-(2,6...) Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCOC3CCN(C3)C(=O)C=C)c2n1 |(-6.67,-.74,;-6.67,.8,;-5.33,1.57,;-5.33,3.11,;-4,3.88,;-2.67,3.11,;-1.33,3.88,;,3.11,;1.33,3.88,;1.33,5.42,;,6.19,;2.67,6.19,;2.67,7.73,;1.33,8.5,;4,5.42,;4,3.88,;5.33,3.11,;6.67,3.88,;2.67,3.11,;2.67,1.57,;,1.57,;1.33,.8,;-1.33,.8,;-1.33,-.74,;,-1.51,;,-3.05,;1.33,-3.82,;2.8,-3.34,;3.7,-4.59,;2.8,-5.83,;1.33,-5.36,;3.57,-7.17,;2.8,-8.5,;5.11,-7.17,;5.88,-8.5,;-2.67,1.57,;-4,.8,)| Show InChI InChI=1S/C25H27Cl2N5O5/c1-5-19(33)31-7-6-15(13-31)37-9-8-32-23-14(12-29-25(28-2)30-23)10-16(24(32)34)20-21(26)17(35-3)11-18(36-4)22(20)27/h5,10-12,15H,1,6-9,13H2,2-4H3,(H,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287007 (8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...) Show SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(NC3CCOCC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O Show InChI InChI=1S/C30H37ClN6O5/c1-4-26(38)36-12-10-35(11-13-36)8-5-9-37-28-20(19-32-30(34-28)33-21-6-14-42-15-7-21)16-24(29(37)39)23-17-22(40-2)18-25(41-3)27(23)31/h4,16-19,21H,1,5-15H2,2-3H3,(H,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287535 (8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)ethyl...) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCCN3CCOCC3)nc2n(CCN(C)C2CN(C2)C(=O)C=C)c1=O |(5.06,7.86,;3.72,7.09,;3.72,5.55,;5.06,4.78,;5.06,3.24,;6.39,2.47,;7.73,3.24,;3.72,2.47,;3.72,.93,;2.39,3.24,;2.39,4.78,;1.06,5.55,;1.06,2.47,;-.28,3.24,;-1.61,2.47,;-2.94,3.24,;-4.28,2.47,;-4.28,.93,;-5.61,.16,;-5.61,-1.38,;-6.94,-2.15,;-6.94,-3.69,;-8.28,-4.46,;-8.28,-6,;-6.94,-6.77,;-5.61,-6,;-5.61,-4.46,;-2.94,.16,;-1.61,.93,;-.28,.16,;-.28,-1.38,;1.06,-2.15,;1.06,-3.69,;-.28,-4.46,;2.39,-4.46,;2.79,-5.95,;4.28,-5.55,;3.88,-4.06,;5.61,-6.32,;5.61,-7.86,;6.94,-5.55,;8.28,-6.32,;1.06,.93,;2.39,.16,)| Show InChI InChI=1S/C30H37Cl2N7O5/c1-5-24(40)38-17-20(18-38)36(2)8-9-39-28-19(16-34-30(35-28)33-6-7-37-10-12-44-13-11-37)14-21(29(39)41)25-26(31)22(42-3)15-23(43-4)27(25)32/h5,14-16,20H,1,6-13,17-18H2,2-4H3,(H,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287001 (8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC(C)(C)O)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(2.67,8.47,;4,7.7,;4,6.16,;5.33,5.39,;5.33,3.85,;6.67,3.08,;8,3.85,;4,3.08,;4,1.54,;2.67,3.85,;2.67,5.39,;1.33,6.16,;1.33,3.08,;,3.85,;-1.33,3.08,;-2.67,3.85,;-4,3.08,;-4,1.54,;-5.33,.77,;-5.33,-.77,;-6.67,-1.54,;-8,-.77,;-8,-2.31,;-6.67,-3.08,;-2.67,.77,;-1.33,1.54,;,.77,;,-.77,;1.33,-1.54,;1.33,-3.08,;2.67,-3.85,;2.67,-5.39,;4,-6.16,;5.33,-5.39,;5.33,-3.85,;4,-3.08,;6.67,-6.16,;8,-5.39,;6.67,-7.7,;8,-8.47,;1.33,1.54,;2.67,.77,)| Show InChI InChI=1S/C29H36Cl2N6O5/c1-6-22(38)36-12-10-35(11-13-36)8-7-9-37-26-18(16-32-28(34-26)33-17-29(2,3)40)14-19(27(37)39)23-24(30)20(41-4)15-21(42-5)25(23)31/h6,14-16,40H,1,7-13,17H2,2-5H3,(H,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287002 (8-((1-((4-acryloylpiperazin-1-yl)methyl)cyclopropy...) Show SMILES CNc1ncc2cc(-c3cc(OC)cc(OC)c3Cl)c(=O)n(CC3(CN4CCN(CC4)C(=O)C=C)CC3)c2n1 Show InChI InChI=1S/C28H33ClN6O4/c1-5-23(36)34-10-8-33(9-11-34)16-28(6-7-28)17-35-25-18(15-31-27(30-2)32-25)12-21(26(35)37)20-13-19(38-3)14-22(39-4)24(20)29/h5,12-15H,1,6-11,16-17H2,2-4H3,(H,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM286984 (8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...) Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1 |(-6.67,-.77,;-6.67,.77,;-5.33,1.54,;-5.33,3.08,;-4,3.85,;-2.67,3.08,;-1.33,3.85,;,3.08,;1.33,3.85,;1.33,5.39,;,6.16,;2.67,6.16,;2.67,7.7,;1.33,8.47,;4,5.39,;4,3.85,;5.33,3.08,;6.67,3.85,;2.67,3.08,;2.67,1.54,;,1.54,;1.33,.77,;-1.33,.77,;-1.33,-.77,;,-1.54,;,-3.08,;1.33,-3.85,;1.33,-5.39,;2.67,-6.16,;4,-5.39,;4,-3.85,;2.67,-3.08,;5.33,-6.16,;6.67,-5.39,;5.33,-7.7,;6.67,-8.47,;-2.67,1.54,;-4,.77,)| Show InChI InChI=1S/C26H30Cl2N6O4/c1-5-20(35)33-11-9-32(10-12-33)7-6-8-34-24-16(15-30-26(29-2)31-24)13-17(25(34)36)21-22(27)18(37-3)14-19(38-4)23(21)28/h5,13-15H,1,6-12H2,2-4H3,(H,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287077 ((S)-8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-...) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N[C@@H](C)CO)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |r,wU:19.20,(4,8.09,;2.67,7.31,;2.67,5.78,;4,5,;4,3.46,;5.33,2.69,;6.67,3.46,;2.67,2.69,;2.67,1.15,;1.33,3.46,;1.33,5,;,5.77,;,2.69,;-1.33,3.46,;-2.67,2.69,;-4,3.46,;-5.33,2.69,;-5.33,1.15,;-6.67,.38,;-6.67,-1.16,;-5.33,-1.93,;-8,-1.93,;-8,-3.47,;-4,.38,;-2.67,1.15,;-1.33,.38,;-1.33,-1.16,;,-1.93,;,-3.47,;1.33,-4.24,;1.33,-5.78,;2.67,-6.55,;4,-5.78,;4,-4.24,;2.67,-3.47,;5.33,-6.55,;5.33,-8.09,;6.67,-5.78,;8,-6.55,;,1.15,;1.33,.38,)| Show InChI InChI=1S/C28H34Cl2N6O5/c1-5-22(38)35-11-9-34(10-12-35)7-6-8-36-26-18(15-31-28(33-26)32-17(2)16-37)13-19(27(36)39)23-24(29)20(40-3)14-21(41-4)25(23)30/h5,13-15,17,37H,1,6-12,16H2,2-4H3,(H,31,32,33)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM286391 (8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NC(C)C)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(2,8.47,;3.33,7.7,;3.33,6.16,;4.67,5.39,;4.67,3.85,;6,3.08,;7.34,3.85,;3.33,3.08,;3.33,1.54,;2,3.85,;2,5.39,;.67,6.16,;.67,3.08,;-.67,3.85,;-2,3.08,;-3.33,3.85,;-4.67,3.08,;-4.67,1.54,;-6,.77,;-6,-.77,;-7.34,-1.54,;-4.67,-1.54,;-3.33,.77,;-2,1.54,;-.67,.77,;-.67,-.77,;.67,-1.54,;.67,-3.08,;2,-3.85,;2,-5.39,;3.33,-6.16,;4.67,-5.39,;4.67,-3.85,;3.33,-3.08,;6,-6.16,;7.34,-5.39,;6,-7.7,;7.34,-8.47,;.67,1.54,;2,.77,)| Show InChI InChI=1S/C28H34Cl2N6O4/c1-6-22(37)35-12-10-34(11-13-35)8-7-9-36-26-18(16-31-28(33-26)32-17(2)3)14-19(27(36)38)23-24(29)20(39-4)15-21(40-5)25(23)30/h6,14-17H,1,7-13H2,2-5H3,(H,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287039 (8-(3-(4-acryloylpiperazin-1-yl)propyl)-2-amino-6-(...) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(1.33,8.47,;2.67,7.7,;2.67,6.16,;4,5.39,;4,3.85,;5.33,3.08,;6.67,3.85,;2.67,3.08,;2.67,1.54,;1.33,3.85,;1.33,5.39,;,6.16,;,3.08,;-1.33,3.85,;-2.67,3.08,;-4,3.85,;-5.33,3.08,;-5.33,1.54,;-6.67,.77,;-4,.77,;-2.67,1.54,;-1.33,.77,;-1.33,-.77,;,-1.54,;,-3.08,;1.33,-3.85,;1.33,-5.39,;2.67,-6.16,;4,-5.39,;4,-3.85,;2.67,-3.08,;5.33,-6.16,;6.67,-5.39,;5.33,-7.7,;6.67,-8.47,;,1.54,;1.33,.77,)| Show InChI InChI=1S/C25H28Cl2N6O4/c1-4-19(34)32-10-8-31(9-11-32)6-5-7-33-23-15(14-29-25(28)30-23)12-16(24(33)35)20-21(26)17(36-2)13-18(37-3)22(20)27/h4,12-14H,1,5-11H2,2-3H3,(H2,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287061 ((S)-8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-ch...) Show SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(N[C@H]3CCOC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |r| Show InChI InChI=1S/C29H35ClN6O5/c1-4-25(37)35-11-9-34(10-12-35)7-5-8-36-27-19(17-31-29(33-27)32-20-6-13-41-18-20)14-23(28(36)38)22-15-21(39-2)16-24(40-3)26(22)30/h4,14-17,20H,1,5-13,18H2,2-3H3,(H,31,32,33)/t20-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287032 (8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...) Show SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(NCCN3CCOCC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O Show InChI InChI=1S/C31H40ClN7O5/c1-4-27(40)38-12-10-36(11-13-38)7-5-8-39-29-22(21-34-31(35-29)33-6-9-37-14-16-44-17-15-37)18-25(30(39)41)24-19-23(42-2)20-26(43-3)28(24)32/h4,18-21H,1,5-17H2,2-3H3,(H,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287545 (1-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-3-(2,6-d...) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCCN3CCOCC3)cc2n(CCOC2CN(C2)C(=O)C=C)c1=O |(5.06,7.86,;3.72,7.09,;3.72,5.55,;5.06,4.78,;5.06,3.24,;6.39,2.47,;7.73,3.24,;3.72,2.47,;3.72,.93,;2.39,3.24,;2.39,4.78,;1.06,5.55,;1.06,2.47,;-.28,3.24,;-1.61,2.47,;-2.94,3.24,;-4.28,2.47,;-4.28,.93,;-5.61,.16,;-5.61,-1.38,;-6.94,-2.15,;-6.94,-3.69,;-8.28,-4.46,;-8.28,-6,;-6.94,-6.77,;-5.61,-6,;-5.61,-4.46,;-2.94,.16,;-1.61,.93,;-.28,.16,;-.28,-1.38,;1.06,-2.15,;1.06,-3.69,;2.39,-4.46,;2.79,-5.95,;4.28,-5.55,;3.88,-4.06,;5.61,-6.32,;5.61,-7.86,;6.94,-5.55,;8.28,-6.32,;1.06,.93,;2.39,.16,)| Show InChI InChI=1S/C30H35Cl2N5O6/c1-4-26(38)36-17-20(18-36)43-12-9-37-22-14-25(33-5-6-35-7-10-42-11-8-35)34-16-19(22)13-21(30(37)39)27-28(31)23(40-2)15-24(41-3)29(27)32/h4,13-16,20H,1,5-12,17-18H2,2-3H3,(H,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287534 (8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCCCN3CCOCC3)nc2n(CCOC2CN(C2)C(=O)C=C)c1=O |(6.39,7.86,;5.06,7.09,;5.06,5.55,;6.39,4.78,;6.39,3.24,;7.73,2.47,;9.06,3.24,;5.06,2.47,;5.06,.93,;3.72,3.24,;3.72,4.78,;2.39,5.55,;2.39,2.47,;1.06,3.24,;-.28,2.47,;-1.61,3.24,;-2.94,2.47,;-2.94,.93,;-4.28,.16,;-4.28,-1.38,;-5.61,-2.15,;-5.61,-3.69,;-6.94,-4.46,;-8.28,-3.69,;-9.61,-4.46,;-9.61,-6,;-8.28,-6.77,;-6.94,-6,;-1.61,.16,;-.28,.93,;1.06,.16,;1.06,-1.38,;2.39,-2.15,;2.39,-3.69,;3.72,-4.46,;4.12,-5.95,;5.61,-5.55,;5.21,-4.06,;6.94,-6.32,;6.94,-7.86,;8.28,-5.55,;9.61,-6.32,;2.39,.93,;3.72,.16,)| Show InChI InChI=1S/C30H36Cl2N6O6/c1-4-24(39)37-17-20(18-37)44-13-10-38-28-19(16-34-30(35-28)33-6-5-7-36-8-11-43-12-9-36)14-21(29(38)40)25-26(31)22(41-2)15-23(42-3)27(25)32/h4,14-16,20H,1,5-13,17-18H2,2-3H3,(H,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM286987 (8-(3-(4-acryloylpiperazin-1-yl)propyl)-2-((cyclopr...) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC3CC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(2.77,8.47,;4.1,7.7,;4.1,6.16,;5.44,5.39,;5.44,3.85,;6.77,3.08,;8.11,3.85,;4.1,3.08,;4.1,1.54,;2.77,3.85,;2.77,5.39,;1.44,6.16,;1.44,3.08,;.1,3.85,;-1.23,3.08,;-2.56,3.85,;-3.9,3.08,;-3.9,1.54,;-5.23,.77,;-5.23,-.77,;-6.57,-1.54,;-8.11,-1.54,;-7.34,-2.87,;-2.56,.77,;-1.23,1.54,;.1,.77,;.1,-.77,;1.44,-1.54,;1.44,-3.08,;2.77,-3.85,;2.77,-5.39,;4.1,-6.16,;5.44,-5.39,;5.44,-3.85,;4.1,-3.08,;6.77,-6.16,;8.11,-5.39,;6.77,-7.7,;8.11,-8.47,;1.44,1.54,;2.77,.77,)| Show InChI InChI=1S/C29H34Cl2N6O4/c1-4-23(38)36-12-10-35(11-13-36)8-5-9-37-27-19(17-33-29(34-27)32-16-18-6-7-18)14-20(28(37)39)24-25(30)21(40-2)15-22(41-3)26(24)31/h4,14-15,17-18H,1,5-13,16H2,2-3H3,(H,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287067 (8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)ethyl...) Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN(C)C3CN(C3)C(=O)C=C)c2n1 |(-6.94,-1.38,;-6.94,.16,;-5.61,.93,;-5.61,2.47,;-4.28,3.24,;-2.94,2.47,;-1.61,3.24,;-.28,2.47,;1.06,3.24,;1.06,4.78,;-.28,5.55,;2.39,5.55,;2.39,7.09,;1.06,7.86,;3.72,4.78,;3.72,3.24,;5.06,2.47,;6.39,3.24,;2.39,2.47,;2.39,.93,;-.28,.93,;1.06,.16,;-1.61,.16,;-1.61,-1.38,;-.28,-2.15,;-.28,-3.69,;-1.61,-4.46,;1.06,-4.46,;1.46,-5.95,;2.94,-5.55,;2.55,-4.06,;4.28,-6.32,;4.28,-7.86,;5.61,-5.55,;6.94,-6.32,;-2.94,.93,;-4.28,.16,)| Show InChI InChI=1S/C25H28Cl2N6O4/c1-6-19(34)32-12-15(13-32)31(3)7-8-33-23-14(11-29-25(28-2)30-23)9-16(24(33)35)20-21(26)17(36-4)10-18(37-5)22(20)27/h6,9-11,15H,1,7-8,12-13H2,2-5H3,(H,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287559 (8-(2-((1-acryloylpiperidin-4-yl)(methyl)amino)ethy...) Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN(C)C3CCN(CC3)C(=O)C=C)c2n1 |(-7.34,-1.16,;-7.34,.38,;-6,1.15,;-6,2.69,;-4.67,3.46,;-3.33,2.69,;-2,3.46,;-.67,2.69,;.67,3.46,;.67,5,;-.67,5.77,;2,5.78,;2,7.32,;3.33,8.09,;3.33,5,;3.33,3.46,;4.67,2.69,;6,3.46,;2,2.69,;2,1.15,;-.67,1.15,;.67,.38,;-2,.38,;-2,-1.16,;-.67,-1.93,;-.67,-3.47,;-2,-4.24,;.67,-4.24,;.67,-5.78,;2,-6.55,;3.33,-5.78,;3.33,-4.24,;2,-3.47,;4.67,-6.55,;4.67,-8.09,;6,-5.78,;7.34,-6.55,;-3.33,1.15,;-4.67,.38,)| Show InChI InChI=1S/C27H32Cl2N6O4/c1-6-21(36)34-9-7-17(8-10-34)33(3)11-12-35-25-16(15-31-27(30-2)32-25)13-18(26(35)37)22-23(28)19(38-4)14-20(39-5)24(22)29/h6,13-15,17H,1,7-12H2,2-5H3,(H,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM286381 (8-(2-((1-acryloylpiperidin-3-yl)oxy)ethyl)-6-(2,6-...) Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCOC3CCCN(C3)C(=O)C=C)c2n1 |(-6.67,,;-6.67,1.54,;-5.33,2.31,;-5.33,3.85,;-4,4.62,;-2.67,3.85,;-1.33,4.62,;,3.85,;1.33,4.62,;1.33,6.16,;,6.93,;2.67,6.93,;2.67,8.47,;4,9.24,;4,6.16,;4,4.62,;5.33,3.85,;6.67,4.62,;2.67,3.85,;2.67,2.31,;,2.31,;1.33,1.54,;-1.33,1.54,;-1.33,,;,-.77,;,-2.31,;1.33,-3.08,;2.67,-2.31,;4,-3.08,;4,-4.62,;2.67,-5.39,;1.33,-4.62,;2.67,-6.93,;1.33,-7.7,;4,-7.7,;4,-9.24,;-2.67,2.31,;-4,1.54,)| Show InChI InChI=1S/C26H29Cl2N5O5/c1-5-20(34)32-8-6-7-16(14-32)38-10-9-33-24-15(13-30-26(29-2)31-24)11-17(25(33)35)21-22(27)18(36-3)12-19(37-4)23(21)28/h5,11-13,16H,1,6-10,14H2,2-4H3,(H,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287519 (8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...) Show SMILES CCN1CCN(CCCNc2ncc3cc(-c4c(Cl)c(OC)cc(OC)c4Cl)c(=O)n(CCOC4CN(C4)C(=O)C=C)c3n2)CC1 |(-10.28,-8.09,;-10.28,-6.55,;-8.95,-5.78,;-8.95,-4.24,;-7.61,-3.47,;-6.28,-4.24,;-4.94,-3.47,;-4.94,-1.93,;-3.61,-1.16,;-3.61,.38,;-2.28,1.15,;-2.28,2.69,;-.94,3.46,;.39,2.69,;1.72,3.46,;3.06,2.69,;4.39,3.46,;4.39,5,;3.06,5.77,;5.73,5.78,;5.73,7.32,;7.06,8.09,;7.06,5,;7.06,3.46,;8.39,2.69,;9.73,3.46,;5.73,2.69,;5.73,1.15,;3.06,1.15,;4.39,.38,;1.72,.38,;1.72,-1.16,;3.06,-1.93,;3.06,-3.47,;4.39,-4.24,;4.79,-5.72,;6.28,-5.32,;5.88,-3.84,;7.61,-6.09,;7.61,-7.63,;8.95,-5.32,;10.28,-6.09,;.39,1.15,;-.94,.38,;-6.28,-5.78,;-7.61,-6.55,)| Show InChI InChI=1S/C32H41Cl2N7O5/c1-5-26(42)40-19-22(20-40)46-15-14-41-30-21(16-23(31(41)43)27-28(33)24(44-3)17-25(45-4)29(27)34)18-36-32(37-30)35-8-7-9-39-12-10-38(6-2)11-13-39/h5,16-18,22H,1,6-15,19-20H2,2-4H3,(H,35,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287030 (8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCCN3CCOCC3)nc2n(CCOC2CN(C2)C(=O)C=C)c1=O |(2.39,7.86,;3.72,7.09,;3.72,5.55,;5.06,4.78,;5.06,3.24,;6.39,2.47,;7.73,3.24,;3.72,2.47,;3.72,.93,;2.39,3.24,;2.39,4.78,;1.06,5.55,;1.06,2.47,;-.28,3.24,;-1.61,2.47,;-2.94,3.24,;-4.28,2.47,;-4.28,.93,;-5.61,.16,;-5.61,-1.38,;-6.94,-2.15,;-6.94,-3.69,;-8.28,-4.46,;-8.28,-6,;-6.94,-6.77,;-5.61,-6,;-5.61,-4.46,;-2.94,.16,;-1.61,.93,;-.28,.16,;-.28,-1.38,;1.06,-2.15,;1.06,-3.69,;2.39,-4.46,;2.79,-5.95,;4.28,-5.55,;3.88,-4.06,;5.61,-6.32,;5.61,-7.86,;6.94,-5.55,;8.28,-6.32,;1.06,.93,;2.39,.16,)| Show InChI InChI=1S/C29H34Cl2N6O6/c1-4-23(38)36-16-19(17-36)43-12-9-37-27-18(15-33-29(34-27)32-5-6-35-7-10-42-11-8-35)13-20(28(37)39)24-25(30)21(40-2)14-22(41-3)26(24)31/h4,13-15,19H,1,5-12,16-17H2,2-3H3,(H,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM286997 (8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(Nc3ccccn3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(2,8.47,;3.33,7.7,;3.33,6.16,;4.67,5.39,;4.67,3.85,;6,3.08,;7.34,3.85,;3.33,3.08,;3.33,1.54,;2,3.85,;2,5.39,;.67,6.16,;.67,3.08,;-.67,3.85,;-2,3.08,;-3.33,3.85,;-4.67,3.08,;-4.67,1.54,;-6,.77,;-6,-.77,;-4.67,-1.54,;-4.67,-3.08,;-6,-3.85,;-7.34,-3.08,;-7.34,-1.54,;-3.33,.77,;-2,1.54,;-.67,.77,;-.67,-.77,;.67,-1.54,;.67,-3.08,;2,-3.85,;2,-5.39,;3.33,-6.16,;4.67,-5.39,;4.67,-3.85,;3.33,-3.08,;6,-6.16,;7.34,-5.39,;6,-7.7,;7.34,-8.47,;.67,1.54,;2,.77,)| Show InChI InChI=1S/C30H31Cl2N7O4/c1-4-24(40)38-14-12-37(13-15-38)10-7-11-39-28-19(18-34-30(36-28)35-23-8-5-6-9-33-23)16-20(29(39)41)25-26(31)21(42-2)17-22(43-3)27(25)32/h4-6,8-9,16-18H,1,7,10-15H2,2-3H3,(H,33,34,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287038 (8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC(F)F)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(2.67,8.47,;4,7.7,;4,6.16,;5.33,5.39,;5.33,3.85,;6.67,3.08,;8,3.85,;4,3.08,;4,1.54,;2.67,3.85,;2.67,5.39,;1.33,6.16,;1.33,3.08,;,3.85,;-1.33,3.08,;-2.67,3.85,;-4,3.08,;-4,1.54,;-5.33,.77,;-5.33,-.77,;-6.67,-1.54,;-6.67,-3.08,;-8,-.77,;-2.67,.77,;-1.33,1.54,;,.77,;,-.77,;1.33,-1.54,;1.33,-3.08,;2.67,-3.85,;2.67,-5.39,;4,-6.16,;5.33,-5.39,;5.33,-3.85,;4,-3.08,;6.67,-6.16,;8,-5.39,;6.67,-7.7,;8,-8.47,;1.33,1.54,;2.67,.77,)| Show InChI InChI=1S/C27H30Cl2F2N6O4/c1-4-21(38)36-10-8-35(9-11-36)6-5-7-37-25-16(14-32-27(34-25)33-15-20(30)31)12-17(26(37)39)22-23(28)18(40-2)13-19(41-3)24(22)29/h4,12-14,20H,1,5-11,15H2,2-3H3,(H,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM286992 (8-(2-((1-acryloylpiperidin-4-yl)oxy)ethyl)-6-(2,6-...) Show SMILES CCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCOC3CCN(CC3)C(=O)C=C)c2n1 |(-7.34,-1.54,;-6,-.77,;-6,.77,;-4.67,1.54,;-4.67,3.08,;-3.33,3.85,;-2,3.08,;-.67,3.85,;.67,3.08,;2,3.85,;2,5.39,;.67,6.16,;3.33,6.16,;3.33,7.7,;2,8.47,;4.67,5.39,;4.67,3.85,;6,3.08,;7.34,3.85,;3.33,3.08,;3.33,1.54,;.67,1.54,;2,.77,;-.67,.77,;-.67,-.77,;.67,-1.54,;.67,-3.08,;2,-3.85,;2,-5.39,;3.33,-6.16,;4.67,-5.39,;4.67,-3.85,;3.33,-3.08,;6,-6.16,;7.34,-5.39,;6,-7.7,;7.34,-8.47,;-2,1.54,;-3.33,.77,)| Show InChI InChI=1S/C27H31Cl2N5O5/c1-5-21(35)33-9-7-17(8-10-33)39-12-11-34-25-16(15-31-27(32-25)30-6-2)13-18(26(34)36)22-23(28)19(37-3)14-20(38-4)24(22)29/h5,13-15,17H,1,6-12H2,2-4H3,(H,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287006 (8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC3CCOCC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(3.33,8.47,;4.67,7.7,;4.67,6.16,;6,5.39,;6,3.85,;7.34,3.08,;8.67,3.85,;4.67,3.08,;4.67,1.54,;3.33,3.85,;3.33,5.39,;2,6.16,;2,3.08,;.67,3.85,;-.67,3.08,;-2,3.85,;-3.33,3.08,;-3.33,1.54,;-4.67,.77,;-4.67,-.77,;-6,-1.54,;-7.34,-.77,;-8.67,-1.54,;-8.67,-3.08,;-7.34,-3.85,;-6,-3.08,;-2,.77,;-.67,1.54,;.67,.77,;.67,-.77,;2,-1.54,;2,-3.08,;3.33,-3.85,;3.33,-5.39,;4.67,-6.16,;6,-5.39,;6,-3.85,;4.67,-3.08,;7.34,-6.16,;8.67,-5.39,;7.34,-7.7,;8.67,-8.47,;2,1.54,;3.33,.77,)| Show InChI InChI=1S/C31H38Cl2N6O5/c1-4-25(40)38-12-10-37(11-13-38)8-5-9-39-29-21(19-35-31(36-29)34-18-20-6-14-44-15-7-20)16-22(30(39)41)26-27(32)23(42-2)17-24(43-3)28(26)33/h4,16-17,19-20H,1,5-15,18H2,2-3H3,(H,34,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287044 (8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCCOC(C)C)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(3.33,8.47,;4.67,7.7,;4.67,6.16,;6,5.39,;6,3.85,;7.34,3.08,;8.67,3.85,;4.67,3.08,;4.67,1.54,;3.33,3.85,;3.33,5.39,;2,6.16,;2,3.08,;.67,3.85,;-.67,3.08,;-2,3.85,;-3.33,3.08,;-3.33,1.54,;-4.67,.77,;-4.67,-.77,;-6,-1.54,;-6,-3.08,;-7.34,-3.85,;-7.34,-5.39,;-8.67,-3.08,;-2,.77,;-.67,1.54,;.67,.77,;.67,-.77,;2,-1.54,;2,-3.08,;3.33,-3.85,;3.33,-5.39,;4.67,-6.16,;6,-5.39,;6,-3.85,;4.67,-3.08,;7.34,-6.16,;8.67,-5.39,;7.34,-7.7,;8.67,-8.47,;2,1.54,;3.33,.77,)| Show InChI InChI=1S/C30H38Cl2N6O5/c1-6-24(39)37-13-11-36(12-14-37)9-7-10-38-28-20(18-34-30(35-28)33-8-15-43-19(2)3)16-21(29(38)40)25-26(31)22(41-4)17-23(42-5)27(25)32/h6,16-19H,1,7-15H2,2-5H3,(H,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM286383 (8-(3-((2R,6S)-4-acryloyl-2,6-dimethylpiperazin-1-y...) Show SMILES CNc1ncc2cc(-c3cc(OC)cc(OC)c3Cl)c(=O)n(CCCN3[C@@H](C)CN(C[C@H]3C)C(=O)C=C)c2n1 |r| Show InChI