BindingDB PrimarySearch

Found 22 hits Enz. Inhib. hit(s) with all data for entry = 2886
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM25826 (5-[(3R)-3-(3-methoxy-5-phenylphenyl)but-1-yn-1-yl]...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	7.0	25
University of Connecticut at Storrs					Assay Description Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...				J Med Chem 51: 6839-52 (2008) Article DOI: 10.1021/jm8009124 BindingDB Entry DOI: 10.7270/Q2W37TMC
University of Connecticut at Storrs					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM25818 (5-[3-(3-methoxy-5-phenylphenyl)but-1-yn-1-yl]-6-me...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.0	25
University of Connecticut at Storrs					Assay Description Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...				J Med Chem 51: 6839-52 (2008) Article DOI: 10.1021/jm8009124 BindingDB Entry DOI: 10.7270/Q2W37TMC
University of Connecticut at Storrs					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM25819 (5-{3-[3-methoxy-5-(2-methylphenyl)phenyl]but-1-yn-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	7.0	25
University of Connecticut at Storrs					Assay Description Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...				J Med Chem 51: 6839-52 (2008) Article DOI: 10.1021/jm8009124 BindingDB Entry DOI: 10.7270/Q2W37TMC
University of Connecticut at Storrs					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM25820 (5-{3-[3-(2,6-dimethylphenyl)-5-methoxyphenyl]but-1...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	7.0	25
University of Connecticut at Storrs					Assay Description Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...				J Med Chem 51: 6839-52 (2008) Article DOI: 10.1021/jm8009124 BindingDB Entry DOI: 10.7270/Q2W37TMC
University of Connecticut at Storrs					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM25824 (5-{3-[4-(2,6-dimethylphenyl)-3-methoxyphenyl]but-1...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.40	n/a	n/a	n/a	n/a	7.0	25
University of Connecticut at Storrs					Assay Description Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...				J Med Chem 51: 6839-52 (2008) Article DOI: 10.1021/jm8009124 BindingDB Entry DOI: 10.7270/Q2W37TMC
University of Connecticut at Storrs					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM25821 (5-(3-{3-[2,6-bis(propan-2-yl)phenyl]-5-methoxyphen...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	7.0	25
University of Connecticut at Storrs					Assay Description Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...				J Med Chem 51: 6839-52 (2008) Article DOI: 10.1021/jm8009124 BindingDB Entry DOI: 10.7270/Q2W37TMC
University of Connecticut at Storrs					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM25825 (5-(3-{4-[2,6-bis(propan-2-yl)phenyl]-3-methoxyphen...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	7.0	25
University of Connecticut at Storrs					Assay Description Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...				J Med Chem 51: 6839-52 (2008) Article DOI: 10.1021/jm8009124 BindingDB Entry DOI: 10.7270/Q2W37TMC
University of Connecticut at Storrs					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM25822 (5-[3-(3-methoxy-4-phenylphenyl)but-1-yn-1-yl]-6-me...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	7.0	25
University of Connecticut at Storrs					Assay Description Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...				J Med Chem 51: 6839-52 (2008) Article DOI: 10.1021/jm8009124 BindingDB Entry DOI: 10.7270/Q2W37TMC
University of Connecticut at Storrs					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM25827 (5-[(3S)-3-(3-methoxy-5-phenylphenyl)but-1-yn-1-yl]...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	7.0	25
University of Connecticut at Storrs					Assay Description Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...				J Med Chem 51: 6839-52 (2008) Article DOI: 10.1021/jm8009124 BindingDB Entry DOI: 10.7270/Q2W37TMC
University of Connecticut at Storrs					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM25823 (5-{3-[3-methoxy-4-(2-methylphenyl)phenyl]but-1-yn-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	7.0	25
University of Connecticut at Storrs					Assay Description Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...				J Med Chem 51: 6839-52 (2008) Article DOI: 10.1021/jm8009124 BindingDB Entry DOI: 10.7270/Q2W37TMC
University of Connecticut at Storrs					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium hominis)	BDBM18497 (6-methyl-5-[(3R)-3-(3,4,5-trimethoxyphenyl)but-1-y...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	7.0	25
University of Connecticut at Storrs					Assay Description Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...				J Med Chem 51: 6839-52 (2008) Article DOI: 10.1021/jm8009124 BindingDB Entry DOI: 10.7270/Q2W37TMC
