Found 788 hits Enz. Inhib. hit(s) with all data for entry = 2265 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Apelin receptor
(Homo sapiens (Human)) | BDBM269868
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](OCCO)c2ncc(C)cn2)nnc1-c1cncc(C)c1 |r,wU:18.19,16.17,(1.57,-2.91,;.24,-3.68,;-1.1,-2.91,;-1.14,-1.35,;-2.48,-.58,;-3.81,-1.35,;-3.81,-2.89,;-5.15,-3.66,;-6.48,-2.89,;-2.48,-3.66,;-2.48,-5.2,;-1.23,-6.1,;.1,-5.33,;1.44,-6.1,;.67,-7.43,;2.21,-7.43,;2.77,-5.33,;2.77,-3.79,;4.1,-6.1,;4.1,-7.64,;5.44,-8.41,;5.44,-9.95,;6.77,-10.72,;5.44,-5.33,;6.77,-6.1,;8.1,-5.33,;8.1,-3.79,;9.44,-3.02,;6.77,-3.02,;5.44,-3.79,;-1.71,-7.57,;-3.25,-7.57,;-3.72,-6.1,;-5.21,-5.7,;-5.98,-7.04,;-7.52,-7.04,;-8.29,-5.7,;-7.52,-4.37,;-8.29,-3.04,;-5.98,-4.37,)| Show InChI InChI=1S/C26H31N7O6S/c1-16-11-19(15-27-12-16)25-30-31-26(33(25)22-20(37-4)7-6-8-21(22)38-5)32-40(35,36)18(3)23(39-10-9-34)24-28-13-17(2)14-29-24/h6-8,11-15,18,23,34H,9-10H2,1-5H3,(H,31,32)/t18-,23-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269868
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](OCCO)c2ncc(C)cn2)nnc1-c1cncc(C)c1 |r,wU:18.19,16.17,(1.57,-2.91,;.24,-3.68,;-1.1,-2.91,;-1.14,-1.35,;-2.48,-.58,;-3.81,-1.35,;-3.81,-2.89,;-5.15,-3.66,;-6.48,-2.89,;-2.48,-3.66,;-2.48,-5.2,;-1.23,-6.1,;.1,-5.33,;1.44,-6.1,;.67,-7.43,;2.21,-7.43,;2.77,-5.33,;2.77,-3.79,;4.1,-6.1,;4.1,-7.64,;5.44,-8.41,;5.44,-9.95,;6.77,-10.72,;5.44,-5.33,;6.77,-6.1,;8.1,-5.33,;8.1,-3.79,;9.44,-3.02,;6.77,-3.02,;5.44,-3.79,;-1.71,-7.57,;-3.25,-7.57,;-3.72,-6.1,;-5.21,-5.7,;-5.98,-7.04,;-7.52,-7.04,;-8.29,-5.7,;-7.52,-4.37,;-8.29,-3.04,;-5.98,-4.37,)| Show InChI InChI=1S/C26H31N7O6S/c1-16-11-19(15-27-12-16)25-30-31-26(33(25)22-20(37-4)7-6-8-21(22)38-5)32-40(35,36)18(3)23(39-10-9-34)24-28-13-17(2)14-29-24/h6-8,11-15,18,23,34H,9-10H2,1-5H3,(H,31,32)/t18-,23-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.110 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269870
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES COCCO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wD:5.4,6.6,(6.64,-12.26,;6.64,-10.72,;5.31,-9.95,;5.31,-8.41,;3.98,-7.64,;3.98,-6.1,;2.64,-5.33,;2.64,-3.79,;1.31,-6.1,;.54,-7.43,;2.08,-7.43,;-.03,-5.33,;-1.36,-6.1,;-1.84,-7.57,;-3.38,-7.57,;-3.85,-6.1,;-5.34,-5.7,;-6.11,-7.04,;-7.65,-7.04,;-8.42,-5.7,;-7.65,-4.37,;-8.42,-3.04,;-6.11,-4.37,;-2.61,-5.2,;-2.61,-3.66,;-1.22,-2.91,;.11,-3.68,;1.44,-2.91,;-1.27,-1.35,;-2.61,-.58,;-3.94,-1.35,;-3.94,-2.89,;-5.27,-3.66,;-6.61,-2.89,;5.31,-5.33,;6.64,-6.1,;7.98,-5.33,;7.98,-3.79,;9.31,-3.02,;6.64,-3.02,;5.31,-3.79,)| Show InChI InChI=1S/C27H33N7O6S/c1-17-12-20(16-28-13-17)26-31-32-27(34(26)23-21(38-5)8-7-9-22(23)39-6)33-41(35,36)19(3)24(40-11-10-37-4)25-29-14-18(2)15-30-25/h7-9,12-16,19,24H,10-11H2,1-6H3,(H,32,33)/t19-,24-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 30 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269870
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES COCCO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wD:5.4,6.6,(6.64,-12.26,;6.64,-10.72,;5.31,-9.95,;5.31,-8.41,;3.98,-7.64,;3.98,-6.1,;2.64,-5.33,;2.64,-3.79,;1.31,-6.1,;.54,-7.43,;2.08,-7.43,;-.03,-5.33,;-1.36,-6.1,;-1.84,-7.57,;-3.38,-7.57,;-3.85,-6.1,;-5.34,-5.7,;-6.11,-7.04,;-7.65,-7.04,;-8.42,-5.7,;-7.65,-4.37,;-8.42,-3.04,;-6.11,-4.37,;-2.61,-5.2,;-2.61,-3.66,;-1.22,-2.91,;.11,-3.68,;1.44,-2.91,;-1.27,-1.35,;-2.61,-.58,;-3.94,-1.35,;-3.94,-2.89,;-5.27,-3.66,;-6.61,-2.89,;5.31,-5.33,;6.64,-6.1,;7.98,-5.33,;7.98,-3.79,;9.31,-3.02,;6.64,-3.02,;5.31,-3.79,)| Show InChI InChI=1S/C27H33N7O6S/c1-17-12-20(16-28-13-17)26-31-32-27(34(26)23-21(38-5)8-7-9-22(23)39-6)33-41(35,36)19(3)24(40-11-10-37-4)25-29-14-18(2)15-30-25/h7-9,12-16,19,24H,10-11H2,1-6H3,(H,32,33)/t19-,24-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360102
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)Show SMILES COCCO[C@H]([C@@H](C)S(=O)(=O)N(C)c1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wD:6.6,5.4,(6.66,-25.04,;6.66,-23.5,;5.32,-22.73,;5.32,-21.19,;3.99,-20.42,;3.99,-18.88,;2.66,-18.11,;2.66,-16.57,;1.32,-18.88,;.55,-20.21,;2.09,-20.21,;-.01,-18.11,;.31,-16.6,;-1.48,-18.58,;-1.93,-20.08,;-3.49,-20.05,;-3.97,-18.58,;-5.43,-18.11,;-6.2,-19.44,;-7.74,-19.44,;-8.51,-18.11,;-7.74,-16.77,;-8.51,-15.44,;-6.2,-16.77,;-2.72,-17.68,;-2.72,-16.14,;-1.34,-15.39,;-.01,-16.16,;1.33,-15.39,;-1.39,-13.83,;-2.72,-13.06,;-4.06,-13.83,;-4.06,-15.37,;-5.39,-16.14,;-6.57,-15.15,;5.32,-18.11,;6.66,-18.88,;7.99,-18.11,;7.99,-16.57,;9.32,-15.8,;6.66,-15.8,;5.32,-16.57,)| Show InChI InChI=1S/C28H35N7O6S/c1-18-13-21(17-29-14-18)27-32-33-28(35(27)24-22(39-6)9-8-10-23(24)40-7)34(4)42(36,37)20(3)25(41-12-11-38-5)26-30-15-19(2)16-31-26/h8-10,13-17,20,25H,11-12H2,1-7H3/t20-,25-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360103
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](OC[C@@H](C)O)c2ncc(C)cn2)nnc1-c1cncc(C)c1 |r,wU:16.17,18.19,21.23,(-9.31,-4.34,;-10.64,-5.11,;-11.98,-4.34,;-12.02,-2.77,;-13.36,-2,;-14.69,-2.77,;-14.69,-4.31,;-16.02,-5.08,;-17.2,-4.09,;-13.36,-5.08,;-13.36,-6.62,;-12.11,-7.52,;-10.65,-7.05,;-9.31,-7.82,;-10.08,-9.15,;-8.54,-9.15,;-7.98,-7.05,;-7.98,-5.51,;-6.65,-7.82,;-6.65,-9.36,;-5.31,-10.13,;-5.31,-11.67,;-3.98,-12.44,;-6.65,-12.44,;-5.31,-7.05,;-3.98,-7.82,;-2.64,-7.05,;-2.64,-5.51,;-1.31,-4.74,;-3.98,-4.74,;-5.31,-5.51,;-12.59,-8.99,;-14.13,-8.99,;-14.6,-7.52,;-16.07,-7.05,;-16.84,-8.38,;-18.38,-8.38,;-19.15,-7.05,;-18.38,-5.71,;-19.15,-4.38,;-16.84,-5.71,)| Show InChI InChI=1S/C27H33N7O6S/c1-16-10-20(14-28-11-16)26-31-32-27(34(26)23-21(38-5)8-7-9-22(23)39-6)33-41(36,37)19(4)24(40-15-18(3)35)25-29-12-17(2)13-30-25/h7-14,18-19,24,35H,15H2,1-6H3,(H,32,33)/t18-,19+,24+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 17 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360103
