Compile Data Set for Download or QSAR

Found 826 hits Enz. Inhib. hit(s) with all data for entry = 2764   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380105 (5-ethoxy-2-methyl-N-[4- (4-oxo-3,4- dihydrophthala...) Show SMILES CCOc1ccc2oc(C)c(C(=O)Nc3ccc(cc3)-c3n[nH]c(=O)c4ccccc34)c2c1 Show InChI InChI=1S/C26H21N3O4/c1-3-32-18-12-13-22-21(14-18)23(15(2)33-22)26(31)27-17-10-8-16(9-11-17)24-19-6-4-5-7-20(19)25(30)29-28-24/h4-14H,3H2,1-2H3,(H,27,31)(H,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM380106 (5-methyl-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl)...) Show SMILES Cc1ccc2[nH]c(cc2c1)C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C24H18N4O2/c1-14-6-11-20-16(12-14)13-21(26-20)24(30)25-17-9-7-15(8-10-17)22-18-4-2-3-5-19(18)23(29)28-27-22/h2-13,26H,1H3,(H,25,30)(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380106 (5-methyl-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl)...) Show SMILES Cc1ccc2[nH]c(cc2c1)C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C24H18N4O2/c1-14-6-11-20-16(12-14)13-21(26-20)24(30)25-17-9-7-15(8-10-17)22-18-4-2-3-5-19(18)23(29)28-27-22/h2-13,26H,1H3,(H,25,30)(H,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM380107 (N-[4-(4-oxo-3,4- dihydrophthalazin-1- yl)phenyl]py...) Show SMILES O=C(Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12)c1cc2ncccn2n1 Show InChI InChI=1S/C21H14N6O2/c28-20-16-5-2-1-4-15(16)19(24-25-20)13-6-8-14(9-7-13)23-21(29)17-12-18-22-10-3-11-27(18)26-17/h1-12H,(H,23,29)(H,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380107 (N-[4-(4-oxo-3,4- dihydrophthalazin-1- yl)phenyl]py...) Show SMILES O=C(Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12)c1cc2ncccn2n1 Show InChI InChI=1S/C21H14N6O2/c28-20-16-5-2-1-4-15(16)19(24-25-20)13-6-8-14(9-7-13)23-21(29)17-12-18-22-10-3-11-27(18)26-17/h1-12H,(H,23,29)(H,25,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM380108 (N-[4-(4-oxo-3,4- dihydrophthalazin-1- yl)phenyl]py...) Show SMILES O=C(Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12)c1cnn2ccccc12 Show InChI InChI=1S/C22H15N5O2/c28-21(18-13-23-27-12-4-3-7-19(18)27)24-15-10-8-14(9-11-15)20-16-5-1-2-6-17(16)22(29)26-25-20/h1-13H,(H,24,28)(H,26,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380108 (N-[4-(4-oxo-3,4- dihydrophthalazin-1- yl)phenyl]py...) Show SMILES O=C(Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12)c1cnn2ccccc12 Show InChI InChI=1S/C22H15N5O2/c28-21(18-13-23-27-12-4-3-7-19(18)27)24-15-10-8-14(9-11-15)20-16-5-1-2-6-17(16)22(29)26-25-20/h1-13H,(H,24,28)(H,26,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM380109 (N-[4-(4-oxo-3,4- dihydrophthalazin-1- yl)phenyl]im...) Show SMILES O=C(Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12)c1cnc2ccccn12 Show InChI InChI=1S/C22H15N5O2/c28-21-17-6-2-1-5-16(17)20(25-26-21)14-8-10-15(11-9-14)24-22(29)18-13-23-19-7-3-4-12-27(18)19/h1-13H,(H,24,29)(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380109 (N-[4-(4-oxo-3,4- dihydrophthalazin-1- yl)phenyl]im...) Show SMILES O=C(Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12)c1cnc2ccccn12 Show InChI InChI=1S/C22H15N5O2/c28-21-17-6-2-1-5-16(17)20(25-26-21)14-8-10-15(11-9-14)24-22(29)18-13-23-19-7-3-4-12-27(18)19/h1-13H,(H,24,29)(H,26,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380110 (5-(benzyloxy)-2-methyl- N-[4-(4-oxo-3,4- dihydroph...) Show SMILES