| Reaction Details |
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 | Report a problem with these data |
| Target | Lysosomal acid glucosylceramidase |
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| Ligand | BDBM18447 |
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| Substrate/Competitor | BDBM18429 |
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| Meas. Tech. | GC Enzyme Assay |
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| pH | 5.9±n/a |
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| Temperature | 294.15±n/a K |
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| IC50 | 700±80 nM |
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| Km | 28000±n/a nM |
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| Citation |  Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ N(4)-Phenyl modifications of N(2)-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease. Bioorg Med Chem Lett17:5783-9 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Lysosomal acid glucosylceramidase |
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| Name: | Lysosomal acid glucosylceramidase |
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| Synonyms: | Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase) |
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| Type: | Enzyme |
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| Mol. Mass.: | 59724.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source. |
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| Residue: | 536 |
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| Sequence: | MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNAT
YCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGF
GGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDD
FQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQP
GDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIA
RDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAK
ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDW
NLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQK
NDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
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| BDBM18447 |
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| BDBM18429 |
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| Name | BDBM18447 |
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| Synonyms: | 2-({4-[(5-chloro-2-methoxyphenyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)ethan-1-ol | NCGC00029010 | Triazine compound, 3 | triazine scaffold, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H21ClN6O2 |
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| Mol. Mass. | 364.83 |
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| SMILES | COc1ccc(Cl)cc1Nc1nc(NCCO)nc(n1)N1CCCC1 |
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| Structure | 
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