Compile Data Set for Download or QSAR

Found 36 hits Enz. Inhib. hit(s) with all data for entry = 2241   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18471 (2-[(4-{[2-(tert-butoxy)phenyl]amino}-6-(pyrrolidin...) Show SMILES CC(C)(C)Oc1ccccc1Nc1nc(NCCO)nc(n1)N1CCCC1 Show InChI InChI=1S/C19H28N6O2/c1-19(2,3)27-15-9-5-4-8-14(15)21-17-22-16(20-10-13-26)23-18(24-17)25-11-6-7-12-25/h4-5,8-9,26H,6-7,10-13H2,1-3H3,(H2,20,21,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18480 (2-({4-[(2-hydroxyethyl)amino]-6-(pyrrolidin-1-yl)-...) Show SMILES OCCNc1nc(Nc2cc(ccc2O)-c2ccccc2)nc(n1)N1CCCC1 Show InChI InChI=1S/C21H24N6O2/c28-13-10-22-19-24-20(26-21(25-19)27-11-4-5-12-27)23-17-14-16(8-9-18(17)29)15-6-2-1-3-7-15/h1-3,6-9,14,28-29H,4-5,10-13H2,(H2,22,23,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18447 (2-({4-[(5-chloro-2-methoxyphenyl)amino]-6-(pyrroli...) Show SMILES COc1ccc(Cl)cc1Nc1nc(NCCO)nc(n1)N1CCCC1 Show InChI InChI=1S/C16H21ClN6O2/c1-25-13-5-4-11(17)10-12(13)19-15-20-14(18-6-9-24)21-16(22-15)23-7-2-3-8-23/h4-5,10,24H,2-3,6-9H2,1H3,(H2,18,19,20,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	5.9	21
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18479 (4-chloro-2-({4-[(2-hydroxyethyl)amino]-6-(pyrrolid...) Show SMILES OCCNc1nc(Nc2cc(Cl)ccc2O)nc(n1)N1CCCC1 Show InChI InChI=1S/C15H19ClN6O2/c16-10-3-4-12(24)11(9-10)18-14-19-13(17-5-8-23)20-15(21-14)22-6-1-2-7-22/h3-4,9,23-24H,1-2,5-8H2,(H2,17,18,19,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	730	n/a	n/a	n/a	n/a	n/a	n/a
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18469 (2-({4-[(2-ethoxyphenyl)amino]-6-(pyrrolidin-1-yl)-...) Show SMILES CCOc1ccccc1Nc1nc(NCCO)nc(n1)N1CCCC1 Show InChI InChI=1S/C17H24N6O2/c1-2-25-14-8-4-3-7-13(14)19-16-20-15(18-9-12-24)21-17(22-16)23-10-5-6-11-23/h3-4,7-8,24H,2,5-6,9-12H2,1H3,(H2,18,19,20,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	770	n/a	n/a	n/a	n/a	n/a	n/a
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18481 (2-({4-[(5-chloro-2-ethoxyphenyl)amino]-6-(pyrrolid...) Show SMILES CCOc1ccc(Cl)cc1Nc1nc(NCCO)nc(n1)N1CCCC1 Show InChI InChI=1S/C17H23ClN6O2/c1-2-26-14-6-5-12(18)11-13(14)20-16-21-15(19-7-10-25)22-17(23-16)24-8-3-4-9-24/h5-6,11,25H,2-4,7-10H2,1H3,(H2,19,20,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	960	n/a	n/a	n/a	n/a	n/a	n/a
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18483 (2-[(4-{[2-(tert-butoxy)-5-chlorophenyl]amino}-6-(p...) Show SMILES CC(C)(C)Oc1ccc(Cl)cc1Nc1nc(NCCO)nc(n1)N1CCCC1 Show InChI InChI=1S/C19H27ClN6O2/c1-19(2,3)28-15-7-6-13(20)12-14(15)22-17-23-16(21-8-11-27)24-18(25-17)26-9-4-5-10-26/h6-7,12,27H,4-5,8-11H2,1-3H3,(H2,21,22,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18465 (2-({4-[(2-methoxyphenyl)amino]-6-(pyrrolidin-1-yl)...) Show SMILES COc1ccccc1Nc1nc(NCCO)nc(n1)N1CCCC1 Show InChI InChI=1S/C16H22N6O2/c1-24-13-7-3-2-6-12(13)18-15-19-14(17-8-11-23)20-16(21-15)22-9-4-5-10-22/h2-3,6-7,23H,4-5,8-11H2,1H3,(H2,17,18,19,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.08E+3	n/a	n/a	n/a	n/a	5.9	21