Cc1oc2ccc(OCc3ccccc3)cc2c1C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C31H23N3O4/c1-19-28(26-17-23(15-16-27(26)38-19)37-18-20-7-3-2-4-8-20)31(36)32-22-13-11-21(12-14-22)29-24-9-5-6-10-25(24)30(35)34-33-29/h2-17H,18H2,1H3,(H,32,36)(H,34,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380111 (5-hydroxy-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl...) Show SMILES Oc1cccc2OC(Cc12)C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM380112 (1-ethyl-N-[4-(4-oxo-3,4- dihydrophthalazin-1- yl)p...) Show SMILES CCn1c(cc2ccccc12)C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C25H20N4O2/c1-2-29-21-10-6-3-7-17(21)15-22(29)25(31)26-18-13-11-16(12-14-18)23-19-8-4-5-9-20(19)24(30)28-27-23/h3-15H,2H2,1H3,(H,26,31)(H,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380112 (1-ethyl-N-[4-(4-oxo-3,4- dihydrophthalazin-1- yl)p...) Show SMILES CCn1c(cc2ccccc12)C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C25H20N4O2/c1-2-29-21-10-6-3-7-17(21)15-22(29)25(31)26-18-13-11-16(12-14-18)23-19-8-4-5-9-20(19)24(30)28-27-23/h3-15H,2H2,1H3,(H,26,31)(H,28,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380113 (4-oxo-N-[4-(4-oxo-3,4- dihydrophthalazin-1- yl)phe...) Show SMILES CC(C)c1c(cn2nc[nH]c(=O)c12)C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C24H20N6O3/c1-13(2)19-18(11-30-21(19)24(33)25-12-26-30)22(31)27-15-9-7-14(8-10-15)20-16-5-3-4-6-17(16)23(32)29-28-20/h3-13H,1-2H3,(H,27,31)(H,29,32)(H,25,26,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM380114 (4-oxo-N-[4-(4-oxo-3,4- dihydrophthalazin-1- yl)phe...) Show SMILES O=C(Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12)c1n[nH]c2CCCC(=O)c12 Show InChI InChI=1S/C22H17N5O3/c28-17-7-3-6-16-18(17)20(26-24-16)22(30)23-13-10-8-12(9-11-13)19-14-4-1-2-5-15(14)21(29)27-25-19/h1-2,4-5,8-11H,3,6-7H2,(H,23,30)(H,24,26)(H,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380114 (4-oxo-N-[4-(4-oxo-3,4- dihydrophthalazin-1- yl)phe...) Show SMILES O=C(Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12)c1n[nH]c2CCCC(=O)c12 Show InChI InChI=1S/C22H17N5O3/c28-17-7-3-6-16-18(17)20(26-24-16)22(30)23-13-10-8-12(9-11-13)19-14-4-1-2-5-15(14)21(29)27-25-19/h1-2,4-5,8-11H,3,6-7H2,(H,23,30)(H,24,26)(H,27,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM380115 (N-[4-(4-oxo-3,4- dihydrophthalazin-1- yl)phenyl]-1...) Show SMILES O=C(Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12)c1n[nH]c2ncccc12 Show InChI InChI=1S/C21H14N6O2/c28-20-15-5-2-1-4-14(15)17(24-27-20)12-7-9-13(10-8-12)23-21(29)18-16-6-3-11-22-19(16)26-25-18/h1-11H,(H,23,29)(H,27,28)(H,22,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380115 (N-[4-(4-oxo-3,4- dihydrophthalazin-1- yl)phenyl]-1...) Show SMILES O=C(Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12)c1n[nH]c2ncccc12 Show InChI InChI=1S/C21H14N6O2/c28-20-15-5-2-1-4-14(15)17(24-27-20)12-7-9-13(10-8-12)23-21(29)18-16-6-3-11-22-19(16)26-25-18/h1-11H,(H,23,29)(H,27,28)(H,22,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380119 (5-chloro-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl)...) Show SMILES Clc1ccc2[nH]nc(C(=O)Nc3ccc(cc3)-c3n[nH]c(=O)c4ccccc34)c2c1 Show InChI InChI=1S/C22H14ClN5O2/c23-13-7-10-18-17(11-13)20(27-25-18)22(30)24-14-8-5-12(6-9-14)19-15-3-1-2-4-16(15)21(29)28-26-19/h1-11H,(H,24,30)(H,25,27)(H,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM380120 (N-[4-(4-oxo-3,4- dihydrophthalazin-1- yl)phenyl]-1...) Show SMILES O=C(Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12)c1nc2ccccc2s1 Show InChI InChI=1S/C22H14N4O2S/c27-20-16-6-2-1-5-15(16)19(25-26-20)13-9-11-14(12-10-13)23-21(28)22-24-17-7-3-4-8-18(17)29-22/h1-12H,(H,23,28)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380120 (N-[4-(4-oxo-3,4- dihydrophthalazin-1- yl)phenyl]-1...) Show SMILES O=C(Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12)c1nc2ccccc2s1 Show InChI InChI=1S/C22H14N4O2S/c27-20-16-6-2-1-5-15(16)19(25-26-20)13-9-11-14(12-10-13)23-21(28)22-24-17-7-3-4-8-18(17)29-22/h1-12H,(H,23,28)(H,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM380121 (2-methyl-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl)...) Show SMILES Cn1nc2CCCCc2c1C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C23H21N5O2/c1-28-21(18-8-4-5-9-19(18)27-28)23(30)24-15-12-10-14(11-13-15)20-16-6-2-3-7-17(16)22(29)26-25-20/h2-3,6-7,10-13H,4-5,8-9H2,1H3,(H,24,30)(H,26,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380121 (2-methyl-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl)...) Show SMILES Cn1nc2CCCCc2c1C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C23H21N5O2/c1-28-21(18-8-4-5-9-19(18)27-28)23(30)24-15-12-10-14(11-13-15)20-16-6-2-3-7-17(16)22(29)26-25-20/h2-3,6-7,10-13H,4-5,8-9H2,1H3,(H,24,30)(H,26,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM380122 (4-methoxy-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl...) Show SMILES COc1cccc2[nH]cc(C(=O)Nc3ccc(cc3)-c3n[nH]c(=O)c4ccccc34)c12 Show InChI InChI=1S/C24H18N4O3/c1-31-20-8-4-7-19-21(20)18(13-25-19)23(29)26-15-11-9-14(10-12-15)22-16-5-2-3-6-17(16)24(30)28-27-22/h2-13,25H,1H3,(H,26,29)(H,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380122 (4-methoxy-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl...) Show SMILES COc1cccc2[nH]cc(C(=O)Nc3ccc(cc3)-c3n[nH]c(=O)c4ccccc34)c12 Show InChI InChI=1S/C24H18N4O3/c1-31-20-8-4-7-19-21(20)18(13-25-19)23(29)26-15-11-9-14(10-12-15)22-16-5-2-3-6-17(16)24(30)28-27-22/h2-13,25H,1H3,(H,26,29)(H,28,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380123 (N-[4-(4-oxo-3,4- dihydrophthalazin-1- yl)phenyl]-1...) Show SMILES O=C(Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12)c1noc2ccccc12 Show InChI InChI=1S/C22H14N4O3/c27-21-16-6-2-1-5-15(16)19(24-25-21)13-9-11-14(12-10-13)23-22(28)20-17-7-3-4-8-18(17)29-26-20/h1-12H,(H,23,28)(H,25,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380124 (5-chloro-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl)...) Show SMILES Clc1cnc2[nH]c(cc2c1)C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C22H14ClN5O2/c23-14-9-13-10-18(26-20(13)24-11-14)22(30)25-15-7-5-12(6-8-15)19-16-3-1-2-4-17(16)21(29)28-27-19/h1-11H,(H,24,26)(H,25,30)(H,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM380125 (5-fluoro-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl)...) Show SMILES Fc1cnc2[nH]cc(C(=O)Nc3ccc(cc3)-c3n[nH]c(=O)c4ccccc34)c2c1 Show InChI InChI=1S/C22H14FN5O2/c23-13-9-17-18(11-25-20(17)24-10-13)21(29)26-14-7-5-12(6-8-14)19-15-3-1-2-4-16(15)22(30)28-27-19/h1-11H,(H,24,25)(H,26,29)(H,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380125 (5-fluoro-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl)...) Show SMILES Fc1cnc2[nH]cc(C(=O)Nc3ccc(cc3)-c3n[nH]c(=O)c4ccccc34)c2c1 Show InChI InChI=1S/C22H14FN5O2/c23-13-9-17-18(11-25-20(17)24-10-13)21(29)26-14-7-5-12(6-8-14)19-15-3-1-2-4-16(15)22(30)28-27-19/h1-11H,(H,24,25)(H,26,29)(H,28,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380126 (6-methyl-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl)...) Show SMILES Cc1cn2cc(nc2cn1)C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C22H16N6O2/c1-13-11-28-12-18(25-19(28)10-23-13)22(30)24-15-8-6-14(7-9-15)20-16-4-2-3-5-17(16)21(29)27-26-20/h2-12H,1H3,(H,24,30)(H,27,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM380127 (1-methyl-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl)...) Show SMILES Cn1cc(C(=O)Nc2ccc(cc2)-c2n[nH]c(=O)c3ccccc23)c2ccccc12 Show InChI InChI=1S/C24H18N4O2/c1-28-14-20(17-6-4-5-9-21(17)28)23(29)25-16-12-10-15(11-13-16)22-18-7-2-3-8-19(18)24(30)27-26-22/h2-14H,1H3,(H,25,29)(H,27,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380127 (1-methyl-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl)...) Show SMILES Cn1cc(C(=O)Nc2ccc(cc2)-c2n[nH]c(=O)c3ccccc23)c2ccccc12 Show InChI InChI=1S/C24H18N4O2/c1-28-14-20(17-6-4-5-9-21(17)28)23(29)25-16-12-10-15(11-13-16)22-18-7-2-3-8-19(18)24(30)27-26-22/h2-14H,1H3,(H,25,29)(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380128 (5-methoxy-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl...) Show SMILES COc1ccc2[nH]nc(C(=O)Nc3ccc(cc3)-c3n[nH]c(=O)c4ccccc34)c2c1 Show InChI InChI=1S/C23H17N5O3/c1-31-15-10-11-19-18(12-15)21(27-25-19)23(30)24-14-8-6-13(7-9-14)20-16-4-2-3-5-17(16)22(29)28-26-20/h2-12H,1H3,(H,24,30)(H,25,27)(H,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380129 (8-chloro-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl)...) Show SMILES Clc1nccn2cc(nc12)C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C21H13ClN6O2/c22-18-19-25-16(11-28(19)10-9-23-18)21(30)24-13-7-5-12(6-8-13)17-14-3-1-2-4-15(14)20(29)27-26-17/h1-11H,(H,24,30)(H,27,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM380130 (5-methoxy-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl...) Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C24H18N4O3/c1-31-17-10-11-20-15(12-17)13-21(26-20)24(30)25-16-8-6-14(7-9-16)22-18-4-2-3-5-19(18)23(29)28-27-22/h2-13,26H,1H3,(H,25,30)(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380130 (5-methoxy-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl...) Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C24H18N4O3/c1-31-17-10-11-20-15(12-17)13-21(26-20)24(30)25-16-8-6-14(7-9-16)22-18-4-2-3-5-19(18)23(29)28-27-22/h2-13,26H,1H3,(H,25,30)(H,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380131 (7-methyl-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl)...) Show SMILES Cc1ccn2cc(nc2c1)C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C23H17N5O2/c1-14-10-11-28-13-19(25-20(28)12-14)23(30)24-16-8-6-15(7-9-16)21-17-4-2-3-5-18(17)22(29)27-26-21/h2-13H,1H3,(H,24,30)(H,27,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM380132 (6-methoxy-1-methyl-N- [4-(4-oxo-3,4- dihydrophthal...) Show SMILES COc1ccc2cc(C(=O)Nc3ccc(cc3)-c3n[nH]c(=O)c4ccccc34)n(C)c2c1 Show InChI InChI=1S/C25H20N4O3/c1-29-21-14-18(32-2)12-9-16(21)13-22(29)25(31)26-17-10-7-15(8-11-17)23-19-5-3-4-6-20(19)24(30)28-27-23/h3-14H,1-2H3,(H,26,31)(H,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380132 (6-methoxy-1-methyl-N- [4-(4-oxo-3,4- dihydrophthal...) Show SMILES COc1ccc2cc(C(=O)Nc3ccc(cc3)-c3n[nH]c(=O)c4ccccc34)n(C)c2c1 Show InChI InChI=1S/C25H20N4O3/c1-29-21-14-18(32-2)12-9-16(21)13-22(29)25(31)26-17-10-7-15(8-11-17)23-19-5-3-4-6-20(19)24(30)28-27-23/h3-14H,1-2H3,(H,26,31)(H,28,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM380133 (N-[4-(4-oxo-3,4- dihydrophthalazin-1- yl)phenyl]-6...) Show SMILES CC(C)Oc1ccc2cc([nH]c2c1)C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C26H22N4O3/c1-15(2)33-19-12-9-17-13-23(28-22(17)14-19)26(32)27-18-10-7-16(8-11-18)24-20-5-3-4-6-21(20)25(31)30-29-24/h3-15,28H,1-2H3,(H,27,32)(H,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380133 (N-[4-(4-oxo-3,4- dihydrophthalazin-1- yl)phenyl]-6...) Show SMILES CC(C)Oc1ccc2cc([nH]c2c1)C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C26H22N4O3/c1-15(2)33-19-12-9-17-13-23(28-22(17)14-19)26(32)27-18-10-7-16(8-11-18)24-20-5-3-4-6-21(20)25(31)30-29-24/h3-15,28H,1-2H3,(H,27,32)(H,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM380134 (7-methoxy-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl...) Show SMILES COc1cccc2cc([nH]c12)C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C24H18N4O3/c1-31-20-8-4-5-15-13-19(26-22(15)20)24(30)25-16-11-9-14(10-12-16)21-17-6-2-3-7-18(17)23(29)28-27-21/h2-13,26H,1H3,(H,25,30)(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380134 (7-methoxy-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl...) Show SMILES COc1cccc2cc([nH]c12)C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C24H18N4O3/c1-31-20-8-4-5-15-13-19(26-22(15)20)24(30)25-16-11-9-14(10-12-16)21-17-6-2-3-7-18(17)23(29)28-27-21/h2-13,26H,1H3,(H,25,30)(H,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM380135 (5-ethoxy-1-methyl-N-[4- (4-oxo-3,4- dihydrophthala...) Show SMILES CCOc1ccc2n(C)c(cc2c1)C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C26H22N4O3/c1-3-33-19-12-13-22-17(14-19)15-23(30(22)2)26(32)27-18-10-8-16(9-11-18)24-20-6-4-5-7-21(20)25(31)29-28-24/h4-15H,3H2,1-2H3,(H,27,32)(H,29,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380135 (5-ethoxy-1-methyl-N-[4- (4-oxo-3,4- dihydrophthala...) Show SMILES CCOc1ccc2n(C)c(cc2c1)C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C26H22N4O3/c1-3-33-19-12-13-22-17(14-19)15-23(30(22)2)26(32)27-18-10-8-16(9-11-18)24-20-6-4-5-7-21(20)25(31)29-28-24/h4-15H,3H2,1-2H3,(H,27,32)(H,29,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM380136 (2-methyl-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl)...) Show SMILES Cn1nc2ccccc2c1C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C23H17N5O2/c1-28-21(18-8-4-5-9-19(18)27-28)23(30)24-15-12-10-14(11-13-15)20-16-6-2-3-7-17(16)22(29)26-25-20/h2-13H,1H3,(H,24,30)(H,26,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380136 (2-methyl-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl)...) Show SMILES Cn1nc2ccccc2c1C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C23H17N5O2/c1-28-21(18-8-4-5-9-19(18)27-28)23(30)24-15-12-10-14(11-13-15)20-16-6-2-3-7-17(16)22(29)26-25-20/h2-13H,1H3,(H,24,30)(H,26,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM380137 (N-[4-(4-oxo-3,4- dihydrophthalazin-1- yl)phenyl]-1...) Show SMILES CC(C)n1nc(C(=O)Nc2ccc(cc2)-c2n[nH]c(=O)c3ccccc23)c2ccccc12 Show InChI InChI=1S/C25H21N5O2/c1-15(2)30-21-10-6-5-9-20(21)23(29-30)25(32)26-17-13-11-16(12-14-17)22-18-7-3-4-8-19(18)24(31)28-27-22/h3-15H,1-2H3,(H,26,32)(H,28,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380137 (N-[4-(4-oxo-3,4- dihydrophthalazin-1- yl)phenyl]-1...) Show SMILES CC(C)n1nc(C(=O)Nc2ccc(cc2)-c2n[nH]c(=O)c3ccccc23)c2ccccc12 Show InChI InChI=1S/C25H21N5O2/c1-15(2)30-21-10-6-5-9-20(21)23(29-30)25(32)26-17-13-11-16(12-14-17)22-18-7-3-4-8-19(18)24(31)28-27-22/h3-15H,1-2H3,(H,26,32)(H,28,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380138 (N-[4-(4-oxo-3,4- dihydrophthalazin-1- yl)phenyl]im...) Show SMILES O=C(Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12)c1cn2ccncc2n1 Show InChI InChI=1S/C21H14N6O2/c28-20-16-4-2-1-3-15(16)19(25-26-20)13-5-7-14(8-6-13)23-21(29)17-12-27-10-9-22-11-18(27)24-17/h1-12H,(H,23,29)(H,26,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 826 total )  |  Next  |  Last  >>

Jump to: