Compile Data Set for Download or QSAR

Found 73 hits Enz. Inhib. hit(s) with all data for entry = 50002614   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50207335 (CHEMBL3961834) Show SMILES Cn1c(Nc2c(F)cccc2Cl)nc2cc(C(=O)Nc3ccc(cc3)C(F)(F)F)c3OC(C)(C)Cc3c12 Show InChI InChI=1S/C26H21ClF4N4O2/c1-25(2)12-16-21-19(33-24(35(21)3)34-20-17(27)5-4-6-18(20)28)11-15(22(16)37-25)23(36)32-14-9-7-13(8-10-14)26(29,30)31/h4-11H,12H2,1-3H3,(H,32,36)(H,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta-induced PGE2 production preincubated for 30 mins followed by incubation wi...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460529 (CHEMBL4228804) Show SMILES CC1(C)Cc2c(O1)c(cc1nc(Nc3c(F)cccc3Cl)[nH]c21)C(=O)Nc1cc(ccc1F)C(F)(F)F Show InChI InChI=1S/C25H18ClF5N4O2/c1-24(2)10-13-19-18(33-23(34-19)35-20-14(26)4-3-5-16(20)28)9-12(21(13)37-24)22(36)32-17-8-11(25(29,30)31)6-7-15(17)27/h3-9H,10H2,1-2H3,(H,32,36)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460527 (CHEMBL4228430) Show SMILES Cn1c(Nc2c(F)cccc2Cl)nc2cc(C(=O)Nc3cccc(c3)C(F)(F)F)c3OC(C)(C)Cc3c12 Show InChI InChI=1S/C26H21ClF4N4O2/c1-25(2)12-16-21-19(33-24(35(21)3)34-20-17(27)8-5-9-18(20)28)11-15(22(16)37-25)23(36)32-14-7-4-6-13(10-14)26(29,30)31/h4-11H,12H2,1-3H3,(H,32,36)(H,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta-induced PGE2 production preincubated for 30 mins followed by incubation wi...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460540 (CHEMBL4227388) Show SMILES Cc1ccc(NC(=O)c2cc3nc(Nc4c(F)cccc4Cl)n(C)c3c3CC(C)(C)Oc23)c(F)c1 Show InChI InChI=1S/C26H23ClF2N4O2/c1-13-8-9-19(18(29)10-13)30-24(34)14-11-20-22(15-12-26(2,3)35-23(14)15)33(4)25(31-20)32-21-16(27)6-5-7-17(21)28/h5-11H,12H2,1-4H3,(H,30,34)(H,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460542 (CHEMBL4227545) Show SMILES CC1(C)Cc2c(O1)c(cc1nc(Nc3c(F)cccc3Cl)[nH]c21)C(=O)Nc1ccc(cc1F)C(F)(F)F Show InChI InChI=1S/C25H18ClF5N4O2/c1-24(2)10-13-19-18(33-23(34-19)35-20-14(26)4-3-5-15(20)27)9-12(21(13)37-24)22(36)32-17-7-6-11(8-16(17)28)25(29,30)31/h3-9H,10H2,1-2H3,(H,32,36)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460537 (CHEMBL4226536) Show SMILES CC1(C)Cc2c(O1)c(cc1nc(Nc3c(Cl)cccc3Cl)[nH]c21)C(=O)Nc1cc(ccc1F)C1CC1 Show InChI InChI=1S/C27H23Cl2FN4O2/c1-27(2)12-16-22-21(32-26(33-22)34-23-17(28)4-3-5-18(23)29)11-15(24(16)36-27)25(35)31-20-10-14(13-6-7-13)8-9-19(20)30/h3-5,8-11,13H,6-7,12H2,1-2H3,(H,31,35)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50207335 (CHEMBL3961834) Show SMILES Cn1c(Nc2c(F)cccc2Cl)nc2cc(C(=O)Nc3ccc(cc3)C(F)(F)F)c3OC(C)(C)Cc3c12 Show InChI InChI=1S/C26H21ClF4N4O2/c1-25(2)12-16-21-19(33-24(35(21)3)34-20-17(27)5-4-6-18(20)28)11-15(22(16)37-25)23(36)32-14-9-7-13(8-10-14)26(29,30)31/h4-11H,12H2,1-3H3,(H,32,36)(H,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460531 (CHEMBL4226545) Show SMILES Cc1cccc(Cl)c1Nc1nc2cc(C(=O)Nc3cc(ccc3F)C(F)(F)F)c3OC(C)(C)Cc3c2[nH]1 Show InChI