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18475 (2-({4-[(2,5-dimethoxyphenyl)amino]-6-(pyrrolidin-1...) Show SMILES COc1ccc(OC)c(Nc2nc(NCCO)nc(n2)N2CCCC2)c1 Show InChI InChI=1S/C17H24N6O3/c1-25-12-5-6-14(26-2)13(11-12)19-16-20-15(18-7-10-24)21-17(22-16)23-8-3-4-9-23/h5-6,11,24H,3-4,7-10H2,1-2H3,(H2,18,19,20,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.53E+3	n/a	n/a	n/a	n/a	n/a	n/a
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18468 (2-({4-[(2-hydroxyethyl)amino]-6-(pyrrolidin-1-yl)-...) Show SMILES OCCNc1nc(Nc2ccccc2O)nc(n1)N1CCCC1 Show InChI InChI=1S/C15H20N6O2/c22-10-7-16-13-18-14(17-11-5-1-2-6-12(11)23)20-15(19-13)21-8-3-4-9-21/h1-2,5-6,22-23H,3-4,7-10H2,(H2,16,17,18,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	5.9	21
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18478 (2-({4-[(2-methoxy-5-phenylphenyl)amino]-6-(pyrroli...) Show SMILES COc1ccc(cc1Nc1nc(NCCO)nc(n1)N1CCCC1)-c1ccccc1 Show InChI InChI=1S/C22H26N6O2/c1-30-19-10-9-17(16-7-3-2-4-8-16)15-18(19)24-21-25-20(23-11-14-29)26-22(27-21)28-12-5-6-13-28/h2-4,7-10,15,29H,5-6,11-14H2,1H3,(H2,23,24,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18460 (2-{[4-(azetidin-1-yl)-6-[(2-methoxyphenyl)amino]-1...) Show SMILES COc1ccccc1Nc1nc(NCCO)nc(n1)N1CCC1 Show InChI InChI=1S/C15H20N6O2/c1-23-12-6-3-2-5-11(12)17-14-18-13(16-7-10-22)19-15(20-14)21-8-4-9-21/h2-3,5-6,22H,4,7-10H2,1H3,(H2,16,17,18,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.31E+3	n/a	n/a	n/a	n/a	5.9	21
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18474 (2-[(4-{[2-(methylsulfanyl)phenyl]amino}-6-(pyrroli...) Show SMILES CSc1ccccc1Nc1nc(NCCO)nc(n1)N1CCCC1 Show InChI InChI=1S/C16H22N6OS/c1-24-13-7-3-2-6-12(13)18-15-19-14(17-8-11-23)20-16(21-15)22-9-4-5-10-22/h2-3,6-7,23H,4-5,8-11H2,1H3,(H2,17,18,19,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.39E+3	n/a	n/a	n/a	n/a	n/a	n/a
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18477 (2-[(4-{[2-methoxy-5-(trifluoromethyl)phenyl]amino}...) Show SMILES COc1ccc(cc1Nc1nc(NCCO)nc(n1)N1CCCC1)C(F)(F)F Show InChI InChI=1S/C17H21F3N6O2/c1-28-13-5-4-11(17(18,19)20)10-12(13)22-15-23-14(21-6-9-27)24-16(25-15)26-7-2-3-8-26/h4-5,10,27H,2-3,6-9H2,1H3,(H2,21,22,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.65E+3	n/a	n/a	n/a	n/a	n/a	n/a
