Compile Data Set for Download or QSAR

Found 25 hits Enz. Inhib. hit(s) with all data for entry = 50001344   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50021574 (BMS-907351 | CABOZANTINIB | CHEBI:72317 | Cabomety...) Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC Show InChI InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0350	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human full length VEGFR2 using poly (Glu, Tyr) as substrate by alpha screen assay				Eur J Med Chem 138: 942-951 (2017) Article DOI: 10.1016/j.ejmech.2017.06.057 BindingDB Entry DOI: 10.7270/Q2MK6GDH
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50021574 (BMS-907351 | CABOZANTINIB | CHEBI:72317 | Cabomety...) Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC Show InChI InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human full length c-MET using poly (Glu, Tyr) as substrate by alpha screen assay				Eur J Med Chem 138: 942-951 (2017) Article DOI: 10.1016/j.ejmech.2017.06.057 BindingDB Entry DOI: 10.7270/Q2MK6GDH
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50306682 ((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...) Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl |r| Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged c-MET preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by Hot-SpotSM kinase assay				Eur J Med Chem 138: 942-951 (2017) Article DOI: 10.1016/j.ejmech.2017.06.057 BindingDB Entry DOI: 10.7270/Q2MK6GDH
					More data for this Ligand-Target Pair				3D Structure (crystal)
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50021574 (BMS-907351 | CABOZANTINIB | CHEBI:72317 | Cabomety...) Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC Show InChI InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human full length KIT using poly (Glu, Tyr) as substrate by alpha screen assay				Eur J Med Chem 138: 942-951 (2017) Article DOI: 10.1016/j.ejmech.2017.06.057 BindingDB Entry DOI: 10.7270/Q2MK6GDH
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50021574 (BMS-907351 | CABOZANTINIB | CHEBI:72317 | Cabomety...) Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC Show InChI InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human full length RET using poly (Glu, Tyr) as substrate by alpha screen assay				Eur J Med Chem 138: 942-951 (2017) Article DOI: 10.1016/j.ejmech.2017.06.057 BindingDB Entry DOI: 10.7270/Q2MK6GDH
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM50021574 (BMS-907351 | CABOZANTINIB | CHEBI:72317 | Cabomety...) Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC Show InChI InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human full length AXL using poly (Glu, Tyr) as substrate by alpha screen assay				Eur J Med Chem 138: 942-951 (2017) Article DOI: 10.1016/j.ejmech.2017.06.057 BindingDB Entry DOI: 10.7270/Q2MK6GDH
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50021574 (BMS-907351 | CABOZANTINIB | CHEBI:72317 | Cabomety...) Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC Show InChI InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human full length FLT3 using poly (Glu, Tyr) as substrate by alpha screen assay				Eur J Med Chem 138: 942-951 (2017) Article DOI: 10.1016/j.ejmech.2017.06.057 BindingDB Entry DOI: 10.7270/Q2MK6GDH
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50021574 (BMS-907351 | CABOZANTINIB | CHEBI:72317 | Cabomety...) Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC Show InChI InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human full length TIE2 using poly (Glu, Tyr) as substrate by alpha screen assay				Eur J Med Chem 138: 942-951 (2017) Article DOI: 10.1016/j.ejmech.2017.06.057 BindingDB Entry DOI: 10.7270/Q2MK6GDH