University of Connecticut at Storrs					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM25820 (5-{3-[3-(2,6-dimethylphenyl)-5-methoxyphenyl]but-1...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.25E+3	n/a	n/a	n/a	n/a	7.0	25
University of Connecticut at Storrs					Assay Description Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...				J Med Chem 51: 6839-52 (2008) Article DOI: 10.1021/jm8009124 BindingDB Entry DOI: 10.7270/Q2W37TMC
University of Connecticut at Storrs					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM25819 (5-{3-[3-methoxy-5-(2-methylphenyl)phenyl]but-1-yn-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.36E+3	n/a	n/a	n/a	n/a	7.0	25
University of Connecticut at Storrs					Assay Description Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...				J Med Chem 51: 6839-52 (2008) Article DOI: 10.1021/jm8009124 BindingDB Entry DOI: 10.7270/Q2W37TMC
University of Connecticut at Storrs					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM25826 (5-[(3R)-3-(3-methoxy-5-phenylphenyl)but-1-yn-1-yl]...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.36E+3	n/a	n/a	n/a	n/a	7.0	25
University of Connecticut at Storrs					Assay Description Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...				J Med Chem 51: 6839-52 (2008) Article DOI: 10.1021/jm8009124 BindingDB Entry DOI: 10.7270/Q2W37TMC
University of Connecticut at Storrs					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM18497 (6-methyl-5-[(3R)-3-(3,4,5-trimethoxyphenyl)but-1-y...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.38E+3	n/a	n/a	n/a	n/a	7.0	25
University of Connecticut at Storrs					Assay Description Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...				J Med Chem 51: 6839-52 (2008) Article DOI: 10.1021/jm8009124 BindingDB Entry DOI: 10.7270/Q2W37TMC
University of Connecticut at Storrs					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM25827 (5-[(3S)-3-(3-methoxy-5-phenylphenyl)but-1-yn-1-yl]...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.38E+3	n/a	n/a	n/a	n/a	7.0	25
University of Connecticut at Storrs					Assay Description Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...				J Med Chem 51: 6839-52 (2008) Article DOI: 10.1021/jm8009124 BindingDB Entry DOI: 10.7270/Q2W37TMC
University of Connecticut at Storrs					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM25822 (5-[3-(3-methoxy-4-phenylphenyl)but-1-yn-1-yl]-6-me...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.42E+3	n/a	n/a	n/a	n/a	7.0	25
University of Connecticut at Storrs					Assay Description Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...				J Med Chem 51: 6839-52 (2008) Article DOI: 10.1021/jm8009124 BindingDB Entry DOI: 10.7270/Q2W37TMC
University of Connecticut at Storrs					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM25818 (5-[3-(3-methoxy-5-phenylphenyl)but-1-yn-1-yl]-6-me...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	7.0	25
University of Connecticut at Storrs					Assay Description Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...				J Med Chem 51: 6839-52 (2008) Article DOI: 10.1021/jm8009124 BindingDB Entry DOI: 10.7270/Q2W37TMC
University of Connecticut at Storrs					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM25823 (5-{3-[3-methoxy-4-(2-methylphenyl)phenyl]but-1-yn-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.77E+3	n/a	n/a	n/a	n/a	7.0	25
University of Connecticut at Storrs					Assay Description Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...				J Med Chem 51: 6839-52 (2008) Article DOI: 10.1021/jm8009124 BindingDB Entry DOI: 10.7270/Q2W37TMC
University of Connecticut at Storrs					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM25824 (5-{3-[4-(2,6-dimethylphenyl)-3-methoxyphenyl]but-1...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.37E+3	n/a	n/a	n/a	n/a	7.0	25
University of Connecticut at Storrs					Assay Description Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...				J Med Chem 51: 6839-52 (2008) Article DOI: 10.1021/jm8009124 BindingDB Entry DOI: 10.7270/Q2W37TMC
University of Connecticut at Storrs					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM25825 (5-(3-{4-[2,6-bis(propan-2-yl)phenyl]-3-methoxyphen...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	7.0	25
University of Connecticut at Storrs					Assay Description Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...				J Med Chem 51: 6839-52 (2008) Article DOI: 10.1021/jm8009124 BindingDB Entry DOI: 10.7270/Q2W37TMC
University of Connecticut at Storrs					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM25821 (5-(3-{3-[2,6-bis(propan-2-yl)phenyl]-5-methoxyphen...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.20E+3	n/a	n/a	n/a	n/a	7.0	25
University of Connecticut at Storrs					Assay Description Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...				J Med Chem 51: 6839-52 (2008) Article DOI: 10.1021/jm8009124 BindingDB Entry DOI: 10.7270/Q2W37TMC
University of Connecticut at Storrs					More data for this Ligand-Target Pair