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](OC[C@@H](C)O)c2ncc(C)cn2)nnc1-c1cncc(C)c1 |r,wU:16.17,18.19,21.23,(-9.31,-4.34,;-10.64,-5.11,;-11.98,-4.34,;-12.02,-2.77,;-13.36,-2,;-14.69,-2.77,;-14.69,-4.31,;-16.02,-5.08,;-17.2,-4.09,;-13.36,-5.08,;-13.36,-6.62,;-12.11,-7.52,;-10.65,-7.05,;-9.31,-7.82,;-10.08,-9.15,;-8.54,-9.15,;-7.98,-7.05,;-7.98,-5.51,;-6.65,-7.82,;-6.65,-9.36,;-5.31,-10.13,;-5.31,-11.67,;-3.98,-12.44,;-6.65,-12.44,;-5.31,-7.05,;-3.98,-7.82,;-2.64,-7.05,;-2.64,-5.51,;-1.31,-4.74,;-3.98,-4.74,;-5.31,-5.51,;-12.59,-8.99,;-14.13,-8.99,;-14.6,-7.52,;-16.07,-7.05,;-16.84,-8.38,;-18.38,-8.38,;-19.15,-7.05,;-18.38,-5.71,;-19.15,-4.38,;-16.84,-5.71,)| Show InChI InChI=1S/C27H33N7O6S/c1-16-10-20(14-28-11-16)26-31-32-27(34(26)23-21(38-5)8-7-9-22(23)39-6)33-41(36,37)19(4)24(40-15-18(3)35)25-29-12-17(2)13-30-25/h7-14,18-19,24,35H,15H2,1-6H3,(H,32,33)/t18-,19+,24+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 21 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360103
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](OC[C@@H](C)O)c2ncc(C)cn2)nnc1-c1cncc(C)c1 |r,wU:16.17,18.19,21.23,(-9.31,-4.34,;-10.64,-5.11,;-11.98,-4.34,;-12.02,-2.77,;-13.36,-2,;-14.69,-2.77,;-14.69,-4.31,;-16.02,-5.08,;-17.2,-4.09,;-13.36,-5.08,;-13.36,-6.62,;-12.11,-7.52,;-10.65,-7.05,;-9.31,-7.82,;-10.08,-9.15,;-8.54,-9.15,;-7.98,-7.05,;-7.98,-5.51,;-6.65,-7.82,;-6.65,-9.36,;-5.31,-10.13,;-5.31,-11.67,;-3.98,-12.44,;-6.65,-12.44,;-5.31,-7.05,;-3.98,-7.82,;-2.64,-7.05,;-2.64,-5.51,;-1.31,-4.74,;-3.98,-4.74,;-5.31,-5.51,;-12.59,-8.99,;-14.13,-8.99,;-14.6,-7.52,;-16.07,-7.05,;-16.84,-8.38,;-18.38,-8.38,;-19.15,-7.05,;-18.38,-5.71,;-19.15,-4.38,;-16.84,-5.71,)| Show InChI InChI=1S/C27H33N7O6S/c1-16-10-20(14-28-11-16)26-31-32-27(34(26)23-21(38-5)8-7-9-22(23)39-6)33-41(36,37)19(4)24(40-15-18(3)35)25-29-12-17(2)13-30-25/h7-14,18-19,24,35H,15H2,1-6H3,(H,32,33)/t18-,19+,24+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.860 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360103
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](OC[C@@H](C)O)c2ncc(C)cn2)nnc1-c1cncc(C)c1 |r,wU:16.17,18.19,21.23,(-9.31,-4.34,;-10.64,-5.11,;-11.98,-4.34,;-12.02,-2.77,;-13.36,-2,;-14.69,-2.77,;-14.69,-4.31,;-16.02,-5.08,;-17.2,-4.09,;-13.36,-5.08,;-13.36,-6.62,;-12.11,-7.52,;-10.65,-7.05,;-9.31,-7.82,;-10.08,-9.15,;-8.54,-9.15,;-7.98,-7.05,;-7.98,-5.51,;-6.65,-7.82,;-6.65,-9.36,;-5.31,-10.13,;-5.31,-11.67,;-3.98,-12.44,;-6.65,-12.44,;-5.31,-7.05,;-3.98,-7.82,;-2.64,-7.05,;-2.64,-5.51,;-1.31,-4.74,;-3.98,-4.74,;-5.31,-5.51,;-12.59,-8.99,;-14.13,-8.99,;-14.6,-7.52,;-16.07,-7.05,;-16.84,-8.38,;-18.38,-8.38,;-19.15,-7.05,;-18.38,-5.71,;-19.15,-4.38,;-16.84,-5.71,)| Show InChI InChI=1S/C27H33N7O6S/c1-16-10-20(14-28-11-16)26-31-32-27(34(26)23-21(38-5)8-7-9-22(23)39-6)33-41(36,37)19(4)24(40-15-18(3)35)25-29-12-17(2)13-30-25/h7-14,18-19,24,35H,15H2,1-6H3,(H,32,33)/t18-,19+,24+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.210 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269877
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](OCC(C)(C)O)c2ncc(C)cn2)nnc1-c1cncc(C)c1 |r,wU:16.17,18.19,(1.36,-2.62,;.02,-3.39,;-1.31,-2.62,;-1.36,-1.05,;-2.69,-.28,;-4.03,-1.05,;-4.03,-2.59,;-5.36,-3.36,;-6.69,-2.59,;-2.69,-3.36,;-2.69,-4.9,;-1.45,-5.81,;-.11,-5.04,;1.22,-5.81,;.45,-7.14,;1.99,-7.14,;2.55,-5.04,;2.55,-3.5,;3.89,-5.81,;3.89,-7.35,;5.22,-8.12,;5.22,-9.66,;6.56,-10.43,;5.22,-11.2,;3.89,-10.43,;5.22,-5.04,;6.56,-5.81,;7.89,-5.04,;7.89,-3.5,;9.22,-2.73,;6.56,-2.73,;5.22,-3.5,;-1.92,-7.27,;-3.46,-7.27,;-3.94,-5.81,;-5.34,-5.33,;-6.11,-6.66,;-7.65,-6.66,;-8.42,-5.33,;-7.65,-3.99,;-8.42,-2.66,;-6.11,-3.99,)| Show InChI InChI=1S/C28H35N7O6S/c1-17-11-20(15-29-12-17)26-32-33-27(35(26)23-21(39-6)9-8-10-22(23)40-7)34-42(37,38)19(3)24(41-16-28(4,5)36)25-30-13-18(2)14-31-25/h8-15,19,24,36H,16H2,1-7H3,(H,33,34)/t19-,24-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.690 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269877
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](OCC(C)(C)O)c2ncc(C)cn2)nnc1-c1cncc(C)c1 |r,wU:16.17,18.19,(1.36,-2.62,;.02,-3.39,;-1.31,-2.62,;-1.36,-1.05,;-2.69,-.28,;-4.03,-1.05,;-4.03,-2.59,;-5.36,-3.36,;-6.69,-2.59,;-2.69,-3.36,;-2.69,-4.9,;-1.45,-5.81,;-.11,-5.04,;1.22,-5.81,;.45,-7.14,;1.99,-7.14,;2.55,-5.04,;2.55,-3.5,;3.89,-5.81,;3.89,-7.35,;5.22,-8.12,;5.22,-9.66,;6.56,-10.43,;5.22,-11.2,;3.89,-10.43,;5.22,-5.04,;6.56,-5.81,;7.89,-5.04,;7.89,-3.5,;9.22,-2.73,;6.56,-2.73,;5.22,-3.5,;-1.92,-7.27,;-3.46,-7.27,;-3.94,-5.81,;-5.34,-5.33,;-6.11,-6.66,;-7.65,-6.66,;-8.42,-5.33,;-7.65,-3.99,;-8.42,-2.66,;-6.11,-3.99,)| Show InChI InChI=1S/C28H35N7O6S/c1-17-11-20(15-29-12-17)26-32-33-27(35(26)23-21(39-6)9-8-10-22(23)40-7)34-42(37,38)19(3)24(41-16-28(4,5)36)25-30-13-18(2)14-31-25/h8-15,19,24,36H,16H2,1-7H3,(H,33,34)/t19-,24-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 39 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269879
((1S,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](OCCO)c2ncc(C)cn2)nnc1-c1cncc(C)c1 |r,wU:18.19,wD:16.17,(1.36,-2.94,;.02,-3.71,;-1.31,-2.94,;-1.36,-1.37,;-2.69,-.6,;-4.03,-1.37,;-4.03,-2.91,;-5.36,-3.68,;-6.69,-2.91,;-2.69,-3.68,;-2.69,-5.22,;-1.45,-6.13,;-.11,-5.36,;1.22,-6.13,;.45,-7.46,;1.99,-7.46,;2.55,-5.36,;2.55,-3.82,;3.89,-6.13,;3.89,-7.67,;5.22,-8.44,;5.22,-9.98,;6.56,-10.75,;5.22,-5.36,;6.56,-6.13,;7.89,-5.36,;7.89,-3.82,;9.22,-3.05,;6.56,-3.05,;5.22,-3.82,;-1.92,-7.59,;-3.46,-7.59,;-3.94,-6.13,;-5.34,-5.64,;-6.11,-6.98,;-7.65,-6.98,;-8.42,-5.64,;-7.65,-4.31,;-8.42,-2.98,;-6.11,-4.31,)| Show InChI InChI=1S/C26H31N7O6S/c1-16-11-19(15-27-12-16)25-30-31-26(33(25)22-20(37-4)7-6-8-21(22)38-5)32-40(35,36)18(3)23(39-10-9-34)24-28-13-17(2)14-29-24/h6-8,11-15,18,23,34H,9-10H2,1-5H3,(H,31,32)/t18-,23+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.880 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269879