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50276855 (CHEMBL4168618) Show SMILES CN1CCC(CC1)Nc1ccc(cc1)-c1n[nH]c2CCN(Cc12)S(=O)(=O)c1c(Cl)cccc1Cl Show InChI InChI=1S/C24H27Cl2N5O2S/c1-30-12-9-18(10-13-30)27-17-7-5-16(6-8-17)23-19-15-31(14-11-22(19)28-29-23)34(32,33)24-20(25)3-2-4-21(24)26/h2-8,18,27H,9-15H2,1H3,(H,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged c-MET preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by Hot-SpotSM kinase assay				Eur J Med Chem 138: 942-951 (2017) Article DOI: 10.1016/j.ejmech.2017.06.057 BindingDB Entry DOI: 10.7270/Q2MK6GDH
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50276855 (CHEMBL4168618) Show SMILES CN1CCC(CC1)Nc1ccc(cc1)-c1n[nH]c2CCN(Cc12)S(=O)(=O)c1c(Cl)cccc1Cl Show InChI InChI=1S/C24H27Cl2N5O2S/c1-30-12-9-18(10-13-30)27-17-7-5-16(6-8-17)23-19-15-31(14-11-22(19)28-29-23)34(32,33)24-20(25)3-2-4-21(24)26/h2-8,18,27H,9-15H2,1H3,(H,28,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	124	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human full length FLT3 using poly (Glu, Tyr) as substrate by alpha screen assay				Eur J Med Chem 138: 942-951 (2017) Article DOI: 10.1016/j.ejmech.2017.06.057 BindingDB Entry DOI: 10.7270/Q2MK6GDH
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50276846 (CHEMBL4176824) Show SMILES CC(=O)N1CCC(CC1)Nc1ccc(cc1)-c1n[nH]c2CCN(Cc12)S(=O)(=O)c1c(Cl)cccc1Cl Show InChI InChI=1S/C25H27Cl2N5O3S/c1-16(33)31-12-9-19(10-13-31)28-18-7-5-17(6-8-18)24-20-15-32(14-11-23(20)29-30-24)36(34,35)25-21(26)3-2-4-22(25)27/h2-8,19,28H,9-15H2,1H3,(H,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	442	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged c-MET preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by Hot-SpotSM kinase assay				Eur J Med Chem 138: 942-951 (2017) Article DOI: 10.1016/j.ejmech.2017.06.057 BindingDB Entry DOI: 10.7270/Q2MK6GDH
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50276845 (CHEMBL4164791) Show SMILES Clc1cccc(Cl)c1S(=O)(=O)N1CCc2[nH]nc(c2C1)-c1ccc(cc1)C(=O)N1CCNCC1 Show InChI InChI=1S/C23H23Cl2N5O3S/c24-18-2-1-3-19(25)22(18)34(32,33)30-11-8-20-17(14-30)21(28-27-20)15-4-6-16(7-5-15)23(31)29-12-9-26-10-13-29/h1-7,26H,8-14H2,(H,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	809	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged c-MET preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by Hot-SpotSM kinase assay				Eur J Med Chem 138: 942-951 (2017) Article DOI: 10.1016/j.ejmech.2017.06.057 BindingDB Entry DOI: 10.7270/Q2MK6GDH
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50276853 (CHEMBL4160311) Show SMILES OCCN1CCN(CC1)C(=O)c1ccc(cc1)-c1n[nH]c2CCN(Cc12)S(=O)(=O)c1c(Cl)cccc1Cl Show InChI InChI=1S/C25H27Cl2N5O4S/c26-20-2-1-3-21(27)24(20)37(35,36)32-9-8-22-19(16-32)23(29-28-22)17-4-6-18(7-5-17)25(34)31-12-10-30(11-13-31)14-15-33/h1-7,33H,8-16H2,(H,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.21E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged c-MET preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by Hot-SpotSM kinase assay				Eur J Med Chem 138: 942-951 (2017) Article DOI: 10.1016/j.ejmech.2017.06.057 BindingDB Entry DOI: 10.7270/Q2MK6GDH