InChI=1S/C26H21ClF4N4O2/c1-12-5-4-6-16(27)20(12)34-24-33-19-10-14(22-15(21(19)35-24)11-25(2,3)37-22)23(36)32-18-9-13(26(29,30)31)7-8-17(18)28/h4-10H,11H2,1-3H3,(H,32,36)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460536 (CHEMBL4225183) Show SMILES CC1(C)Cc2c(O1)c(cc1nc(Nc3c(F)cccc3Cl)[nH]c21)C(=O)Nc1cc(ccc1F)C1CC1 Show InChI InChI=1S/C27H23ClF2N4O2/c1-27(2)12-16-22-21(32-26(33-22)34-23-17(28)4-3-5-19(23)30)11-15(24(16)36-27)25(35)31-20-10-14(13-6-7-13)8-9-18(20)29/h3-5,8-11,13H,6-7,12H2,1-2H3,(H,31,35)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460541 (CHEMBL4225710) Show SMILES Cn1c(Nc2c(F)cccc2Cl)nc2cc(C(=O)Nc3ccc(cn3)C(F)(F)F)c3OC(C)(C)Cc3c12 Show InChI InChI=1S/C25H20ClF4N5O2/c1-24(2)10-14-20-17(32-23(35(20)3)34-19-15(26)5-4-6-16(19)27)9-13(21(14)37-24)22(36)33-18-8-7-12(11-31-18)25(28,29)30/h4-9,11H,10H2,1-3H3,(H,32,34)(H,31,33,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta-induced PGE2 production preincubated for 30 mins followed by incubation wi...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460534 (CHEMBL4229061) Show SMILES CC1(C)Cc2c(O1)c(cc1nc(Nc3c(Cl)cccc3Cl)[nH]c21)C(=O)Nc1ccc(cn1)C(F)(F)F Show InChI InChI=1S/C24H18Cl2F3N5O2/c1-23(2)9-13-18-16(31-22(33-18)34-19-14(25)4-3-5-15(19)26)8-12(20(13)36-23)21(35)32-17-7-6-11(10-30-17)24(27,28)29/h3-8,10H,9H2,1-2H3,(H,30,32,35)(H2,31,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta-induced PGE2 production preincubated for 30 mins followed by incubation wi...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460539 (CHEMBL4225160) Show SMILES Cn1c(Nc2c(F)cccc2Cl)nc2cc(C(=O)Nc3ccc(cc3)C3CC3)c3OC(C)(C)Cc3c12 Show InChI InChI=1S/C28H26ClFN4O2/c1-28(2)14-19-24-22(32-27(34(24)3)33-23-20(29)5-4-6-21(23)30)13-18(25(19)36-28)26(35)31-17-11-9-16(10-12-17)15-7-8-15/h4-6,9-13,15H,7-8,14H2,1-3H3,(H,31,35)(H,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460539 (CHEMBL4225160) Show SMILES Cn1c(Nc2c(F)cccc2Cl)nc2cc(C(=O)Nc3ccc(cc3)C3CC3)c3OC(C)(C)Cc3c12 Show InChI InChI=1S/C28H26ClFN4O2/c1-28(2)14-19-24-22(32-27(34(24)3)33-23-20(29)5-4-6-21(23)30)13-18(25(19)36-28)26(35)31-17-11-9-16(10-12-17)15-7-8-15/h4-6,9-13,15H,7-8,14H2,1-3H3,(H,31,35)(H,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460533 (CHEMBL4225008) Show SMILES CC1(C)Cc2c(O1)c(cc1nc(Nc3c(Cl)cccc3Cl)[nH]c21)C(=O)Nc1ccccc1C(F)(F)F Show InChI InChI=1S/C25H19Cl2F3N4O2/c1-24(2)11-13-19-18(32-23(33-19)34-20-15(26)7-5-8-16(20)27)10-12(21(13)36-24)22(35)31-17-9-4-3-6-14(17)25(28,29)30/h3-10H,11H2,1-2H3,(H,31,35)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460528 (CHEMBL4224969) Show SMILES CC1(C)Cc2c(O1)c(cc1nc(Nc3c(F)cccc3Cl)[nH]c21)C(=O)Nc1ccc(F)c(c1)C(F)(F)F Show InChI InChI=1S/C25H18ClF5N4O2/c1-24(2)10-13-19-18(33-23(34-19)35-20-15(26)4-3-5-17(20)28)9-12(21(13)37-24)22(36)32-11-6-7-16(27)14(8-11)25(29,30)31/h3-9H,10H2,1-2H3,(H,32,36)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460526 (CHEMBL4224733) Show SMILES CC1(C)Cc2c(O1)c(cc1nc(Nc3c(F)cccc3Cl)[nH]c21)C(=O)Nc1ccccc1C(F)(F)F