InChI=1S/C28H35ClN6O4/c1-7-24(36)33-15-17(2)34(18(3)16-33)9-8-10-35-26-19(14-31-28(30-4)32-26)11-22(27(35)37)21-12-20(38-5)13-23(39-6)25(21)29/h7,11-14,17-18H,1,8-10,15-16H2,2-6H3,(H,30,31,32)/t17-,18+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287003 (8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...) Show SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(NCC(F)F)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O Show InChI InChI=1S/C27H31ClF2N6O4/c1-4-23(37)35-10-8-34(9-11-35)6-5-7-36-25-17(15-31-27(33-25)32-16-22(29)30)12-20(26(36)38)19-13-18(39-2)14-21(40-3)24(19)28/h4,12-15,22H,1,5-11,16H2,2-3H3,(H,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287528 (8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...) Show SMILES CCN1CCN(CCNc2ncc3cc(-c4c(Cl)c(OC)cc(OC)c4Cl)c(=O)n(CCOC4CN(C4)C(=O)C=C)c3n2)CC1 |(-5.61,-8.47,;-6.94,-7.7,;-6.94,-6.16,;-8.28,-5.39,;-8.28,-3.85,;-6.94,-3.08,;-6.94,-1.54,;-5.61,-.77,;-5.61,.77,;-4.28,1.54,;-4.28,3.08,;-2.94,3.85,;-1.61,3.08,;-.28,3.85,;1.06,3.08,;2.39,3.85,;2.39,5.39,;1.06,6.16,;3.72,6.16,;3.72,7.7,;5.06,8.47,;5.06,5.39,;5.06,3.85,;6.39,3.08,;7.73,3.85,;3.72,3.08,;3.72,1.54,;1.06,1.54,;2.39,.77,;-.28,.77,;-.28,-.77,;1.06,-1.54,;1.06,-3.08,;2.39,-3.85,;2.79,-5.34,;4.28,-4.94,;3.88,-3.45,;5.61,-5.71,;5.61,-7.25,;6.94,-4.94,;8.28,-5.71,;-1.61,1.54,;-2.94,.77,;-5.61,-3.85,;-5.61,-5.39,)| Show InChI InChI=1S/C31H39Cl2N7O5/c1-5-25(41)39-18-21(19-39)45-14-13-40-29-20(17-35-31(36-29)34-7-8-38-11-9-37(6-2)10-12-38)15-22(30(40)42)26-27(32)23(43-3)16-24(44-4)28(26)33/h5,15-17,21H,1,6-14,18-19H2,2-4H3,(H,34,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287041 (8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...) Show SMILES COCCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1 |(-8,-3.85,;-6.67,-3.08,;-6.67,-1.54,;-5.33,-.77,;-5.33,.77,;-4,1.54,;-4,3.08,;-2.67,3.85,;-1.33,3.08,;,3.85,;1.33,3.08,;2.67,3.85,;2.67,5.39,;1.33,6.16,;4,6.16,;4,7.7,;2.67,8.47,;5.33,5.39,;5.33,3.85,;6.67,3.08,;8,3.85,;4,3.08,;4,1.54,;1.33,1.54,;2.67,.77,;,.77,;,-.77,;1.33,-1.54,;1.33,-3.08,;2.67,-3.85,;2.67,-5.39,;4,-6.16,;5.33,-5.39,;5.33,-3.85,;4,-3.08,;6.67,-6.16,;8,-5.39,;6.67,-7.7,;8,-8.47,;-1.33,1.54,;-2.67,.77,)| Show InChI InChI=1S/C28H34Cl2N6O5/c1-5-22(37)35-12-10-34(11-13-35)8-6-9-36-26-18(17-32-28(33-26)31-7-14-39-2)15-19(27(36)38)23-24(29)20(40-3)16-21(41-4)25(23)30/h5,15-17H,1,6-14H2,2-4H3,(H,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287037 (8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2-chl...) Show SMILES CNc1ncc2cc(-c3cc(OC)cc(OC)c3Cl)c(=O)n(CCOC3CN(C3)C(=O)C=C)c2n1 Show InChI InChI=1S/C24H26ClN5O5/c1-5-20(31)29-12-16(13-29)35-7-6-30-22-14(11-27-24(26-2)28-22)8-18(23(30)32)17-9-15(33-3)10-19(34-4)21(17)25/h5,8-11,16H,1,6-7,12-13H2,2-4H3,(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287514 ((R)-8-((1-(1-acryloylazetidin-3-yl)pyrrolidin-2-yl...) Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(C[C@H]3CCCN3C3CN(C3)C(=O)C=C)c2n1 |r,wD:24.24,(-6.67,-.86,;-6.67,.68,;-5.33,1.45,;-5.33,2.99,;-4,3.76,;-2.67,2.99,;-1.33,3.76,;,2.99,;1.33,3.76,;1.33,5.3,;,6.07,;2.67,6.07,;2.67,7.61,;4,8.38,;4,5.3,;4,3.76,;5.33,2.99,;6.67,3.76,;2.67,2.99,;2.67,1.45,;,1.45,;1.33,.68,;-1.33,.68,;-1.33,-.86,;-2.67,-1.63,;-4.13,-1.16,;-5.04,-2.4,;-4.13,-3.65,;-2.67,-3.17,;-1.58,-4.26,;-1.58,-5.8,;-.04,-5.8,;-.04,-4.26,;1.05,-6.89,;.65,-8.38,;2.54,-6.49,;3.63,-7.58,;-2.67,1.45,;-4,.68,)| Show InChI InChI=1S/C27H30Cl2N6O4/c1-5-21(36)33-12-17(13-33)34-8-6-7-16(34)14-35-25-15(11-31-27(30-2)32-25)9-18(26(35)37)22-23(28)19(38-3)10-20(39-4)24(22)29/h5,9-11,16-17H,1,6-8,12-14H2,2-4H3,(H,30,31,32)/t16-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287512 ((R)¿N-(1-(2-(6-(2,6-dichloro-3,5-dimethoxyphenyl)-...) Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN3CCC[C@H](C3)NC(=O)C=C)c2n1 |r,wD:29.32,(-6.67,-1.93,;-6.67,-.39,;-5.33,.38,;-5.33,1.92,;-4,2.69,;-2.67,1.92,;-1.33,2.69,;,1.92,;1.33,2.69,;1.33,4.23,;,5,;2.67,5.01,;2.67,6.55,;4,7.32,;4,4.23,;4,2.69,;5.33,1.92,;6.67,2.69,;2.67,1.92,;2.67,.38,;,.38,;1.33,-.39,;-1.33,-.39,;-1.33,-1.93,;,-2.7,;,-4.24,;-1.33,-5.01,;-1.33,-6.55,;,-7.32,;1.33,-6.55,;1.33,-5.01,;2.67,-7.32,;4,-6.55,;4,-5.01,;5.33,-7.32,;6.67,-6.55,;-2.67,.38,;-4,-.39,)| Show InChI InChI=1S/C26H30Cl2N6O4/c1-5-20(35)31-16-7-6-8-33(14-16)9-10-34-24-15(13-30-26(29-2)32-24)11-17(25(34)36)21-22(27)18(37-3)12-19(38-4)23(21)28/h5,11-13,16H,1,6-10,14H2,2-4H3,(H,31,35)(H,29,30,32)/t16-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM286975 (8-(3-((3S,5R)-4-acryloyl-3,5-dimethylpiperazin-1-y...) Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3C[C@H](C)N([C@H](C)C3)C(=O)C=C)c2n1 |r,wU:31.32,28.29,(-6.67,-.77,;-6.67,.77,;-5.33,1.54,;-5.33,3.08,;-4,3.85,;-2.67,3.08,;-1.33,3.85,;,3.08,;1.33,3.85,;1.33,5.39,;,6.16,;2.67,6.16,;2.67,7.7,;1.33,8.47,;4,5.39,;4,3.85,;5.33,3.08,;6.67,3.85,;2.67,3.08,;2.67,1.54,;,1.54,;1.33,.77,;-1.33,.77,;-1.33,-.77,;,-1.54,;,-3.08,;1.33,-3.85,;1.33,-5.39,;2.67,-6.16,;2.67,-7.7,;4,-5.39,;4,-3.85,;5.33,-3.08,;2.67,-3.08,;5.33,-6.16,;6.67,-5.39,;5.33,-7.7,;6.67,-8.47,;-2.67,1.54,;-4,.77,)| Show InChI InChI=1S/C28H34Cl2N6O4/c1-7-22(37)36-16(2)14-34(15-17(36)3)9-8-10-35-26-18(13-32-28(31-4)33-26)11-19(27(35)38)23-24(29)20(39-5)12-21(40-6)25(23)30/h7,11-13,16-17H,1,8-10,14-15H2,2-6H3,(H,31,32,33)/t16-,17+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287069 (8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...) Show SMILES CCOCCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1 |(-8,-5.39,;-8,-3.85,;-6.67,-3.08,;-6.67,-1.54,;-5.33,-.77,;-5.33,.77,;-4,1.54,;-4,3.08,;-2.67,3.85,;-1.33,3.08,;,3.85,;1.33,3.08,;2.67,3.85,;2.67,5.39,;1.33,6.16,;4,6.16,;4,7.7,;2.67,8.47,;5.33,5.39,;5.33,3.85,;6.67,3.08,;8,3.85,;4,3.08,;4,1.54,;1.33,1.54,;2.67,.77,;,.77,;,-.77,;1.33,-1.54,;1.33,-3.08,;2.67,-3.85,;2.67,-5.39,;4,-6.16,;5.33,-5.39,;5.33,-3.85,;4,-3.08,;6.67,-6.16,;8,-5.39,;6.67,-7.7,;8,-8.47,;-1.33,1.54,;-2.67,.77,)| Show InChI InChI=1S/C29H36Cl2N6O5/c1-5-23(38)36-13-11-35(12-14-36)9-7-10-37-27-19(18-33-29(34-27)32-8-15-42-6-2)16-20(28(37)39)24-25(30)21(40-3)17-22(41-4)26(24)31/h5,16-18H,1,6-15H2,2-4H3,(H,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9815834 (2017) BindingDB Entry DOI: 10.7270/Q2B85B83
					More data for this Ligand-Target Pair

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