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50276854 (CHEMBL4168226) Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1n[nH]c2CCN(Cc12)S(=O)(=O)c1c(Cl)cccc1Cl Show InChI InChI=1S/C24H25Cl2N5O3S/c1-29-11-13-30(14-12-29)24(32)17-7-5-16(6-8-17)22-18-15-31(10-9-21(18)27-28-22)35(33,34)23-19(25)3-2-4-20(23)26/h2-8H,9-15H2,1H3,(H,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.66E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged c-MET preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by Hot-SpotSM kinase assay				Eur J Med Chem 138: 942-951 (2017) Article DOI: 10.1016/j.ejmech.2017.06.057 BindingDB Entry DOI: 10.7270/Q2MK6GDH
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50276851 (CHEMBL4167248) Show SMILES Clc1cccc(Cl)c1S(=O)(=O)N1CCc2[nH]nc(c2C1)-c1ccc(cc1)C(=O)N1CCCC1 Show InChI InChI=1S/C23H22Cl2N4O3S/c24-18-4-3-5-19(25)22(18)33(31,32)29-13-10-20-17(14-29)21(27-26-20)15-6-8-16(9-7-15)23(30)28-11-1-2-12-28/h3-9H,1-2,10-14H2,(H,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.23E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged c-MET preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by Hot-SpotSM kinase assay				Eur J Med Chem 138: 942-951 (2017) Article DOI: 10.1016/j.ejmech.2017.06.057 BindingDB Entry DOI: 10.7270/Q2MK6GDH
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50276850 (CHEMBL4173099) Show SMILES CC(=O)Nc1ccc(cc1)-c1n[nH]c2CCN(Cc12)S(=O)(=O)c1c(Cl)cccc1Cl Show InChI InChI=1S/C20H18Cl2N4O3S/c1-12(27)23-14-7-5-13(6-8-14)19-15-11-26(10-9-18(15)24-25-19)30(28,29)20-16(21)3-2-4-17(20)22/h2-8H,9-11H2,1H3,(H,23,27)(H,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged c-MET preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by Hot-SpotSM kinase assay				Eur J Med Chem 138: 942-951 (2017) Article DOI: 10.1016/j.ejmech.2017.06.057 BindingDB Entry DOI: 10.7270/Q2MK6GDH
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50276852 (CHEMBL4162881) Show SMILES OCCNC(=O)c1ccc(cc1)-c1n[nH]c2CCN(Cc12)S(=O)(=O)c1c(Cl)cccc1Cl Show InChI InChI=1S/C21H20Cl2N4O4S/c22-16-2-1-3-17(23)20(16)32(30,31)27-10-8-18-15(12-27)19(26-25-18)13-4-6-14(7-5-13)21(29)24-9-11-28/h1-7,28H,8-12H2,(H,24,29)(H,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.64E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged c-MET preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by Hot-SpotSM kinase assay				Eur J Med Chem 138: 942-951 (2017) Article DOI: 10.1016/j.ejmech.2017.06.057 BindingDB Entry DOI: 10.7270/Q2MK6GDH
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50276843 (CHEMBL4164843) Show SMILES COCCNC(=O)c1ccc(cc1)-c1n[nH]c2CCN(Cc12)S(=O)(=O)c1c(Cl)cccc1Cl Show InChI InChI=1S/C22H22Cl2N4O4S/c1-32-12-10-25-22(29)15-7-5-14(6-8-15)20-16-13-28(11-9-19(16)26-27-20)33(30,31)21-17(23)3-2-4-18(21)24/h2-8H,9-13H2,1H3,(H,25,29)(H,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged c-MET preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by Hot-SpotSM kinase assay				Eur J Med Chem 138: 942-951 (2017) Article DOI: 10.1016/j.ejmech.2017.06.057 BindingDB Entry DOI: 10.7270/Q2MK6GDH
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50276847 (CHEMBL4161698) Show SMILES CC(=O)N1CCC(CC1)Nc1ccc(cc1)-c1n[nH]c2CCN(Cc12)S(=O)(=O)c1cccc(c1)[N+]([O-])=O Show InChI InChI=1S/C25H28N6O5S/c1-17(32)29-12-9-20(10-13-29)26-19-7-5-18(6-8-19)25-23-16-30(14-11-24(23)27-28-25)37(35,36)22-4-2-3-21(15-22)31(33)34/h2-8,15,20,26H,9-14,16H2,1H3,(H,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.86E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged c-MET preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by Hot-SpotSM kinase assay				Eur J Med Chem 138: 942-951 (2017) Article DOI: 10.1016/j.ejmech.2017.06.057 BindingDB Entry DOI: 10.7270/Q2MK6GDH
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50276857 (CHEMBL4161379) Show SMILES Clc1cccc(Cl)c1S(=O)(=O)N1CCc2[nH]nc(c2C1)-c1ccc(cc1)C(=O)N1CCCCC1 Show InChI InChI=1S/C24H24Cl2N4O3S/c25-19-5-4-6-20(26)23(19)34(32,33)30-14-11-21-18(15-30)22(28-27-21)16-7-9-17(10-8-16)24(31)29-12-2-1-3-13-29/h4-10H,1-3,11-15H2,(H,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.05E+4	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged c-MET preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by Hot-SpotSM kinase assay				Eur J Med Chem 138: 942-951 (2017) Article DOI: 10.1016/j.ejmech.2017.06.057 BindingDB Entry DOI: 10.7270/Q2MK6GDH
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50276848 (CHEMBL4166206) Show SMILES CC(=O)N1CCC(CC1)Nc1ccc(cc1)-c1n[nH]c2CCN(Cc12)S(=O)(=O)c1cccnc1 Show InChI InChI=1S/C24H28N6O3S/c1-17(31)29-12-8-20(9-13-29)26-19-6-4-18(5-7-19)24-22-16-30(14-10-23(22)27-28-24)34(32,33)21-3-2-11-25-15-21/h2-7,11,15,20,26H,8-10,12-14,16H2,1H3,(H,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged c-MET preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by Hot-SpotSM kinase assay				Eur J Med Chem 138: 942-951 (2017) Article DOI: 10.1016/j.ejmech.2017.06.057 BindingDB Entry DOI: 10.7270/Q2MK6GDH
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50276844 (CHEMBL4165198) Show SMILES CC(=O)N1CCC(CC1)Nc1ccc(cc1)-c1n[nH]c2CCN(Cc12)S(=O)(=O)c1cccs1 Show InChI InChI=1S/C23H27N5O3S2/c1-16(29)27-11-8-19(9-12-27)24-18-6-4-17(5-7-18)23-20-15-28(13-10-21(20)25-26-23)33(30,31)22-3-2-14-32-22/h2-7,14,19,24H,8-13,15H2,1H3,(H,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged c-MET preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by Hot-SpotSM kinase assay				Eur J Med Chem 138: 942-951 (2017) Article DOI: 10.1016/j.ejmech.2017.06.057 BindingDB Entry DOI: 10.7270/Q2MK6GDH
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50276856 (CHEMBL4163204) Show SMILES CC(=O)N1CCC(CC1)Nc1ccc(cc1)-c1n[nH]c2CCN(Cc12)S(=O)(=O)c1ccc(C)cc1 Show InChI InChI=1S/C26H31N5O3S/c1-18-3-9-23(10-4-18)35(33,34)31-16-13-25-24(17-31)26(29-28-25)20-5-7-21(8-6-20)27-22-11-14-30(15-12-22)19(2)32/h3-10,22,27H,11-17H2,1-2H3,(H,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged c-MET preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by Hot-SpotSM kinase assay				Eur J Med Chem 138: 942-951 (2017) Article DOI: 10.1016/j.ejmech.2017.06.057 BindingDB Entry DOI: 10.7270/Q2MK6GDH
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50276842 (CHEMBL4167104) Show SMILES CC(=O)N1CCC(CC1)Nc1ccc(cc1)-c1n[nH]c2CCN(Cc12)S(=O)(=O)c1cccc2cccnc12 Show InChI InChI=1S/C28H30N6O3S/c1-19(35)33-15-11-23(12-16-33)30-22-9-7-21(8-10-22)27-24-18-34(17-13-25(24)31-32-27)38(36,37)26-6-2-4-20-5-3-14-29-28(20)26/h2-10,14,23,30H,11-13,15-18H2,1H3,(H,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged c-MET preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by Hot-SpotSM kinase assay				Eur J Med Chem 138: 942-951 (2017) Article DOI: 10.1016/j.ejmech.2017.06.057 BindingDB Entry DOI: 10.7270/Q2MK6GDH
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50276849 (CHEMBL4173469) Show SMILES CC(=O)N1CCC(CC1)Nc1ccc(cc1)-c1n[nH]c2CCN(Cc12)S(=O)(=O)c1cccc2ccccc12 Show InChI InChI=1S/C29H31N5O3S/c1-20(35)33-16-13-24(14-17-33)30-23-11-9-22(10-12-23)29-26-19-34(18-15-27(26)31-32-29)38(36,37)28-8-4-6-21-5-2-3-7-25(21)28/h2-12,24,30H,13-19H2,1H3,(H,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged c-MET preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by Hot-SpotSM kinase assay				Eur J Med Chem 138: 942-951 (2017) Article DOI: 10.1016/j.ejmech.2017.06.057 BindingDB Entry DOI: 10.7270/Q2MK6GDH
					More data for this Ligand-Target Pair