Show InChI InChI=1S/C25H19ClF4N4O2/c1-24(2)11-13-19-18(32-23(33-19)34-20-15(26)7-5-8-16(20)27)10-12(21(13)36-24)22(35)31-17-9-4-3-6-14(17)25(28,29)30/h3-10H,11H2,1-2H3,(H,31,35)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460533 (CHEMBL4225008) Show SMILES CC1(C)Cc2c(O1)c(cc1nc(Nc3c(Cl)cccc3Cl)[nH]c21)C(=O)Nc1ccccc1C(F)(F)F Show InChI InChI=1S/C25H19Cl2F3N4O2/c1-24(2)11-13-19-18(32-23(33-19)34-20-15(26)7-5-8-16(20)27)10-12(21(13)36-24)22(35)31-17-9-4-3-6-14(17)25(28,29)30/h3-10H,11H2,1-2H3,(H,31,35)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460543 (CHEMBL4226526) Show SMILES Cc1cccc(Cl)c1Nc1nc2cc(C(=O)Nc3ccc(F)c(c3)C(F)(F)F)c3OC(C)(C)Cc3c2[nH]1 Show InChI InChI=1S/C26H21ClF4N4O2/c1-12-5-4-6-17(27)20(12)34-24-33-19-10-14(22-15(21(19)35-24)11-25(2,3)37-22)23(36)32-13-7-8-18(28)16(9-13)26(29,30)31/h4-10H,11H2,1-3H3,(H,32,36)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460527 (CHEMBL4228430) Show SMILES Cn1c(Nc2c(F)cccc2Cl)nc2cc(C(=O)Nc3cccc(c3)C(F)(F)F)c3OC(C)(C)Cc3c12 Show InChI InChI=1S/C26H21ClF4N4O2/c1-25(2)12-16-21-19(33-24(35(21)3)34-20-17(27)8-5-9-18(20)28)11-15(22(16)37-25)23(36)32-14-7-4-6-13(10-14)26(29,30)31/h4-11H,12H2,1-3H3,(H,32,36)(H,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460546 (CHEMBL4227610) Show SMILES Cc1cc(ccc1NC(=O)c1cc2nc(Nc3c(F)cccc3Cl)[nH]c2c2CC(C)(C)Oc12)C(F)(F)F Show InChI InChI=1S/C26H21ClF4N4O2/c1-12-9-13(26(29,30)31)7-8-18(12)32-23(36)14-10-19-20(15-11-25(2,3)37-22(14)15)34-24(33-19)35-21-16(27)5-4-6-17(21)28/h4-10H,11H2,1-3H3,(H,32,36)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta-induced PGE2 production preincubated for 30 mins followed by incubation wi...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460536 (CHEMBL4225183) Show SMILES CC1(C)Cc2c(O1)c(cc1nc(Nc3c(F)cccc3Cl)[nH]c21)C(=O)Nc1cc(ccc1F)C1CC1 Show InChI InChI=1S/C27H23ClF2N4O2/c1-27(2)12-16-22-21(32-26(33-22)34-23-17(28)4-3-5-19(23)30)11-15(24(16)36-27)25(35)31-20-10-14(13-6-7-13)8-9-18(20)29/h3-5,8-11,13H,6-7,12H2,1-2H3,(H,31,35)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta-induced PGE2 production preincubated for 30 mins followed by incubation wi...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460546 (CHEMBL4227610) Show SMILES Cc1cc(ccc1NC(=O)c1cc2nc(Nc3c(F)cccc3Cl)[nH]c2c2CC(C)(C)Oc12)C(F)(F)F Show InChI InChI=1S/C26H21ClF4N4O2/c1-12-9-13(26(29,30)31)7-8-18(12)32-23(36)14-10-19-20(15-11-25(2,3)37-22(14)15)34-24(33-19)35-21-16(27)5-4-6-17(21)28/h4-10H,11H2,1-3H3,(H,32,36)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460535 (CHEMBL4226379) Show SMILES CC1(C)Cc2c(O1)c(cc1nc(Nc3c(F)cccc3Cl)[nH]c21)C(=O)Nc1cc(ccc1F)C(F)F Show InChI InChI=1S/C25H19ClF4N4O2/c1-25(2)10-13-19-18(32-24(33-19)34-20-14(26)4-3-5-16(20)28)9-12(21(13)36-25)23(35)31-17-8-11(22(29)30)6-7-15(17)27/h3-9,22H,10H2,1-2H3,(H,31,35)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460545 (CHEMBL4226878) Show SMILES CC1(C)Cc2c(O1)c(cc1nc(Nc3c(Cl)cccc3Cl)[nH]c21)C(=O)Nc1c(F)cccc1F Show InChI InChI=1S/C24H18Cl2F2N4O2/c1-24(2)10-12-18-17(29-23(31-18)32-19-13(25)5-3-6-14(19)26)9-11(21(12)34-24)22(33)30-20-15(27)7-4-8-16(20)28/h3-9H,10H2,1-2H3,(H,30,33)(H2,29,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.40	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460534 (CHEMBL4229061) Show SMILES CC1(C)Cc2c(O1)c(cc1nc(Nc3c(Cl)cccc3Cl)[nH]c21)C(=O)Nc1ccc(cn1)C(F)(F)F Show InChI InChI=1S/C24H18Cl2F3N5O2/c1-23(2)9-13-18-16(31-22(33-18)34-19-14(25)4-3-5-15(19)26)8-12(20(13)36-23)21(35)32-17-7-6-11(10-30-17)24(27,28)29/h3-8,10H,9H2,1-2H3,(H,30,32,35)(H2,31,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.40	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460535 (CHEMBL4226379) Show SMILES CC1(C)Cc2c(O1)c(cc1nc(Nc3c(F)cccc3Cl)[nH]c21)C(=O)Nc1cc(ccc1F)C(F)F Show InChI InChI=1S/C25H19ClF4N4O2/c1-25(2)10-13-19-18(32-24(33-19)34-20-14(26)4-3-5-16(20)28)9-12(21(13)36-25)23(35)31-17-8-11(22(29)30)6-7-15(17)27/h3-9,22H,10H2,1-2H3,(H,31,35)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.20	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460542 (CHEMBL4227545) Show SMILES CC1(C)Cc2c(O1)c(cc1nc(Nc3c(F)cccc3Cl)[nH]c21)C(=O)Nc1ccc(cc1F)C(F)(F)F Show InChI InChI=1S/C25H18ClF5N4O2/c1-24(2)10-13-19-18(33-23(34-19)35-20-14(26)4-3-5-15(20)27)9-12(21(13)37-24)22(36)32-17-7-6-11(8-16(17)28)25(29,30)31/h3-9H,10H2,1-2H3,(H,32,36)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.60	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460529 (CHEMBL4228804) Show SMILES CC1(C)Cc2c(O1)c(cc1nc(Nc3c(F)cccc3Cl)[nH]c21)C(=O)Nc1cc(ccc1F)C(F)(F)F Show InChI InChI=1S/C25H18ClF5N4O2/c1-24(2)10-13-19-18(33-23(34-19)35-20-14(26)4-3-5-16(20)28)9-12(21(13)37-24)22(36)32-17-8-11(25(29,30)31)6-7-15(17)27/h3-9H,10H2,1-2H3,(H,32,36)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.60	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460526 (CHEMBL4224733) Show SMILES CC1(C)Cc2c(O1)c(cc1nc(Nc3c(F)cccc3Cl)[nH]c21)C(=O)Nc1ccccc1C(F)(F)F Show InChI InChI=1S/C25H19ClF4N4O2/c1-24(2)11-13-19-18(32-23(33-19)34-20-15(26)7-5-8-16(20)27)10-12(21(13)36-24)22(35)31-17-9-4-3-6-14(17)25(28,29)30/h3-10H,11H2,1-2H3,(H,31,35)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.70	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta-induced PGE2 production preincubated for 30 mins followed by incubation wi...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460538 (CHEMBL4224767) Show SMILES Cc1cccc(Cl)c1Nc1nc2cc(C(=O)Nc3cc(ccc3F)C3CC3)c3OC(C)(C)Cc3c2[nH]1 Show InChI InChI=1S/C28H26ClFN4O2/c1-14-5-4-6-19(29)23(14)33-27-32-22-12-17(25-18(24(22)34-27)13-28(2,3)36-25)26(35)31-21-11-16(15-7-8-15)9-10-20(21)30/h4-6,9-12,15H,7-8,13H2,1-3H3,(H,31,35)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460543 (CHEMBL4226526) Show SMILES Cc1cccc(Cl)c1Nc1nc2cc(C(=O)Nc3ccc(F)c(c3)C(F)(F)F)c3OC(C)(C)Cc3c2[nH]1 Show InChI InChI=1S/C26H21ClF4N4O2/c1-12-5-4-6-17(27)20(12)34-24-33-19-10-14(22-15(21(19)35-24)11-25(2,3)37-22)23(36)32-13-7-8-18(28)16(9-13)26(29,30)31/h4-10H,11H2,1-3H3,(H,32,36)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta-induced PGE2 production preincubated for 30 mins followed by incubation wi...