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18473 (2-{[4-(pyrrolidin-1-yl)-6-{[2-(trifluoromethoxy)ph...) Show SMILES OCCNc1nc(Nc2ccccc2OC(F)(F)F)nc(n1)N1CCCC1 Show InChI InChI=1S/C16H19F3N6O2/c17-16(18,19)27-12-6-2-1-5-11(12)21-14-22-13(20-7-10-26)23-15(24-14)25-8-3-4-9-25/h1-2,5-6,26H,3-4,7-10H2,(H2,20,21,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18482 (2-[(4-{[5-chloro-2-(propan-2-yloxy)phenyl]amino}-6...) Show SMILES CC(C)Oc1ccc(Cl)cc1Nc1nc(NCCO)nc(n1)N1CCCC1 Show InChI InChI=1S/C18H25ClN6O2/c1-12(2)27-15-6-5-13(19)11-14(15)21-17-22-16(20-7-10-26)23-18(24-17)25-8-3-4-9-25/h5-6,11-12,26H,3-4,7-10H2,1-2H3,(H2,20,21,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.44E+3	n/a	n/a	n/a	n/a	n/a	n/a
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18461 (2-({4-[(2-methylphenyl)amino]-6-(pyrrolidin-1-yl)-...) Show SMILES Cc1ccccc1Nc1nc(NCCO)nc(n1)N1CCCC1 Show InChI InChI=1S/C16H22N6O/c1-12-6-2-3-7-13(12)18-15-19-14(17-8-11-23)20-16(21-15)22-9-4-5-10-22/h2-3,6-7,23H,4-5,8-11H2,1H3,(H2,17,18,19,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.94E+3	n/a	n/a	n/a	n/a	5.9	21
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18476 (2-({4-[(2,4-dimethoxyphenyl)amino]-6-(pyrrolidin-1...) Show SMILES COc1ccc(Nc2nc(NCCO)nc(n2)N2CCCC2)c(OC)c1 Show InChI InChI=1S/C17H24N6O3/c1-25-12-5-6-13(14(11-12)26-2)19-16-20-15(18-7-10-24)21-17(22-16)23-8-3-4-9-23/h5-6,11,24H,3-4,7-10H2,1-2H3,(H2,18,19,20,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18457 (2-{[4-(butylamino)-6-[(2-methoxyphenyl)amino]-1,3,...) Show SMILES CCCCNc1nc(NCCO)nc(Nc2ccccc2OC)n1 Show InChI InChI=1S/C16H24N6O2/c1-3-4-9-17-14-20-15(18-10-11-23)22-16(21-14)19-12-7-5-6-8-13(12)24-2/h5-8,23H,3-4,9-11H2,1-2H3,(H3,17,18,19,20,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.10E+3	n/a	n/a	n/a	n/a	5.9	21
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18448 (2-({4-[(3-methylphenyl)amino]-6-(pyrrolidin-1-yl)-...) Show SMILES Cc1cccc(Nc2nc(NCCO)nc(n2)N2CCCC2)c1 Show InChI InChI=1S/C16H22N6O/c1-12-5-4-6-13(11-12)18-15-19-14(17-7-10-23)20-16(21-15)22-8-2-3-9-22/h4-6,11,23H,2-3,7-10H2,1H3,(H2,17,18,19,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.19E+3	n/a	n/a	n/a	n/a	5.9	21
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18449 (2-({4-[(4-chlorophenyl)amino]-6-(pyrrolidin-1-yl)-...) Show SMILES OCCNc1nc(Nc2ccc(Cl)cc2)nc(n1)N1CCCC1 Show InChI InChI=1S/C15H19ClN6O/c16-11-3-5-12(6-4-11)18-14-19-13(17-7-10-23)20-15(21-14)22-8-1-2-9-22/h3-6,23H,1-2,7-10H2,(H2,17,18,19,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.34E+3	n/a	n/a	n/a	n/a	5.9	21
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18464 (2-({4-[(3-chlorophenyl)amino]-6-(pyrrolidin-1-yl)-...) Show SMILES OCCNc1nc(Nc2cccc(Cl)c2)nc(n1)N1CCCC1 Show InChI InChI=1S/C15H19ClN6O/c16-11-4-3-5-12(10-11)18-14-19-13(17-6-9-23)20-15(21-14)22-7-1-2-8-22/h3-5,10,23H,1-2,6-9H2,(H2,17,18,19,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.69E+3	n/a	n/a	n/a	n/a	5.9	21
