Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM50265157 ((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Notre Dame Curated by ChEMBL | Assay Description Inhibition of APMA activated recombinant human full length MMP2 expressed in mouse cells using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substra... | ACS Med Chem Lett 9: 708-713 (2018) Article DOI: 10.1021/acsmedchemlett.8b00163 BindingDB Entry DOI: 10.7270/Q25M688J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil collagenase (Homo sapiens (Human)) | BDBM50265157 ((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Notre Dame Curated by ChEMBL | Assay Description Inhibition of recombinant human MMP8 catalytic domain (Phe99 to Gln269 residues) expressed in Escherichia coli using McaKPLGL-Dpa-AR-NH2 as substrate... | ACS Med Chem Lett 9: 708-713 (2018) Article DOI: 10.1021/acsmedchemlett.8b00163 BindingDB Entry DOI: 10.7270/Q25M688J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Matrix metalloproteinase-9 (Homo sapiens (Human)) | BDBM50265157 ((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Notre Dame Curated by ChEMBL | Assay Description Inhibition of recombinant human MMP9 catalytic domain (Phe107 to Pro449 residues) expressed in Escherichia coli using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)... | ACS Med Chem Lett 9: 708-713 (2018) Article DOI: 10.1021/acsmedchemlett.8b00163 BindingDB Entry DOI: 10.7270/Q25M688J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage metalloelastase (Homo sapiens (Human)) | BDBM50265157 ((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Notre Dame Curated by ChEMBL | Assay Description Inhibition of recombinant human MMP12 catalytic domain using Mca-PLGL-DpaAR-NH2 as substrate by fluorescence spectrophotometric method | ACS Med Chem Lett 9: 708-713 (2018) Article DOI: 10.1021/acsmedchemlett.8b00163 BindingDB Entry DOI: 10.7270/Q25M688J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human)) | BDBM50265157 ((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 61 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Notre Dame Curated by ChEMBL | Assay Description Inhibition of recombinant human C-terminal His6-tagged ADAM17 (Arg215 to Asn671 residues) expressed in baculovirus infected Sf21 cells using Mca-PLAQ... | ACS Med Chem Lett 9: 708-713 (2018) Article DOI: 10.1021/acsmedchemlett.8b00163 BindingDB Entry DOI: 10.7270/Q25M688J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Matrix metalloproteinase-14 (Homo sapiens (Human)) | BDBM50265157 ((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 68 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Notre Dame Curated by ChEMBL | Assay Description Inhibition of recombinant human MMP14 catalytic domain (89 to 265 residues) expressed in Escherichia coli using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-A... | ACS Med Chem Lett 9: 708-713 (2018) Article DOI: 10.1021/acsmedchemlett.8b00163 BindingDB Entry DOI: 10.7270/Q25M688J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Disintegrin and metalloproteinase domain-containing protein 10 (Homo sapiens (Human)) | BDBM50367253 (CHEMBL4167357) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 73 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Notre Dame Curated by ChEMBL | Assay Description Inhibition of recombinant human C-terminal His10-tagged ADAM10 (Thr214 to Glu672 residues) expressed in baculovirus infected Sf21 cells using McaKPLG... | ACS Med Chem Lett 9: 708-713 (2018) Article DOI: 10.1021/acsmedchemlett.8b00163 BindingDB Entry DOI: 10.7270/Q25M688J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Matrilysin (Homo sapiens (Human)) | BDBM50265157 ((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Notre Dame Curated by ChEMBL | Assay Description Inhibition of recombinant human MMP7 expressed in Escherichia coli using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate by fluorescence spe... | ACS Med Chem Lett 9: 708-713 (2018) Article DOI: 10.1021/acsmedchemlett.8b00163 BindingDB Entry DOI: 10.7270/Q25M688J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage metalloelastase (Homo sapiens (Human)) | BDBM50367253 (CHEMBL4167357) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Notre Dame Curated by ChEMBL | Assay Description Inhibition of recombinant human MMP12 catalytic domain using Mca-PLGL-DpaAR-NH2 as substrate by fluorescence spectrophotometric method | ACS Med Chem Lett 9: 708-713 (2018) Article DOI: 10.1021/acsmedchemlett.8b00163 BindingDB Entry DOI: 10.7270/Q25M688J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interstitial collagenase (Homo sapiens (Human)) | BDBM50265157 ((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 348 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Notre Dame Curated by ChEMBL | Assay Description Inhibition of recombinant human MMP1 catalytic domain (Phe100 to Gln268 residues) expressed in Escherichia coli using McaKPLGL-Dpa-AR-NH2 as substrat... | ACS Med Chem Lett 9: 708-713 (2018) Article DOI: 10.1021/acsmedchemlett.8b00163 BindingDB Entry DOI: 10.7270/Q25M688J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Stromelysin-1 (Homo sapiens (Human)) | BDBM50265157 ((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 484 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Notre Dame Curated by ChEMBL | Assay Description Inhibition of recombinant human MMP3 catalytic domain expressed in Escherichia coli using MOCAc-Arg-Pro-LysPro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 as su... | ACS Med Chem Lett 9: 708-713 (2018) Article DOI: 10.1021/acsmedchemlett.8b00163 BindingDB Entry DOI: 10.7270/Q25M688J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human)) | BDBM50367253 (CHEMBL4167357) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Notre Dame Curated by ChEMBL | Assay Description Inhibition of recombinant human C-terminal His6-tagged ADAM17 (Arg215 to Asn671 residues) expressed in baculovirus infected Sf21 cells using Mca-PLAQ... | ACS Med Chem Lett 9: 708-713 (2018) Article DOI: 10.1021/acsmedchemlett.8b00163 BindingDB Entry DOI: 10.7270/Q25M688J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Disintegrin and metalloproteinase domain-containing protein 9 (Homo sapiens (Human)) | BDBM50265157 ((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Notre Dame Curated by ChEMBL | Assay Description Inhibition of recombinant human C-terminal His10-tagged ADAM9 (Ala206 to Asp697 residues) expressed in mouse cells using McaPLAQAV-Dpa-RSSSR-NH2 as s... | ACS Med Chem Lett 9: 708-713 (2018) Article DOI: 10.1021/acsmedchemlett.8b00163 BindingDB Entry DOI: 10.7270/Q25M688J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil collagenase (Homo sapiens (Human)) | BDBM50367253 (CHEMBL4167357) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 8.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Notre Dame Curated by ChEMBL | Assay Description Inhibition of recombinant human MMP8 catalytic domain (Phe99 to Gln269 residues) expressed in Escherichia coli using McaKPLGL-Dpa-AR-NH2 as substrate... | ACS Med Chem Lett 9: 708-713 (2018) Article DOI: 10.1021/acsmedchemlett.8b00163 BindingDB Entry DOI: 10.7270/Q25M688J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM50367253 (CHEMBL4167357) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Notre Dame Curated by ChEMBL | Assay Description Inhibition of APMA activated recombinant human full length MMP2 expressed in mouse cells using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substra... | ACS Med Chem Lett 9: 708-713 (2018) Article DOI: 10.1021/acsmedchemlett.8b00163 BindingDB Entry DOI: 10.7270/Q25M688J | |||||||||||
More data for this Ligand-Target Pair |