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460547 (CHEMBL4226413) Show SMILES Cc1cccc(Cl)c1Nc1nc2cc(C(=O)Nc3cc(ccc3F)C(F)F)c3OC(C)(C)Cc3c2[nH]1 Show InChI InChI=1S/C26H22ClF3N4O2/c1-12-5-4-6-16(27)20(12)33-25-32-19-10-14(22-15(21(19)34-25)11-26(2,3)36-22)24(35)31-18-9-13(23(29)30)7-8-17(18)28/h4-10,23H,11H2,1-3H3,(H,31,35)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460532 (CHEMBL4225834) Show SMILES Cc1cccc(Cl)c1Nc1nc2cc(C(=O)Nc3ccc(cc3)C(F)(F)F)c3OC(C)(C)Cc3c2[nH]1 Show InChI InChI=1S/C26H22ClF3N4O2/c1-13-5-4-6-18(27)20(13)33-24-32-19-11-16(22-17(21(19)34-24)12-25(2,3)36-22)23(35)31-15-9-7-14(8-10-15)26(28,29)30/h4-11H,12H2,1-3H3,(H,31,35)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta-induced PGE2 production preincubated for 30 mins followed by incubation wi...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460541 (CHEMBL4225710) Show SMILES Cn1c(Nc2c(F)cccc2Cl)nc2cc(C(=O)Nc3ccc(cn3)C(F)(F)F)c3OC(C)(C)Cc3c12 Show InChI InChI=1S/C25H20ClF4N5O2/c1-24(2)10-14-20-17(32-23(35(20)3)34-19-15(26)5-4-6-16(19)27)9-13(21(14)37-24)22(36)33-18-8-7-12(11-31-18)25(28,29)30/h4-9,11H,10H2,1-3H3,(H,32,34)(H,31,33,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460528 (CHEMBL4224969) Show SMILES CC1(C)Cc2c(O1)c(cc1nc(Nc3c(F)cccc3Cl)[nH]c21)C(=O)Nc1ccc(F)c(c1)C(F)(F)F Show InChI InChI=1S/C25H18ClF5N4O2/c1-24(2)10-13-19-18(33-23(34-19)35-20-15(26)4-3-5-17(20)28)9-12(21(13)37-24)22(36)32-11-6-7-16(27)14(8-11)25(29,30)31/h3-9H,10H2,1-2H3,(H,32,36)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460530 (CHEMBL4228221) Show SMILES CC1(C)Cc2c(O1)c(cc1nc(Nc3c(F)cccc3Cl)[nH]c21)C(=O)Nc1ccc(cn1)C(F)(F)F Show InChI InChI=1S/C24H18ClF4N5O2/c1-23(2)9-13-18-16(31-22(33-18)34-19-14(25)4-3-5-15(19)26)8-12(20(13)36-23)21(35)32-17-7-6-11(10-30-17)24(27,28)29/h3-8,10H,9H2,1-2H3,(H,30,32,35)(H2,31,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460532 (CHEMBL4225834) Show SMILES Cc1cccc(Cl)c1Nc1nc2cc(C(=O)Nc3ccc(cc3)C(F)(F)F)c3OC(C)(C)Cc3c2[nH]1 Show InChI InChI=1S/C26H22ClF3N4O2/c1-13-5-4-6-18(27)20(13)33-24-32-19-11-16(22-17(21(19)34-24)12-25(2,3)36-22)23(35)31-15-9-7-14(8-10-15)26(28,29)30/h4-11H,12H2,1-3H3,(H,31,35)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460545 (CHEMBL4226878) Show SMILES CC1(C)Cc2c(O1)c(cc1nc(Nc3c(Cl)cccc3Cl)[nH]c21)C(=O)Nc1c(F)cccc1F Show InChI InChI=1S/C24H18Cl2F2N4O2/c1-24(2)10-12-18-17(29-23(31-18)32-19-13(25)5-3-6-14(19)26)9-11(21(12)34-24)22(33)30-20-15(27)7-4-8-16(20)28/h3-9H,10H2,1-2H3,(H,30,33)(H2,29,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta-induced PGE2 production preincubated for 30 mins followed by incubation wi...