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18454 (1-({4-[(2-methoxyphenyl)amino]-6-(pyrrolidin-1-yl)...) Show SMILES COc1ccccc1Nc1nc(NCC(O)Cc2ccccc2)nc(n1)N1CCCC1 Show InChI InChI=1S/C23H28N6O2/c1-31-20-12-6-5-11-19(20)25-22-26-21(27-23(28-22)29-13-7-8-14-29)24-16-18(30)15-17-9-3-2-4-10-17/h2-6,9-12,18,30H,7-8,13-16H2,1H3,(H2,24,25,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	5.9	21
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18459 (2-{[4-(3,3-difluoropyrrolidin-1-yl)-6-[(2-methoxyp...) Show SMILES COc1ccccc1Nc1nc(NCCO)nc(n1)N1CCC(F)(F)C1 Show InChI InChI=1S/C16H20F2N6O2/c1-26-12-5-3-2-4-11(12)20-14-21-13(19-7-9-25)22-15(23-14)24-8-6-16(17,18)10-24/h2-5,25H,6-10H2,1H3,(H2,19,20,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.75E+3	n/a	n/a	n/a	n/a	5.9	21
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18452 (2-N-butyl-4-N-(5-chloro-2-methoxyphenyl)-6-(pyrrol...) Show SMILES CCCCNc1nc(Nc2cc(Cl)ccc2OC)nc(n1)N1CCCC1 Show InChI InChI=1S/C18H25ClN6O/c1-3-4-9-20-16-22-17(24-18(23-16)25-10-5-6-11-25)21-14-12-13(19)7-8-15(14)26-2/h7-8,12H,3-6,9-11H2,1-2H3,(H2,20,21,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.77E+3	n/a	n/a	n/a	n/a	5.9	21
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18466 (2-({4-[(3-methoxyphenyl)amino]-6-(pyrrolidin-1-yl)...) Show SMILES COc1cccc(Nc2nc(NCCO)nc(n2)N2CCCC2)c1 Show InChI InChI=1S/C16H22N6O2/c1-24-13-6-4-5-12(11-13)18-15-19-14(17-7-10-23)20-16(21-15)22-8-2-3-9-22/h4-6,11,23H,2-3,7-10H2,1H3,(H2,17,18,19,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.25E+3	n/a	n/a	n/a	n/a	5.9	21
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18467 (2-({4-[(4-methoxyphenyl)amino]-6-(pyrrolidin-1-yl)...) Show SMILES COc1ccc(Nc2nc(NCCO)nc(n2)N2CCCC2)cc1 Show InChI InChI=1S/C16H22N6O2/c1-24-13-6-4-12(5-7-13)18-15-19-14(17-8-11-23)20-16(21-15)22-9-2-3-10-22/h4-7,23H,2-3,8-11H2,1H3,(H2,17,18,19,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.80E+3	n/a	n/a	n/a	n/a	5.9	21
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18462 (2-({4-[(4-methylphenyl)amino]-6-(pyrrolidin-1-yl)-...) Show SMILES Cc1ccc(Nc2nc(NCCO)nc(n2)N2CCCC2)cc1 Show InChI InChI=1S/C16H22N6O/c1-12-4-6-13(7-5-12)18-15-19-14(17-8-11-23)20-16(21-15)22-9-2-3-10-22/h4-7,23H,2-3,8-11H2,1H3,(H2,17,18,19,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	5.9	21
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18455 (2-({4-[(5-chloro-2-methoxyphenyl)amino]-6-(morphol...) Show SMILES COc1ccc(Cl)cc1Nc1nc(NCCO)nc(n1)N1CCOCC1 Show InChI InChI=1S/C16H21ClN6O3/c1-25-13-3-2-11(17)10-12(13)19-15-20-14(18-4-7-24)21-16(22-15)23-5-8-26-9-6-23/h2-3,10,24H,4-9H2,1H3,(H2,18,19,20,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.21E+4	n/a	n/a	n/a	n/a	5.9	21
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18484 (2-{[4-(phenylamino)-6-(pyrrolidin-1-yl)-1,3,5-tria...) Show SMILES OCCNc1nc(Nc2ccccc2)nc(n1)N1CCCC1 Show InChI InChI=1S/C15H20N6O/c22-11-8-16-13-18-14(17-12-6-2-1-3-7-12)20-15(19-13)21-9-4-5-10-21/h1-3,6-7,22H,4-5,8-11H2,(H2,16,17,18,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.65E+4	n/a	n/a	n/a	n/a	n/a	n/a
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18458 (2-{[4-(benzylamino)-6-[(2-methoxyphenyl)amino]-1,3...) Show SMILES COc1ccccc1Nc1nc(NCCO)nc(NCc2ccccc2)n1 Show InChI InChI=1S/C19H22N6O2/c1-27-16-10-6-5-9-15(16)22-19-24-17(20-11-12-26)23-18(25-19)21-13-14-7-3-2-4-8-14/h2-10,26H,11-13H2,1H3,(H3,20,21,22,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.88E+4	n/a	n/a	n/a	n/a	5.9	21
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18453 (1-({4-[(2-methoxyphenyl)amino]-6-(pyrrolidin-1-yl)...) Show SMILES COc1ccccc1Nc1nc(NCC(C)O)nc(n1)N1CCCC1 Show InChI InChI=1S/C17H24N6O2/c1-12(24)11-18-15-20-16(19-13-7-3-4-8-14(13)25-2)22-17(21-15)23-9-5-6-10-23/h3-4,7-8,12,24H,5-6,9-11H2,1-2H3,(H2,18,19,20,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.07E+4	n/a	n/a	n/a	n/a	5.9	21
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18470 (2-({4-[(2-phenoxyphenyl)amino]-6-(pyrrolidin-1-yl)...) Show SMILES OCCNc1nc(Nc2ccccc2Oc2ccccc2)nc(n1)N1CCCC1 Show InChI InChI=1S/C21H24N6O2/c28-15-12-22-19-24-20(26-21(25-19)27-13-6-7-14-27)23-17-10-4-5-11-18(17)29-16-8-2-1-3-9-16/h1-5,8-11,28H,6-7,12-15H2,(H2,22,23,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.17E+4	n/a	n/a	n/a	n/a	n/a	n/a
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18463 (2-({4-[(2-chlorophenyl)amino]-6-(pyrrolidin-1-yl)-...) Show SMILES OCCNc1nc(Nc2ccccc2Cl)nc(n1)N1CCCC1 Show InChI InChI=1S/C15H19ClN6O/c16-11-5-1-2-6-12(11)18-14-19-13(17-7-10-23)20-15(21-14)22-8-3-4-9-22/h1-2,5-6,23H,3-4,7-10H2,(H2,17,18,19,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	5.9	21
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18456 (2-({4-[(5-chloro-2-methoxyphenyl)amino]-6-(piperid...) Show SMILES COc1ccc(Cl)cc1Nc1nc(NCCO)nc(n1)N1CCCCC1 Show InChI InChI=1S/C17H23ClN6O2/c1-26-14-6-5-12(18)11-13(14)20-16-21-15(19-7-10-25)22-17(23-16)24-8-3-2-4-9-24/h5-6,11,25H,2-4,7-10H2,1H3,(H2,19,20,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.11E+4	n/a	n/a	n/a	n/a	5.9	21
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM18472 (2-[(4-{[2-(benzyloxy)phenyl]amino}-6-(pyrrolidin-1...) Show SMILES OCCNc1nc(Nc2ccccc2OCc2ccccc2)nc(n1)N1CCCC1 Show InChI InChI=1S/C22H26N6O2/c29-15-12-23-20-25-21(27-22(26-20)28-13-6-7-14-28)24-18-10-4-5-11-19(18)30-16-17-8-2-1-3-9-17/h1-5,8-11,29H,6-7,12-16H2,(H2,23,24,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.14E+4	n/a	n/a	n/a	n/a	n/a	n/a
NIH					Assay Description Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...				Bioorg Med Chem Lett 17: 5783-9 (2007) Article DOI: 10.1016/j.bmcl.2007.08.050 BindingDB Entry DOI: 10.7270/Q2Q81BBW
					More data for this Ligand-Target Pair