((1S,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](OCCO)c2ncc(C)cn2)nnc1-c1cncc(C)c1 |r,wU:18.19,wD:16.17,(1.36,-2.94,;.02,-3.71,;-1.31,-2.94,;-1.36,-1.37,;-2.69,-.6,;-4.03,-1.37,;-4.03,-2.91,;-5.36,-3.68,;-6.69,-2.91,;-2.69,-3.68,;-2.69,-5.22,;-1.45,-6.13,;-.11,-5.36,;1.22,-6.13,;.45,-7.46,;1.99,-7.46,;2.55,-5.36,;2.55,-3.82,;3.89,-6.13,;3.89,-7.67,;5.22,-8.44,;5.22,-9.98,;6.56,-10.75,;5.22,-5.36,;6.56,-6.13,;7.89,-5.36,;7.89,-3.82,;9.22,-3.05,;6.56,-3.05,;5.22,-3.82,;-1.92,-7.59,;-3.46,-7.59,;-3.94,-6.13,;-5.34,-5.64,;-6.11,-6.98,;-7.65,-6.98,;-8.42,-5.64,;-7.65,-4.31,;-8.42,-2.98,;-6.11,-4.31,)| Show InChI InChI=1S/C26H31N7O6S/c1-16-11-19(15-27-12-16)25-30-31-26(33(25)22-20(37-4)7-6-8-21(22)38-5)32-40(35,36)18(3)23(39-10-9-34)24-28-13-17(2)14-29-24/h6-8,11-15,18,23,34H,9-10H2,1-5H3,(H,31,32)/t18-,23+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 29 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269881
((1S,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](OCC(C)(C)O)c2ncc(C)cn2)nnc1-c1cncc(C)c1 |r,wU:18.19,wD:16.17,(1.28,-3.3,;-.05,-4.07,;-1.39,-3.3,;-1.44,-1.74,;-2.77,-.97,;-4.1,-1.74,;-4.1,-3.28,;-5.44,-4.05,;-6.77,-3.28,;-2.77,-4.05,;-2.77,-5.77,;-1.52,-6.67,;-.19,-5.9,;1.14,-6.67,;1.91,-8.01,;.37,-8.01,;2.48,-5.9,;2.48,-4.36,;3.81,-6.67,;3.81,-8.21,;5.14,-8.98,;5.14,-10.52,;6.48,-11.29,;5.14,-12.06,;3.81,-11.29,;5.14,-5.9,;5.14,-4.36,;6.48,-3.59,;7.81,-4.36,;9.15,-3.59,;7.81,-5.9,;6.48,-6.67,;-2,-8.14,;-3.54,-8.14,;-4.02,-6.67,;-5.35,-5.9,;-6.12,-7.24,;-7.66,-7.24,;-8.43,-5.9,;-7.66,-4.57,;-8.43,-3.24,;-6.12,-4.57,)| Show InChI InChI=1S/C28H35N7O6S/c1-17-11-20(15-29-12-17)26-32-33-27(35(26)23-21(39-6)9-8-10-22(23)40-7)34-42(37,38)19(3)24(41-16-28(4,5)36)25-30-13-18(2)14-31-25/h8-15,19,24,36H,16H2,1-7H3,(H,33,34)/t19-,24+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269881
((1S,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](OCC(C)(C)O)c2ncc(C)cn2)nnc1-c1cncc(C)c1 |r,wU:18.19,wD:16.17,(1.28,-3.3,;-.05,-4.07,;-1.39,-3.3,;-1.44,-1.74,;-2.77,-.97,;-4.1,-1.74,;-4.1,-3.28,;-5.44,-4.05,;-6.77,-3.28,;-2.77,-4.05,;-2.77,-5.77,;-1.52,-6.67,;-.19,-5.9,;1.14,-6.67,;1.91,-8.01,;.37,-8.01,;2.48,-5.9,;2.48,-4.36,;3.81,-6.67,;3.81,-8.21,;5.14,-8.98,;5.14,-10.52,;6.48,-11.29,;5.14,-12.06,;3.81,-11.29,;5.14,-5.9,;5.14,-4.36,;6.48,-3.59,;7.81,-4.36,;9.15,-3.59,;7.81,-5.9,;6.48,-6.67,;-2,-8.14,;-3.54,-8.14,;-4.02,-6.67,;-5.35,-5.9,;-6.12,-7.24,;-7.66,-7.24,;-8.43,-5.9,;-7.66,-4.57,;-8.43,-3.24,;-6.12,-4.57,)| Show InChI InChI=1S/C28H35N7O6S/c1-17-11-20(15-29-12-17)26-32-33-27(35(26)23-21(39-6)9-8-10-22(23)40-7)34-42(37,38)19(3)24(41-16-28(4,5)36)25-30-13-18(2)14-31-25/h8-15,19,24,36H,16H2,1-7H3,(H,33,34)/t19-,24+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 25 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269883
(1S,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl...)Show SMILES COCCO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:6.6,wD:5.4,(6.48,-13.22,;6.48,-11.68,;5.14,-10.91,;5.14,-9.37,;3.81,-8.6,;3.81,-7.06,;2.48,-6.29,;2.48,-4.75,;1.14,-7.06,;1.91,-8.39,;.37,-8.39,;-.19,-6.29,;-1.52,-7.06,;-2,-8.52,;-3.54,-8.52,;-4.02,-7.06,;-5.35,-6.29,;-6.12,-7.62,;-7.66,-7.62,;-8.43,-6.29,;-7.66,-4.95,;-8.43,-3.62,;-6.12,-4.95,;-2.77,-6.15,;-2.77,-4.43,;-1.39,-3.69,;-.05,-4.46,;1.28,-3.69,;-1.44,-2.12,;-2.77,-1.35,;-4.1,-2.12,;-4.1,-3.66,;-5.44,-4.43,;-6.77,-3.66,;5.14,-6.29,;5.14,-4.75,;6.48,-3.98,;7.81,-4.75,;9.15,-3.98,;7.81,-6.29,;6.48,-7.06,)| Show InChI InChI=1S/C27H33N7O6S/c1-17-12-20(16-28-13-17)26-31-32-27(34(26)23-21(38-5)8-7-9-22(23)39-6)33-41(35,36)19(3)24(40-11-10-37-4)25-29-14-18(2)15-30-25/h7-9,12-16,19,24H,10-11H2,1-6H3,(H,32,33)/t19-,24+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.460 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269884
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](OCCO)c2ncc(C)cn2)n1-c1c(OC)cccc1OC |r,wU:18.19,16.17,(-9.97,-9.05,;-8.43,-9.05,;-7.66,-7.71,;-8.43,-6.38,;-7.66,-5.04,;-6.12,-5.04,;-5.35,-6.38,;-6.12,-7.71,;-4.02,-7.15,;-3.54,-8.61,;-2,-8.61,;-1.52,-7.15,;-.19,-6.38,;1.14,-7.15,;1.91,-8.48,;.37,-8.48,;2.48,-6.38,;2.48,-4.84,;3.81,-7.15,;3.81,-8.69,;5.14,-9.46,;5.14,-11,;6.48,-11.77,;5.14,-6.38,;5.14,-4.84,;6.48,-4.07,;7.81,-4.84,;9.15,-4.07,;7.81,-6.38,;6.48,-7.15,;-2.77,-6.24,;-2.77,-4.52,;-1.39,-3.78,;-.05,-4.55,;1.28,-3.78,;-1.44,-2.21,;-2.77,-1.44,;-4.1,-2.21,;-4.1,-3.75,;-5.44,-4.52,;-6.77,-3.75,)| Show InChI InChI=1S/C26H31N7O7S/c1-16-14-27-24(28-15-16)23(40-13-12-34)17(2)41(35,36)32-26-31-30-25(18-8-6-11-21(29-18)39-5)33(26)22-19(37-3)9-7-10-20(22)38-4/h6-11,14-15,17,23,34H,12-13H2,1-5H3,(H,31,32)/t17-,23-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 8.90 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269884
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](OCCO)c2ncc(C)cn2)n1-c1c(OC)cccc1OC |r,wU:18.19,16.17,(-9.97,-9.05,;-8.43,-9.05,;-7.66,-7.71,;-8.43,-6.38,;-7.66,-5.04,;-6.12,-5.04,;-5.35,-6.38,;-6.12,-7.71,;-4.02,-7.15,;-3.54,-8.61,;-2,-8.61,;-1.52,-7.15,;-.19,-6.38,;1.14,-7.15,;1.91,-8.48,;.37,-8.48,;2.48,-6.38,;2.48,-4.84,;3.81,-7.15,;3.81,-8.69,;5.14,-9.46,;5.14,-11,;6.48,-11.77,;5.14,-6.38,;5.14,-4.84,;6.48,-4.07,;7.81,-4.84,;9.15,-4.07,;7.81,-6.38,;6.48,-7.15,;-2.77,-6.24,;-2.77,-4.52,;-1.39,-3.78,;-.05,-4.55,;1.28,-3.78,;-1.44,-2.21,;-2.77,-1.44,;-4.1,-2.21,;-4.1,-3.75,;-5.44,-4.52,;-6.77,-3.75,)| Show InChI InChI=1S/C26H31N7O7S/c1-16-14-27-24(28-15-16)23(40-13-12-34)17(2)41(35,36)32-26-31-30-25(18-8-6-11-21(29-18)39-5)33(26)22-19(37-3)9-7-10-20(22)38-4/h6-11,14-15,17,23,34H,12-13H2,1-5H3,(H,31,32)/t17-,23-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.260 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269886
((2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-ethenyl-...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cncc(C=C)c1 |r,wU:16.17,(2,-3.8,;.66,-4.57,;-.67,-3.8,;-.67,-2.26,;-2,-1.49,;-3.34,-2.26,;-3.34,-3.8,;-4.67,-4.57,;-6.01,-3.8,;-2,-4.57,;-2,-6.11,;-.76,-7.02,;.57,-6.25,;1.91,-7.02,;2.68,-8.35,;1.14,-8.35,;3.24,-6.25,;3.24,-4.71,;4.58,-7.02,;5.91,-6.25,;5.91,-4.71,;7.24,-3.94,;8.58,-4.71,;9.91,-3.94,;8.58,-6.25,;7.24,-7.02,;-1.23,-8.48,;-2.77,-8.48,;-3.25,-7.02,;-4.79,-7.02,;-5.56,-8.35,;-7.1,-8.35,;-7.87,-7.02,;-7.1,-5.68,;-7.87,-4.35,;-9.41,-4.35,;-5.56,-5.68,)| Show InChI InChI=1S/C24H24FN7O4S/c1-5-16-10-17(12-26-11-16)23-29-30-24(32(23)22-19(35-3)7-6-8-20(22)36-4)31-37(33,34)15(2)9-21-27-13-18(25)14-28-21/h5-8,10-15H,1,9H2,2-4H3,(H,30,31)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 11 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360117
((2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-ethyl-3-pyrid...)Show SMILES CCc1cncc(c1)-c1nnc(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC |r,wD:16.17,(-9.66,6.22,;-8.12,6.22,;-7.35,4.88,;-8.12,3.55,;-7.35,2.22,;-5.81,2.22,;-5.04,3.55,;-5.81,4.88,;-3.5,3.55,;-3.02,2.09,;-1.48,2.09,;-1.01,3.55,;.32,4.32,;1.66,3.55,;.32,2.78,;2.99,2.78,;2.99,4.32,;2.99,5.86,;4.33,3.55,;5.66,4.32,;6.99,3.55,;8.33,4.32,;8.33,5.86,;9.66,6.63,;6.99,6.63,;5.66,5.86,;-2.25,4.45,;-2.25,5.99,;-3.59,6.76,;-4.92,5.99,;-6.26,6.76,;-3.59,8.3,;-2.25,9.07,;-.92,8.3,;-.92,6.76,;.41,5.99,;1.75,6.76,)| Show InChI InChI=1S/C24H26FN7O4S/c1-5-16-10-17(12-26-11-16)23-29-30-24(32(23)22-19(35-3)7-6-8-20(22)36-4)31-37(33,34)15(2)9-21-27-13-18(25)14-28-21/h6-8,10-15H,5,9H2,1-4H3,(H,30,31)/t15-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360118
((2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-ethyl-3-pyrid...)Show SMILES CCc1cncc(c1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC |r,wU:16.17,(-9.66,6,;-8.12,6,;-7.35,4.67,;-8.12,3.33,;-7.35,2,;-5.81,2,;-5.04,3.33,;-5.81,4.67,;-3.5,3.33,;-3.02,1.87,;-1.48,1.87,;-1.01,3.33,;.32,4.1,;1.66,3.33,;.32,2.56,;2.99,2.56,;2.99,4.1,;2.99,5.64,;4.33,3.33,;5.66,4.1,;6.99,3.33,;8.33,4.1,;8.33,5.64,;9.66,6.41,;6.99,6.41,;5.66,5.64,;-2.25,4.24,;-2.25,5.78,;-3.59,6.55,;-4.92,5.78,;-6.26,6.55,;-3.59,8.09,;-2.25,8.86,;-.92,8.09,;-.92,6.55,;.41,5.78,;1.75,6.55,)| Show InChI InChI=1S/C24H26FN7O4S/c1-5-16-10-17(12-26-11-16)23-29-30-24(32(23)22-19(35-3)7-6-8-20(22)36-4)31-37(33,34)15(2)9-21-27-13-18(25)14-28-21/h6-8,10-15H,5,9H2,1-4H3,(H,30,31)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 6.70 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360119
((2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-ethyl-3-pyrid...)Show SMILES CCc1cncc(c1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC |r,wU:16.17,(-9.66,6.43,;-8.12,6.43,;-7.35,5.1,;-8.12,3.77,;-7.35,2.43,;-5.81,2.43,;-5.04,3.77,;-5.81,5.1,;-3.5,3.77,;-3.02,2.3,;-1.48,2.3,;-1.01,3.77,;.32,4.54,;1.66,3.77,;.32,3,;2.99,3,;2.99,4.54,;2.99,6.08,;4.33,3.77,;5.66,4.54,;6.99,3.77,;8.33,4.54,;8.33,6.08,;9.66,6.85,;6.99,6.85,;5.66,6.08,;-2.25,4.67,;-2.25,6.21,;-3.59,6.98,;-4.92,6.21,;-6.26,6.98,;-3.59,8.52,;-2.25,9.29,;-.92,8.52,;-.92,6.98,;.41,6.21,;1.75,6.98,)| Show InChI InChI=1S/C24H26FN7O4S/c1-5-16-10-17(12-26-11-16)23-29-30-24(32(23)22-19(35-3)7-6-8-20(22)36-4)31-37(33,34)15(2)9-21-27-13-18(25)14-28-21/h6-8,10-15H,5,9H2,1-4H3,(H,30,31)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 6.30 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360120
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)Show SMILES CN[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:2.1,3.3,(2.97,13.76,;4.3,14.53,;4.3,16.07,;2.97,16.84,;2.97,18.38,;1.63,16.07,;.86,14.73,;2.4,14.73,;.3,16.84,;-1.04,16.07,;-1.2,14.53,;-2.7,14.21,;-3.47,15.55,;-5.01,15.55,;-5.78,16.88,;-7.32,16.88,;-8.09,15.55,;-7.32,14.21,;-8.09,12.88,;-9.63,12.88,;-5.78,14.21,;-2.44,16.69,;-2.76,18.2,;-4.23,18.67,;-5.72,18.28,;-6.49,19.61,;-4.55,20.18,;-3.4,21.21,;-1.94,20.73,;-1.62,19.23,;-.15,18.75,;1.33,19.15,;5.63,16.84,;6.97,16.07,;8.3,16.84,;8.3,18.38,;9.63,19.15,;6.97,19.15,;5.63,18.38,)| Show InChI InChI=1S/C25H30N8O5S/c1-15-13-27-23(28-14-15)21(26-3)16(2)39(34,35)32-25-31-30-24(17-9-7-12-20(29-17)38-6)33(25)22-18(36-4)10-8-11-19(22)37-5/h7-14,16,21,26H,1-6H3,(H,31,32)/t16-,21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360121
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)Show SMILES CN[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:2.1,3.3,(2.97,14.2,;4.3,14.97,;4.3,16.51,;2.97,17.28,;2.97,18.82,;1.63,16.51,;.86,15.18,;2.4,15.18,;.3,17.28,;-1.04,16.51,;-1.2,14.98,;-2.7,14.66,;-3.47,16,;-5.01,16,;-5.78,17.33,;-7.32,17.33,;-8.09,16,;-7.32,14.66,;-8.09,13.33,;-9.63,13.33,;-5.78,14.66,;-2.44,17.14,;-2.76,18.65,;-4.23,19.12,;-5.72,18.72,;-6.49,20.06,;-4.55,20.63,;-3.4,21.66,;-1.94,21.18,;-1.62,19.68,;-.15,19.2,;1.33,19.6,;5.63,17.28,;6.97,16.51,;8.3,17.28,;8.3,18.82,;9.63,19.59,;6.97,19.59,;5.63,18.82,)| Show InChI InChI=1S/C25H30N8O5S/c1-15-13-27-23(28-14-15)21(26-3)16(2)39(34,35)32-25-31-30-24(17-9-7-12-20(29-17)38-6)33(25)22-18(36-4)10-8-11-19(22)37-5/h7-14,16,21,26H,1-6H3,(H,31,32)/t16-,21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.440 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360122
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)Show SMILES CN[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:2.1,3.3,(2.97,14.08,;4.3,14.85,;4.3,16.39,;2.97,17.16,;2.97,18.7,;1.63,16.39,;.86,15.06,;2.4,15.06,;.3,17.16,;-1.04,16.39,;-1.2,14.86,;-2.7,14.54,;-3.47,15.87,;-5.01,15.87,;-5.78,17.21,;-7.32,17.21,;-8.09,15.87,;-7.32,14.54,;-8.09,13.21,;-9.63,13.21,;-5.78,14.54,;-2.44,17.02,;-2.76,18.53,;-4.23,19,;-5.72,18.6,;-6.49,19.94,;-4.55,20.51,;-3.4,21.54,;-1.94,21.06,;-1.62,19.56,;-.15,19.08,;1.33,19.48,;5.63,17.16,;6.97,16.39,;8.3,17.16,;8.3,18.7,;9.63,19.47,;6.97,19.47,;5.63,18.7,)| Show InChI InChI=1S/C25H30N8O5S/c1-15-13-27-23(28-14-15)21(26-3)16(2)39(34,35)32-25-31-30-24(17-9-7-12-20(29-17)38-6)33(25)22-18(36-4)10-8-11-19(22)37-5/h7-14,16,21,26H,1-6H3,(H,31,32)/t16-,21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 7.10 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360123
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)Show SMILES CN[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:2.1,3.3,(2.97,14.11,;4.3,14.88,;4.3,16.42,;2.97,17.19,;2.97,18.73,;1.63,16.42,;.86,15.09,;2.4,15.09,;.3,17.19,;-1.04,16.42,;-1.2,14.89,;-2.7,14.57,;-3.47,15.9,;-5.01,15.9,;-5.78,17.24,;-7.32,17.24,;-8.09,15.9,;-7.32,14.57,;-8.09,13.24,;-9.63,13.24,;-5.78,14.57,;-2.44,17.05,;-2.76,18.55,;-4.23,19.03,;-5.72,18.63,;-6.49,19.96,;-4.55,20.54,;-3.4,21.57,;-1.94,21.09,;-1.62,19.58,;-.15,19.11,;1.33,19.51,;5.63,17.19,;6.97,16.42,;8.3,17.19,;8.3,18.73,;9.63,19.5,;6.97,19.5,;5.63,18.73,)| Show InChI InChI=1S/C25H30N8O5S/c1-15-13-27-23(28-14-15)21(26-3)16(2)39(34,35)32-25-31-30-24(17-9-7-12-20(29-17)38-6)33(25)22-18(36-4)10-8-11-19(22)37-5/h7-14,16,21,26H,1-6H3,(H,31,32)/t16-,21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360124
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)Show SMILES CN[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:2.1,3.3,(2.97,13.61,;4.3,14.38,;4.3,15.92,;2.97,16.69,;2.97,18.23,;1.63,15.92,;.86,14.59,;2.4,14.59,;.3,16.69,;-1.04,15.92,;-1.2,14.39,;-2.7,14.07,;-3.47,15.41,;-5.01,15.41,;-5.78,16.74,;-7.32,16.74,;-8.09,15.41,;-7.32,14.07,;-8.09,12.74,;-9.63,12.74,;-5.78,14.07,;-2.44,16.55,;-2.76,18.06,;-4.23,18.53,;-5.72,18.13,;-6.49,19.47,;-4.55,20.04,;-3.4,21.07,;-1.94,20.59,;-1.62,19.09,;-.15,18.61,;1.33,19.01,;5.63,16.69,;6.97,15.92,;8.3,16.69,;8.3,18.23,;9.63,19,;6.97,19,;5.63,18.23,)| Show InChI InChI=1S/C25H30N8O5S/c1-15-13-27-23(28-14-15)21(26-3)16(2)39(34,35)32-25-31-30-24(17-9-7-12-20(29-17)38-6)33(25)22-18(36-4)10-8-11-19(22)37-5/h7-14,16,21,26H,1-6H3,(H,31,32)/t16-,21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 12.6 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360125
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)Show SMILES CN[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:2.1,3.3,(2.97,14.95,;4.3,15.72,;4.3,17.26,;2.97,18.03,;2.97,19.57,;1.63,17.26,;.86,15.93,;2.4,15.93,;.3,18.03,;-1.04,17.26,;-1.2,15.73,;-2.7,15.41,;-3.47,16.74,;-5.01,16.74,;-5.78,18.08,;-7.32,18.08,;-8.09,16.74,;-7.32,15.41,;-8.09,14.08,;-9.63,14.08,;-5.78,15.41,;-2.44,17.89,;-2.76,19.39,;-4.23,19.87,;-5.72,19.47,;-6.49,20.8,;-4.55,21.38,;-3.4,22.41,;-1.94,21.93,;-1.62,20.42,;-.15,19.95,;1.33,20.35,;5.63,18.03,;6.97,17.26,;8.3,18.03,;8.3,19.57,;9.63,20.34,;6.97,20.34,;5.63,19.57,)| Show InChI InChI=1S/C25H30N8O5S/c1-15-13-27-23(28-14-15)21(26-3)16(2)39(34,35)32-25-31-30-24(17-9-7-12-20(29-17)38-6)33(25)22-18(36-4)10-8-11-19(22)37-5/h7-14,16,21,26H,1-6H3,(H,31,32)/t16-,21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.340 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270010
((1S,2R)-1-(5-chloro-2-pyrimidinyl)-N-(4-(2,6-dimet...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1 |r,wU:3.3,2.1,(5.04,-21.28,;5.81,-19.95,;5.04,-18.62,;3.5,-18.62,;2.73,-17.28,;2.73,-19.95,;1.96,-21.28,;4.07,-20.72,;1.4,-19.18,;.07,-19.95,;.07,-21.49,;-1.4,-21.97,;-2.3,-20.72,;-3.84,-20.72,;-4.61,-19.39,;-6.15,-19.39,;-6.92,-20.72,;-6.15,-22.05,;-6.92,-23.39,;-4.61,-22.05,;-1.4,-19.48,;-1.91,-17.63,;-3.39,-17.23,;-4.48,-18.32,;-5.97,-17.92,;-3.79,-15.74,;-2.7,-14.65,;-1.22,-15.05,;-.82,-16.54,;.67,-16.94,;1.76,-15.85,;5.81,-17.28,;7.35,-17.28,;8.12,-15.95,;7.35,-14.62,;8.12,-13.28,;5.81,-14.62,;5.04,-15.95,)| Show InChI InChI=1S/C24H26ClN7O5S/c1-14-9-16(11-26-10-14)23-29-30-24(32(23)20-18(35-3)7-6-8-19(20)36-4)31-38(33,34)15(2)21(37-5)22-27-12-17(25)13-28-22/h6-13,15,21H,1-5H3,(H,30,31)/t15-,21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269897
((1R,2S)-1-(5-chloropyrimidin-2-yl)-N-(4-(2,6-dimet...)Show SMILES CCO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1 |r,wU:4.4,3.2,(4.81,-4.69,;4.81,-3.15,;3.48,-2.38,;3.48,-.84,;2.14,-.07,;2.14,1.47,;.81,-.84,;.04,-2.17,;1.58,-2.17,;-.52,-.07,;-1.86,-.84,;-2.33,-2.3,;-3.87,-2.3,;-4.35,-.84,;-5.84,-.44,;-6.93,-1.53,;-8.41,-1.13,;-8.81,.36,;-7.72,1.45,;-8.12,2.93,;-6.24,1.05,;-3.1,.07,;-3.1,1.61,;-1.77,2.38,;-.44,1.61,;.9,2.38,;-1.77,3.92,;-3.1,4.69,;-4.44,3.92,;-4.44,2.38,;-5.77,1.61,;-7.1,2.38,;4.81,-.07,;6.14,-.84,;7.48,-.07,;7.48,1.47,;8.81,2.24,;6.14,2.24,;4.81,1.47,)| Show InChI InChI=1S/C25H28ClN7O5S/c1-6-38-22(23-28-13-18(26)14-29-23)16(3)39(34,35)32-25-31-30-24(17-10-15(2)11-27-12-17)33(25)21-19(36-4)8-7-9-20(21)37-5/h7-14,16,22H,6H2,1-5H3,(H,31,32)/t16-,22-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.270 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269898
((1R,2S)-1-(5-chloropyrimidin-2-yl)-N-(4-(2,6-dimet...)Show SMILES CCO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1 |r,wU:4.4,3.2,(4.81,-4.75,;4.81,-3.21,;3.48,-2.44,;3.48,-.9,;2.14,-.13,;2.14,1.41,;.81,-.9,;.04,-2.24,;1.58,-2.24,;-.52,-.13,;-1.86,-.9,;-2.33,-2.37,;-3.87,-2.37,;-4.35,-.9,;-5.84,-.5,;-6.24,.98,;-7.72,1.38,;-8.81,.29,;-8.41,-1.2,;-6.93,-1.59,;-3.1,0,;-3.5,1.78,;-2.41,2.87,;-1.08,2.1,;.25,2.87,;-2.81,4.35,;-4.3,4.75,;-5.39,3.66,;-4.99,2.18,;-6.48,1.78,;-6.88,3.27,;4.81,-.13,;6.14,-.9,;7.48,-.13,;7.48,1.41,;8.81,2.18,;6.14,2.18,;4.81,1.41,)| Show InChI InChI=1S/C24H26ClN7O5S/c1-5-37-21(22-27-13-17(25)14-28-22)15(2)38(33,34)31-24-30-29-23(16-8-7-11-26-12-16)32(24)20-18(35-3)9-6-10-19(20)36-4/h6-15,21H,5H2,1-4H3,(H,30,31)/t15-,21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.530 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269898