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460540 (CHEMBL4227388) Show SMILES Cc1ccc(NC(=O)c2cc3nc(Nc4c(F)cccc4Cl)n(C)c3c3CC(C)(C)Oc23)c(F)c1 Show InChI InChI=1S/C26H23ClF2N4O2/c1-13-8-9-19(18(29)10-13)30-24(34)14-11-20-22(15-12-26(2,3)35-23(14)15)33(4)25(31-20)32-21-16(27)6-5-7-17(21)28/h5-11H,12H2,1-4H3,(H,30,34)(H,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460537 (CHEMBL4226536) Show SMILES CC1(C)Cc2c(O1)c(cc1nc(Nc3c(Cl)cccc3Cl)[nH]c21)C(=O)Nc1cc(ccc1F)C1CC1 Show InChI InChI=1S/C27H23Cl2FN4O2/c1-27(2)12-16-22-21(32-26(33-22)34-23-17(28)4-3-5-18(23)29)11-15(24(16)36-27)25(35)31-20-10-14(13-6-7-13)8-9-19(20)30/h3-5,8-11,13H,6-7,12H2,1-2H3,(H,31,35)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460530 (CHEMBL4228221) Show SMILES CC1(C)Cc2c(O1)c(cc1nc(Nc3c(F)cccc3Cl)[nH]c21)C(=O)Nc1ccc(cn1)C(F)(F)F Show InChI InChI=1S/C24H18ClF4N5O2/c1-23(2)9-13-18-16(31-22(33-18)34-19-14(25)4-3-5-15(19)26)8-12(20(13)36-23)21(35)32-17-7-6-11(10-30-17)24(27,28)29/h3-8,10H,9H2,1-2H3,(H,30,32,35)(H2,31,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460544 (CHEMBL4227894) Show SMILES Cc1cccc(Cl)c1Nc1nc2cc(C(=O)Nc3ccc(cn3)C(F)(F)F)c3OC(C)(C)Cc3c2[nH]1 Show InChI InChI=1S/C25H21ClF3N5O2/c1-12-5-4-6-16(26)19(12)33-23-31-17-9-14(21-15(20(17)34-23)10-24(2,3)36-21)22(35)32-18-8-7-13(11-30-18)25(27,28)29/h4-9,11H,10H2,1-3H3,(H,30,32,35)(H2,31,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta-induced PGE2 production preincubated for 30 mins followed by incubation wi...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460531 (CHEMBL4226545) Show SMILES Cc1cccc(Cl)c1Nc1nc2cc(C(=O)Nc3cc(ccc3F)C(F)(F)F)c3OC(C)(C)Cc3c2[nH]1 Show InChI InChI=1S/C26H21ClF4N4O2/c1-12-5-4-6-16(27)20(12)34-24-33-19-10-14(22-15(21(19)35-24)11-25(2,3)37-22)23(36)32-18-9-13(26(29,30)31)7-8-17(18)28/h4-10H,11H2,1-3H3,(H,32,36)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460544 (CHEMBL4227894) Show SMILES Cc1cccc(Cl)c1Nc1nc2cc(C(=O)Nc3ccc(cn3)C(F)(F)F)c3OC(C)(C)Cc3c2[nH]1 Show InChI InChI=1S/C25H21ClF3N5O2/c1-12-5-4-6-16(26)19(12)33-23-31-17-9-14(21-15(20(17)34-23)10-24(2,3)36-21)22(35)32-18-8-7-13(11-30-18)25(27,28)29/h4-9,11H,10H2,1-3H3,(H,30,32,35)(H2,31,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of recombinant human mPGES1 expressed in CHO cells assessed as reduction in PGE2 production using PGH2 as substrate incubated for 10 mins ...				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460547 (CHEMBL4226413) Show SMILES Cc1cccc(Cl)c1Nc1nc2cc(C(=O)Nc3cc(ccc3F)C(F)F)c3OC(C)(C)Cc3c2[nH]1 Show InChI InChI=1S/C26H22ClF3N4O2/c1-12-5-4-6-16(27)20(12)33-25-32-19-10-14(22-15(21(19)34-25)11-26(2,3)36-22)24(35)31-18-9-13(23(29)30)7-8-17(18)28/h4-10,23H,11H2,1-3H3,(H,31,35)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	162	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of mPGES1 in human whole blood assessed as reduction in LPS-induced PGE2 production measured after 20 to 24 hrs				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460540 (CHEMBL4227388) Show SMILES