((1R,2S)-1-(5-chloropyrimidin-2-yl)-N-(4-(2,6-dimet...)Show SMILES CCO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1 |r,wU:4.4,3.2,(4.81,-4.75,;4.81,-3.21,;3.48,-2.44,;3.48,-.9,;2.14,-.13,;2.14,1.41,;.81,-.9,;.04,-2.24,;1.58,-2.24,;-.52,-.13,;-1.86,-.9,;-2.33,-2.37,;-3.87,-2.37,;-4.35,-.9,;-5.84,-.5,;-6.24,.98,;-7.72,1.38,;-8.81,.29,;-8.41,-1.2,;-6.93,-1.59,;-3.1,0,;-3.5,1.78,;-2.41,2.87,;-1.08,2.1,;.25,2.87,;-2.81,4.35,;-4.3,4.75,;-5.39,3.66,;-4.99,2.18,;-6.48,1.78,;-6.88,3.27,;4.81,-.13,;6.14,-.9,;7.48,-.13,;7.48,1.41,;8.81,2.18,;6.14,2.18,;4.81,1.41,)| Show InChI InChI=1S/C24H26ClN7O5S/c1-5-37-21(22-27-13-17(25)14-28-22)15(2)38(33,34)31-24-30-29-23(16-8-7-11-26-12-16)32(24)20-18(35-3)9-6-10-19(20)36-4/h6-15,21H,5H2,1-4H3,(H,30,31)/t15-,21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.530 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360130
((2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)Show SMILES COc1cccc(n1)-c1nnc(N(CC[Si](C)(C)C)S(=O)(=O)[C@@H](C)[C@H](O)C(C)(C)C)n1-c1c(OC)cccc1OC |r,wD:22.23,24.25,(-18.06,-10.79,;-16.53,-10.95,;-15.63,-9.71,;-16.25,-8.3,;-15.35,-7.05,;-13.82,-7.21,;-13.19,-8.62,;-14.09,-9.87,;-11.66,-8.78,;-10.89,-10.12,;-9.38,-9.8,;-9.22,-8.26,;-7.89,-7.49,;-7.89,-5.95,;-6.55,-5.18,;-6.55,-3.64,;-5.22,-2.87,;-7.89,-2.87,;-6.55,-2.1,;-6.55,-8.26,;-5.78,-6.93,;-7.32,-9.6,;-5.22,-9.03,;-5.22,-10.57,;-3.89,-8.26,;-3.89,-6.72,;-2.55,-9.03,;-1.22,-8.26,;-2.55,-10.57,;-1.22,-9.8,;-10.63,-7.64,;-10.95,-6.13,;-12.41,-5.66,;-13.56,-6.69,;-15.02,-6.21,;-12.73,-4.15,;-11.59,-3.12,;-10.12,-3.59,;-9.8,-5.1,;-8.34,-5.58,;-7.19,-4.55,)| Show InChI InChI=1S/C28H43N5O6SSi/c1-19(25(34)28(2,3)4)40(35,36)32(17-18-41(8,9)10)27-31-30-26(20-13-11-16-23(29-20)39-7)33(27)24-21(37-5)14-12-15-22(24)38-6/h11-16,19,25,34H,17-18H2,1-10H3/t19-,25-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 42 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269901
((2S,3R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@@H](O)C(C)(C)C)n1-c1c(OC)cccc1OC |r,wD:16.17,18.19,(-8.29,-8.35,;-6.8,-8.75,;-5.71,-7.66,;-6.11,-6.17,;-5.02,-5.09,;-3.54,-5.48,;-3.14,-6.97,;-4.23,-8.06,;-1.65,-7.37,;-1.17,-8.84,;.37,-8.84,;.84,-7.37,;2.18,-6.6,;3.51,-7.37,;2.74,-8.7,;4.28,-8.7,;4.84,-6.6,;4.84,-5.06,;6.18,-7.37,;6.18,-8.91,;7.51,-6.6,;8.84,-7.37,;7.51,-5.06,;8.84,-5.83,;-.4,-6.47,;-.4,-4.93,;-1.74,-4.16,;-3.07,-4.93,;-4.4,-4.16,;-1.74,-2.62,;-.4,-1.85,;.93,-2.62,;.93,-4.16,;2.26,-4.93,;3.6,-4.16,)| Show InChI InChI=1S/C23H31N5O6S/c1-14(20(29)23(2,3)4)35(30,31)27-22-26-25-21(15-10-8-13-18(24-15)34-7)28(22)19-16(32-5)11-9-12-17(19)33-6/h8-14,20,29H,1-7H3,(H,26,27)/t14-,20-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269902
((2S,3S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@H](O)C(C)(C)C)n1-c1c(OC)cccc1OC |r,wU:18.19,wD:16.17,(-8.29,-8.35,;-6.8,-8.75,;-5.71,-7.66,;-6.11,-6.17,;-5.02,-5.09,;-3.54,-5.48,;-3.14,-6.97,;-4.23,-8.06,;-1.65,-7.37,;-1.17,-8.84,;.37,-8.84,;.84,-7.37,;2.18,-6.6,;3.51,-7.37,;2.74,-8.7,;4.28,-8.7,;4.84,-6.6,;4.84,-5.06,;6.18,-7.37,;6.18,-8.91,;7.51,-6.6,;8.84,-7.37,;7.51,-5.06,;8.84,-5.83,;-.4,-6.47,;-.4,-4.93,;-1.74,-4.16,;-3.07,-4.93,;-4.4,-4.16,;-1.74,-2.62,;-.4,-1.85,;.93,-2.62,;.93,-4.16,;2.26,-4.93,;3.6,-4.16,)| Show InChI InChI=1S/C23H31N5O6S/c1-14(20(29)23(2,3)4)35(30,31)27-22-26-25-21(15-10-8-13-18(24-15)34-7)28(22)19-16(32-5)11-9-12-17(19)33-6/h8-14,20,29H,1-7H3,(H,26,27)/t14-,20+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 24 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269902
((2S,3S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@H](O)C(C)(C)C)n1-c1c(OC)cccc1OC |r,wU:18.19,wD:16.17,(-8.29,-8.35,;-6.8,-8.75,;-5.71,-7.66,;-6.11,-6.17,;-5.02,-5.09,;-3.54,-5.48,;-3.14,-6.97,;-4.23,-8.06,;-1.65,-7.37,;-1.17,-8.84,;.37,-8.84,;.84,-7.37,;2.18,-6.6,;3.51,-7.37,;2.74,-8.7,;4.28,-8.7,;4.84,-6.6,;4.84,-5.06,;6.18,-7.37,;6.18,-8.91,;7.51,-6.6,;8.84,-7.37,;7.51,-5.06,;8.84,-5.83,;-.4,-6.47,;-.4,-4.93,;-1.74,-4.16,;-3.07,-4.93,;-4.4,-4.16,;-1.74,-2.62,;-.4,-1.85,;.93,-2.62,;.93,-4.16,;2.26,-4.93,;3.6,-4.16,)| Show InChI InChI=1S/C23H31N5O6S/c1-14(20(29)23(2,3)4)35(30,31)27-22-26-25-21(15-10-8-13-18(24-15)34-7)28(22)19-16(32-5)11-9-12-17(19)33-6/h8-14,20,29H,1-7H3,(H,26,27)/t14-,20+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269901
((2S,3R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@@H](O)C(C)(C)C)n1-c1c(OC)cccc1OC |r,wD:16.17,18.19,(-8.29,-8.35,;-6.8,-8.75,;-5.71,-7.66,;-6.11,-6.17,;-5.02,-5.09,;-3.54,-5.48,;-3.14,-6.97,;-4.23,-8.06,;-1.65,-7.37,;-1.17,-8.84,;.37,-8.84,;.84,-7.37,;2.18,-6.6,;3.51,-7.37,;2.74,-8.7,;4.28,-8.7,;4.84,-6.6,;4.84,-5.06,;6.18,-7.37,;6.18,-8.91,;7.51,-6.6,;8.84,-7.37,;7.51,-5.06,;8.84,-5.83,;-.4,-6.47,;-.4,-4.93,;-1.74,-4.16,;-3.07,-4.93,;-4.4,-4.16,;-1.74,-2.62,;-.4,-1.85,;.93,-2.62,;.93,-4.16,;2.26,-4.93,;3.6,-4.16,)| Show InChI InChI=1S/C23H31N5O6S/c1-14(20(29)23(2,3)4)35(30,31)27-22-26-25-21(15-10-8-13-18(24-15)34-7)28(22)19-16(32-5)11-9-12-17(19)33-6/h8-14,20,29H,1-7H3,(H,26,27)/t14-,20-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 31 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360135
((1R,2R)-1-cyclopropyl-N-(4-(2,6-dimethoxyphenyl)-5...)Show SMILES COc1cccc(n1)-c1nnc(N(CC[Si](C)(C)C)S(=O)(=O)[C@@H](C)[C@H](O)C2CC2)n1-c1c(OC)cccc1OC |r,wD:22.23,24.25,(-18.17,-10.79,;-16.63,-10.95,;-15.73,-9.71,;-16.36,-8.3,;-15.45,-7.05,;-13.92,-7.21,;-13.29,-8.62,;-14.2,-9.87,;-11.76,-8.78,;-10.99,-10.12,;-9.48,-9.8,;-9.32,-8.26,;-7.99,-7.49,;-7.99,-5.95,;-6.66,-5.18,;-6.66,-3.64,;-5.32,-2.87,;-7.99,-2.87,;-6.66,-2.1,;-6.66,-8.26,;-5.89,-6.93,;-7.43,-9.6,;-5.32,-9.03,;-5.32,-10.57,;-3.99,-8.26,;-3.99,-6.72,;-2.66,-9.03,;-1.89,-10.37,;-1.12,-9.03,;-10.73,-7.64,;-11.05,-6.13,;-12.52,-5.66,;-13.66,-6.69,;-15.12,-6.21,;-12.84,-4.15,;-11.69,-3.12,;-10.23,-3.59,;-9.91,-5.1,;-8.44,-5.58,;-7.3,-4.55,)| Show InChI InChI=1S/C27H39N5O6SSi/c1-18(25(33)19-14-15-19)39(34,35)31(16-17-40(5,6)7)27-30-29-26(20-10-8-13-23(28-20)38-4)32(27)24-21(36-2)11-9-12-22(24)37-3/h8-13,18-19,25,33H,14-17H2,1-7H3/t18-,25-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 52 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269906
((1R,2S)-1-cyclopropyl-N-(4-(2,6-dimethoxyphenyl)-5...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@@H](O)C2CC2)n1-c1c(OC)cccc1OC |r,wD:16.17,18.19,(-8.41,-8.33,;-6.92,-8.73,;-5.83,-7.64,;-6.23,-6.16,;-5.14,-5.07,;-3.65,-5.47,;-3.25,-6.95,;-4.34,-8.04,;-1.77,-7.35,;-1.29,-8.82,;.25,-8.82,;.73,-7.35,;2.06,-6.58,;3.39,-7.35,;2.62,-8.69,;4.16,-8.69,;4.73,-6.58,;4.73,-5.04,;6.06,-7.35,;6.06,-8.89,;7.39,-6.58,;8.93,-6.58,;8.16,-5.25,;-.52,-6.45,;-.52,-4.91,;-1.85,-4.14,;-3.19,-4.91,;-4.52,-4.14,;-1.85,-2.6,;-.52,-1.83,;.81,-2.6,;.81,-4.14,;2.15,-4.91,;3.48,-4.14,)| Show InChI InChI=1S/C22H27N5O6S/c1-13(20(28)14-11-12-14)34(29,30)26-22-25-24-21(15-7-5-10-18(23-15)33-4)27(22)19-16(31-2)8-6-9-17(19)32-3/h5-10,13-14,20,28H,11-12H2,1-4H3,(H,25,26)/t13-,20-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 110 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269906
((1R,2S)-1-cyclopropyl-N-(4-(2,6-dimethoxyphenyl)-5...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@@H](O)C2CC2)n1-c1c(OC)cccc1OC |r,wD:16.17,18.19,(-8.41,-8.33,;-6.92,-8.73,;-5.83,-7.64,;-6.23,-6.16,;-5.14,-5.07,;-3.65,-5.47,;-3.25,-6.95,;-4.34,-8.04,;-1.77,-7.35,;-1.29,-8.82,;.25,-8.82,;.73,-7.35,;2.06,-6.58,;3.39,-7.35,;2.62,-8.69,;4.16,-8.69,;4.73,-6.58,;4.73,-5.04,;6.06,-7.35,;6.06,-8.89,;7.39,-6.58,;8.93,-6.58,;8.16,-5.25,;-.52,-6.45,;-.52,-4.91,;-1.85,-4.14,;-3.19,-4.91,;-4.52,-4.14,;-1.85,-2.6,;-.52,-1.83,;.81,-2.6,;.81,-4.14,;2.15,-4.91,;3.48,-4.14,)| Show InChI InChI=1S/C22H27N5O6S/c1-13(20(28)14-11-12-14)34(29,30)26-22-25-24-21(15-7-5-10-18(23-15)33-4)27(22)19-16(31-2)8-6-9-17(19)32-3/h5-10,13-14,20,28H,11-12H2,1-4H3,(H,25,26)/t13-,20-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 49 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360138
((1R,2R)-1-cyclohexyl-N-(4-(2,6-dimethoxyphenyl)-5-...)Show SMILES COc1cccc(n1)-c1nnc(N(CC[Si](C)(C)C)S(=O)(=O)[C@@H](C)[C@H](O)C2CCCCC2)n1-c1c(OC)cccc1OC |r,wD:22.23,24.25,(-19.42,-10.59,;-17.88,-10.76,;-16.98,-9.51,;-17.6,-8.1,;-16.7,-6.86,;-15.17,-7.02,;-14.54,-8.42,;-15.45,-9.67,;-13.01,-8.59,;-12.24,-9.92,;-10.73,-9.6,;-10.57,-8.07,;-9.24,-7.3,;-9.24,-5.76,;-7.91,-4.99,;-7.91,-3.45,;-6.57,-2.68,;-9.24,-2.68,;-7.91,-1.91,;-7.91,-8.07,;-7.14,-6.73,;-8.68,-9.4,;-6.57,-8.84,;-6.57,-10.38,;-5.24,-8.07,;-5.24,-6.53,;-3.9,-8.84,;-3.9,-10.38,;-2.57,-11.15,;-1.24,-10.38,;-1.24,-8.84,;-2.57,-8.07,;-11.98,-7.44,;-12.3,-5.94,;-13.76,-5.46,;-14.91,-6.49,;-16.37,-6.01,;-14.08,-3.95,;-12.94,-2.92,;-11.48,-3.4,;-11.16,-4.9,;-9.69,-5.38,;-8.55,-4.35,)| Show InChI InChI=1S/C30H45N5O6SSi/c1-21(28(36)22-13-9-8-10-14-22)42(37,38)34(19-20-43(5,6)7)30-33-32-29(23-15-11-18-26(31-23)41-4)35(30)27-24(39-2)16-12-17-25(27)40-3/h11-12,15-18,21-22,28,36H,8-10,13-14,19-20H2,1-7H3/t21-,28-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269909
((1R,2S)-1-cyclohexyl-N-(4-(2,6-dimethoxyphenyl)-5-...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@@H](O)C2CCCCC2)n1-c1c(OC)cccc1OC |r,wD:16.17,18.19,(-8.96,-8.33,;-7.48,-8.73,;-6.39,-7.64,;-6.79,-6.16,;-5.7,-5.07,;-4.21,-5.47,;-3.81,-6.95,;-4.9,-8.04,;-2.32,-7.35,;-1.85,-8.82,;-.31,-8.82,;.17,-7.35,;1.5,-6.58,;2.84,-7.35,;2.07,-8.69,;3.61,-8.69,;4.17,-6.58,;4.17,-5.04,;5.5,-7.35,;5.5,-8.89,;6.84,-6.58,;8.17,-7.35,;9.5,-6.58,;9.5,-5.04,;8.17,-4.27,;6.84,-5.04,;-1.08,-6.45,;-1.08,-4.91,;-2.41,-4.14,;-3.74,-4.91,;-5.08,-4.14,;-2.41,-2.6,;-1.08,-1.83,;.26,-2.6,;.26,-4.14,;1.59,-4.91,;2.92,-4.14,)| Show InChI InChI=1S/C25H33N5O6S/c1-16(23(31)17-10-6-5-7-11-17)37(32,33)29-25-28-27-24(18-12-8-15-21(26-18)36-4)30(25)22-19(34-2)13-9-14-20(22)35-3/h8-9,12-17,23,31H,5-7,10-11H2,1-4H3,(H,28,29)/t16-,23-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269909
((1R,2S)-1-cyclohexyl-N-(4-(2,6-dimethoxyphenyl)-5-...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@@H](O)C2CCCCC2)n1-c1c(OC)cccc1OC |r,wD:16.17,18.19,(-8.96,-8.33,;-7.48,-8.73,;-6.39,-7.64,;-6.79,-6.16,;-5.7,-5.07,;-4.21,-5.47,;-3.81,-6.95,;-4.9,-8.04,;-2.32,-7.35,;-1.85,-8.82,;-.31,-8.82,;.17,-7.35,;1.5,-6.58,;2.84,-7.35,;2.07,-8.69,;3.61,-8.69,;4.17,-6.58,;4.17,-5.04,;5.5,-7.35,;5.5,-8.89,;6.84,-6.58,;8.17,-7.35,;9.5,-6.58,;9.5,-5.04,;8.17,-4.27,;6.84,-5.04,;-1.08,-6.45,;-1.08,-4.91,;-2.41,-4.14,;-3.74,-4.91,;-5.08,-4.14,;-2.41,-2.6,;-1.08,-1.83,;.26,-2.6,;.26,-4.14,;1.59,-4.91,;2.92,-4.14,)| Show InChI InChI=1S/C25H33N5O6S/c1-16(23(31)17-10-6-5-7-11-17)37(32,33)29-25-28-27-24(18-12-8-15-21(26-18)36-4)30(25)22-19(34-2)13-9-14-20(22)35-3/h8-9,12-17,23,31H,5-7,10-11H2,1-4H3,(H,28,29)/t16-,23-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360141
((1R,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)Show SMILES COc1cccc(n1)-c1nnc(N(CC[Si](C)(C)C)S(=O)(=O)[C@@H](C)[C@H](O)C2CCOCC2)n1-c1c(OC)cccc1OC |r,wD:24.25,22.23,(-19.49,-10.37,;-17.96,-10.53,;-17.06,-9.29,;-17.68,-7.88,;-16.78,-6.63,;-15.25,-6.79,;-14.62,-8.2,;-15.53,-9.45,;-13.09,-8.36,;-12.32,-9.7,;-10.81,-9.38,;-10.65,-7.84,;-9.32,-7.07,;-9.32,-5.53,;-7.98,-4.76,;-7.98,-3.22,;-6.65,-2.45,;-9.32,-2.45,;-7.98,-1.68,;-7.98,-7.84,;-7.21,-6.51,;-8.75,-9.18,;-6.65,-8.61,;-6.65,-10.15,;-5.32,-7.84,;-5.32,-6.3,;-3.98,-8.61,;-3.98,-10.15,;-2.65,-10.92,;-1.32,-10.15,;-1.32,-8.61,;-2.65,-7.84,;-12.06,-7.22,;-12.38,-5.71,;-13.84,-5.24,;-14.99,-6.27,;-16.45,-5.79,;-14.16,-3.73,;-13.02,-2.7,;-11.55,-3.17,;-11.23,-4.68,;-9.77,-5.16,;-8.62,-4.13,)| Show InChI InChI=1S/C29H43N5O7SSi/c1-20(27(35)21-14-17-41-18-15-21)42(36,37)33(16-19-43(5,6)7)29-32-31-28(22-10-8-13-25(30-22)40-4)34(29)26-23(38-2)11-9-12-24(26)39-3/h8-13,20-21,27,35H,14-19H2,1-7H3/t20-,27-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 80 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269912
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@@H](O)C2CCOCC2)n1-c1c(OC)cccc1OC |r,wD:16.17,18.19,(-8.93,-8.38,;-7.44,-8.78,;-6.35,-7.69,;-6.75,-6.2,;-5.66,-5.11,;-4.17,-5.51,;-3.78,-7,;-4.86,-8.09,;-2.29,-7.4,;-1.81,-8.86,;-.27,-8.86,;.2,-7.4,;1.54,-6.63,;2.87,-7.4,;2.1,-8.73,;3.64,-8.73,;4.2,-6.63,;4.2,-5.09,;5.54,-7.4,;5.54,-8.94,;6.87,-6.63,;8.21,-7.4,;9.54,-6.63,;9.54,-5.09,;8.21,-4.32,;6.87,-5.09,;-1.04,-6.49,;-1.04,-4.95,;-2.38,-4.18,;-3.71,-4.95,;-5.04,-4.18,;-2.38,-2.64,;-1.04,-1.87,;.29,-2.64,;.29,-4.18,;1.63,-4.95,;2.96,-4.18,)| Show InChI InChI=1S/C24H31N5O7S/c1-15(22(30)16-11-13-36-14-12-16)37(31,32)28-24-27-26-23(17-7-5-10-20(25-17)35-4)29(24)21-18(33-2)8-6-9-19(21)34-3/h5-10,15-16,22,30H,11-14H2,1-4H3,(H,27,28)/t15-,22-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269913
((1S,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@H](O)C2CCOCC2)n1-c1c(OC)cccc1OC |r,wU:18.19,wD:16.17,(-8.89,-8.11,;-7.41,-8.51,;-6.32,-7.42,;-6.71,-5.94,;-5.63,-4.85,;-4.14,-5.25,;-3.74,-6.73,;-4.83,-7.82,;-2.25,-7.13,;-1.78,-8.6,;-.24,-8.6,;.24,-7.13,;1.57,-6.36,;2.91,-7.13,;3.68,-8.47,;2.14,-8.47,;4.24,-6.36,;4.24,-4.82,;5.57,-7.13,;5.57,-8.67,;6.91,-6.36,;8.24,-7.13,;9.58,-6.36,;9.58,-4.82,;8.24,-4.05,;6.91,-4.82,;-1.01,-6.23,;-1.01,-4.69,;-2.34,-3.92,;-3.67,-4.69,;-5.01,-3.92,;-2.34,-2.38,;-1.01,-1.61,;.33,-2.38,;.33,-3.92,;1.66,-4.69,;2.99,-3.92,)| Show InChI InChI=1S/C24H31N5O7S/c1-15(22(30)16-11-13-36-14-12-16)37(31,32)28-24-27-26-23(17-7-5-10-20(25-17)35-4)29(24)21-18(33-2)8-6-9-19(21)34-3/h5-10,15-16,22,30H,11-14H2,1-4H3,(H,27,28)/t15-,22+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 85 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269912
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@@H](O)C2CCOCC2)n1-c1c(OC)cccc1OC |r,wD:16.17,18.19,(-8.93,-8.38,;-7.44,-8.78,;-6.35,-7.69,;-6.75,-6.2,;-5.66,-5.11,;-4.17,-5.51,;-3.78,-7,;-4.86,-8.09,;-2.29,-7.4,;-1.81,-8.86,;-.27,-8.86,;.2,-7.4,;1.54,-6.63,;2.87,-7.4,;2.1,-8.73,;3.64,-8.73,;4.2,-6.63,;4.2,-5.09,;5.54,-7.4,;5.54,-8.94,;6.87,-6.63,;8.21,-7.4,;9.54,-6.63,;9.54,-5.09,;8.21,-4.32,;6.87,-5.09,;-1.04,-6.49,;-1.04,-4.95,;-2.38,-4.18,;-3.71,-4.95,;-5.04,-4.18,;-2.38,-2.64,;-1.04,-1.87,;.29,-2.64,;.29,-4.18,;1.63,-4.95,;2.96,-4.18,)| Show InChI InChI=1S/C24H31N5O7S/c1-15(22(30)16-11-13-36-14-12-16)37(31,32)28-24-27-26-23(17-7-5-10-20(25-17)35-4)29(24)21-18(33-2)8-6-9-19(21)34-3/h5-10,15-16,22,30H,11-14H2,1-4H3,(H,27,28)/t15-,22-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 29 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269913
((1S,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@H](O)C2CCOCC2)n1-c1c(OC)cccc1OC |r,wU:18.19,wD:16.17,(-8.89,-8.11,;-7.41,-8.51,;-6.32,-7.42,;-6.71,-5.94,;-5.63,-4.85,;-4.14,-5.25,;-3.74,-6.73,;-4.83,-7.82,;-2.25,-7.13,;-1.78,-8.6,;-.24,-8.6,;.24,-7.13,;1.57,-6.36,;2.91,-7.13,;3.68,-8.47,;2.14,-8.47,;4.24,-6.36,;4.24,-4.82,;5.57,-7.13,;5.57,-8.67,;6.91,-6.36,;8.24,-7.13,;9.58,-6.36,;9.58,-4.82,;8.24,-4.05,;6.91,-4.82,;-1.01,-6.23,;-1.01,-4.69,;-2.34,-3.92,;-3.67,-4.69,;-5.01,-3.92,;-2.34,-2.38,;-1.01,-1.61,;.33,-2.38,;.33,-3.92,;1.66,-4.69,;2.99,-3.92,)| Show InChI InChI=1S/C24H31N5O7S/c1-15(22(30)16-11-13-36-14-12-16)37(31,32)28-24-27-26-23(17-7-5-10-20(25-17)35-4)29(24)21-18(33-2)8-6-9-19(21)34-3/h5-10,15-16,22,30H,11-14H2,1-4H3,(H,27,28)/t15-,22+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269916
((2S,3R)—N-(4-(4,6-dimethoxy-5-pyrimidinyl)-5-...)Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)nnc1-c1cncc(C)c1 |r,wU:18.19,16.17,(2.17,-4.02,;1.08,-5.11,;-.4,-4.71,;-.8,-3.23,;-2.29,-2.83,;-3.38,-3.92,;-2.98,-5.4,;-4.07,-6.49,;-5.56,-6.09,;-1.49,-5.8,;-1.09,-7.29,;.37,-7.77,;1.7,-7,;3.04,-7.77,;2.27,-9.1,;4.37,-8.54,;3.81,-6.43,;3.04,-5.1,;5.35,-6.43,;6.12,-7.77,;6.12,-5.1,;7.66,-5.1,;8.43,-3.76,;7.66,-2.43,;8.43,-1.1,;6.12,-2.43,;5.35,-3.76,;.37,-9.31,;-1.09,-9.78,;-2,-8.54,;-3.54,-8.54,;-4.31,-7.2,;-5.85,-7.2,;-6.62,-8.54,;-5.85,-9.87,;-6.62,-11.2,;-4.31,-9.87,)| Show InChI InChI=1S/C22H24FN9O4S/c1-12-6-15(8-24-7-12)19-29-30-22(32(19)17-20(35-4)27-11-28-21(17)36-5)31-37(33,34)14(3)13(2)18-25-9-16(23)10-26-18/h6-11,13-14H,1-5H3,(H,30,31)/t13-,14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269916
((2S,3R)—N-(4-(4,6-dimethoxy-5-pyrimidinyl)-5-...)Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)nnc1-c1cncc(C)c1 |r,wU:18.19,16.17,(2.17,-4.02,;1.08,-5.11,;-.4,-4.71,;-.8,-3.23,;-2.29,-2.83,;-3.38,-3.92,;-2.98,-5.4,;-4.07,-6.49,;-5.56,-6.09,;-1.49,-5.8,;-1.09,-7.29,;.37,-7.77,;1.7,-7,;3.04,-7.77,;2.27,-9.1,;4.37,-8.54,;3.81,-6.43,;3.04,-5.1,;5.35,-6.43,;6.12,-7.77,;6.12,-5.1,;7.66,-5.1,;8.43,-3.76,;7.66,-2.43,;8.43,-1.1,;6.12,-2.43,;5.35,-3.76,;.37,-9.31,;-1.09,-9.78,;-2,-8.54,;-3.54,-8.54,;-4.31,-7.2,;-5.85,-7.2,;-6.62,-8.54,;-5.85,-9.87,;-6.62,-11.2,;-4.31,-9.87,)| Show InChI InChI=1S/C22H24FN9O4S/c1-12-6-15(8-24-7-12)19-29-30-22(32(19)17-20(35-4)27-11-28-21(17)36-5)31-37(33,34)14(3)13(2)18-25-9-16(23)10-26-18/h6-11,13-14H,1-5H3,(H,30,31)/t13-,14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
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