Cc1ccc(NC(=O)c2cc3nc(Nc4c(F)cccc4Cl)n(C)c3c3CC(C)(C)Oc23)c(F)c1 Show InChI InChI=1S/C26H23ClF2N4O2/c1-13-8-9-19(18(29)10-13)30-24(34)14-11-20-22(15-12-26(2,3)35-23(14)15)33(4)25(31-20)32-21-16(27)6-5-7-17(21)28/h5-11H,12H2,1-4H3,(H,30,34)(H,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	177	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of mPGES1 in human whole blood assessed as reduction in LPS-induced PGE2 production measured after 20 to 24 hrs				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460537 (CHEMBL4226536) Show SMILES CC1(C)Cc2c(O1)c(cc1nc(Nc3c(Cl)cccc3Cl)[nH]c21)C(=O)Nc1cc(ccc1F)C1CC1 Show InChI InChI=1S/C27H23Cl2FN4O2/c1-27(2)12-16-22-21(32-26(33-22)34-23-17(28)4-3-5-18(23)29)11-15(24(16)36-27)25(35)31-20-10-14(13-6-7-13)8-9-19(20)30/h3-5,8-11,13H,6-7,12H2,1-2H3,(H,31,35)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	197	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of mPGES1 in human whole blood assessed as reduction in LPS-induced PGE2 production measured after 20 to 24 hrs				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460528 (CHEMBL4224969) Show SMILES CC1(C)Cc2c(O1)c(cc1nc(Nc3c(F)cccc3Cl)[nH]c21)C(=O)Nc1ccc(F)c(c1)C(F)(F)F Show InChI InChI=1S/C25H18ClF5N4O2/c1-24(2)10-13-19-18(33-23(34-19)35-20-15(26)4-3-5-17(20)28)9-12(21(13)37-24)22(36)32-11-6-7-16(27)14(8-11)25(29,30)31/h3-9H,10H2,1-2H3,(H,32,36)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	208	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of mPGES1 in human whole blood assessed as reduction in LPS-induced PGE2 production measured after 20 to 24 hrs				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460531 (CHEMBL4226545) Show SMILES Cc1cccc(Cl)c1Nc1nc2cc(C(=O)Nc3cc(ccc3F)C(F)(F)F)c3OC(C)(C)Cc3c2[nH]1 Show InChI InChI=1S/C26H21ClF4N4O2/c1-12-5-4-6-16(27)20(12)34-24-33-19-10-14(22-15(21(19)35-24)11-25(2,3)37-22)23(36)32-18-9-13(26(29,30)31)7-8-17(18)28/h4-10H,11H2,1-3H3,(H,32,36)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	222	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of mPGES1 in human whole blood assessed as reduction in LPS-induced PGE2 production measured after 20 to 24 hrs				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50460529 (CHEMBL4228804) Show SMILES CC1(C)Cc2c(O1)c(cc1nc(Nc3c(F)cccc3Cl)[nH]c21)C(=O)Nc1cc(ccc1F)C(F)(F)F Show InChI InChI=1S/C25H18ClF5N4O2/c1-24(2)10-13-19-18(33-23(34-19)35-20-14(26)4-3-5-16(20)28)9-12(21(13)37-24)22(36)32-17-8-11(25(29,30)31)6-7-15(17)27/h3-9H,10H2,1-2H3,(H,32,36)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	256	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of mPGES1 in human whole blood assessed as reduction in LPS-induced PGE2 production measured after 20 to 24 hrs				Bioorg Med Chem Lett 28: 1211-1218 (2018) Article DOI: 10.1016/j.bmcl.2018.02.048 BindingDB Entry DOI: 10.7270/Q2N300K5
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 73 total )  |  Next  |  Last  >>

Jump to: